Yumi Fukuchi

Profile Information

Affiliation: Hoshi University, Hoshi University

Degree: 博士（薬学）(北海道大学)

J-GLOBAL ID: 201601010444495994
researchmap Member ID: B000253379

External link: https://kaken.nii.ac.jp/d/r/40250237.ja.html

Research Interests

Research Areas

Research History

Jun, 2011 - Present

Assistant Professor, Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
Feb, 2008 - May, 2011

Researcher, Division of Hematology, Department of Internal Medicine, Keio University School of Medicine
Apr, 2003 - Jan, 2008

Researcher, Division of Cellular Therapy (Kitamura Lab.), Institute of Medical Science, the University of Tokyo
May, 2001 - Mar, 2003

Researcher, Division of Cellular Therapy (Tsuji Lab.), Institute of Medical Science,, the University of Tokyo
Apr, 1998 - Apr, 2001

Researcher, Division of Hematology, Department of Internal Medicine, Keio University School of Medicine
Apr, 1997 - Mar, 1998

Researcher, Central Institute of Experimental Animals
Aug, 1992 - Mar, 1997

Researcher, Ueyama 'hu-mouse' project, Kanagawa Academy of Science and Technology
Apr, 1991 - Jul, 1992

Mitsubishi Chemical Corporation

Education

Sep, 1999 - Sep, 1999

Ph.D. in Pharmaceutical Science, Hokkaido University
Apr, 1989 - Mar, 1991

Pharmaceutical Science, Hokkaido University
Apr, 1985 - Mar, 1989

Pharmaceutical Science, Meiji Pharmaceutical University

Awards

Dec, 2005

Travel Award of the American Society for Hematology, the American Society for Hematology

Yumi Fukuchi
Oct, 2005

Incitement Award of the Japanese Society for Hematology, the Japanese Society for Hematology

Yumi Fukuchi
Dec, 2004

Travel Award of the American Society for Hematology, the American Society for Hematology

Yumi Fukuchi

Papers

Single‑agent nintedanib suppresses metastatic osteosarcoma growth by inhibiting tumor vascular formation

Takatsune Shimizu, Atsunobu Sagara, Yumi Fukuchi, Akihiro Muto

Oncology Letters, 27(3), Mar, 2024
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation

Shunsuke Soma, Koichi Murakami, Yumi Fukuchi, Hiroyoshi Kunimoto, Hideaki Nakajima

Stem Cells, Oct 10, 2023
Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo.

Takatsune Shimizu, Eiji Sugihara, Hideyuki Takeshima, Hiroyuki Nobusue, Rui Yamaguchi, Sayaka Yamaguchi-Iwai, Yumi Fukuchi, Toshikazu Ushijima, Akihiro Muto, Hideyuki Saya

Cells, 11(22), Nov 15, 2022
MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo

Takatsune Shimizu, Kiyomi Kimura, Eiji Sugihara, Sayaka Yamaguchi‐Iwai, Hiroyuki Nobusue, Oltea Sampetrean, Yuji Otsuki, Yumi Fukuchi, Kaori Saitoh, Keiko Kato …

Journal of Orthopaedic Research, Mar 26, 2021
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.

Koichi Murakami, Daisuke Kurotaki, Wataru Kawase, Shunsuke Soma, Yumi Fukuchi, Hiroyoshi Kunimoto, Ryusuke Yoshimi, Shuhei Koide, Motohiko Oshima, Takako Hishiki …

Cell reports, 34(1) 108579-108579, Jan 5, 2021
Establishment of a High-risk MDS/AML Cell Line YCU-AML1 and its Xenograft Model Harboring t(3;3) and Monosomy 7.

Hiroyoshi Kunimoto, Yumi Fukuchi, Koichi Murakami, Junji Ikeda, Hiroshi Teranaka, Ikuma Kato, Takuya Miyazaki, Makiko Enaka, Takayuki Mitsuhashi, Etsuko Yamazaki …

HemaSphere, 4(5) e469, Oct, 2020
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer

Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y …

Molecular Pain, 14, Jan 1, 2018
Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

Takatsune Shimizu, Walied A. Kamel, Sayaka Yamaguchi-Iwai, Yumi Fukuchi, Akihiro Muto, Hideyuki Saya

CANCER SCIENCE, 108(9) 1793-1802, Sep, 2017 Peer-reviewed
Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

Shimizu Takatsune, Kamel Walied A, Yamaguchi-Iwai Sayaka, Fukuchi Yumi, Muto Akihiro, Saya Hideyuki

Cancer Science, 108(9) 1793-1802, Sep 1, 2017
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.

Kamel WA, Sugihara E, Nobusue H, Yamaguchi-Iwai S, Onishi N, Maki K, Fukuchi Y, Matsuo K, Muto A, Saya H …

Molecular cancer therapeutics, 16(1) 182-192, Jan, 2017 Peer-reviewed
Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Takeru Amiya, Nobuhiro Nakamoto, Po-sung Chu, Toshiaki Teratani, Hideaki Nakajima, Yumi Fukuchi, Nobuhito Taniki, Akihiro Yamaguchi, Shunsuke Shiba, Rei Miyake …

SCIENTIFIC REPORTS, 6 35146, Oct, 2016 Peer-reviewed
Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients

M. Sakurai, H. Kunimoto, N. Watanabe, Y. Fukuchi, S. Yuasa, S. Yamazaki, T. Nishimura, K. Sadahira, K. Fukuda, H. Okano …

LEUKEMIA, 28(12) 2344-2354, Dec, 2014 Peer-reviewed
IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress

Takatsune Shimizu, Eiji Sugihara, Sayaka Yamaguchi-Iwai, Sakura Tamaki, Yuko Koyama, Walied Kamel, Arisa Ueki, Tomoki Ishikawa, Tatsuyuki Chiyoda, Satoru Osuka …

CANCER RESEARCH, 74(22) 6531-6541, Nov, 2014 Peer-reviewed
Tet2-mutated myeloid progenitors possess aberrant in vitro self-renewal capacity

Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Keiyo Takubo, Shinichiro Okamoto, Hideaki Nakajima

BLOOD, 123(18) 2897-2899, May, 2014 Peer-reviewed
Robo4 Plays a Role in Bone Marrow Homing and Mobilization, but Is Not Essential in the Long-Term Repopulating Capacity of Hematopoietic Stem Cells

Yuko Goto-Koshino, Yumi Fukuchi, Fumi Shibata, Daichi Abe, Kana Kuroda, Shinichiro Okamoto, Toshio Kitamura, Hideaki Nakajima

PLOS ONE, 7(11) e50849, Nov, 2012 Peer-reviewed
Direct reprogramming of terminally differentiated B cells into erythroid lineage

Ken Sadahira, Yumi Fukuchi, Hiroyoshi Kunimono, Masatoshi Sakurai, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima

FEBS LETTERS, 586(20) 3645-3652, Oct, 2012 Peer-reviewed
Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Ken Sadahira, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima

SCIENTIFIC REPORTS, 2 273, Feb, 2012 Peer-reviewed
Two types of C/EBP alpha mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models

Naoko Kato, Jiro Kitaura, Noriko Doki, Yukiko Komeno, Naoko Watanabe-Okochi, Katsuhiro Togami, Fumio Nakahara, Toshihiko Oki, Yutaka Enomoto, Yumi Fukuchi …

BLOOD, 117(1) 221-233, Jan, 2011 Peer-reviewed
TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool

Hideaki Nakajima, Miyuki Ito, David S. Smookler, Fumi Shibata, Yumi Fukuchi, Yoshihiro Morikawa, Yuichi Ikeda, Fumio Arai, Toshio Suda, Rama Khokha …

BLOOD, 116(22) 4474-4482, Nov, 2010 Peer-reviewed
Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells

Hideaki Nakajima, Miyuki Ito, Yoshihiro Morikawa, Tadasuke Komori, Yumi Fukuchi, Fumi Shibata, Shinichiro Okamoto, Toshio Kitamura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 390(1) 65-70, Dec, 2009 Peer-reviewed

Misc.

Regulation of Mitophagy By O-Linked N-Acetylglucosamine Transferase Is Essential for Hematopoietic Stem Cell Maintenance

Koichi Murakami, Daisuke Kurotaki, Wataru Kawase, Shunsuke Soma, Yumi Fukuchi, Hiroyoshi Kunimoto, Ryusuke Yoshimi, Shuhei Koide, Motohiko Oshima, Takako Hishiki …

BLOOD, 132, Nov, 2018
O-GlcNAc化による造血幹細胞ミトコンドリアダイナミクスの制御(O-GlcNAcylation is critical for mitochondrial dynamics in hematopoietic stem cells)

村上紘一, 黒滝大翼, 川瀬航, 相馬俊介, 福地由美, 國本博義, 吉見竜介, 小出周平, 大島基彦, 小田真由美 …

臨床血液, 59(9) 1483-1483, Sep, 2018
A CRITICAL ROLE FOR O-GLCNACYLATION IN MURINE FETAL LIVER AND ADULT HEMATOPOIESIS

S. Soma, Y. Fukuchi, S. Okamoto, H. Nakajima

HAEMATOLOGICA, 100 125-126, Jun, 2015
Tet2 Uniquely Regulates Self-Renewal and Long Term Repopulating Capacity of Fetal Liver and Bone Marrow Hematopoietic Stem Cells

Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Daichi Abe, Ken Sadahira, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima

BLOOD, 120(21), Nov, 2012
Impaired Hematopoietic Differentiation of iPSCs Derived From Patients with FPD/AML

Masatoshi Sakurai, Hiroyoshi Kunimoto, Naohide Watanabe, Yumi Fukuchi, Ken Sadahira, Shinsuke Yuasa, Keiichi Fukuda, Satoshi Yamazaki, Hiromitsu Nakauchi, Yasuhiro Ebihara …

BLOOD, 120(21), Nov, 2012
Disruption of Tet2 Leads to Enhanced Self-Renewal and Competitive Repopulating Capacity of Fetal Liver Hematopoietic Stem Cells

Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Ken Sadahira, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima

BLOOD, 118(21) 1009-1010, Nov, 2011
Differential Role of Myeloid Transcription Factors, C/EBP alpha and PU.1 In Leukemogenesis by MLL-Fusion Oncogenes

Yumi Fukuchi, Kana Kuroda, Ken Sadahira, Ryouichi Ono, Daniel G. Tenen, Toshio Kitamura, Tetsuya Nosaka, Shinichiro Okamoto, Hideaki Nakajima

BLOOD, 116(21) 664-664, Nov, 2010
DIFFERENTIAL ROLE OF MYELOID TRANSCRIPTION FACTORS, C/EBP alpha AND PU.1 IN LEUKEMOGENESIS BY MLL-FUSION ONCOGENES

Y. Fukuchi, K. Kuroda, K. Sadahira, T. Kitamura, Y. Ikeda, S. Okamoto, H. Nakajima

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95 12-12, Jun, 2010
TIMP-3 inhibition of angiopoietin-1 signaling recruits hematopoietic stem cells from the bone marrow niche.

Hideaki Nakajima, Miyuki Ito, David Smookler, Fumi Shibata, Yumi Fukuchi, Yuko Goto-Koshino, Fumio Arai, Toshio Suda, Rama Khokha, Toshio Kitamura

BLOOD, 110(11) 378A-378A, Nov, 2007
Robo4/Magic roundabout is a novel surface marker for murine and human hematopoietic stem cells.

Fumi Shibata, Yuko Goto-Koshino, Miyuki Ito, Yumi Fukuchi, Yoshihiro Morikawa, Hiromichi Matsushita, Hayato Miyachi, Toshio Kitamura, Hideaki Nakajima

BLOOD, 108(11) 204A-205A, Nov, 2006
Activation of C/EBP alpha in hematopoietic stem cells leads to growth suppression and impairment of megakaryocyte differentiation.

Y Fukuchi, F Shibata, M Ito, Y Goto-Koshino, Y Sotomaru, M Ito, T Kitamura, H Nakajima

BLOOD, 106(11) 638A-638A, Nov, 2005
Immune suppressor factor confers enhanced supporting activity for hematopoietic stem cells in bone marrow stroma

H Nakajima, F Shibata, Y Fukuchi, Y Goto-Koshino, M Ito, H Aburatani, T Kitamura

EXPERIMENTAL HEMATOLOGY, 33(7) 70-70, Jul, 2005
Conditional expression of C/EBP alpha in mice reveals developmental plasticity of lymphoid and erythroid/megakaryocyte precursors in vivo.

Y Fukuchi, F Shibata, M Ito, Y Goto-Koshino, Y Sotomaru, M Ito, T Kitamura, H Nakajima

BLOOD, 104(11) 193A-193A, Nov, 2004
Immune suppressor factor confers enhanced supporting activity for hematopoietic stem cells in bone marrow stroma.

H Nakajima, F Shibata, Y Fukuchi, Y Goto-Koshino, M Ito, T Kitamura

BLOOD, 104(11) 148A-148A, Nov, 2004
MCL-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells.

Y Fukuchi, M Kizaki, C Kawamura, A Umezawa, JI Hata, Y Ikeda

BLOOD, 96(11) 349A-349A, Nov, 2000
All-trans retinoic acid directly up-regulates thrombopoietin mRNA in bone marrow stromal cells.

K Kinjo, Y Miyakawa, Y Fukuchi, H Uchida, T Nakazato, K Ito, Y Ikeda, M Kizaki

BLOOD, 96(11) 689A-689A, Nov, 2000
Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3.

C Kawamura, M Kizaki, H Uchida, Y Fukuchi, Y Hattori, Y Ikeda

BLOOD, 96(11) 473A-473A, Nov, 2000
GM-CSF and arsenic trioxide (As2O3) induce differentiation, but not apoptosis, of retinoic acid (RA)-resistant APL in vitro and in vivo by modulating Jak2 tyrosine kinase and BAX.

A Muto, M Kizaki, Y Fukuchi, K Kinjo, Y Ikeda

BLOOD, 92(10) 510A-510A, Nov, 1998
Establishment of a retinoic acid resistant human APL model in hGM-CSF transgenic SCID mice and their application to the in vivo study of arsenic trioxide (As2O3).

K Kinjo, A Kizaki, A Muto, N Awaya, H Ueno, A Umezawa, Y Fukuchi, M Ito, Y Ueyama, Y Ikeda

BLOOD, 90(10) 1480-1480, Nov, 1997

Professional Memberships

THE JAPANESE SOCIETY OF HEMATOLOGY

Research Projects

アクチビンAによる慢性骨髄性白血病の分化/アポトーシス誘導の増殖抑制機構

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1999 - 2000

福地由美
Mechanisms of apoptosis and differentiation induced by arsenic trioxide in leukemic cells and its clinical application

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2000

KIZAKI Masahiro, IKEDA Yasuo, FUKUCHI Yumi
ヒト造血系維持モデルとしてのヒトSCF遺伝子導入-SCIDマウスの検討

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1997 - 1998

福地由美
ヒト造血系細胞維持モデルのためのヒトSCF遺伝子導入マウスの作製

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1996 - 1996

福地由美

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Research History

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