Daisuke Takao - My portal

Profile Information

Affiliation: The University of Tokyo

Degree: PhD(東京大学大学院)

J-GLOBAL ID: 201601007354486073
researchmap Member ID: B000263651

External link: https://daisuketakao.wixsite.com/labwork

Research Interests

Research Areas

Life sciences / Cell biology /

Research History

Sep, 2019 - Present

Graduate School of Medicine, The University of Tokyo
Apr, 2018 - Aug, 2019

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Jul, 2016 - Mar, 2018

助教, 中心体生物学研究部門, 大学共同利用機関法人情報・システム研究機構国立遺伝学研究所
Feb, 2013 - Jun, 2016

学振海外特別研究員/ポスドク研究員, ミシガン大学
Apr, 2009 - Jan, 2013

NIBBリサーチフェロー/学振特別研究員PD, イメージングサイエンス研究領域時空間制御研究室, 大学共同利用機関法人自然科学研究機構基礎生物学研究所

Education

Apr, 2004 - Mar, 2009

広域科学専攻, 総合文化研究科, 東京大学大学院
Apr, 2000 - Mar, 2004

Department of Biology, School of Sciences, Kyushu University

Awards

Jun, 2020

若手優秀発表賞, 日本細胞生物学会
Sep, 2017

EMBO Conference, Science Slam Talk Award

Daisuke Takao
Aug, 2017

NIG Intern Best Instructor Award

Daisuke Takao
Sep, 2015

Bradley M. Patten Award for Excellence in Postdoctoral Research

Daisuke Takao
Sep, 2011

Zoological Science Award

Daisuke Takao
Sep, 2011

Fujii Award

Daisuke Takao

Papers

Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.

Takumi Chinen, Kaho Yamazaki, Kaho Hashimoto, Ken Fujii, Koki Watanabe, Yutaka Takeda, Shohei Yamamoto, Yuka Nozaki, Yuki Tsuchiya, Daisuke Takao …

The Journal of cell biology, 220(2), Feb 1, 2021 Peer-reviewed
NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells

Chinen, T., Yamamoto, S., Takeda, Y., Watanabe, K., Kuroki, K., Hashimoto, K., Takao, D., Kitagawa, D.

EMBO Journal, 39(2) e102378, 2020 Peer-reviewed
ゲノムワイドCRISPRスクリーニングによる一次繊毛解体・細胞周期再エントリー制御因子の同定

黒木花菜子, 高尾大輔, 知念拓実, 豊田敦, 寺井悟朗, 岩切淳一, 浅井潔, 北川大樹

日本生化学会大会プログラム・講演要旨集, 92回 [2P-375], Sep, 2019
First person – Daisuke Takao

Takao, D.

Biology Open, 8(9), 2019
Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation

Takao, D., Watanabe, K., Kuroki, K., Kitagawa, D.

Biology Open, 8(9), 2019
A theory of centriole duplication based on self-organized spatial pattern formation

Takao, D., Yamamoto, S., Kitagawa, D.

The Journal of cell biology, 218(11) 3537-3547, 2019
NPHP proteins are binding partners of nucleoporins at the base of the primary cilium

Lynne Blasius, T., Takao, D., Verhey, K.J.

PLoS ONE, 14(9), 2019
The Cep57-pericentrin module organizes PCM expansion and centriole engagement

Watanabe, K., Takao, D., Ito, K.K., Takahashi, M., Kitagawa, D.

Nature Communications, 10(1) 931-931, 2019 Peer-reviewed
【一次繊毛の世界細胞から突き出した1本の毛を巡る論争】繊毛のアンテナ機能を保証するコンパートメント化メカニズム

高尾大輔

実験医学, 36(6) 926-932, Apr, 2018
Simulation of intra-ciliary diffusion suggests a novel role of primary cilia as a cell-signaling enhancer

Takao, D., Kamimura, S.

Development Growth and Differentiation, 59(5) 415-422, 2017 Peer-reviewed
Protein Interaction Analysis Provides a Map of the Spatial and Temporal Organization of the Ciliary Gating Zone

Takao, D., Wang, L., Boss, A., Verhey, K.J.

Current Biology, 27(15) 2296-+, 2017 Peer-reviewed
Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium

Luo, W., Ruba, A., Takao, D., Zweifel, L.P., Lim, R.Y.H., Verhey, K.J., Yang, W.

Scientific Reports, 7(1) 15793, 2017 Peer-reviewed
Gated entry into the ciliary compartment

Takao, D., Verhey, K.J.

Cellular and Molecular Life Sciences, 73(1) 119-127, 2016 Peer-reviewed
Methods for studying ciliary import mechanisms

Takao, D., Verhey, K.J.

Methods in Molecular Biology, 1454 1-14, 2016 Peer-reviewed
An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry

Takao, D., Dishinger, J.F., Kee, H.L., Pinskey, J.M., Allen, B.L., Verhey, K.J.

Current Biology, 24(19) 2288-2294, 2014 Peer-reviewed
Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation

Takao, D., Nemoto, T., Abe, T., Kiyonari, H., Kajiura-Kobayashi, H., Shiratori, H., Nonaka, S.

Developmental Biology, 376(1) 23-30, 2013 Peer-reviewed
X-ray diffraction recording from single axonemes of eukaryotic flagella

Nishiura, M., Toba, S., Takao, D., Miyashiro, D., Sakakibara, H., Matsuo, T., Kamimura, S., Oiwa, K., Yagi, N., Iwamoto, H.

Journal of Structural Biology, 178(3) 329-337, 2012 Peer-reviewed
High-Speed Imaging of Amoeboid Movements Using Light-Sheet Microscopy

Takao, D., Taniguchi, A., Takeda, T., Sonobe, S., Nonaka, S.

PLoS ONE, 7(12) e50846, 2012 Peer-reviewed
Single-cell electroporation of fluorescent probes into sea urchin sperm cells and subsequent FRAP analysis

Takao, D., Kamimura, S.

Zoological Science, 27(3) 279-284, 2010 Peer-reviewed
Geometry-specific heterogeneity of the apparent diffusion rate of materials inside sperm cells

Takao, D., Kamimura, S.

Biophysical Journal, 98(8) 1582-1588, 2010 Peer-reviewed

Presentations

A theory of centriole duplication based on self-organized spatial pattern formation

Daisuke Takao

Seminar at University of California San Diego, 2018 Invited
Modeling the pattern formation of Plk4 towards fundamental understanding of centriole duplication

Daisuke Takao

2018 ASCB/EMBO Meeting, 2018
Protein interaction analysis provides a map of the spatial and temporal organization of the ciliary gating zone

Daisuke Takao

EMBO Conference: Centrosome and Spindle Pole Bodies, 2017
運動性鞭毛・繊毛の最前線～生体ナノマシンの制御機構～

高尾大輔

第54回日本生物物理学会年会, 2016 Invited
Mapping the spatial and functional interactions of transition zone proteins and nucleoporins during ciliary gating

Daisuke Takao

2016 ASCB Meeting, 2016
Distinct pathways for ciliary entry of cytosolic and membrane proteins

Daisuke Takao

2015 Invited
繊毛へ選択的にタンパク質を輸送するメカニズムの解明

高尾大輔

第4回生物物理学セミナー, 2014 Invited
An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry

Daisuke Takao

2014 ASCB/IFCB Meeting, 2014
Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left–right axis formation

Daisuke Takao

2013 FASEB Science Research Conferences: The Biology of Cilia & Flagella, 2013
A new function of primary cilia: a cell-signaling enhancer

Daisuke Takao

2010 FASEB Summer Research Conferences: The Biology of Cilia & Flagella, 2010
FRAP analysis combined with a single-cell electroporation technique in sea-urchin spermatozoa

Daisuke Takao

Biophysical Society 53rd Annual Meeting, 2009
Determination of calcein diffusion rate in the flagella of sea-urchin spermatozoa

Daisuke Takao

FASEB Summer Research Conferences: The Biology of Cilia & Flagella, 2007
Measurement of the intra-flagellar pH of sea-urchin spermatozoa

Daisuke Takao

International Workshop Dynein 2005, 2005

Professional Memberships

Research Projects

Comprehensive analysis of molecular machineries for mitotic spindle formation in human cells and its application to development of next generation anti-cancer drug.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2024
情報抽出イメージングによる繊毛輸送メカニズムの理解

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2023

高尾大輔
Analysis of centriole duplication process

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Takao Daisuke
創薬スクリーニングに向けた細胞内微細構造の計測・評価システムの確立

薬学振興会平成30年度基礎的研究助成, 2019

高尾大輔
一次繊毛への入力シグナルを細胞内へ伝達する分子基盤の網羅的な解析

第30回加藤記念研究助成, 2019

高尾大輔
細胞機能解析のための生体分子パターン計測技術の確立

2018年度コニカミノルタ画像科学奨励賞, 2018

高尾大輔
超解像イメージングと畳み込みニューラルネットワークによる細胞分裂プロセスの定量的評価システムの開発

島津科学技術振興財団2018年度研究開発助成, 2018

高尾大輔
分子パターン形成の可視化による中心体複製メカニズムの解析

武田科学振興財団2018年度ライフサイエンス研究助成, 2018

高尾大輔
中心体複製メカニズムに関わる内在性分子の時空間マッピング

国際科学技術財団研究助成, 2017

高尾大輔
超微小空間における分子の動態の可視化と定量化による中心体複製メカニズムの解明

上原記念生命科学財団研究奨励金, 2017

高尾大輔
一次繊毛へ選択的にタンパク質を輸送するメカニズムの解明

日本学術振興会海外特別研究員, Apr, 2014 - Mar, 2016

高尾大輔
マウス胚ノードにおけるカルシウムシグナルの解析と左右決定機構の解明

日本学術振興会特別研究員PD, Apr, 2011 - Mar, 2014

高尾大輔
マウス胚ノードにおけるカルシウムシグナルの解析と左右決定機構の解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2011 - 2013

高尾大輔

Social Activities

第300回やさしい科学技術セミナー

Lecturer, Planner

Aug 21, 2017