Motohide Ichino - My portal

Profile Information

Affiliation: 助教, 医学教育センター

Degree: 博士（医学）(聖マリアンナ医科大学)

Other name(s) (e.g. nickname): motoichino
J-GLOBAL ID: 201201098011740719
researchmap Member ID: 7000000549

External link: http://www-user.yokohama-cu.ac.jp/~immunol/

研究では、慢性骨髄性白血病（CML）における血球系細胞分化不全と転写因子IRF8の関わりについて研究を進めています。また、感染症（マラリア）による血球系細胞分化（とくに樹状細胞）と免疫抑制との関わりにも興味をもっています。教育では、免疫学や基礎生物学の基礎医学教育に力を注いでいます。能動的学習法としてのPBL・TBLを積極的に講義に取り入れています。

Research Interests

Research Areas

Research History

Apr, 2012 - Present

助教（免疫学教室助教兼任）, 医学教育センター
Apr, 2007 - Present

助教, 横浜市立大学医学部免疫学教室
Apr, 1999 - Mar, 2007

助手, 横浜市立大学医学部寄生虫学講座
Sep, 1996 - Mar, 1999

Fogarty Fellow, Food and Drug Administration (FDA)
Oct, 1994 - Aug, 1998

助手, 聖マリアンナ医科大学医学部免疫学・病害動物学講座

Education

Apr, 1989 - Mar, 1992

東京大学大学院理学系研究科博士課程動物学専攻
Apr, 1987 - Mar, 1989

Graduate School of Science, The University of Tokyo
- 1987

Department of Biological Sciences, Faculty of Science, The University of Tokyo

Awards

Dec, 2004

医学教育奨励賞, 財団法人横浜総合医学振興財団

市野素英

Papers

Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity

Tatsuma Ban, Go R. Sato, Akira Nishiyama, Ai Akiyama, Marie Takasuna, Marina Umehara, Shinsuke Suzuki, Motohide Ichino, Satoko Matsunaga, Ayuko Kimura …

IMMUNITY, 45(2) 319-332, Aug, 2016 Peer-reviewed
Apoptosis of antigen-specific CTLs contributes to low immune response in gut-associated lymphoid tissue post vaccination

Masaru Shimada, Shinji Yoshizaki, Motohide Ichino, Dennis M. Klinman, Kenji Okuda

VACCINE, 32(40) 5198-5205, Sep, 2014 Peer-reviewed
Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, NakaIRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophilszawa M, Ozato K, Tamura T

Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A …

Nat Commun, 5 4978-4992, Sep, 2014 Peer-reviewed
Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development

Michio Yamamoto, Takayuki Kato, Chie Hotta, Akira Nishiyama, Daisuke Kurotaki, Masahiro Yoshinari, Masamichi Takami, Motohide Ichino, Masatoshi Nakazawa, Toshifumi Matsuyama …

PLOS ONE, 6(10) e25812, Oct, 2011 Peer-reviewed
Aberrant differentiation of dendritic cells in malaria infection

Tamura T, Ichino M

The Waksman Foundation of Japan Inc. Report of Researches in 2010, 21-27, 2011
DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity

Masaru Shimada, Shinji Yoshizaki, Nao Jounai, Asami Kondo, Motohide Ichino, Akihide Ryo, Kenji Okuda

VACCINE, 28(31) 4920-4927, Jul, 2010 Peer-reviewed
Partial protection against SIV challenge by vaccination of adenovirus and MVA vectors in rhesus monkeys

H-B Wang, A. Kondo, A. Yoshida, S. Yoshizaki, S. Abe, L-L Bao, N. Mizuki, M. Ichino, D. Klinman, K. Okuda …

GENE THERAPY, 17(1) 4-13, Jan, 2010 Peer-reviewed
Chimeric adenovirus 5/35 vector containing the clade CHIV gag gene induces a cross-reactive immune response against HIV

Ke-Qin Xin, Yuka Sekimoto, Toru Takahashi, Hiroyuki Mizuguchi, Motohide Ichino, Atsushi Yoshida, Kenji Okuda

VACCINE, 25(19) 3809-3815, May, 2007 Peer-reviewed
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells

Ke-Qin Xin, Hiroaki Mizukami, Masashi Urabe, Yoshihiko Toda, Kaori Shinoda, Atsushi Yoshida, Kenji Oomura, Yoshitsugu Kojima, Motohide Ichino, Dennis Klinman …

JOURNAL OF VIROLOGY, 80(24) 11899-11910, Dec, 2006 Peer-reviewed
Hyperproduction of IFN-gamma by CpG oligodeoxynucleotide-induced exacerbation of atopic dermatitis-like skin lesion in some NC/Nga mice

M Takakura, F Takeshita, M Aihara, KQ Xin, M Ichino, K Okuda, Z Ikezawa

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 125(6) 1156-1162, Dec, 2005 Peer-reviewed
A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria-tetanus-pertussis vaccine

T Sugai, M Mori, M Nakazawa, M Ichino, T Naruto, N Kobayashi, Y Kobayashi, M Minami, S Yokota

VACCINE, 23(46-47) 5450-5456, Nov, 2005 Peer-reviewed
CpG oligodeoxynucleotides prevent the development of scleroderma-like syndrome in tight-skin mice by stimulating a Th1 immune response

Y Shen, M Ichino, M Nakazawa, M Minami

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 124(6) 1141-1148, Jun, 2005 Peer-reviewed
Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma

Y Shen, M Ichino, M Nakazawa, T Ikejima, Y Kojima, K Okuda, M Minami

JOURNAL OF AUTOIMMUNITY, 24(3) 183-190, May, 2005 Peer-reviewed
Factors associated with the development of neonatal tolerance after the administration of a plasmid DNA vaccine

M Ichino, G Mor, J Conover, WR Weiss, M Takeno, KJ Ishii, DM Klinman

JOURNAL OF IMMUNOLOGY, 162(7) 3814-3818, Apr, 1999 Peer-reviewed
Activity and safety of DNA plasmids encoding IL-4 and IFN gamma

KJ Ishii, WR Weiss, M Ichino, D Verthelyi, DM Klinman

GENE THERAPY, 6(2) 237-244, Feb, 1999 Peer-reviewed
A plasmid encoding murine granulocyte-macrophage colony stimulating factor increases protection conferred by a malaria DNA vaccine

Weiss WR, Ishii KJ, Hedstrom RC, Sedegah M, Ichino M, Barnhart K, Klinman DM, Hoffman SL

J Immunol, 161(5) 2325-2332, Sep, 1998 Peer-reviewed
Inhibition of Fas/Fas ligand-mediated apoptotic cell death of lymphocytes in vitro by circulating anti-Fas ligand autoantibodies in patients with systemic lupus erythematosus

N Suzuki, M Ichino, S Mihara, S Kaneko, T Sakane

ARTHRITIS AND RHEUMATISM, 41(2) 344-353, Feb, 1998 Peer-reviewed
Mechanisms of KE298, 2-acetylthiomethyl-3-(4-methylbenzoyl) propionic acid, to suppress abnormal synovial cell functions in patients with rheumatoid arthritis

T Sakane, N Suzuki, Y Hirose, K Miura, S Wakisaka, H Nagafuchi, M Ichino, T Tomita, H Hashimoto, T Ochi …

JOURNAL OF RHEUMATOLOGY, 24(11) 2213-2220, Nov, 1997 Peer-reviewed
In vivo mechanisms for the inhibition of T lymphocyte activation by long-term therapy with tacrolimus (FK-506) - Experience in patients with Behcet's disease

N Suzuki, S Kaneko, M Ichino, S Mihara, S Wakisaka, T Sakane

ARTHRITIS AND RHEUMATISM, 40(6) 1157-1167, Jun, 1997 Peer-reviewed
DNA vaccines: safety and efficacy issues

Klinman DM, Takeno M, Ichino M, Gu M, Yamshchikov G, Mor G, Conover J

Springer Semin Immunopathol, 19(2) 245-256, Feb, 1997 Peer-reviewed

Teaching Experience

Professional Memberships

Research Projects

転写因子IRF8の発現抑制を介したマラリアによる樹状細胞分化阻害メカニズムの解明

科学研究費補助金(基盤研究(C)), 日本学術振興会, 2016 - 2018

市野素英
Aberrant differentiation of dendritic cells in malaria infection associated with decreased expression of IRF4/IRF8

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

ICHINO Motohide, TAMURA Tomohiko, NISHIYAMA Akira, HOTTA Chie
The study of treatment of Tsk/+mouse with immunological methods

Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C), Ministry of Education, Culture, Sports, Science and Technology, 2003 - 2004

Masatoshi NAKAZAWA, 南陸彦, 市野素英
Curative effects of CpG DNA administration on scleroderma-like syndrome of Tsk/+mice

Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C), Ministry of Education, Culture, Sports, Science and Technology, 2001 - 2002

Motohide ICHINO, 中澤正年
マラリア原虫による免疫抑制機構の解析

科学研究費補助金(特定領域研究(C)), 特定領域研究(C), 日本学術振興会, 2001 - 2001

市野素英, 南睦彦, 中澤正年
全身性エリテマトーデス(SLE)におけるFasLの発現と機能解析

科学研究費補助金(奨励研究(A)), 奨励研究(A), 日本学術振興会, 1996 - 1996

市野素英
気管支喘息の病態と抗原特異的T細胞機能の制御

科学研究費補助金(一般研究(C)), 一般研究(C), 日本学術振興会, 1995 - 1995

山下直美, 市野素英