中江大 (Dai Nakae) - マイポータル

基本情報

所属: 帝京平成大学健康医療スポーツ学部医療スポーツ学科動物医療コース教授

学位: 医学博士(1989年5月奈良県立医科大学)

J-GLOBAL ID: 201401037262479497
researchmap会員ID: B000242583

外部リンク: http://kaken.nii.ac.jp/d/r/90207712.ja.html

研究キーワード

研究分野

経歴

2022年4月 - 現在

帝京平成大学, 健康医療スポーツ学部医療スポーツ学科動物医療コース, 教授
2015年4月 - 2022年3月

東京農業大学, 応用生物科学部食品安全健康学科食品安全評価学研究室, 教授

論文

201

Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet

Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae

Journal of Toxicologic Pathology 36(1) 1-10 2023年
Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet

Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae

JOURNAL OF TOXICOLOGIC PATHOLOGY 36(1) 1-10 2023年
Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet. (Lipids in Health and Disease, (2020), 19, 1, (251), 10.1186/s12944-020-01423-3)

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

Lipids in Health and Disease 21(1) 2022年12月
Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats

Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi …

Particle and Fibre Toxicology 19(1) 2022年12月
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet.

Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae

Journal of toxicologic pathology 35(2) 149-157 2022年4月
Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet.

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

Lipids in health and disease 21(1) 2-2 2022年1月7日
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet

Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki Kemuriyama, Dai Nakae

Journal of Toxicologic Pathology 35(2) 149-157 2022年
CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet

Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae

JOURNAL OF TOXICOLOGIC PATHOLOGY 35(2) 149-157 2022年
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

FEBS Open Bio 11(11) 2950-2965 2021年11月
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

FEBS OPEN BIO 11(11) 2950-2965 2021年11月
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.

Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

FEBS open bio 11(11) 2950-2965 2021年11月
Histological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins.

Motoki Hojo, Yukio Yamamoto, Yoshimitsu Sakamoto, Ai Maeno, Aya Ohnuki, Jin Suzuki, Akiko Inomata, Takako Moriyasu, Yuhji Taquahashi, Jun Kanno …

Cancer science 112(6) 2185-2198 2021年3月4日
Glomerular Hyperfiltration With Hyperglycemia in the Spontaneously Diabetic Torii (SDT) Fatty Rat, an Obese Type 2 Diabetic Model

Ryuhei Sano, Yukihito Ishii, Masao Yamanaka, Yuzo Yasui, Yusuke Kemmochi, Fuko Kuroki, Miki Sugimoto, Sumiaki Fukuda, Tomohiko Sasase, Katsuhiro Miyajima …

Physiological Research 70(1) 45-54 2021年2月
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

Lipids in health and disease 19(1) 251-251 2020年12月14日
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet

Noriko Suzuki-Kemuriyama, Akari Abe, Kiniko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

Lipids in Health and Disease 19(1) 2020年12月
Identification of descarbonsildenafil in an adulterated dietary supplement and evaluation of its inhibitory activity for phosphodiesterase type 5 (PDE5)

Yoko Ichikawa-Kaji, Junichi Nakajima, Shoko Kikkawa, Fujio Ishizawa, Rei Nishiyama, Kiyoko Kishimoto, Nozomi Uemura, Miki Satoh, Jin Suzuki, Akiko Inomata …

Journal of the Food Hygienic Society of Japan 61(1) 34-40 2020年2月
Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model.

Tomoyuki Saito, Yasufumi Toriniwa, Yukihito Ishii, Atsuhiro Uemura, Katsuhiro Miyajima, Kinuko Uno, Yuki Shirai, Dai Nakae, Takeshi Ohta

Journal of toxicologic pathology 31(4) 283-291 2018年10月
Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes

Emi Fukai, Haruna Sato, Masatoshi Watanabe, Dai Nakae, Yukari Totsuka

Cancer Science 109(4) 1024-1031 2018年4月1日査読有り
Hepatic lesions induced by feeding western diets to Zucker fatty rats, an insulin-resistant model

Tomoyuki Saito, Yasufumi Toriniwa, Yukihito Ishii, Atsuhiro Uemura, Katsuhiro Miyajima, Kinuko Uno, Yuki Shirai, Dai Nakae, Takeshi Ohta

Journal of Toxicologic Pathology 31(4) 283-291 2018年
Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model

Tomoyuki Saito, Yasufumi Toriniwa, Yukihito Ishii, Atsuhiro Uemura, Katsuhiro Miyajima, Kinuko Uno, Yuki Shirai, Dai Nakae, Takeshi Ohta

JOURNAL OF TOXICOLOGIC PATHOLOGY 31(4) 283-291 2018年

もっとみる

MISC

A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet (vol 19, 251, 2020)

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

LIPIDS IN HEALTH AND DISEASE 21(1) 2022年1月
2型糖尿病モデルdb/db及びKK-Ayマウスにおける高脂肪食給餌による肝臓への影響

万代康平, 美谷島克宏, 北村沙也夏, 山口彩音, 宇野絹子, 黒木楓子, 西田芽衣, 白坂航大, 筒井誉大, 武呂大和 …

第48回日本毒性学会講演要旨 46(Suppl.) S109-S110 2021年7月
Responses to the standard for exchange of nonclinical data (SEND) in non-US countries

Takayuki Anzai, Masamichi Kaminishi, Keizo Sato, Laura Kaufman, Hijiri Iwata, Dai Nakae

Journal of Toxicologic Pathology 28(2) 57-64 2015年4月1日査読有り責任著者
Nitric oxide and cancer development

Robert A. Floyd, Yashige Kotake, Rheal A. Towner, We-Xing Guo, Dai Nakae, Yoichi Konishi

Journal of Toxicologic Pathology 20(2) 77-92 2007年7月2日査読有り
Antioxidant and signal-normalizing properties of phenyl N-tert-butyl nitrone and its derivatives in chemoprevention of hepatocellular carcinoma

D. Nakae, R. A. Floyd

CHEMICO-BIOLOGICAL INTERACTIONS 161(3) 196-196 2006年7月筆頭著者
コリン欠乏アミノ酸(CDAA)食によるマウス肝発がんに対するOgg1遺伝子欠損の修飾効果

傳田阿由美, 中江大, 笹平智則, 木下アンナ, 鰐渕英機, 福島昭治, 國安弘基

日本癌学会学術総会記事 65th 2006年
S-nitrosylation in the development of choline deficiency-induced hepatocellular carcinoma

WX Guo, RH Broyles, R Towner, K Hensley, D Nakae, Y Kotake, RA Floyd

FREE RADICAL BIOLOGY AND MEDICINE 39 S165-S165 2005年
Role of nitric oxide in hepatocellular carcinoma development

RA Floyd, R Towner, WX Guo, K Hensley, RH Broyles, D Nakae, Y Kotake

FREE RADICAL BIOLOGY AND MEDICINE 39 S84-S84 2005年査読有り
O-11 Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)

YOSHIDA Midori, NAKAE Dai, MAEKAWA Akihiko

Journal of toxicological sciences 29(4) 398-398 2004年10月29日
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine

S. Fukushima, H. Wanibuchi, K. Morimura, S. Iwai, D. Nakae, H. Kishida, H. Tsuda, N. Uehara, K. Imaida, T. Shirai …

Toxicological Sciences 80(1) 109-114 2004年7月査読有り
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver

M Yoshida, D Nakae, A Maekawa

TOXICOLOGY AND APPLIED PHARMACOLOGY 197(3) 243-244 2004年6月査読有り
Inhibitory effect of hydroxymatairesinol on the development of endometrial adenocarcinomas in rats

SI Katsuda, M Yoshida, N Saarinen, A Smeds, D Nakae, R Santti, A Maekawa

TOXICOLOGY AND APPLIED PHARMACOLOGY 197(3) 200-201 2004年6月
Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)

Nakae Dai, Takahashi Masakazu, Yoshida Midori, Uematsu Fumiyuki, Maekawa Akihiko

Journal of toxicological sciences 28(4) 242-242 2003年10月31日
Effect of neonatal exposure of high dose p-tert octylphenol on the ovary in rats (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)

Yoshida Midori, Katashima Sayumi, Maekawa Akihiko, Nakae Dai

Journal of toxicological sciences 28(4) 321-321 2003年10月31日
Narama, I., Imaida, K., Iwata, H., Nakae, D., Nishikawa, A., Harada, T.: A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology.

Isao Narama, Katsumi Imaida, Hijiri Iwata, Dai Nakae, Akiyoshi Nishikawa, Takanori Harada

J. Toxicol. Pathol. 16(1) 1-17 2003年
A flow cytometry study on nitric oxide and ROS formation in primary hepatocytes isolated from rats fed with an amino acid diet.

Y Kotake, H Kishida, D Nakae, RA Floyd

FREE RADICAL BIOLOGY AND MEDICINE 33 S260-S260 2002年
Dimethylarsinic acid induces 8-hydroxy-2 '-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats

M Vijayaraghavan, H Wanibuchi, R Karim, S Yamamoto, C Masuda, D Nakae, Y Konishi, S Fukushima

CANCER LETTERS 165(1) 11-17 2001年4月
Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats

Yutaka Hatanaka, Dai Nakae, Mamoru Mutai, Kaoru Hashizume, Yuki Kamihara, Noriaki Kinoshita, Yoichi Tani, Gen-Ichi Danno, Shigeo Ohta, Yoichi Konishi …

Japanese Journal of Cancer Research 92(12) 1270-1277 2001年
有機ヒ素化合物によるラット肝発癌促進作用

鰐渕英機, 西川隆之, 魏民, 木下アンナ, 中江大, 小西陽一, 福島昭治

日本病理学会会誌 89(1) 191-191 2000年3月
Age and organ dependent spontaneous generation of nuclear 8-hydroxydeoxyguanosine in male Fischer 344 rats

D Nakae, H Akai, H Kishida, O Kusuoka, M Tsutsumi, Y Konishi

LABORATORY INVESTIGATION 80(2) 249-261 2000年2月

もっとみる

共同研究・競争的資金等の研究課題

がん研究の資材有効保存と利用に関する研究

日本学術振興会科学研究費助成事業特定領域研究 2005年 - 2009年

清木元治, 松居靖久, 丹羽太貫, 佐竹正延, 立松正衛, 福島昭治, 中江大
食餌中の栄養素組成の変動操作のみで誘導される内因性発がんの機構に関する研究

日本学術振興会科学研究費助成事業基盤研究(C) 2004年 - 2005年

中江大, 高橋正一, 増村健一
環境因子の発がんリスク評価

日本学術振興会科学研究費助成事業重点領域研究 1996年 - 1999年

福島昭治, 津田洋幸, 立松正衛, 広瀬雅雄, 今井田克己, 中江大, 高橋道人
膵癌の発生・増殖と進展及びその制御に関する基礎的研究

日本学術振興会科学研究費助成事業基盤研究(A) 1996年 - 1999年

小西陽一, 堤雅弘, 傳田阿由美, 中江大, 辻内俊文
ラット肝における酸化性DNA障害依存性発癌機構と肝細胞壊死

日本学術振興会科学研究費助成事業奨励研究(A) 1992年 - 1992年

中江大

中江大

基本情報

研究キーワード

研究分野

経歴

論文

MISC

共同研究・競争的資金等の研究課題

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