Yasuo Sakuma

Last updated: Apr 1, 2016 at 14:59
 
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Name
Yasuo Sakuma
Nickname
Yasuo Sakuma
E-mail
y-sakumau-ths.ac.jp
Mobile mail
lordosis_quotientdocomo.ne.jp
URL
http://bit.ly/1fuLVBQ
Affiliation
University of Tokyo Health Sciences
Section
Office of the President
Job title
President
Degree
M.D.(Yokohama City University), Ph.D.(Yokohama City University)
Other affiliation
The Rockefeller UniversityNippon Medical School
Research funding number
70094307
Twitter ID
@ysakuma
Google Analytics
UA-30763004-1
ORCID ID
0000-0001-6816-3779

Profile

Yasuo Sakuma was born in Kamakura, Japan, on December 3, 1946. He received an M.D. in 1971 and a Ph.D. in 1975, both from Yokohama City University. The Positions he held include Research Associate, Department of Physiology, Yokohama City University, Yokohama, 1975; Assistant Professor, Division of Physiology and Behavior, Behavior Research Institute, Gunma University School of Medicine, Maebashi, 1976; Postdoctoral Fellow, Rockefeller University, New York, 1976; Visiting Associate Professor, Rockefeller University, New York, 1978; Associate Professor, Department of Physiology, Niigata University School of Medicine, Niigata, 1981; Professor, Department of Physiology, Hirosaki University School of Medicine, Hirosaki, 1988; Professor and Head, Department of Physiology, Nippon Medical School, Tokyo, 1993-present.
His main interests were initially reproductive neuroendocrinology; later he become involved in female rat reproductive behavior and eventually shifted to the study of the neural basis for sexual motivation. His research also focuses on cell physiology of GnRH, mechanism for the onset of puberty, and neural actions of estrogen.
He is a member of The Physiological Society of Japan, Japan Endocrine Society, Japan Neuroscience Society, The Physiological Society (U.K.), American Physiological Society, Society for Neuroscience, International Society of Neuroendocrinology, and Society for Behavioral Neuroendocrinology. He is Editor-in-Chief of The Journal of Physiological Sciences, the organ of The Physiological Society of Japan. CV on web: http://bit.ly/1fuLVBQ

Research Areas

 
 

Academic & Professional Experience

 
Apr 2012
 - 
Today
President, University of Tokyo Health Sciences
 
Apr 2012
 - 
Today
Professor emeritus, Nippon Medical School
 
Sep 2008
 - 
Today
Adjunct Professor, The Rockefeller University
 
Sep 1978
 - 
Mar 1980
Visiting Associate Professor, The Rockefeller University
 
Sep 1976
 - 
Aug 1978
Postdoctral Fellow, The Rockefeller University
 
Apr 1976
 - 
Jul 1976
Assistant Professor, Gunma University Medical School
 
Aug 1976
 - 
Mar 1981
Associate Professor, Gunma Univeristy Medical School
 
Apr 1975
 - 
Mar 1976
Research Associate, Yokohama City University Medical School
 

Published Papers

 
Urakawa S, Mitsushima D, Shimozuru M, Sakuma Y, Kondo Y
PloS one   9 e87911   2014   [Refereed]
Wada-Kiyama Y, Suzuki C, Hamada T, Rai D, Kiyama R, Kaneda M, Sakuma Y
Biochemical and biophysical research communications   434 287-292   May 2013   [Refereed]
Ishii H, Kobayashi M, Munetomo A, Miyamoto T, Sakuma Y
The Journal of steroid biochemistry and molecular biology   133 120-128   Jan 2013   [Refereed]
Ishii H, Kobayashi M, Munetomo A, Miyamoto T, Sakuma Y
Journal of Steroid Biochemistry and Molecular Biology   133(1) 120-128   2013   [Refereed]
Koyama M, Yin C, Ishii H, Sakuma Y, Kato M
Endocrinology   153(2) 806-814   Feb 2012   [Refereed]

Misc

 
近藤照彦, 武田淳史, 近藤翔太, 小林功, 佐久間康夫
適応医学   17(1) 14   Jun 2013
加藤昌克, 佐久間康夫
月刊内分泌・糖尿病・代謝内科   36 105-109   Apr 2013
尹成珠, 石井寛高, 佐久間康夫, 加藤昌克
日本内分泌学会雑誌   88(2) 639   Sep 2012

Books etc

 
メディカル・サイエンス・インターナショナル   May 2005   ISBN:4895924092
東 英穂, 西崎 知之, 福田 淳, 佐久間 康夫, 片山 芳文, 吉村 恵
丸善   Mar 2004   ISBN:4621073605
丸善   Jan 1999   ISBN:462104544X

Conference Activities & Talks

 
Estrogens and the Brain Circuitry for Sexual Behavior in the Female Rat [Invited]
Yasuo Sakuma
The 12th IBRO Associate School Program   Dec 2009   
Steroid hormones and the Brain sex difference in the rat [Invited]
Yasuo Sakuma
Seminar at Xi'an Jiaotong University   Nov 2008   
Hormonal environment and brain sex differentiation in the rat [Invited]
Yasuo Sakuma
Strategies to Reduce Risks on the Brain Development Contingent to Urbanization. Japan-China Bilateral Seminar supported by JSPS   Oct 2008   
Neuronal migration or survival, but not neurogenesis contributes to brain sex differentiation in the rat. international symposium for gonad and brain sex differentiation [Invited]
Yasuo Sakuma
International Symposium for Gonad and Brain Sex Differentiation   Sep 2008   
Estrogens and the brain circuitry for sexual behavior in the female rat [Invited]
Yasuo Sakuma
Chinese Society of Andrology   Apr 2007   
Hormons, brain and behaviour [Invited]
Yasuo Sakuma
The 11th IBRO Associate School Program   Dec 2006   
Sex difference in estrogen receptor beta expression in the brain: Its ontogeny and functional implications [Invited]
Yasuo Sakuma
The 6th US-Taiwan Neuroscience Symposium: A Satellite Symposium of the 2003 SFN Annual Meeting   Nov 2003   
Estrogen receptor and brain sex differentiation [Invited]
Yasuo Sakuma
International Symposium on Environmental Endocrine Disrupters 2002, Ministry of the Environment, Government of Japan   Nov 2002   
The role of midbrain GnRH in the regulation of female rat sexual behavior [Invited]
Yasuo Sakuma
Second International Symposium on the Comparative Biology of GnRH: Molecular Forms and Receptors   Jun 2001   
Estrogen-induced changes in neural impulse flow in the brain [Invited]
Yasuo Sakuma
The 4th International Congress of Neuroendocrinology Satellite Symposium, Steroids in the Brain:From Transcription Factors to Behavior   Oct 1998   
Site- and sex-specific effects of estrogen on neuronal impulse flow. [Invited]
Yasuo Sakuma
Symposium at The 2nd Meeting of European Neuroscience   Apr 1996   
Electrophysiological correlates of female rat sexual behavior [Invited]
Yasuo Sakuma
Symposium on Sexual Orientation at XXIV International Ethological Conference   Aug 1995   
Differential effects of estrogen on preoptic efferents to the "reproductive brain" of the female rat [Invited]
Yasuo Sakuma
The second joint meeting of the physiological societies' of Japan, U. K. and Eire   Mar 1995   
Differential mechanisms for the initiation and execution of female rat reproductive behavior [Invited]
Yasuo Sakuma
Joint Russian-Japanese Symposium on Physiology of Adaptation   Oct 1993   
Preoptic mechanisms to initiate and carry out female rat reproductive behavior [Invited]
Yasuo Sakuma
Symposium on Mechanisms of Reproductive Behavior at The 17th International Union of Physiological Sciences Congress   Aug 1993   
Sex-hormone dependent behavior of the female rat [Invited]
Yasuo Sakuma
Invited Lecture at Tianjin Medical College   Oct 1992   
Regulation of reproductive behavior by neuropeptides [Invited]
Yasuo Sakuma
Seminar at Tianjin Family Planning Institute, Tianjin, China   Oct 1992   
Neural and hormonal regulation of female rat reproductive behavior [Invited]
Yasuo Sakuma
Weekly Lectures on Neuroendocrinology for Graduate Students and the Faculty, Ningxa Medical College,   Sep 1992   
Sex steroids and hypothalamic cell activity: developmental effects and regional differences [Invited]
Yasuo Sakuma
The Neuroendocrine Hypothalamus, British Neuroendocrine Group-Physiological Societies Symposium   Jul 1991   
Involvement of neurotrophic factors in the sex-hormone dependent masculinization of the rat brain [Invited]
Yasuo Sakuma
Symposium on Growth Factors, Second International Congress of Neuroendocrinology   Jun 1990   
Sexual differentiation of electrical properties of the brain [Invited]
Yasuo Sakuma
Kochi International Symposium on Pheromones and Reproduction   Jul 1988   
Testosterone-induced defeminization of the rat hypothalamus: Blockade by antibody to nerve growth factor [Invited]
Yasuo Sakuma
Tokyo Metropolitan Institute for Neuroscience Workshop on Developmental Aspects of Neuroendocrinology   Feb 1988   
Electrophysiological characterization of estrogen-sensitive neural circuitries for the reproductive behavior [Invited]
Yasuo Sakuma
Symposium on Sexual expression, The 2nd International Congress of Neuroscience   Aug 1987   
Role of opioid peptides in regulating sexual behavior [Invited]
Yasuo Sakuma
Symposium, The 8th Asia and Oceania Congress of Endocrinology   Dec 1986   
Electrophysiological effects of sex, steroids on neurons in the central nervous system. [Invited]
Yasuo Sakuma
The Rockefeller University Seminar on Reproductive Biology   Nov 1983   
Inhibition of hypothalamic unit activity by microiontophoresis of antiserum against LH-RH. [Invited]
Yasuo Sakuma
International Symposium on Cellular and Molecular Bases of Neuroendocrine Processes   Dec 1976   
Characteristics of the responses of hypothalamic arcuate and medial preoptic neurons to LH-RH during the rat estrous cycle. [Invited]
Yasuo Sakuma
Workshop Conference of International Society of Psychoneuroendocrinology   Sep 1974   

Research Grants & Projects

 
JSPS: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Chiotse ORIKASA
Although the SDN-POA was significantly larger in males than in females at PD15, the total numbers of neurons comprising the SDN-POA were not significantly different between sexes. Sexual dimorphism in the SDN-POA results from male-specific postnat...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2006 - 2009    Investigator(s): Yasuo SAKUMA
In the rat, estrogen determines sexual phenotype of the brain, acting at a critical period as neonates. The sexual phenotype thus established persists into adulthood, both in morphology and electrophysiology. In the adults, the volume of the sexua...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2004 - 2008    Investigator(s): Yasuo SAKUMA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2004 - 2008    Investigator(s): 勝木元也, 長濱嘉孝, Toshikuni SASAOKA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Kato MASAKATSU
Law conductance voltage-and calcium-activated potassium (BK) channels and A-type γ-aminobutyric acid receptor (GABAAR) expressed in rat GnRH neurons were investigated. Brain was removed from adult GnRH-EGFP transgenic rat under anesthesia, and neu...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2007    Investigator(s): Ryoichi KIYAMA
In this study, we aimed to characterize the functions and the networks of estrogen-responsive genes by means of proteomic analysis to unravel signaling pathways of the genes responding to estrogen which were revealed by expression profiling using ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2007    Investigator(s): Tomohiro HAMADA
Estrogen plays an essential role for reproduction, plasticity and neuroprotection to affect on the central nervous system. The purpose of the present study is to examine the mechanisms of estrogen action using the visualized neurons that are respo...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2006    Investigator(s): Chitose ORIKASA
Estrogen plays critical role in sexual differentiation of the developing brain and sex-specific regulation of reproductive neuroendocrinology in adult. Cellular estrogen signaling is conveyed by nuclear estrogen receptors (ERs) which include the c...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Masakatsu KATO
Voltage-gated ionic channel currents and GABAA receptor current in rat GnRH neurons were analyzed. Under deep anesthesia, brains were excised from adult GnRH-EGFP transgenic rats. After dissection, brains were enzymatically dispersed and the neuro...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2005    Investigator(s): Yasuo SAKUMA
Transgenic rats expressing enhanced green fluorescent protein (EGFP) under the control of an estrogen receptor (ER) alpha promoter were generated to tag ERalpha-positive neurons in the brain. Two transgenes, one containing sequences for promoter A...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2004    Investigator(s): Ishwar PARHAR
Gonadotropin-releasing hormone(GnRH) is a highly conserved molecule, which is important for reproduction in vertebrate species. The present study was undertaken to identify molecules that control GnRH neuronal differentiation, migration and gene e...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2002    Investigator(s): Shinji HAYASHI
This research project is to propose new research field to be urgently established. To emphasize the importance of "the lypophilic signal molecules on brain function", we organized two symposia and supported three others listed below that are relat...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2001 - 2002    Investigator(s): Chitose ORIKASA
In this project, we investigated the physiological role of estrogen receptor β (ERβ) in sexual differentiation of developing brain and sex specific regulation of reproductive neuroendocrinology in the adult rats. By using non-isotoic in situ hybri...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2001 - 2002    Investigator(s): Masakatsu KATO
Gonadotropin releasing hormone (GnRH) neurons play an important role in reproductive neuroendocrinology. Functional analysis of these neurons is, however, limited although it has been facilitated by producing transgenic mice to specifically label ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1998 - 2000    Investigator(s): Yasuo SAKUMA
Estrogens are involved in both endocrine and behavioral sex differentiation during brain development and sex-specific regulation of reproductive neuroendocrinology and behavior in adulthood. Cellular estrogen signaling is conveyed by nuclear estro...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 2000    Investigator(s): Masakatsu KATO
GnRH neurons in the medial preoptic area and the hypothalamus play an important role in the central control of reproductive functions, such as onset of puberty and female ovulation cycle. However, physiological characterization of GnRH neurons has...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1996 - 1997    Investigator(s): Masakatsu KATO
In the present research, we analyzed the effects of somatostatin (SRIF) and growth hormone releasing hormone (GHRH) on male rat pituitary cells in primary culture. Among pituitary cells we focused somatotrophs and folliculo-stellate cells.First, w...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(総合研究(A))
Project Year: 1990 - 1991    Investigator(s): Akira YOKOYAMA
The purpose of the present research group is to elucidate the location of the pulse generator, which is thought to regulate the pulsatile release of luteinizing hormone (LH) through the pulsatile LH releasing homone (LHRH) release, in the hypothal...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1989 - 1991    Investigator(s): Yasuo SAKUMA
Lordosis reflex is an estrogen-dependent, essential component of the female rat sexual behavior. We examined electrical stimulation effects of the POA on lordosis in the free-moving, estrogen- and progesterone-treated ovariectomized 'rats, which w...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1987 - 1988    Investigator(s): Yasuo SAKUMA
Injection of antibody to nerve growth factor into the cerebral lateral ventricle blocked testosterone-induced behavioral defeminization of neonatal female rat. When tested as adults following ovariectomy and the combined estrogen-progesterone trea...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1986 - 1987    Investigator(s): Takao AKAISHI
Our previous studies have shown that estrogen affects the electrical activity of the oxytocin-producing cells in the female hypothalamus. Contrary to this, the vasopressin-producing cells are not affected at all in their activity by estrogen treat...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1985 - 1986    Investigator(s): Yasuo Sakuma
The ventromedial nucleus of the hypothalamus (VMN) is associated with estrogen-dependent neural regulation of autonomic, neuroendocrine and behavioral functions. VMN cells with axons to the midbrain central gray (CG) have been demonstrated as one ...