阿部匠

J-GLOBALへ         更新日: 16/05/25 12:26
 
アバター
研究者氏名
阿部匠
 
アベ タクミ
eメール
abe-thoku-iryo-u.ac.jp
URL
https://kaken.nii.ac.jp/d/r/80453273.ja.html
所属
北海道医療大学
部署
薬学部
職名
助教
学位
薬学博士(北海道大学)
科研費研究者番号
80453273

研究分野

 
 

経歴

 
2007年4月
 - 
現在
北海道医療大学 薬学部 助教
 
2009年1月
 - 
2009年8月
米国Scripps研究所 化学科 (Kim. D. Janda教授) 博士研究員
 

学歴

 
2002年4月
 - 
2007年3月
北海道大学大学院薬学研究科 創薬科学専攻薬品製造化学分野 博士課程
 
1998年4月
 - 
2002年3月
北海道医療大学 薬学部 
 

受賞

 
2014年12月
有機合成化学協会 アステラス製薬研究企画賞 「金属錯体のエージングを利用した新規反応の開発」
 
2011年11月
日本薬学会北海道支部 奨励賞 「多官能性合成素子の開発と天然物合成への応用」
 

論文

 
Tomoki Itoh, Takumi Abe, Tominari Choshi, Takashi Nishiyama, Reiko Yanada, Minoru Ishikura
European Journal of Organic Chemistry   2016 2290-2299   2016年5月
Copyright © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Concise syntheses of 9-methoxyellipticine, 3,4-dihydroellipticine (μ-alkaloid D), 1,2,3,4-tetrahydroellipticine, 2-methyl-1,2,3,4-tetrahydroellipticine, olivacine, 3,4-dihydroolivacine, ...
阿部 匠, 石倉 稔
有機合成化学協会誌   74(2) 117-129   2016年1月
In our continuing study of the reactivity and synthetic application of indolylborate as a versatile synthetic intermediate, we found that the use of indolylborate in palladium-catalyzed cross-coupling reaction is highly effective for the synthesis...
Ishikura M, Abe T, Choshi T, Hibino S
Natural product reports      2015年7月   [査読有り]
Tomoki Itoh, Takumi Abe, Shuhei Nakamura, Minoru Ishikura
Heterocycles   91 1423-1428   2015年1月
A one-pot conversion of skatole to tryptanthrin, an indolo[2,1-b]quinazoline alkaloid, was achieved by Cu-mediated oxidation.
Takumi Abe, Minoru Ishikura
Heterocycles   90 673-680   2015年1月
© 2015 The Japan Institute of Heterocyclic Chemistry. The palladium-catalyzed intramolecular oxidative coupling reaction of 1,1'-carbonyldiindoles was achieved by using Pd(OAc)2 and Cu(OAc)2, producing 1,1'-carbonyl-2,2'-biindolyls, which were the...
Takumi Abe, Tomoki Itoh, Tominari Choshi, Satoshi Hibino, Minoru Ishikura
Tetrahedron Letters   55 5268-5270   2014年9月
© 2014 Elsevier Ltd. All rights reserved. A one-pot approach to indolo[2,1-b]quinazolines from indole-3-carbaldehydes through the Dakin oxidation was developed. It was shown that the reaction proceeded through the condensation of indole-3-carbalde...
Mami Fujii, Takashi Nishiyama, Tominari Choshi, Nanase Satsuki, Takaya Fujiwaki, Takumi Abe, Minoru Ishikura, Satoshi Hibino
Tetrahedron   70 1805-1810   2014年3月
A novel one-pot synthesis of carbazole-1,4-quinone by consecutive Pd-catalyzed cyclocarbonylation, desilylation, and oxidation reactions is described. We propose a possible mechanism of the cyclocarbonylation reaction between 3-iodo-2-propenylindo...
Takumi Abe, Toshiaki Ikeda, Tomoki Itoh, Noriyuki Hatae, Eiko Toyota, Minoru Ishikura
Heterocycles   88 187-191   2014年1月
A one-pot synthesis of 3,3'-bisindolylmethanes was developed through the intermolecular Pummerer reaction using indole as a nucleophile. © 2014 The Japan Institute of Heterocyclic Chemistry.
Noriyuki Hatae, Risa Satoh, Hitomi Chiba, Takahiro Osaki, Takashi Nishiyama, Minoru Ishikura, Takumi Abe, Satoshi Hibino, Tominari Choshi, Chiaki Okada, Eiko Toyota
Medicinal Chemistry Research   23 4956-4961   2014年1月
© Springer Science+Business Media New York 2014. Calothrixin B, whose structure consists of a pentacyclic indolo[3,2-j]phenanthridine framework, was originally isolated as a secondary metabolite from Calothrix cyanobacteria and was found to exhibi...
Hatae N, Nakamura J, Okujima T, Ishikura M, Abe T, Hibino S, Choshi T, Okada C, Yamada H, Uno H, Toyota E
Bioorganic & medicinal chemistry letters   23(16) 4637-4640   2013年8月   [査読有り]
Takumi Abe
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   71 62-63   2013年7月
The development of biomimetic reactions is one of the major challenges for synthetic chemists, because mimicking these complicated reactions in the laboratory by simple catalytic systems is difficult to achieve in general. Vitamine B6-dependent am...
Abe T, Nakamura S, Yanada R, Choshi T, Hibino S, Ishikura M
Organic letters   15(14) 3622-3625   2013年7月   [査読有り]
Ishikura M, Abe T, Choshi T, Hibino S
Natural product reports   30(5) 694-752   2013年5月   [査読有り]
阿部 匠
有機合成化学協会誌   71(1) 62-63   2013年1月
The development of biomimetic reactions is one of the major challenges for synthetic chemists, because mimicking these complicated reactions in the laboratory by simple catalytic systems is difficult to achieve in general. Vitamine B6-dependent am...
阿部 匠
薬学雑誌   133(1) 99-106   2013年
阿部 匠
薬学雑誌. 乙号   133(1) 99-106   2013年
  This review describes a synthesis of indole compounds using multifunctional synthons. The multifunctional synthons, trienes and gramines, were respectively synthesized using Pd-catalyzed tandem cyclization/cross-coupling reaction of indolylborat...
Takumi Abe, Hiroyuki Komatsu, Toshiaki Ikeda, Noriyuki Hatae, Eiko Toyota, Minoru Ishikura
Heterocycles   86 505-513   2012年12月
A short total synthesis of a bisindole alkaloid, yuechukene, was achieved through the dimerization of β-dehydroprenylindole generated in situ from 1-(indol-3-yl)-3-methylbut-2-en-1-amine. © 2012 The Japan Institute of Heterocyclic Chemistry.
Takumi Abe, Toshiaki Ikeda, Tominari Choshi, Satoshi Hibino, Noriyuki Hatae, Eiko Toyata, Reiko Yanada, Minoru Ishikura
European Journal of Organic Chemistry   5018-5027   2012年9月
The palladium-catalyzed tandem cyclization/cross-coupling reaction of triethyl(indol-2-yl)borate with vinyl bromide was successfully used in the concise total synthesis of the indolophenanthridine alkaloids, calothrixins A and B. Palladium-catalyz...
Matsumoto K, Choshi T, Hourai M, Zamami Y, Sasaki K, Abe T, Ishikura M, Hatae N, Iwamura T, Tohyama S, Nobuhiro J, Hibino S
Bioorganic & medicinal chemistry letters   22(14) 4762-4764   2012年7月   [査読有り]
Abe T, Ikeda T, Yanada R, Ishikura M
Organic letters   13(13) 3356-3359   2011年7月   [査読有り]
Koji Yamada, Sayaka Yamaguchi, Noriyuki Hatae, Takumi Abe, Tatsunori Iwamura, Minoru Ishikura
Heterocycles   83 815-826   2011年3月
A novel and simple protocol for the synthesis of 1-(2-aminoethyl)- pyrano[3,2-e]indole derivatives has been developed using the Pictet-Spengler reaction of Nb-benzylserotonin with αβ-unsaturated aldehydes in the presence of Et3N in 2-propanol or M...
Ishikura M, Yamada K, Abe T
Natural product reports   27(11) 1630-1680   2010年11月   [査読有り]
Takumi Abe, Hiroyuki Takeda, Yumi Takahashi, Yoshihisa Miwa, Koji Yamada, Minora Ishikura
European Journal of Organic Chemistry   3281-3294   2010年6月
Cu- and Rh-catalyzed coupling reactions of 2-azabicyclo[2.2.1]hept-5-en-3- ones (1) with arylboronic acids were successful carried out under microwave irradiation conditions and yielded N-aryl and C-aryl derivatives of 1, respectively. © 2010 Wile...
Takumi Abe, Hiroyuki Takeda, Yoshihisa Miwa, Koji Yamada, Reiko Yanada, Minoru Ishikura
Helvetica Chimica Acta   93 233-241   2010年2月
It was shown that dichloramine-T (1) reacted with cyclohexene in acetonitrile to give N 1-(2-chlorocyclohexyl) amidine 2a and N-(2-chlorocyclohexyl)acetamide (3) via the competitive addition of acetonitrile and N-chloro-N-tosylamino anion to cyclo...
Lowery CA, Abe T, Park J, Eubanks LM, Sawada D, Kaufmann GF, Janda KD
Journal of the American Chemical Society   131(43) 15584-15585   2009年11月   [査読有り]
Koji Yamada, Yuichi Namerikawa, Takumi Abe, Minoru Ishikura
Heterocycles   77 825-828   2009年2月
The reaction of Nβ-benzylserotonin with α,β-unsaturated and aryl aldehydes in the presence of a base produced 1H-azepino[5,4,3-cd]indoles. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.
Takumi Abe, Hiroyuki Takeda, Yumi Takahashi, Yoshihisa Miwa, Koji Yamada, Minoru Ishikura
Heterocycles   75 2931-2936   2008年12月
Rhodium-catalyzed arylation of 2-azabicyclo[2.2.1]hept-5-en-3-one was successfully performed by applying microwave irradiation. © 2008 The Japan Institute of Heterocyclic Chemistry.
Takumi Abe, Hiroyuki Takeda, Koji Yamada, Minoru Ishikura
Heterocycles   76 133-136   2008年12月
Copper-catalyzed N-arylation reaction of 2-azabicyclo[2.2.1]hept-5-en-3-one (ABH) with arylboronic acids was successively performed in the presence of KOH and trimethylamine-N-oxide under microwave irradiation. © The Japan Institute of Heterocycli...
Minoru Ishikura, Norinobu Takahashi, Koji Yamada, Takumi Abe, Reiko Yanada
Helvetica Chimica Acta   91 1828-1837   2008年10月
Palladium-catalyzed tandem cyclization-cross-coupling reaction of indolylborate 2 and vinyl bromide 5 was successfully applied in a short formal synthesis of olivacine. The reaction of 2 with 5 in the presence of Pd(OAc) 2 readily afforded three k...
Minoru Ishikura, Norinobu Takahashi, Koji Yamada, Takumi Abe
Heterocycles   75 107-118   2008年1月
The palladium-catalyzed tandem cyclization-cross-coupling protocol using 1H-indol-2-yltrialkylborate (indolylborate) proved to be a versatile approach to the generation of 2-(4-piperidylmethyl)indole, which was successfully used for the preparatio...
Takuya Washio, Reika Yamaguchi, Takumi Abe, Hisanori Nambu, Masahiro Anada, Shunichi Hashimoto
Tetrahedron   63 12037-12046   2007年11月
Catalytic asymmetric syntheses of (-)-centrolobine and (-)-de-O-methylcentrolobine have been achieved, incorporating a hetero-Diels-Alder (HDA) reaction between 4-aryl-2-silyloxy-1,3-butadienes and phenylpropargyl aldehyde derivatives as a key ste...
Minoru Ishikura, Hiroyuki Komatsu, Koji Yamada, Takumi Abe, Reiko Yanada
Heterocycles   71 2325-2329   2007年11月
Regioselectivity on the reaction of (1-methylindol-2-yl)cyanocuprate with N-(prop-2-en-l-ylidene)aminium chlorides was investigated. © 2007 The Japan Institute of Heterocyclic Chemistry.
Anada M, Tanaka M, Washio T, Yamawaki M, Abe T, Hashimoto S
Organic letters   9(22) 4559-4562   2007年10月   [査読有り]
Minoru Yamawaki, Masahiko Tanaka, Takumi Abe, Masahiro Anada, Shunichi Hashimoto
Heterocycles   72 709-721   2007年4月
The enantioselective aziridination of alkenes with [N-(4-nitrophenylsulfonyl) imino[phenyliodinane catalyzed by dirhodium(II) tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate[, Rh2(S-TCPTTL)4, is described. While such enantioselectivities are hi...
Hideyuki Tsutsui, Naoyuki Shimada, Takumi Abe, Masahiro Anada, Makoto Nakajima, Seiichi Nakamura, Hisanori Nambu, Shunichi Hashimoto
Advanced Synthesis and Catalysis   349 521-526   2007年3月
The first successful example of the enantioselective intermolecular 1,3-dipolar cycloaddition of a chiral dirhodium(II) catalyst-associated carbonyl ylide with an aromatic aldehyde dipolarophile is described. The tandem carbonyl ylide formation/cy...
Practical synthesis of Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate].
Tsutsui H, Abe T, Nakamura S, Anada M, Hashimoto S
Chemical & pharmaceutical bulletin   53(10) 1366-1368   2005年10月   [査読有り]

競争的資金等の研究課題

 
エージング金属錯体の反応性開拓研究
文部科学省: 科学研究費補助金 若手研究B
研究期間: 2016年4月 - 2020年3月    代表者: 阿部匠
アレルギー皮膚疾患患者に用いることのできる優しい新規染料の合成探索
一般財団法人ホーユー科学財団: 研究助成
研究期間: 2016年4月 - 2017年3月    代表者: 阿部匠
金属錯体のエージングを利用した新規反応の開発
アステラス製薬: 有機合成化学協会研究企画賞
研究期間: 2015年4月 - 2017年3月    代表者: 阿部匠
トリエンの銅触媒カルボ6p-電子環状反応を用いる縮環型カルバゾールの合成
公益財団法人秋山記念生命科学振興財団: 研究助成(奨励)
研究期間: 2015年6月 - 2016年3月    代表者: 阿部匠
心筋様細胞への分化促進剤の設計と合成探索
一般財団法人北海道心臓協会: 研究開発調査助成
研究期間: 2015年7月       代表者: 阿部匠