SHINICHI TSUJIMOTO

Profile Information

Affiliation: Assistant Professor, School of Medicine Medical Course Pediatrics, Yokohama City University

Degree: 博士（医学）(Mar, 2018, 横浜市立大学)

Contact information: shnchyokohama-cu.ac.jp
Researcher number: 50838034
J-GLOBAL ID: 202001009753480637
researchmap Member ID: R000001530

External link: http://www-user.yokohama-cu.ac.jp/~shonika

小児がん、特に小児白血病のゲノム解析及び生殖細胞系列のゲノム解析を行っている。また、小児白血病の臨床研究も行っている。

Research Interests

Research Areas

Life sciences / Fetal medicine/Pediatrics / 白血病

Research History

Apr, 2020 - Present

Hospital Pediatrics, Yokohama City University
Apr, 2018 - Mar, 2020

National Center for Child Health and Development
Apr, 2015 - Mar, 2018

発生成育小児医療学講座(成育医療研究センター共同研究員), 横浜市立大学医学部医学科医学研究科医科学専攻
Apr, 2014 - Mar, 2015

横浜労災病院
Apr, 2011 - Mar, 2014

聖路加国際病院
Apr, 2009 - Mar, 2011

独立行政法人国立病院機構長崎医療センター

Education

Apr, 2015 - Mar, 2018

Yokohama City University
Apr, 2003 - Mar, 2009

Shimane University

Committee Memberships

Apr, 2021

脳腫瘍委員会, 日本小児がん研究グループ
Mar, 2019

AML委員会, 日本小児がん研究グループ

Major Papers

High-dose cytarabine induction therapy and flow cytometric measurable residual disease monitoring for children with acute myeloid leukemia.

Daisuke Tomizawa, Jun Matsubayashi, Shotaro Iwamoto, Hidefumi Hiramatsu, Daisuke Hasegawa, Hiroshi Moritake, Daiichiro Hasegawa, Kiminori Terui, Asahito Hama, Shin-Ichi Tsujimoto …

Leukemia, Nov 6, 2023
Severe RAS-Associated Lymphoproliferative Disease Case with Increasing αβ Double-Negative T Cells with Atypical Features.

Daisuke Kurita, Norio Shiba, Takashi Ohya, Ayako Murase, Yuko Shimosato, Masahiro Yoshitomi, Seira Hattori, Koji Sasaki, Kenichi Nishimura, Shin-Ichi Tsujimoto …

Journal of clinical immunology, Aug 29, 2023
Risk-Stratified Therapy for Pediatric Acute Myeloid Leukemia.

Daisuke Tomizawa, Shin-Ichi Tsujimoto

Cancers, 15(16), Aug 18, 2023
Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant.

Hisashi Ishida, Shin-Ichi Tsujimoto, Daisuke Hasegawa, Hirotoshi Sakaguchi, Shohei Yamamoto, Masakatsu Yanagimachi, Katsuyoshi Koh, Akihiro Watanabe, Asahito Hama, Yuko Cho …

Haematologica, Jul 20, 2023
Prevalence of pathogenic variants in cancer-predisposing genes in second cancer after childhood solid cancers.

Masanori Yoshida, Kazuhiko Nakabayashi, Wentao Yang, Aiko Sato-Otsubo, Shin-Ichi Tsujimoto, Hiroko Ogata-Kawata, Tomoko Kawai, Keisuke Ishiwata, Mika Sakamoto, Kohji Okamura …

Cancer medicine, 12(10) 11264-11273, Apr 6, 2023
Low NUDT15 expression levels due to biallelic NUDT15 variants and 6-mercaptopurine intolerance.

Masanori Yoshida, Scott A Brown, Takaya Moriyama, Rina Nishii, Shin-Ichi Tsujimoto, Yuji Yamada, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Tomoyuki Utano …

British journal of haematology, 199(2) 270-276, Jul 29, 2022
A phase III clinical trial evaluating efficacy and safety of minimal residual disease-based risk stratification for children with acute myeloid leukemia, incorporating a randomized study of gemtuzumab ozogamicin in combination with post-induction chemotherapy for non-low-risk patients (JPLSG-AML-20)

Daisuke Tomizawa, Shin-ichi Tsujimoto, Shiro Tanaka, Jun Matsubayashi, Takahiro Aoki, Shotaro Iwamoto, Daisuke Hasegawa, Kozo Nagai, Kentaro Nakashima, Koji Kawaguchi …

Japanese Journal of Clinical Oncology, 52(10) 1225-1231, Jul 9, 2022 Peer-reviewed
Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia.

Genki Yamato, Tomoko Kawai, Norio Shiba, Junji Ikeda, Yusuke Hara, Kentaro Ohki, Shin-Ichi Tsujimoto, Taeko Kaburagi, Kenichi Yoshida, Yuichi Shiraishi …

Blood advances, 6(11) 3207-3219, Jun 14, 2022
小児がん集学的治療における外科系診療科の果たす役割小児脳腫瘍の集学的治療における脳神経外科の役割

山本哲哉, 立石健祐, 末永潤, 三宅勇平, 辻本信一, 竹内正宣, 広川大輔, 福島紘子, 水本斉志

日本外科系連合学会誌, 47(3) 311-311, May, 2022
NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia

Masanori Yoshida, Kazuhiko Nakabayashi, Wentao Yang, Aiko Sato-Otsubo, Shin-ichi Tsujimoto, Hiroko Ogata-Kawata, Tomoko Kawai, Keisuke Ishiwata, Mika Sakamoto, Kohji Okamura …

Blood Advances, 5(23) 5420-5428, Dec 14, 2021
ChIP-seq Revealed the Target Genes of PRDM16 in Pediatric Acute Myeloid Leukemia

Masahiro Yoshitomi, Junji Ikeda, Shinichi Tsujimoto, Mitsumasa Osuna, Atsuhiro Iizuka, Hiroaki Hayashi, Masanobu Takeuchi, Reo Tanoshima, Shuichi Ito, Norio Shiba

PEDIATRIC BLOOD & CANCER, 68, Nov, 2021
Association of Multiple Gene Polymorphisms Including Homozygous NUDT15 R139C With Thiopurine Intolerance During the Treatment of Acute Lymphoblastic Leukemia.

Ko Kudo, Tomohiko Sato, Yuka Takahashi, Kentaro Yuzawa, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Jun Shimada, Katsuki Otani, Shinichi Tusjimoto …

Journal of pediatric hematology/oncology, 43(8) e1173-e1176, Nov 1, 2021
Droplet digital polymerase chain reaction assay for the detection of the minor clone of KIT D816V in paediatric acute myeloid leukaemia especially showing RUNX1-RUNX1T1 transcripts.

Koji Sasaki, Shinichi Tsujimoto, Mayuko Miyake, Yuri Uchiyama, Junji Ikeda, Masahiro Yoshitomi, Yuko Shimosato, Mayu Tokumasu, Hidemasa Matsuo, Kenichi Yoshida …

British journal of haematology, 194(2) 414-422, Jun 13, 2021
Comparison of clonazepam and levetiracetam in children for prevention of busulfan-induced seizure in hematopoietic stem cell transplantation(和訳中)

Tsujimoto Shin-ichi, Shirai Ryota, Utano Tomoyuki, Osumi Tomoo, Matsumoto Kana, Shioda Yoko, Kiyotani Chikako, Uchiyama Toru, Deguchi Takao, Terashima Keita …

International Journal of Hematology, 111(3) 463-466, Mar, 2020
Allogeneic Bone Marrow Transplantation versus Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies in Children: A Systematic Review and Meta-Analysis.

Yuko Shimosato, Reo Tanoshima, Shin-Ichi Tsujimoto, Masanobu Takeuchi, Norio Shiba, Tohru Kobayashi, Shuichi Ito

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 26(1) 88-93, Jan, 2020 Peer-reviewed
Experience on Haploidentical Stem Cell Transplantation With Post-transplant Cyclophosphamide for Children With Hematological Malignancies

Shinichi Tsujimoto, Tomoo Osumi, Kenichi Sakamoto, Kyohei Isshiki, Takanori Mizuno, Meri Uchiyama, Masahiro Sugawa, Yukihiro Matsukawa, Yoko Shioda, Chikako Kiyotani …

PEDIATRIC BLOOD & CANCER, 66 S93-S93, Dec, 2019
NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, Kazuhiko Nakabayashi, Aiko Sato, Shinichi Tsujimoto, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Yuki Yuza, Masatoshi Takagi, Hiroyuki Takahashi …

PEDIATRIC BLOOD & CANCER, 66 S5-S6, Dec, 2019
Acute promyelocytic leukemia with a cryptic insertion of RARA into TBL1XR1.

Tomoo Osumi, Akihiro Watanabe, Kohji Okamura, Kazuhiko Nakabayashi, Masanori Yoshida, Shin-Ichi Tsujimoto, Meri Uchiyama, Hiroyuki Takahashi, Daisuke Tomizawa, Kenichiro Hata …

Genes, chromosomes & cancer, 58(11) 820-823, Nov, 2019 Peer-reviewed
Intraventricular Rituximab in Pediatric CD20-positive Refractory Primary Central Nervous System Lymphoma.

Yuko Wada-Shimosato, Junji Ikeda, Shin-Ichi Tsujimoto, Koji Sasaki, Masakatsu Yanagimachi, Ryosuke Kajiwara, Norio Shiba, Hidetoshi Murata, Nobutaka Kawahara, Shoji Yamanaka …

Journal of pediatric hematology/oncology, 41(7) 571-573, Oct, 2019 Peer-reviewed
Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.

Shinichi Tsujimoto, Tomoo Osumi, Meri Uchiyama, Ryota Shirai, Takaya Moriyama, Rina Nishii, Yuji Yamada, Ko Kudo, Masahiro Sekiguchi, Yuki Arakawa …

Leukemia, 32(12) 2710-2714, Dec, 2018 Peer-reviewed
Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.

Tomoo Osumi, Shin-Ichi Tsujimoto, Moe Tamura, Meri Uchiyama, Kazuhiko Nakabayashi, Kohji Okamura, Masanori Yoshida, Daisuke Tomizawa, Akihiro Watanabe, Hiroyuki Takahashi …

Cancer research, 78(16) 4452-4458, Aug 15, 2018 Peer-reviewed

Misc.

【小児・AYA世代がん診療の現在と未来】造血器腫瘍の現在と未来急性骨髄性白血病

辻本信一

小児科診療, 86(8) 906-911, Aug, 2023
ゲノム解析に基づく小児AMLの予後予測と治療

池田順治, 辻本信一

血液内科, 87(2) 216-220, Aug, 2023
日本人小児がん患者に対する制吐目的のオランザピンの有効性および安全性

歌野智之, 竹林晃, 加藤元博, 辻本信一, 田之島玲大, 山谷明正

臨床薬理の進歩, (44) 125-132, Jun, 2023
ラブドイド細胞の出現を伴うmyxoid pleomorphic liposarcomaの1例

加藤生真, 新井拓真, 川端佑介, 辻本信一, 石川善啓, 竹山昌伸, 山中正二, 孝橋賢一, 小田義直, 藤井誠志

日本整形外科学会雑誌, 97(6) S1317-S1317, Jun, 2023
Stevens-Johnson症候群と鑑別を要したチオテパによる皮膚障害の1例

鈴木毅, 渡邉裕子, 渡邊友也, 高村直子, 山口由衣, 辻本信一

日本皮膚科学会雑誌, 133(4) 703-703, Apr, 2023
【小児の治療方針】血液・腫瘍急性骨髄性白血病

辻本信一

小児科診療, 86(春増刊) 461-464, Apr, 2023
当院における小児がん患者のリハビリテーション治療について

栗田大輔, 山内裕子, 辻本信一, 大砂光正, 竹内正宣, 池田順治, 田野島玲大, 柴徳生, 伊藤秀一

日本小児科学会雑誌, 127(2) 381-381, Feb, 2023
大規模解析データから見えてくる白血病の予後予測と治療層別化次世代のAMLの予後予測と治療層別化

辻本信一

日本小児血液・がん学会雑誌, 59(4) 171-171, Oct, 2022
大規模解析データから見えてくる白血病の予後予測と治療層別化次世代のAMLの予後予測と治療層別化

辻本信一

日本小児血液・がん学会雑誌, 59(4) 171-171, Oct, 2022
Adaptive samplingを用いたロングリードシークエンス解析パイプラインの構築(An attempt to build a long-read sequencing pipeline using adaptive sampling.)

中村航, 須川正啓, Mateos Raul N., 飯田直子, 千葉健一, 平田真, 辻本信一, 柴徳生, 白石友一

日本癌学会総会記事, 81回 P-3114, Sep, 2022
小児がん集学的治療における外科系診療科の果たす役割小児脳腫瘍の集学的治療における脳神経外科の役割

山本哲哉, 立石健祐, 末永潤, 三宅勇平, 辻本信一, 竹内正宣, 広川大輔, 福島紘子, 水本斉志

日本外科系連合学会誌, 47(3) 311-311, May, 2022
自己免疫性溶血性貧血,血小板減少を合併したランゲルハンス細胞組織球症の早期乳児例

吉川奈央子, 西村謙一, 神山裕二, 大砂光正, 林邉廉, 村瀬絢子, 服部成良, 江中牧子, 辻本信一, 竹内正宜 …

日本小児科学会雑誌, 126(2) 331-331, Feb, 2022
小児・Adolescent and Young Adult(AYA)世代がん患者長期フォローアップへの取り組み

吉富誠弘, 田野島玲大, 秋山典子, 飯塚敦広, 林弘明, 辻本信一, 竹内正宣, 柴徳生, 伊藤秀一

神奈川医学会雑誌, 49(1) 51-51, Jan, 2022
Thiotepaによる皮膚障害を認めた小児髄芽腫の1例

竹内正宣, 林弘明, 吉富誠弘, 飯塚敦広, 辻本信一, 田野島玲大, 柴徳生, 渡邊友也, 伊藤秀一

日本小児臨床薬理学会雑誌, 34(1) 24-28, Sep, 2021
【小児で経験する「血液の異常」-血液疾患の鑑別とトピックス】各論:白血球の異常白血球数・分画の異常の鑑別

辻本信一

小児内科, 53(7) 1084-1088, Jul, 2021
著明な乳酸アシドーシスと重症貧血を呈した急性リンパ性白血病によるOncologic emergencyの1例

大西康裕, 多賀谷貴史, 植松悟子, 西村奈穂, 辻本信一, 富澤大輔, 松本公一

日本小児救急医学会雑誌, 20(2) 335-335, May, 2021
A Bioadhesive Barrier-Forming Lipid Solution for Oral Mucositis of Pediatric Patients with Chemotherapy or Radiation Therapy

Reo Tanoshima, Atsuhiro Iizuka, Hiroaki Hayashi, Yuko Shimosato, Masahiro Yoshitomi, Koji Sasaki, Shinichi Tsujimoto, Masanobu Takeuchi, Nobuhide Ohashi, Norio Shiba

PEDIATRIC BLOOD & CANCER, 67, Dec, 2020
小児ALLにおけるSandwich ELISAを用いたNUDT15蛋白定量(NUDT15 quantification using sandwich ELISA in pediatric ALL children)

Yoshida Masanori, Moriyama Takaya, Nishii Rina, Tsujimoto Shinichi, Osumi Tomoo, Yamada Yuji, Tomizawa Daisuke, Kiyokawa Nobutaka, Yang Jun, Kato Motohiro

日本小児血液・がん学会雑誌, 57(4) 218-218, Oct, 2020
小児急性骨髄性白血病においてDOCK1遺伝子高発現は予後不良因子となり得る(High gene expression of DOCK1 shows poor prognosis in children with acute myeloid leukemia)

Yoshitomi Masahiro, Ikeda Jyunji, Tsujimoto Shinichi, Ito Shuichi, Hasegawa Daisuke, Iwamoto Shotaro, Hayashi Yasuhide, Adachi Souichi, Tomizawa Daisuke, Shiba Norio

日本小児血液・がん学会雑誌, 57(4) 221-221, Oct, 2020
小児の化学療法、放射線療法に伴う口腔粘膜炎への局所管理ハイドロゲル創傷被覆・保護剤の使用経験(A bioadhesive barrier-forming lipid solution for oral mucositis of pediatric patients with chemotherapy or radiation therapy)

Tanoshima Reo, Iizuka Atsuhiro, Hayashi Hiroaki, Shimosato Yuko, Yoshitomi Masahiro, Sasaki Koji, Tsujimoto Shinichi, Takeuchi Masanobu, Ohashi Nobuhide, Shiba Norio

日本小児血液・がん学会雑誌, 57(4) 335-335, Oct, 2020

Research Projects

PRDM16高発現難治小児AMLに対するエピゲノム解析に基づいた新規治療法の開発

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2024

辻本信一
Elucidation of the pathophysiology of RARB translocation-positive acute promyelocytic leukemia and development of new target therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021

TSUJIMOTO Shinichi

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Major Papers

Misc.

Research Projects

Menu

Coauthors