Hikaru Ito

Profile Information

Affiliation: Kagawa University

Degree: 博士（医学）(東京医科歯科大学)

Researcher number: 50587392
J-GLOBAL ID: 201101074455100119
researchmap Member ID: B000003127

External link: https://hikaruito-labo.netlify.app/

Research Interests

Research Areas

Life sciences / Neuroanatomy and physiology /

Research History

Apr, 2021 - Present

associate professor, Life Science Research Center and Faculty of Medicine, Kagawa University
Jan, 2019 - Mar, 2021

Assistant Professor, Institute of Research, Center for Experimental Animals, Tokyo Medical and Dental University
Dec, 2015 - Dec, 2018

Assistant Professor, Department of Neurobiology, Hiroshima University
Mar, 2014 - Nov, 2015

Postdoctoral associate, Stem Cell Institute, Dept. of Neurology, University of Minnesota
Apr, 2013 - Mar, 2014

Visiting postdoctoral associate, Integrative Physiology and Neuroscience, Washington State University
Apr, 2010 - Mar, 2013

Medical Research Institute, Tokyo Medical and Dental University
Apr, 2006 - Mar, 2010

大学院（博士課程）, 東京医科歯科大学神経病理学分野

Committee Memberships

2022 - Present

教育研修委員会委員, 国立大学法人動物実験施設協議会

Awards

2015

最優秀論文賞, 東京医科歯科大学難治疾患研究所

伊藤日加瑠, 塩飽裕紀, 岡澤均
2013

優秀発表賞, 東京医科歯科大学脳機能統合機能研究センター

伊藤日加瑠
2013

優秀発表賞, 東京医科歯科大学難治疾患研究所

伊藤日加瑠
2010

優秀論文賞, 東京医科歯科大学難治疾患研究所
2010

若手優秀発表賞, 包括脳ネットワーク・夏のワークショップ（神経科学学会）

Papers

Chronic non-discriminatory social defeat stress during the perinatal period induces depressive-like outcomes in female mice

Masumi Ito, Hikaru Ito, Kaori Miyoshi, Masami Kanai-Azuma

Brain Research, 148734-148734, Dec, 2023 Peer-reviewedCorresponding author
Neural mechanisms underlying uninstructed orofacial movements during reward-based learning behaviors

Wan-Ru Li, Takashi Nakano, Kohta Mizutani, Takanori Matsubara, Masahiro Kawatani, Yasutaka Mukai, Teruko Danjo, Hikaru Ito, Hidenori Aizawa, Akihiro Yamanaka …

Current Biology, 33(16) 3436-3451.e7, Aug, 2023 Peer-reviewed
Targeting retrovirus-derived Rtl8a and 8b causes late onset obesity and neurodevelopmental defects

Yoshifumi Fujioka, Hirosuke Shiura, Masayuki Ishii, Ryuichi Ono, Tsutomu Endo, Hiroshi Kiyonari, Yoshikazu Hirate, Hikaru Ito, Masami Kanai-Azuma, Takashi Kohda …

May 28, 2023
A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas

Hiroshi YOMOGITA, Hikaru ITO, Kento HASHIMOTO, Akihiko KUDO, Toshiaki FUKUSHIMA, Tsutomu ENDO, Yoshikazu HIRATE, Yoshihiro AKIMOTO, Masayuki KOMADA, Yoshiakira KANAI …

Journal of Reproduction and Development, 69(1) 32-40, Feb, 2023 Peer-reviewed
Primary motor cortex drives expressive facial movements related to reward processing in mice

Wanru Li, Takashi Nakano, Kohta Mizutani, Masahiro Kawatani, Takanori Matsubara, Teruko Danjo, Yasutaka Mukai, Akihiro Yamanaka, Hikaru Ito, Hidenori Aizawa …

Oct 30, 2022
Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix.

Hikaru Ito, Kanako Nozaki, Kenji Sakimura, Manabu Abe, Shigeto Yamawaki, Hidenori Aizawa

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 46(2) 442-454, 2021 Peer-reviewedLead author
Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress.

Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi …

The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(38) 7241-7254, Sep 16, 2020 Peer-reviewed
Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress.

Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Ezgi Hatice Sahin, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro A Kato, Hidenori Aizawa

Neuropharmacology, 162 107835-107835, Jan 1, 2020 Peer-reviewed
Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.

Yosuke Yamawaki, Satomi Shirawachi, Akiko Mizokami, Kanako Nozaki, Hikaru Ito, Satoshi Asano, Kana Oue, Hidenori Aizawa, Shigeto Yamawaki, Masato Hirata …

Neurochemistry international, 131 104563-104563, Dec, 2019 Peer-reviewed
Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice

Yosuke Yamawaki, Norika Yoshioka, Kanako Nozaki, Hikaru Ito, Keisuke Oda, Kana Harada, Satomi Shirawachi, Satoshi Asano, Hidenori Aizawa, Shigeto Yamawaki …

Brain Research, 1680 13-38, Feb 1, 2018 Peer-reviewed
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa …

NATURE COMMUNICATIONS, 8 1864, Nov, 2017 Peer-reviewed
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

Shigeki Iwase, Emily Brookes, Saurabh Agarwal, Aimee I. Badeaux, Hikaru Ito, Christina N. Vallianatos, Giulio Srubek Tomassy, Tomas Kasza, Grace Lin, Andrew Thompson …

CELL REPORTS, 14(5) 1000-1009, Feb, 2016 Peer-reviewed
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells

H. Ito, H. Shiwaku, C. Yoshida, H. Homma, H. Luo, X. Chen, K. Fujita, L. Musante, U. Fischer, S. G. M. Frints …

MOLECULAR PSYCHIATRY, 20(4) 459-471, Apr, 2015 Peer-reviewed
Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain

Kazuhiko Tagawa, Hidenori Homma, Ayumu Saito, Kyota Fujita, Xigui Chen, Seiya Imoto, Tsutomu Oka, Hikaru Ito, Kazumi Motoki, Chisato Yoshida …

HUMAN MOLECULAR GENETICS, 24(2) 540-558, Jan, 2015 Peer-reviewed
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.

Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S …

EMBO molecular medicine, 7(1) 78-101, Dec, 2014 Peer-reviewed
Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1

Sam S. Barclay, Takuya Tamura, Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Teppei Shimamura, Asuka Katsuta, Hiroki Shiwaku, Masaki Sone, Seiya Imoto …

HUMAN MOLECULAR GENETICS, 23(5) 1345-1364, Mar, 2014 Peer-reviewed
Sox2 Transcriptionally Regulates Pqbp1, an Intellectual Disability-Microcephaly Causative Gene, in Neural Stem Progenitor Cells

Chan Li, Hikaru Ito, Kyota Fujita, Hiroki Shiwaku, Yunlong Qi, Kazuhiko Tagawa, Takuya Tamura, Hitoshi Okazawa

PLoS ONE, 8(7) e68627, Jul 16, 2013 Peer-reviewed
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases

Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku …

NATURE COMMUNICATIONS, 4, May, 2013 Peer-reviewed
Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network

Yoko Nakamura, Kazuhiko Tagawa, Tsutomu Oka, Toshikazu Sasabe, Hikaru Ito, Hiroki Shiwaku, Albert R. La Spada, Hitoshi Okazawa

HUMAN MOLECULAR GENETICS, 21(5) 1099-1110, Mar, 2012 Peer-reviewed
Dynamic Changes of the Phosphoproteome in Postmortem Mouse Brains

Tsutomu Oka, Kazuhiko Tagawa, Hikaru Ito, Hitoshi Okazawa

PLOS ONE, 6(6), Jun, 2011 Peer-reviewed

Misc.

Polyglutamine toxicity and nourodegeneration

63(4) 339-344, Jul, 2012
DNA damage repair in Spinocerebellar ataxia 1

Takuya Tamura, Masaki Sone, Sam Barclay, Hikaru Ito, Hiroki Shiwaku, Kazuhiko Tagawa, Hitoshi Okazawa

NEUROSCIENCE RESEARCH, 71 E193-E193, 2011
Mutant Huntingtin impairs Ku70-mediated DNA repair

Yasushi Enokido, Takuya Tamura, Hikaru Ito, Akihiko Komuro, Hiroki Shiwaku, Erich E. Wanker, Hitoshi Okazawa

NEUROSCIENCE RESEARCH, 68 E94-E94, 2010

Teaching Experience

Apr, 2021 - Present

Biology (Kagawa University)
脳神経医学（神経解剖学） (広島大学)
人体構造学（組織学、脳実習） (広島大学)
細胞科学 (広島大学)

Education

Apr, 2006 - Mar, 2010

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

Professional Memberships

2019 - Present

日本実験動物学会
2013 - Present

日本神経科学学会

Research Projects

In vivo study of the maternal envionment and delivery system.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
雌マウスを用いた新たなうつ病モデルの開発と病態解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

伊藤日加瑠
Pathophysiological mechanisms for microcephaly and macrocephaly

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Hikaru Ito
Generation of myogenic stem cells from iPS cells via blastocyst complementation.

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2016 - Mar, 2018

Ito Hikaru, Asakura Atsushi, Asakura Yoko
新規病態関連分子をターゲットとしたポリグルタミン病の治療効果

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2011 - 2013

伊藤日加瑠

Profile Information

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Awards

Papers

Misc.

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