Shigeru Sasaki

Profile Information

Affiliation: 助教, 医薬品化学研究所有機合成化学研究室, 星薬科大学

Degree: 博士（薬学）(Mar, 2014, 星薬科大学)

J-GLOBAL ID: 201601013774142370
researchmap Member ID: B000252097

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Papers

Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine

Tomohisa Mori, Yoshinori Takemura, Takamichi Arima, Yoshiyuki Iwase, Michiko Narita, Kanako Miyano, Yusuke Hamada, Yukari Suda, Akinobu Matsuzawa, Kazuyuki Sugita …

Biochemical and Biophysical Research Communications, 534 988-994, Jan 1, 2021
Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N -Propargyl Enamines

Yuya Chikayuki, Takakane Miyashige, Shiori Yonekawa, Akiko Kirita, Natsuko Matsuo, Hiroyoshi Teramoto, Shigeru Sasaki, Kimio Higashiyama, Takayasu Yamauchi

Synthesis (Germany), 52(7) 1113-1121, Apr, 2020 Peer-reviewed
Transition metal-free cyclization of N-boc-N-propargylenamines

Yuya Chikayuki, Yasuaki Kouno, Shiori Yonekawa, Haruka Ishikawa, Yoko Waki, Hiroyoshi Teramoto, Shigeru Sasaki, Kimio Higashiyama, Takayasu Yamauchi

Heterocycles, 100(5) 719-746, 2020 Peer-reviewed
Synthesis of thiourea derivatives from m-methoxycinnamic acid as antiangiogenic candidate

Juni Ekowati, Iwan Sahrial Hamid, Kholis Amalia Nofianti, Shigeru Sasaki

Jurnal Teknologi, 81(4) 105-114, 2019 Peer-reviewed
Substituent effects in regio- And stereoselective ring-opening reaction of aziridines with ET3N·3HF for β-fluoroamine synthesis

Shigeru Sasaki, Satono Watanabe, Kaori Shiino, Yuko Yanaka, Shiho Kaneko, Kana Miyamoto, Ayano Yasui, Hina Sakaino, Hiroyoshi Teramoto, Takayasu Yamauchi …

Heterocycles, 97(2) 823-841, 2018 Peer-reviewed
Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)<inf>3</inf>-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters

Shigeru Sasaki, Tatuo Suzuki, Toshihiro Uchiya, Shigenobu Toyota, Akira Hirano, Mao Tanemura, Hiroyoshi Teramoto, Takayasu Yamauchi, Kimio Higashiyama

Journal of Fluorine Chemistry, 192 78-85, 2016 Peer-reviewed
Design and synthesis of a piperidinone scaffold as an analgesic through kappa-opioid receptor: Structure-activity relationship study of matrine alkaloids

Hiroyoshi Teramoto, Takayasu Yamauchi, Yasushi Terado, Sanae Odagiri, Shigeru Sasaki, Kimio Higashiyama

Chemical and Pharmaceutical Bulletin, 64(5) 410-419, 2016 Peer-reviewed
Development of κ opioid receptor agonists by focusing on phenyl substituents of 4-dimethylamino-3-phenylpiperidine derivatives: Structure-activity relationship study of matrine type alkaloids

Hiroyoshi Teramoto, Takayasu Yamauchi, Shigeru Sasaki, Kimio Higashiyama

Chemical and Pharmaceutical Bulletin, 64(5) 420-431, 2016 Peer-reviewed
Bisoxazoline-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones: Enantiofacial control by changing the bisoxazoline substituent

Shigeru Sasaki, Takayasu Yamauchi, Masatomi Kanai, Akihiro Ishii, Kimio Higashiyama

Bulletin of the Chemical Society of Japan, 88(1) 200-208, 2015 Peer-reviewed
Total synthesis of the proposed structures of eushearilide

Takayasu Yamauchi, Jun Ichi Takidaira, Kenya Okamoto, Takaya Sugiura, Hiroki Horikoshi, Shintaro Kudo, Shigeru Sasaki, Noriko Mizushima, Kimio Higashiyama

Heterocycles, 88(2) 1175-1189, 2014 Peer-reviewed
Structure modification of ethyl p-methoxycinnamate and their bioassay as chemopreventive agent against mice's fibrosarcoma

Juni Ekowati, Bimo A. Tejo, Shigeru Sasaki, Kimio Highasiyama, Sukardiman, Siswandono, Tutuk Budiati

International Journal of Pharmacy and Pharmaceutical Sciences, 4(SUPPL.3) 528-532, 2012 Peer-reviewed
Brønsted acid catalyzed friedel-crafts alkylation reactions of trifluoromethyl-α,β-ynones with indoles

Shigeru Sasaki, Yuta Ikekame, Manabu Tanayama, Takayasu Yamauchi, Kimio Higashiyama

Synlett, 23(18) 2699-2703, 2012 Peer-reviewed
Direct aldol reaction of trifluoromethyl ketones with ketones catalyzed by Et<inf>2</inf>Zn and secondary amines

Shigeru Sasaki, Kasumi Kikuchi, Takayasu Yamauchi, Kimio Higashiyama

Synlett, (10) 1431-1434, 2011 Peer-reviewed
Efficient microwave-assisted prenylation of pinostrobin and biological evaluation of its derivatives as antitumor agents

Hadi Poerwono, Shigeru Sasaki, Yoshiyuki Hattori, Kimio Higashiyama

Bioorganic and Medicinal Chemistry Letters, 20(7) 2086-2089, Apr, 2010 Peer-reviewed
Dy(OTf)<inf>3</inf>/Pybox-catalyzed enantioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated trifluoromethyl ketones

Shigeru Sasaki, Takayasu Yamauchi, Kimio Higashiyama

Tetrahedron Letters, 51(17) 2326-2328, Apr, 2010 Peer-reviewed
Chemoselective reduction of ketones: Trifluoromethylketones versus methylketones

Shigeru Sasaki, Takayasu Yamauchi, Hajime Kubo, Masatomi Kanai, Akihiro Ishii, Kimio Higashiyama

Tetrahedron Letters, 46(9) 1497-1500, Feb 28, 2005 Peer-reviewed

Research Projects

Investigation on relationship between glycan structure and antibody-drug conjugate function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023

Profile Information

Research Areas

Papers

Research Projects

Menu

Coauthors