Mikiko Tada

Profile Information

Degree: 博士（医学）(横浜市立大学)

J-GLOBAL ID: 201401003948247523
researchmap Member ID: 7000006806

External link: http://www-user.yokohama-cu.ac.jp/~neuro/wp/

神経変性疾患および脳血管疾患の臨床および研究に携わっています。研究面では特に筋萎縮性側索硬化症の病態解明を目指し、神経病理の観点からの研究を行っています。

Research Interests

Research Areas

Life sciences / Neuroanatomy and physiology /

Research History

Awards

Apr, 2018

生命の彩, 公益信託「生命の彩」ALS研究助成基金

多田美紀子

Papers

Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice.

Takuya Ikeda, Keita Takahashi, Minatsu Higashi, Hiroyasu Komiya, Tetsuya Asano, Akihiro Ogasawara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Kenichi Tanaka …

Cell death discovery, 9(1) 454-454, Dec 14, 2023
RNA foci in two bi-allelic RFC1 expansion carriers.

Taishi Wada, Hiroshi Doi, Masaki Okubo, Mikiko Tada, Naohisa Ueda, Hidefumi Suzuki, Wakana Tominaga, Haruki Koike, Hiroyasu Komiya, Shun Kubota …

Annals of neurology, Dec 7, 2023
Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima …

Frontiers in Neurology, 13, Sep 27, 2022
Patients with biallelic GGC repeat expansions in NOTCH2NLC exhibiting a typical neuronal intranuclear inclusion disease phenotype.

Shinichi Kameyama, Takeshi Mizuguchi, Hiroshi Doi, Shigeru Koyano, Masaki Okubo, Mikiko Tada, Hiroshi Shimizu, Hiromi Fukuda, Naomi Tsuchida, Yuri Uchiyama …

Genomics, 114(5) 110469-110469, Aug 27, 2022
舞踏運動を主徴とし、抗リン脂質抗体と抗amphiphysin抗体が陽性であった69歳男性例

森下良志, 原田康平, 古宮裕泰, 橋口俊太, 田中健一, 多田美紀子, 土井宏, 田中章景

臨床神経学, 62(8) 676-676, Aug, 2022
舞踏運動を主徴とし、抗リン脂質抗体と抗amphiphysin抗体が陽性であった69歳男性例

森下良志, 原田康平, 古宮裕泰, 橋口俊太, 田中健一, 多田美紀子, 土井宏, 田中章景

臨床神経学, 62(8) 676-676, Aug, 2022
Anti-inflammatory effects of siponimod on astrocytes

Akihiro Ogasawara, Hideyuki Takeuchi, Hiroyasu Komiya, Yuki Ogawa, Koki Nishimura, Shun Kubota, Shunta Hashiguchi, Keita Takahashi, Misako Kunii, Kenichi Tanaka …

Neuroscience Research, Aug, 2022
Ocular flutter as the presenting manifestation of autoimmune glial fibrillary acidic protein astrocytopathy.

Taishi Wada, Yuichi Higashiyama, Misako Kunii, Takashi Jono, Takuo Kobayashi, Shun Kubota, Mikiko Tada, Makoto Hara, Akio Kimura, Hiroshi Doi …

Clinical neurology and neurosurgery, 219 107307-107307, Aug, 2022
Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice.

Tetsuya Asano, Haruko Nakamura, Yuko Kawamoto, Mikiko Tada, Yayoi Kimura, Hiroshi Takano, Ryoji Yao, Hiroya Saito, Takuya Ikeda, Hiroyasu Komiya …

eNeuro, 9(3), May 6, 2022
Parallel Appearance of Polyglutamine and Transactivation-Responsive DNA-Binding Protein 43 and Their Complementary Subcellular Localization in Brains of Patients With Spinocerebellar Ataxia Type 2.

Shigeru Koyano, Saburo Yagishita, Mikiko Tada, Hiroshi Doi, Toshiki Uchihara, Fumiaki Tanaka

Journal of neuropathology and experimental neurology, 81(7) 535-544, May 2, 2022
腋窩多汗症に対するボツリヌス毒素局注療法後に広範な筋無力症状を呈した50歳女性例

城野誉士, 東山雄一, 宮地洋輔, 窪田瞬, 國井美紗子, 多田美紀子, 竹内英之, 田中章景

臨床神経学, 62(4) 317-317, Apr, 2022
心筋症で発症した抗横紋筋抗体陽性重症筋無力症の67歳男性例

原田康平, 田中健一, 城野誉士, 宮地洋輔, 多田美紀子, 土井宏, 竹内英之, 田中章景

臨床神経学, 62(4) 329-329, Apr, 2022
神経フェリチン症の肺病変肺内フェリチン封入体と高度肺気腫を呈した1剖検報告

田中玲子, 澤住知枝, 木村活生, 多田美紀子, 土井宏, 千葉佐和子, 大谷方子, 上田直久, 田中章景, 稲山嘉明

診断病理, 39(2) 120-125, Apr, 2022
"COVID arm" detected by MR neurography.

Hiroyasu Komiya, Kohei Harada, Ryoji Morishita, Shunta Hashiguchi, Mikiko Tada, Kenichi Tanaka, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka

eNeurologicalSci, 25 100377-100377, Dec, 2021
SGTA associates with intracellular aggregates in neurodegenerative diseases.

Shun Kubota, Hiroshi Doi, Shigeru Koyano, Kenichi Tanaka, Hiroyasu Komiya, Atsuko Katsumoto, Shingo Ikeda, Shunta Hashiguchi, Haruko Nakamura, Ryoko Fukai …

Molecular brain, 14(1) 59-59, Mar 23, 2021
多発脳神経麻痺と左上肢の筋力低下を認め、腕神経叢生検により診断し得たNeurolymphomatosisの80歳男性例

小林卓雄, 東山雄一, 窪田瞬, 國井美紗子, 多田美紀子, 竹内英之, 田中章景

臨床神経学, 61(1) 67-67, Jan, 2021
The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK1.

Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Kensuke Daida, Aya Ikeda, Kotaro Ogaki, Atsuhito Fuse, Akio Mori, Masashi Takanashi, Toshiki Nakahara …

Neurobiology of aging, 97 146.e1-146.e13, Jan, 2021
Hepatitis B Virus-related Vasculitic Neuropathy in an Inactive Virus Carrier Treated with Intravenous Immunoglobulin.

Kaori Kusama, Yoshiharu Nakae, Mikiko Tada, Yuichi Higashiyama, Yosuke Miyaji, Genpei Yamaura, Misako Kunii, Kenichi Tanaka, Ken Ohyama, Haruki Koike …

Internal medicine (Tokyo, Japan), 59(23) 3075-3078, Dec 1, 2020
ALSモデルマウスの病勢進行に伴ったCCR2の中枢神経における細胞局在変化

古宮裕泰, 竹内英之, 小川有紀, 高橋慶太, 勝元敦子, 國井美紗子, 多田美紀子, 土井宏, 田中章景

神経免疫学, 25(1) 110-110, Oct, 2020
腋窩多汗症に対するA型ボツリヌス毒素局注療法後に広範な筋無力症状を認めた1例

城野誉士, 宮地洋輔, 東山雄一, 小林卓雄, 和田大司, 窪田瞬, 國井美紗子, 多田美紀子, 竹内英之, 土井宏 …

臨床神経生理学, 48(5) 597-597, Oct, 2020

Misc.

成長ホルモン投与により一定期間、高次脳機能・ADLを維持し得た4H症候群の1例

釘本千春, 多賀須むつき, 古宮裕泰, 酒井竜一郎, 多田美紀子, 上木英人, 児矢野繁, 城倉健, 土井宏, 田中章景

神経治療学, 34(6) S227-S227, Nov, 2017
四肢筋力低下で発症したMcLeod症候群の55歳男性例

多賀須むつき, 古宮裕泰, 多田美紀子, 植松絵里, 田中健一, 上木英人, 児矢野繁, 田中章景

臨床神経学, 57(6) 332-332, Jun, 2017
IgG4関連ニューロパチーと鑑別を要した家族性アミロイドポリニューロパチー(ATTR-FAP)の71歳男性例

古宮裕泰, 多田美紀子, 石戸淳一, 多賀須むつき, 田中健一, 上木英人, 児矢野繁, 田中章景

臨床神経学, 56(12) 886-886, Dec, 2016
脳炎後難治性てんかんの意識消失発作に対し免疫療法が有効で抗NMDAR抗体の関与が示唆された症例

國井美紗子, 田中健一, 多田美紀子, 窪田瞬, 東山雄一, 上木英人, 児矢野繁, 高橋幸利, 田中章景

神経免疫学, 20(1) 133-133, Sep, 2015
Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

Shunta Hashiguchi, Takayuki Momoo, Yoko Murohashi, Masanao Endo, Megumi Shimamura, Takashi Kawasaki, Sachie Kanada, Akinori Nozawa, Mikiko Tada, Shigeru Koyano …

INTERNAL MEDICINE, 54(12) 1547-1552, 2015
Incidence and Extent of Alpha-Synucleinopathy in the Human Aging Peripheral and Central Nervous System

Sayaka Funabe, Hiroyuki Hatsuta, Tadashi Adachi, Mikiko Sugiyama, Yuko Saito, Tomio Arai, Motoji Sawabe, Nobutaka Hattori, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 69(5) 553-553, May, 2010
Whipple's Disease: An Endless Infection Forty Four Years of Disease and 15 Years of Brain Involvement, Report of a Case

Sayaka Funabe, Hiroyuki Hatsuta, Tadashi Adachi, Mikiko Sugiyama, Yuko Saito, Tomio Arai, Motoji Sawabe, Nobutaka Hattori, Shigeo Murayama

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 69(5) 553-553, May, 2010

Research Projects

Analysis of pathological dynamics of membrane-less organelles in SALS

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
扁桃体腫大を伴う側頭葉てんかんの病態背景の解明と新規治療法の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

國井美紗子, 土井宏, 東山雄一, 田中章景, 多田美紀子
DEAD box RNA helicases are involved in sporadic ALS pathology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

TADA Mikiko
Study of pathogenesis caused by hypouricemia in multiple system atrophy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

KOYANO Shigeru
Elucidation of abnormal accumulation of DDX17 in motor neuron of ALS

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Tada Mikiko, Tanaka Fumiaki, Doi Hiroshi, Takeuchi Hideyuki, Koyano Shigeru
Analysis of polyglutamine aggregation protein in ALS/FTLD

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

TADA Mikiko, DOI Hiroshi, KOYANO Shigeru, TANAKA Fumiaki
Calcium-signaling abnormality of polyglutamine diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

KOYANO Shigeru
Analysis of RNA binding proteins in polyglutamine disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

TANAKA Fumiaki, DOI Hiroshi, KOYANO Shigeru, TADA Mikiko

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