Daiki Masukawa

Profile Information

Affiliation: Lecturer, School of Medicine Medical Course , Pharmacology, Yokohama City University

Degree: 博士（薬科学）(星薬科大学大学院)

Researcher number: 10711898
ORCID ID: https://orcid.org/0000-0002-3094-0058
J-GLOBAL ID: 201601009792200037
researchmap Member ID: 7000015688

External link: http://www-user.yokohama-cu.ac.jp/~pharmac/

横浜市立大学薬理学教室講師

中枢神経系と末梢臓器は互いに連絡を取り合い、生体内恒常性を維持している。現在は末梢で起こるイベントが、どのようにして中枢神経系に伝達されるのか、脳高次機能学に影響はあるのか、脳に伝えられた情報はどのようなフィードバックを末梢にするのかを明らかにしようと考えています。

Research Interests

Research Areas

Research History

Apr, 2024 - Present

School of Medicine Medical Course Pharmacology, Yokohama City University
Apr, 2019 - Mar, 2024

Yokohama City University
Apr, 2017 - Mar, 2019

Yokohama City University
Apr, 2014 - Mar, 2017

Yokohama City University

Education

Apr, 2011 - Mar, 2013

Hoshi University
Apr, 2007 - Mar, 2011

Hoshi University

Committee Memberships

Apr, 2019 - Present

学術評議員, 日本薬理学会
Apr, 2017 - Present

遺伝子組換え実験安全委員会, 横浜市立大学医学部
2020 - 2020

第93回日本薬理学会実行委員（事務局長）, 日本薬理学会

Awards

Apr, 2020

Medical Research Encouragement Award

Daiki Masukawa
Mar, 2020

President's Award Young Incentive Award, Yokohama City University

Papers

Enhancement of haloperidol-induced catalepsy by GPR143, an L-DOPA receptor, in striatal cholinergic interneurons.

Masami Arai, Etsuko Suzuki, Satoshi Kitamura, Momoyo Otaki, Kaori Kanai, Miwako Yamasaki, Masahiko Watanabe, Yuki Kambe, Koshi Murata, Yuuki Takada …

The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(11), Jan 29, 2024 Peer-reviewedCorresponding author
Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate.

Hiraku Uchimura, Kaori Kanai, Masami Arai, Miyu Inoue, Akitoyo Hishimoto, Daiki Masukawa, Yoshio Goshima

Journal of pharmacological sciences, 152(3) 178-181, Jul, 2023
Coupling between GPR143 and dopamine D2 receptor is required for selective potentiation of dopamine D2 receptor function by L-3,4-dihydroxyphenylalanine in the dorsal striatum.

Daiki Masukawa, Satoshi Kitamura, Rei Tajika, Hiraku Uchimura, Masami Arai, Yuuki Takada, Tetsu Arisawa, Momoyo Otaki, Kaori Kanai, Kenta Kobayashi …

Journal of neurochemistry, Feb 20, 2023
L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α1B Receptor at the Second Transmembrane Interface.

Daiki Masukawa, Ryo Takahagi, Yuka Nakao, Yoshio Goshima

Biological & pharmaceutical bulletin, 46(7) 869-873, 2023
Involvement of A5/A7 noradrenergic neurons and B2 serotonergic neurons in nociceptive processing: a fiber photometry study.

Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Junichi Sakaguchi, Yoko Ikoma, Yoshimune Sameshima, Yuki Kambe, Akihiro Yamanaka, Tomoyuki Kuwaki

Neural regeneration research, 17(4) 881-886, Apr, 2022
Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.

Masayuki Nakano, Motokazu Koga, Tatsuo Hashimoto, Natsuki Matsushita, Daiki Masukawa, Yusuke Mizuno, Hiraku Uchimura, Ryo Niikura, Tomoyuki Miyazaki, Fumio Nakamura …

Journal of pharmacological sciences, 148(2) 214-220, Feb, 2022
L-DOPA-Induced Neurogenesis in the Hippocampus Is Mediated through GPR143, a Distinct Mechanism of Dopamine

Yuka Kasahara, Daiki Masukawa, Kenta Kobayashi, Miwako Yamasaki, Masahiko Watanabe, Yoshio Goshima

Stem Cells, 40(2) 215-226, Jan 19, 2022
Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus.

Shunpei Moriya, Hitoshi Takahashi, Daiki Masukawa, Makiko Yamada, Jun Ishigooka, Katsuji Nishimura

Journal of pharmacological sciences, 145(2) 198-201, Feb, 2021
Distribution of mRNA for GPR143, a receptor of 3,4-L-dihydroxyphenylalanine, and of immunoreactivities for nicotinic acetylcholine receptors in the nigrostriatal and mesolimbic regions.

Yuka Kasahara, Daiki Masukawa, Yoshie Nakamura, Koshi Murata, Tatsuo Hashimoto, Kohtaro Takizawa, Motokazu Koga, Fumio Nakamura, Yugo Fukazawa, Kengo Funakoshi …

Neuroscience research, 170 370-375, Sep 4, 2020 Peer-reviewed
Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice.

Daiki Masukawa, Daisuke Nishizawa, Kaori Kanai, Satoshi Kitamura, Yuka Kasahara, Tatsuo Hashimoto, Ryo Takahagi, Junko Hasegawa, Kyoko Nakayama, Naomi Sato …

Journal of pharmacological sciences, 144(2) 89-93, Jul 16, 2020 Peer-reviewed
Enhancement of the rewarding effects of 3,4-methylenedioxymethamphetamine in orexin knockout mice.

Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuki

Behavioural brain research, 396 112802-112802, Jul 9, 2020 Peer-reviewed
Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice.

Shunpei Moriya, Hitoshi Takahashi, Daiki Masukawa, Makiko Yamada, Jun Ishigooka, Katsuji Nishimura

Journal of pharmacological sciences, Jun 17, 2020 Peer-reviewed
Involvement of A13 dopaminergic neurons located in the zona incerta in nociceptive processing: a fiber photometry study.

Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Honami Setoyama, Yunsu Hwang, Akihiro Yamanaka, Tomoyuki Kuwaki

Molecular brain, 13(1) 60-60, Apr 14, 2020 Peer-reviewed
Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation.

Kentaro Togashi, Masaya Hasegawa, Jun Nagai, Ken Kotaka, Arina Yazawa, Miyuki Takahashi, Daiki Masukawa, Yoshio Goshima, Kenneth Hensley, Toshio Ohshima

Journal of the neurological sciences, 413 116802-116802, Mar 26, 2020 Peer-reviewed
Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer.

Keiichi Yazawa, Fumio Nakamura, Daiki Masukawa, Sho Sato, Yukihiko Hiroshima, Yasuhiro Yabushita, Ryutaro Mori, Ryusei Matsuyama, Ikuma Kato, Hideki Taniguchi …

Translational oncology, 13(3) 100746-100746, Mar, 2020 Peer-reviewed
Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study.

Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka, Tomoyuki Kuwaki

Molecular brain, 13(1) 14-14, Jan 31, 2020 Peer-reviewed
Overexpression of the gene product of ocular albinism 1 (GPR143/OA1) but not its mutant forms inhibits neurite outgrowth in PC12 cells.

Masukawa D, Yamada K, Goshima Y

Journal of pharmacological sciences, Sep, 2019 Peer-reviewed
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.

Caleb AA, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H …

Neurobiology of disease, 132 104603-104603, Sep, 2019 Peer-reviewed
l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson's Disease.

Goshima Y, Masukawa D, Kasahara Y, Hashimoto T, Aladeokin AC

Frontiers in pharmacology, 10 1119-1119, 2019 Peer-reviewed
Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies.

Goshima Y, Watanabe S, Seki E, Koga M, Masukawa D, Nakamura F, Komori T, Arai N

Neuroscience research, Dec, 2018 Peer-reviewed

Misc.

ドーパ受容体候補分子からみるドーパ療法の応用および問題点

増川太輝

Clinical Neuroscience, 36(10) 1130-1132, Oct, 2018 Peer-reviewedInvited
ドーパ受容体の生理学的および薬理学的作用

増川太輝

Clinical Neuroscience, 36(9) 1004-1005, Sep, 2018 Peer-reviewedInvited
ドーパ神経伝達物質仮説：ドーパ受容体は存在するか？

増川太輝

Clinical Neuroscience, 36(8) 878-879, Aug, 2018 Peer-reviewedInvited
L-DOPAの肺高血圧モデル肺血管におけるフェニレフリン応答の修飾作用

古賀資和, 古賀資和, 増川太輝, 中村史雄, 中村史雄, 菅原陽, 水野祐介, 後藤隆久, 五嶋良郎

日本薬理学雑誌, 150(Supplement), 2017
L‐DOPAによって誘発される行動薬理学的変化の解析

上田傑, 増川太輝, 古賀資和, 中村史雄, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 132nd 88, 2015
GPR143遺伝子欠損マウスにおけるドパミン受容体作動薬の効果

北村慧, 増川太輝, 古賀資和, 中村史雄, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 133rd 44, 2015
INVOLVEMENT OF MU- AND DELTA-OPIOID RECEPTOR FUNCTION IN THE REWARDING EFFECT OF PENTAZOCINE

T. Mori, T. Itoh, K. Yoshizawa, T. Saeki, D. Masukawa, M. Shibasaki, T. Suzuki

ALCOHOL AND ALCOHOLISM, 49, Sep, 2014
薬物依存の研究(第495報) DOPAのmethamphetamine誘発報酬効果形成における関与

岩瀬祥之, 森友久, 中村美聖, 肥田野翔, 芝崎真裕, 増川太輝, 東山公男, 五嶋良郎, 鈴木勉

日本アルコール・薬物医学会雑誌, 49(4) 228-228, Aug, 2014
DOPA-INDUCED DEPRESSOR AND BRADYCARDIAC RESPONSE IN THE OA1-DEFICIENT MICE

D. Masukawa, F. Nakamura, Y. Goshima

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 115 260-260, Jul, 2014
THE GENE PRODUCT OF OCULAR ALBINISM 1 IS THE G PROTEIN-COUPLED RECEPTOR AND MEDIATES DEPRESSOR AND BRADYCARDIC RESPONSES TO DOPA IN THE NUCLEUS TRACTUS SOLITARII

Y. Goshima, F. Nakamura, D. Masukawa

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 115 280-280, Jul, 2014
Distribution of L-DOPA receptor, ocular albinism 1 (OA-1)-immunoreactivities in central and peripheral tissues

Nobuhiko Fukuda, Saki Naito, Daiki Masukawa, Moemi Kaneda, Fumio Nakamura, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 208P-208P, 2014
中枢神経系におけるOA1の分布と機能

増川太輝, 中村史雄, 古賀資和, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 131st 46, 2014
中枢神経系におけるL‐DOPA受容体OA1の発現分布

増川太輝, 中村史雄, 古賀資和, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 130th 41, 2014
神経障害性疼痛マウスにおけるモルヒネの鎮痛効果の低下は、脳内濃度の低下に起因する

永江麻里奈, 金田光正, 深川正敏, 李欣, 増川太輝, 五十嵐信智, 落合和, 成田年, 鈴木勉, 杉山清

日本薬剤学会年会講演要旨集, 28年会 217-217, Apr, 2013
神経障害性疼痛マウスのモルヒネの脳内濃度と鎮痛作用の関係

永江麻里奈, 金田光正, 峰尾あゆみ, 増川太輝, 五十嵐信智, 落合和, 成田年, 鈴木勉, 杉山清

日本薬学会年会要旨集, 133年会(4) 122-122, Mar, 2013
Studies on drug dependence (Rept. 469): Effects of chronic treatment with zolpidem on morphine induced reward effects

Daiki Masukawa, Masahiro Shibasaki, Kazunori Ishii, Yui Yamagishi, Tomohisa Mori, Tsutomu Suzuki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121 66P-66P, 2013
P1-309 神経障害性疼痛時にはモルヒネの脳内到達量が減少する(がん薬物療法(緩和ケア),ポスター,一般演題,岐路に立つ医療〜千年紀の目覚め〜よみがえれ!ニッポン!薬の改革は我らが手で!)

金田光正, 永江麻里奈, 柳田梨沙, 峰尾あゆみ, 増川太輝, 五十嵐信智, 落合和, 成田年, 鈴木勉, 杉山清

日本医療薬学会年会講演要旨集, 22 318-318, Oct 10, 2012
神経障害性疼痛時におけるモルヒネの脳内到達量の減少

杉山清, 金田光正, 永江麻里奈, 柚原亜美, 柳田梨沙, 峰尾あゆみ, 増川太輝, 五十嵐信智, 成田年, 鈴木勉 …

日本薬剤師会学術大会講演要旨集, 45回 420-420, Oct, 2012
INFLUENCE OF CHRONIC TREATMENT OF ZOLPIDEM ON ACTIVATION OF DOPAMINERGIC SYSTEM IN NUCLEUS ACCUMBENCE

D. Masukawa, M. Shibasaki, T. Mori, K. Ishii, Y. Yamagishi, T. Suzuki

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 36 127A-127A, Sep, 2012
EFFECTS OF LIPOPOLYSACCHARIDES ON THE METHAMPHETAMINE-INDUCED REWARDING EFFECTS

M. Shibasaki, D. Masukawa, M. Mitake, T. Imai, Y. Akita, T. Mori, T. Suzuki

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 36 130A-130A, Sep, 2012

Presentations

L-DOPA modulates anxiety-like behavior through coupling between GPR143 and dopamine D2 receptors in the indirect pathway striatal neurons

Daiki Masukawa, Yoshio Goshima

NEURO2022, Jul, 2022
線条体間接路における L-DOPA の生理学的役割解明

増川太輝

第95回薬理学会年会, Mar 9, 2022
Functional analysis of GPR143, an L-DOPA receptor, in GPCRs hetero-oligomers

Daiki Masukawa, Yoshio Goshima

The 94th Annual Meeting of the Japanese Pharmacological Society, Mar 10, 2021 Invited
Impairment of nicotine-induced behavioral changes in L-DOPA receptor gene (Gpr143)-deficient mice, and genetic associations of single nucleotide polymorphisms in the GPR143 gene with severity of nicotine dependence in Japanese in dividuals.

Daiki Masukawa, Nishiawa Daisuke, Yuka Kasahara, Satoshi Kitamura, Kaori Kanai, Kazutaka Ikeda, Yoshio Goshima

Jul, 2020
An optogenetic approach for functional analysis of L-DOPAergic neurotransmission in the nucleus tractus solitarii

MASUKAWA Daiki

Jul 27, 2019
ドーパ受容体 GPR143 遺伝子欠損マウスにおけるニコチンの効果および喫煙患者における GPR143 の一塩基多型解析

増川太輝

第140回薬理学会関東部会, Jul 6, 2019
An optogenetic approach to identify L-DOPA as a neurotransmitter in the nucleus tractus solitarii

MASUKAWA Daiki

Mar 15, 2019
延髄孤束核における L-DOPA 神経伝達機構の解明

増川太輝

薬理学会関東部会, Oct 20, 2018
The localization and innervation of rBAT and tyrosine hydroxylase positive neuron

MASUKAWA Daiki

Jul 28, 2018
Tyrosine hydroxylase and/or rBAT positive neuron in primary afferent innervates in the nucleus tractus solitarii

MASUKAWA Daiki

18 th world congress of basic and clinical pharmacology, Jul 5, 2018
ドーパ受容体 GPR143 とアドレナリン α1 受容体との機能的連関と複合体形成

増川太輝

第136回日本薬理学会関東部会, Jul 8, 2017
DOPA-GPR143 signal augments α1-adrenergic receptor response

MASUKAWA Daiki

Mar 15, 2017
DOPA-GPR143 signal augments pressor response mediated by α1-adrenergic receptor

MASUKAWA Daiki

Mar 9, 2016

Teaching Experience

Professional Memberships

Research Projects

幻覚作用を有する薬物による行動と脳内ドーパ変化

厚生労働科学研究費, 指定薬物の指定に係る試験法の評価検証に資する研究, 厚生労働省, Apr, 2022 - Mar, 2024
ニコチンによる中枢末梢連関を介する自律神経制御機構の解明

一般研究, 公益財団法人喫煙科学研究財団, Apr, 2021 - Mar, 2024
The analysis for the circuits of L-DOPA-containing neurons in the central nervous system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
ドーパ性神経伝達の神経回路およびその作用機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

増川太輝
Roles of L-DOPA as a neurotransmitter and L-DOPA reuptake systems involved

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

GOSHIMA Yoshio
Dopa as a neurotransmitter in heart failure and acute kidney injury

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Hashimoto Tatsuo
L-DOPA 受容体 GPR143 とアドレナリン α1 受容体との機能連関およびその生体内役割の解析

わかば研究助成, 一般財団法人横浜総合医学振興財団, Jul, 2019 - Aug, 2020

増川太輝
ドーパに関する新規受容体探索および構造活性相関解析

研究助成金（研究奨励金）, 上原記念生命科学財団, Feb, 2019 - Mar, 2020

増川太輝
下位脳幹弧束核領域におけるドーパ神経伝達の機能解明

科学研究費補助金（若手研究）, 文部科学省, Apr, 2018 - Mar, 2020

増川太輝
L-DOPA 受容体 GPR143 が関わる精神・神経疾患の病態解明

医学系研究助成, 医学系研究助成, 武田科学振興財団, 2020
Functional analysis of DOPAergic transmission in cardiovascular system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

GOSHIMA Yoshio, FUKAZAWA Yugo, ICHINOSE Hiroshi
下位脳幹弧束核におけるドーパ-グルタミン酸神経伝達間相互作用の機能解析

科学研究費補助金 (若手研究(B)), 文部科学省, Apr, 2015 - Mar, 2017

増川太輝

Industrial Property Rights

特開2017-100958 血圧制御異常の新規治療法

五嶋良郎, 中村史雄, 増川大輝, 及川雅人
特開2022-20919 ドーパミンＤ２受容体・ドーパ受容体相互作用阻害ペプチド

五嶋良郎、増川太輝

Other

麻薬研究者免許

2022 - Present
薬理学エデュケーター（公益社団法人日本薬理学会認定）

Jan, 2021 - Present

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

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