佐々木 秀

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アバター
研究者氏名
佐々木 秀
eメール
s-sasakihoshi.ac.jp
所属
星薬科大学
部署
医薬品化学研究所 有機合成化学研究室
学位
薬学博士(星薬科大学)
科研費研究者番号
00459968

論文

 
Hiroyoshi Teramoto, Takayasu Yamauchi, Yasushi Terado, Sanae Odagiri, Shigeru Sasaki, Kimio Higashiyama
Chemical and Pharmaceutical Bulletin   64 410-419   2016年5月
© 2016 The Pharmaceutical Society of Japan.The matrine-type alkaloid 4-dimethylamino-1-pentanoylpiperidine (3a) has an antinociceptive effect through its impact on the κ-opioid receptor (KOR). Derivatives of 3a were synthesized by altering its ami...
Hiroyoshi Teramoto, Takayasu Yamauchi, Shigeru Sasaki, Kimio Higashiyama
Chemical and Pharmaceutical Bulletin   64 420-431   2016年5月
© 2016 The Pharmaceutical Society of Japan.A series of new κ opioid receptor (KOR) agonists were developed from the lead compound 4-dimethylamino-1-pentanoylpiperidine (3), a matrine-type alkaloid. Derivatives of 3 were synthesized with a variety ...
Shigeru Sasaki, Tatuo Suzuki, Toshihiro Uchiya, Shigenobu Toyota, Akira Hirano, Mao Tanemura, Hiroyoshi Teramoto, Takayasu Yamauchi, Kimio Higashiyama
Journal of Fluorine Chemistry   192 78-85   2016年1月
© 2016 Elsevier B.V.We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc = tert-butyloxycarbonyl) esters and carbonyl compounds affords ...
Shigeru Sasaki, Takayasu Yamauchi, Masatomi Kanai, Akihiro Ishii, Kimio Higashiyama
Bulletin of the Chemical Society of Japan   88 200-208   2015年1月
© 2014 The Chemical Society of Japan. Bisoxazoline (BOX)-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcohols. The effect of the size of t...
Takayasu Yamauchi, Jun Ichi Takidaira, Kenya Okamoto, Takaya Sugiura, Hiroki Horikoshi, Shintaro Kudo, Shigeru Sasaki, Noriko Mizushima, Kimio Higashiyama
Heterocycles   88 1175-1189   2014年1月
Total synthesis of (3R,16Z,20E,23S)- and (3R,16Z,20E,23R)-eushearilide was accomplished in 15 steps, respectively. Using either enantiomer of one of the four building blocks to assemble the phosphonium salt for the latter Wittig reaction, two dias...