Hiroshi SUDO

Profile Information

Affiliation: Hoshi University

Degree: 博士（薬学）(千葉大学大学院)

J-GLOBAL ID: 201601019369909734
researchmap Member ID: B000253665

Research Interests

Medicinal botany

Research Areas

Life sciences / Environmental and pharmaceutical development resources /

Research History

Apr, 2011 - Present

Hoshi University
Apr, 2002 - Mar, 2011

株式会社常磐植物化学研究所
Apr, 1987 - Mar, 2002

生化学研究所, 鐘紡株式会社
Apr, 1985 - Mar, 1987

三菱化成植物工学研究所

Education

Apr, 1981 - Mar, 2015

Faculty of Horticulture, Chiba University
Apr, 1999 - Mar, 2002

千葉大学大学院

Papers

Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine A in Asparagus officinalis.

Ryo Nakabayashi, Kei Hashimoto, Tetsuya Mori, Kiminori Toyooka, Hiroshi Sudo, Kazuki Saito

Plant biotechnology (Tokyo, Japan), 38(3) 311-315, Sep 25, 2021
Allylic Hydroxylation Activity Is a Source of Saponin Chemodiversity in the Genus Glycyrrhiza

Much Z Fanani, Satoru Sawai, Hikaru Seki, Masato Ishimori, Kiyoshi Ohyama, Ery O Fukushima, Hiroshi Sudo, Kazuki Saito, Toshiya Muranaka

Plant and Cell Physiology, 62(2) 262-271, May 11, 2021 Peer-reviewed
Metabolomics with 15N Labeling for Characterizing Missing Monoterpene Indole Alkaloids in Plants

Ryo Nakabayashi, Tetsuya Mori, Noriko Takeda, Kiminori Toyooka, Hiroshi Sudo, Hiroshi Tsugawa, Kazuki Saito

Analytical Chemistry, 92(8) 5670-5675, Apr 21, 2020 Peer-reviewed
Producing the sulfur-containing metabolite asparaptine in Asparagus calluses and a suspension cell line

Ryo Nakabayashi, Tomoko Nishizawa, Tetsuya Mori, Hiroshi Sudo, Isao Fujii, Takashi Asano, Kazuki Saito

Plant Biotechnology, 36(4) 265-267, Dec 25, 2019 Peer-reviewed
Molecular Basis of C-30 Product Regioselectivity of Legume Oxidases Involved in High-Value Triterpenoid Biosynthesis

Much Zaenal Fanani, Ery Odette Fukushima, Satoru Sawai, Jianwei Tang, Masato Ishimori, Hiroshi Sudo, Kiyoshi Ohyama, Hikaru Seki, Kazuki Saito, Toshiya Muranaka

Frontiers in Plant Science, 10 1520-1520, Nov 26, 2019 Peer-reviewed
Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin.

Yuhta Nomura, Hikaru Seki, Tomonori Suzuki, Kiyoshi Ohyama, Masaharu Mizutani, Tomomi Kaku, Keita Tamura, Eiichiro Ono, Manabu Horikawa, Hiroshi Sudo …

The Plant journal : for cell and molecular biology, 99(6) 1127-1143, Sep, 2019 Peer-reviewed
Analysis of Compounds of Curcuma Rhizome Using Mass Spectrometry and Investigation of the Antioxidant Activity of Rhizome Extracts

Kasai H, Yamane Y, Ikegami Kawai M, Sudo H

Medicinal & Aromatic Plants, 08(04), 2019 Peer-reviewed
Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations

Supaart Sirikantaramas, Arthitaya Meeprasert, Thanyada Rungrotmongkol, Hideyoshi Fuji, Tyuji Hoshino, Hiroshi Sudo, Mami Yamazaki, Kazuki Saito

PHYTOCHEMISTRY, 113 50-56, May, 2015 Peer-reviewed
Rapid identification of a narcotic plant Papaver bracteatum using flow cytometry

Masako Aragane, Daisuke Watanabe, Jun'Ichi Nakajima, Masao Yoshida, Masao Yoshizawa, Tomohiro Abe, Rei Nishiyama, Jin Suzuki, Takako Moriyasu, Dai Nakae …

Journal of Natural Medicines, 68(4) 677-685, 2014 Peer-reviewed
Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila.

Takashi Asano, Kanae Kobayashi, Emi Kashihara, Hiroshi Sudo, Ryosuke Sasaki, Yoko Iijima, Koh Aoki, Daisuke Shibata, Kazuki Saito, Mami Yamazaki

Phytochemistry, 91 128-39, Jul, 2013 Peer-reviewed
Multi-Gene Transformation for Pathway Engineering of Secondary Metabolites

Hideyuki Suzuki, Eiji Takita, Kiyoshi Ohyama, Satoru Sawai, Hikaru Seki, Nozomu Sakurai, Toshiya Muranaka, Masao Ishimoto, Hiroshi Sudo, Kazuki Saito …

The Handbook of Plant Metabolomics, 227-244, Apr, 2013 Peer-reviewed
Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin

Hikaru Seki, Satoru Sawai, Kiyoshi Ohyama, Masaharu Mizutani, Toshiyuki Ohnishi, Hiroshi Sudo, Ery Odette Fukushima, Tomoyoshi Akashi, Toshio Aoki, Kazuki Saito …

Plant Cell, 23(11) 4112-4123, Nov, 2011 Peer-reviewed
Biosynthetic system of camptothecin: An anticancer plant product

Mami Yamazaki, Takashi Asano, Yasuyo Yamazaki, Supaart Sirikantaramas, Hiroshi Sudo, Kazuki Saito

Pure and Applied Chemistry, 82(1) 213-218, 2010 Peer-reviewed
Expressed sequence tags from rhizomes of Glycyrrhiza uralensis

Hiroshi Sudo, Hikaru Seki, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Atsushi Toyoda, Yasushi Totoki, Yoshiyuki Sakaki, Osamu Lida, Toshiro Shibata …

PLANT BIOTECHNOLOGY, 26(1) 105-107, Mar, 2009
Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin

Hikaru Seki, Kiyoshi Ohyama, Satoru Sawai, Masaharu Mizutani, Toshiyuki Ohnishi, Hiroshi Sudo, Tomoyoshi Akashi, Toshio Aoki, Kazuki Saito, Toshiya Muranaka

Proceedings of the National Academy of Sciences of the United States of America, 105(37) 14204-14209, Sep 16, 2008 Peer-reviewed
Camptothecin Production in Cell Cultures of Ophiorrhiza Species

Takashi Asano, Hiroshi Sudo, Mami Yamazaki, Kazuki Saito

Medicinal Plant Biotechnology: From Basic Research to Industrial Applications, 451-467, Mar 20, 2008 Peer-reviewed
P-260 The Study on Camptothecin Transporter in Ophiorrhiza pumila

Sirikantaramas Supaart, Sudo Hiroshi, Asano Takashi, Saito Kazuki, Yamazaki Mami

International Symposium on the Chemistry of Natural Products, 2006 "P-260", Jul 23, 2006
P-401 ELUCIDATION OF CAMPTOTHECIN BIOSYNTHETIC MECHANISM IN OPHIORRHIZA PUMILA HAIRY ROOT

Asano Takashi, Sudo Hiroshi, Kitayama Masahiko, Yamazaki Mami, Saito Kazuki

International Symposium on the Chemistry of Natural Products, 2006 "P-401", Jul 23, 2006
Camptothecins and Two New Monoterpene Glucosides from Ophiorrhiza liukiuensis

KITAJIMA Mariko, FUJII Norie, YOSHINO Fumie, SUDO Hiroshi, SAITO Kazuki, AIMI Norio, TAKAYAMA Hiromitsu

Chemical and Pharmaceutical Bulletin, 53(10) 1355-1358, Oct 1, 2005
Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-C-13]glucose

Y Yamazaki, M Kitajima, M Arita, H Takayama, H Sudo, M Yamazaki, N Aimi, K Saito

PLANT PHYSIOLOGY, 134(1) 161-170, Jan, 2004 Peer-reviewed

Misc.

The molecular basis that determines the glycyrrhizin productivity in the licorice plants

FANANI Much Z, FANANI Much Z, SAWAI Satoru, SAWAI Satoru, SAWAI Satoru, SAWAI Satoru, SEKI Hikaru, SEKI Hikaru, ISHIMORI Masato, OHYAMA Kiyoshi …

イソプレノイド研究会例会講演要旨集, 31st (CD-ROM), 2021
Evolution of β-amyrin 11-oxidase activity underlies saponin chemodiversity in Glycyrrhiza species

FANANI Much Zaenal, SAWAI Satoru, SAWAI Satoru, SAWAI Satoru, SAWAI Satoru, SEKI Hikaru, SEKI Hikaru, ISHIMORI Masato, SUDO Hiroshi, FUKUSHIMA Ery O. …

日本農芸化学会大会講演要旨集(Web), 2020, 2020
Evolution of P450 enzymes activity drives saponin chemodiversity in medicinal Glycyrrhiza plants

FANANI Much Zaenal, SAWAI Satoru, SAWAI Satoru, SAWAI Satoru, SAWAI Satoru, SEKI Hikaru, SEKI Hikaru, ISHIMORI Masato, SUDO Hiroshi, FUKUSHIMA Ery Odette …

日本植物生理学会年会(Web), 61st, 2020
薬用植物カンゾウのグリチルリチン生合成に関わる糖転移酵素遺伝子の単離と機能解析

關光, 大山清, 水谷正治, 須藤浩, 斉藤和季, 村中俊哉

日本生薬学会年会講演要旨集, 60回 141-141, Aug, 2013
3P-221 Identification of a glycosyltransferase involved in the biosynthesis of glycyrrhizin

seki Hikaru, Ohyama Kiyoshi, Mizutani Masaharu, Sudo Hiroshi, Saito Kazuki, Muranaka Toshiya

65 243-243, 2013
カンゾウ属植物が生成するサポニンの化学的多様性起源の分子生物学的研究

澤井学, 石森雅人, 大山清, 關光, 須藤浩, 明石智義, 青木俊夫, 村中俊哉, 斉藤和季

日本生薬学会年会講演要旨集, 59回 63-63, Aug, 2012
マメ科カンゾウ属植物のトリテルペン生合成P450に関する研究

桐田理生, 大山清, 澤井学, 澤井学, 澤井学, 石森雅人, 關光, 關光, 關光, 須藤浩 …

日本化学会講演予稿集, 92nd(4), 2012
カンゾウ属植物のサポニン生合成に関わるP450遺伝子の多様性

澤井学, 澤井学, 澤井学, 石森雅人, 大山清, 大山清, 關光, 關光, 關光, 須藤浩 …

日本植物細胞分子生物学会大会・シンポジウム講演要旨集, 30th, 2012
Molecular Origin of the Chemical Diversity of Saponins in Glycyrrhiza Species

Sawai Satoru, Ishimori Msato, Ohyama Kiyoshi, Seki Hikaru, Sudo Hiroshi, Akashi Tomoyoshi, Aoki Toshio, Muranaka Toshiya, Saito Kazuki

Plant and Cell Physiology Supplement, 2011 250-250, 2011
カンゾウ属植物におけるグリチルリチン生合成に関わるP450遺伝子の多様性

石森雅人, 澤井学, 澤井学, 關光, 關光, 大山清, 須藤浩, 須藤浩, 明石智義, 青木俊夫 …

日本薬学会年会要旨集, 129th(2), 2009
グリチルリチン生合成のゲノム機能科学と応用:合成生物学アプローチによるグリチルレチン酸の生産とカンゾウ属植物での化学的多様性の分子基盤

澤井学, 澤井学, 石森雅人, 關光, 關光, 大山清, 須藤浩, 須藤浩, 明石智義, 青木俊夫 …

日本生薬学会年会講演要旨集, 56th, 2009
カンゾウ属植物のグリチルリチン生産に関わるP450遺伝子の多様性

澤井学, 澤井学, 石森雅人, 關光, 關光, 大山清, 須藤浩, 須藤浩, 明石智義, 青木俊夫 …

日本植物細胞分子生物学会大会・シンポジウム講演要旨集, 27th, 2009
カンゾウ培養細胞のグリチルリチン輸送特性と輸送体遺伝子の探索

中山祥子, 加藤革己, 寺坂和祥, 林宏明, 關光, 關光, 村中俊哉, 村中俊哉, 須藤浩, 須藤浩 …

日本植物細胞分子生物学会大会・シンポジウム講演要旨集, 27th, 2009
Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species.

Takashi Asano, Hiroshi Sudo, Mami Yamazaki, Kazuki Saito

Methods in molecular biology (Clifton, N.J.), 547 337-45, 2009
Biosynthetic system of camptothecin, an anticancer plant product

Mami Yamazaki, Takashi Asano, Jun Okuyama, Supaart Sirikantaramas, Hiroshi Sudo, Kazuki Saito

JOURNAL OF BIOTECHNOLOGY, 136 S147-S148, Oct, 2008
甘草グリチルリチン生合成遺伝子の同定(2)酵母発現系を用いた遺伝子機能同定

澤井学, 澤井学, 關光, 關光, 大山清, 須藤浩, 須藤浩, 水谷正治, 大西利幸, 明石智義 …

日本生薬学会年会講演要旨集, 55th, 2008
甘草グリチルリチン生合成遺伝子の同定(1)ESTライブラリーの構築と遺伝子マイニング

關光, 關光, 大山清, 須藤浩, 須藤浩, 水谷正治, 大西利幸, 高上馬希重, 櫻井望, 鈴木秀幸 …

日本生薬学会年会講演要旨集, 55th, 2008
薬用植物カンゾウのグリチルリチン生合成に関わるP450遺伝子のクローニング(2)

關光, 關光, 大山清, 澤井学, 澤井学, 明石智義, 水谷正治, 大西利幸, 須藤浩, 須藤浩 …

日本植物細胞分子生物学会大会・シンポジウム講演要旨集, 26th, 2008
Transport of camptothecin in hairy roots of Ophiorrhiza pumila

Supaart Sirikantaramas, Hiroshi Sudo, Takashi Asano, Mami Yamazaki, Kazuki Saito

PHYTOCHEMISTRY, 68(22-24) 2881-2886, Nov, 2007
RNAi法を用いたチャボイナモリ毛状根のカンプトテシン生合成機構の解明

浅野孝, 菅谷知世, 林香代子, 須藤浩, 斉藤和季, 山崎真巳

日本生薬学会年会講演要旨集, 54回 101-101, Sep, 2007

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