土屋友房 (Tomofusa Tsuchiya) - マイポータル

基本情報

所属: 立命館大学総合科学技術研究機構創薬科学研究センター
: (兼任)理工学研究科
: (兼任)生命科学研究科

学位: 薬学博士(東京大学)

J-GLOBAL ID: 201301073167811521
researchmap会員ID: 7000006091

研究キーワード

多剤耐性菌、多剤排出ポンプ、MRSA、多剤耐性緑膿菌

研究分野

経歴

学歴

- 1968年3月

東京大学, 薬学部, 薬学科
- 1948年3月

東京大学大学院, 薬学系研究科

論文

Action mechanism of 6, 6 '-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities

Shinya Okamura, Eri Nishiyama, Tomohiro Yamazaki, Nao Otsuka, Shoko Taniguchi, Wakano Ogawa, Tsutomu Hatano, Tomofusa Tsuchiya, Teruo Kuroda

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850(6) 1245-1252 2015年6月
Characterization of MATE-Type Multidrug Efflux Pumps from Klebsiella pneumoniae MGH78578

Wakano Ogawa, Yusuke Minato, Hayata Dodan, Motoyasu Onishi, Tomofusa Tsuchiya, Teruo Kuroda

PLOS ONE 10(3) 2015年3月
Overexpression of vmeTUV encoding a multidrug efflux transporter of Vibrio parahaemolyticus causes bile acid resistance

Taira Matsuo, Wakano Ogawa, Tomofusa Tsuchiya, Teruo Kuroda

GENE 541(1) 19-25 2014年5月
Suppression of stop codon UGA in acrB can contribute to antibiotic resistance in Klebsiella pneumoniae ATCC10031

Motoyasu Onishi, Minako Mizusawa, Tomofusa Tsuchiya, Teruo Kuroda, Wakano Ogawa

GENE 534(2) 313-319 2014年1月
Characterization of all RND-type multidrug efflux transporters in Vibrio parahaemolyticus

Taira Matsuo, Koji Nakamura, Toshio Kodama, Taro Mikami, Hirotaka Hiyoshi, Tomofusa Tsuchiya, Wakano Ogawa, Teruo Kuroda

MICROBIOLOGYOPEN 2(5) 725-742 2013年10月
Functionally Cloned pdrM from Streptococcus pneumoniae Encodes a Na+ Coupled Multidrug Efflux Pump

Kohei Hashimoto, Wakano Ogawa, Toshihiro Nishioka, Tomofusa Tsuchiya, Teruo Kuroda

PLOS ONE 8(3) 8:e59525. 2013年3月
Functional study of the novel multidrug efflux pump KexD from Klebsiella pneumoniae

Wakano Ogawa, Motoyasu Onishi, Ruiting Ni, Tomofusa Tsuchiya, Teruo Kuroda

GENE 498(2) 177-182 2012年5月
SugE, a New Member of the SMR Family of Transporters, Contributes to Antimicrobial Resistance in Enterobacter cloacae

Gui-Xin He, Chu Zhang, Robert R. Crow, Conner Thorpe, Huizhong Chen, Sanath Kumar, Tomofusa Tsuchiya, Manuel F. Varela

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 55(8) 3954-3957 2011年8月
Quercetin Diacylglycoside Analogues Showing Dual Inhibition of DNA Gyrase and Topoisomerase IV as Novel Antibacterial Agents

Abugafar M. L. Hossion, Yoshito Zamami, Rafiya K. Kandahary, Tomofusa Tsuchiya, Wakano Ogawa, Akimasa Iwado, Kenji Sasaki

JOURNAL OF MEDICINAL CHEMISTRY 54(11) 3686-3703 2011年6月
Patch clamp analysis of the respiratory chain in Bacillus subtilis

Koji Nakamura, Satoshi Ikeda, Taira Matsuo, Aiko Hirata, Masaya Takehara, Tetsuo Hiyama, Fujio Kawamura, Iwao Kusaka, Tomofusa Tsuchiya, Teruo Kuroda …

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808(4) 1103-1107 2011年4月
Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents

Abugafar M. L. Hossion, Nao Otsuka, Rafiya K. Kandahary, Tomofusa Tsuchiya, Wakano Ogawa, Akimasa Iwado, Yoshito Zamami, Kenji Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(17) 5349-5352 2010年9月
Gene cloning and characteristics of the RND-type multidrug efflux pump MuABC-OpmB possessing two RND components in Pseudomonas aeruginosa

Takehiko Mima, Naoki Kohira, Yang Li, Hiroshi Sekiya, Wakano Ogawa, Teruo Kuroda, Tomofusa Tsuchiya

MICROBIOLOGY-SGM 155 3509-3517 2009年11月
Modulation of Vibrio mimicus hemolysin through limited proteolysis by an endogenous metalloprotease

Tamaki Mizuno, Syed Z. Sultan, Yoshimi Kaneko, Tomonaga Yoshimura, Yoko Maehara, Hiroshi Nakao, Tomofusa Tsuchiya, Sumio Shinoda, Shin-ichi Miyoshi

FEBS JOURNAL 276(3) 825-834 2009年2月
Gene cloning and characterization of EfmA, a multidrug efflux pump, from Enterococcus faecium.

Nishioka, T, W. Ogawa, T. Kuroda, T. Katsu, T. Tsuchiya

Biol. Pharm. Bull. 32 483-488 2009年
Synergistic effect of kaempferol glycosides purified from Laurus nobilis and fluoroquinolones on methicillin-resistant Staphylococcus aureus.

Liu, M. H, N. Otsuka, K. Noyori, S. Shiota, W. Ogawa, T. Kuroda, T. Hatano, T. Tsuchiya

Biol. Pharm. Bull. 32 489-492 2009年
Enhancement of antibacterial effects of epigallocatechin gallate, using ascorbic acid

Tsutomu Hatano, Mayumi Tsugawa, Miwako Kusuda, Shoko Taniguchi, Takashi Yoshida, Sumiko Shiota, Tomofusa Tsuchiya

PHYTOCHEMISTRY 69(18) 3111-3116 2008年12月
Expression and function of TETRAN, a new type of membrane transporter

Hironori Ushijima, Miki Hiasa, Takushi Namba, Hyun-Jung Hwang, Tatsuya Hoshino, Shinji Mima, Tomofusa Tsuchiya, Yoshinori Moriyama, Tohru Mizushima

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 374(2) 325-330 2008年9月
Variation of extracellular proteases produced by Vibrio vulnificus clinical isolates: Genetic diversity of the metalloprotease gene (vvp), and serine protease secretion by vvp-negative strains

Jiyou Wang, Tomoko Sasaki, Yoko Maehara, Hiroshi Nakao, Tomofusa Tsuchiya, Shin-ichi Miyoshi

MICROBIAL PATHOGENESIS 44(6) 494-500 2008年6月
Properties and expression of a multidrug efflux pump AcrAB-KocC from Klebsiella pneumoniae.

Li, D-W, M. Ohishi, T.Kishino, T. Matsuo, W. Ogawa, T. Kuroda, T. Tsuchiya

Biol. Pharm. Bull. 31 577-582 2008年
Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis.

Otsuka, N, M. H. Liu, S. Shiota, W. Ogawa, T. Kuroda, T. Hatano, T. Tsuchiya

Biol. Pharm. Bull. 31 1794-1797 2008年

もっとみる

担当経験のある科目(授業)

所属学協会

日本薬学会、日本医療薬学会、日本細菌学会、日本化学療法学会

産業財産権

特開2014-148495 抗菌剤，及び抗菌活性増強剤