Takatoshi Hikida

Profile Information

Researcher number: 70421378
ORCID ID: https://orcid.org/0000-0002-8653-311X
J-GLOBAL ID: 201101009658812541
researchmap Member ID: B000002807

Research Interests

Research Areas

Research History

Apr, 2017 - Present

Professor, Institute for Protein Research, Osaka University
Oct, 2011 - Mar, 2017

Associate Professor, Kyoto University Graduate School of Medicine
Oct, 2011 - Mar, 2015

Visiting Scientist, Osaka Bioscience Institute
Oct, 2009 - Mar, 2013

Researcher, JST, PRESTO
Sep, 2005 - Sep, 2011

Reseach Associate, Osaka Bioscience Institute
Apr, 2003 - Aug, 2005

Postdoctoral Fellow, Johns Hopkins University School of Medicine
Apr, 2002 - Mar, 2003

Postdoctoral Researcher, Kyoto University School of Medicine
Mar, 2002

MD., PhD., Kyoto University

Awards

Sep, 2017

Young Investigator Award, neuronal circuit mechanisms in cognitive learning and psychiatric disorders, Japanese Society of Neuropsychopharmacology

Takatoshi Hikida
Sep, 2016

JSBP Young Investigator Program Most Encouragement Award, JSBP

Takatoshi Hikida
Sep, 2014

Young Investigator Award, JSBP

Takatoshi Hikida
Jun, 2014

JSNP Excellent Presentation Award for CINP 2014, JSNP

Takatoshi Hikida
Sep, 2012

Young Investigater Award, Regulatory mechanisms of basal ganglia circuit in decision-making and drug addiction, Japanese Society of Biological Psychiatry

Takatoshi Hikida
Sep, 2011

Young Investigator Award, Regulatory mechanism of basal ganglia circuit, Japan Neuroscience Society

Takatoshi Hikida
Jul, 2010

平成22年度包括脳ネットワーク若手優秀発表賞, Distinct roles of synaptic transmission in the direct and indirect striatal pathways to reward and aversive behavior, 包括脳科学研究推進支援ネットワーク、日本神経科学学会

疋田貴俊
May, 2009

Hayaishi encouragement award, Osaka Bioscience Institute

Takatoshi Hikida

Major Papers

105

A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene–environment interactions

Hirotaka Nomiya, Koki Sakurai, Yoichi Miyamoto, Masahiro Oka, Yoshihiro Yoneda, Takatoshi Hikida, Masami Yamada

Scientific Reports, 14(1), Feb 9, 2024 Peer-reviewedCorresponding author
Clozapine N-oxide, compound 21, and JHU37160 do not influence effortful reward-seeking behavior in mice

Yoshiatsu Aomine, Yoshinobu Oyama, Koki Sakurai, Tom Macpherson, Takaaki Ozawa, Takatoshi Hikida

Psychopharmacology, Oct 4, 2023 Peer-reviewedLast authorCorresponding author
Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice.

Siyao Li, Koki Sakurai, Masahiro Ohgidani, Takahiro A Kato, Takatoshi Hikida

Molecular brain, 16(1) 59-59, Jul 12, 2023 Peer-reviewedLast authorCorresponding author
Dual Roles for Nucleus Accumbens Core Dopamine D1-Expressing Neurons Projecting to the Substantia Nigra Pars Reticulata in Limbic and Motor Control in Male Mice.

Suthinee Attachaipanich, Takaaki Ozawa, Tom Macpherson, Takatoshi Hikida

eNeuro, 10(6), Jun, 2023 Peer-reviewedLast authorCorresponding author
Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice.

Tadaaki Nishioka, Suthinee Attachaipanich, Kosuke Hamaguchi, Michael Lazarus, Alban de Kerchove d'Exaerde, Tom Macpherson, Takatoshi Hikida

Nature communications, 14(1) 2284-2284, Apr 21, 2023 Peer-reviewedLast authorCorresponding author
Circuit, molecular, and developmental mechanisms in decision-making behavior.

Tom Macpherson, Minae Niwa, Hirofumi Morishita, Takatoshi Hikida

Frontiers in neuroscience, 17 1192237-1192237, Apr, 2023 Peer-reviewedInvitedLast author
Preliminary study of the social withdrawal (hikikomori) spectrum in French adolescents: focusing on the differences in pathology and related factors compared with Japanese adolescents.

Yukiko Hamasaki, Nancy Pionnié-Dax, Géraldine Dorard, Nicolas Tajan, Takatoshi Hikida

BMC psychiatry, 22(1) 477-477, Jul 16, 2022 Peer-reviewedLast author
Importin α3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice

Yoshiatsu Aomine, Koki Sakurai, Tom Macpherson, Takaaki Ozawa, Yoichi Miyamoto, Yoshihiro Yoneda, Masahiro Oka, Takatoshi Hikida

Frontiers in Neuroscience, 16 905991, Jun 30, 2022 Peer-reviewedLast authorCorresponding author
Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice

Tom Macpherson, Ji Yoon Kim, Takatoshi Hikida

Frontiers in Neuroscience, 16 885380, Jun 28, 2022 Peer-reviewedLast authorCorresponding author
Computational Mechanisms of Osmoregulation: A Reinforcement Learning Model for Sodium Appetite.

Yuuki Uchida, Takatoshi Hikida, Yuichi Yamashita

Frontiers in neuroscience, 16 857009-857009, May 19, 2022 Peer-reviewedCorresponding author
Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit.

Hanna Jaaro-Peled, Sunil Kumar, Dalton Hughes, Akiko Sumitomo, Sun-Hong Kim, Sandra Zoubovsky, Yuki Hirota-Tsuyada, Diana Zala, Julie Bruyere, Brittany M Katz …

Molecular psychiatry, 27(3) 1805-1815, Mar, 2022 Peer-reviewed
Trends in big data analyses by multicenter collaborative translational research in psychiatry.

Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto …

Psychiatry and clinical neurosciences, 76(1) 1-14, Jan, 2022 Peer-reviewed
Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice.

Koki Sakurai, Taichi Itou, Makiko Morita, Emiko Kasahara, Tetsuji Moriyama, Tom Macpherson, Takaaki Ozawa, Yoichi Miyamoto, Yoshihiro Yoneda, Atsuo Sekiyama …

PLoS ONE, 16(11) e0258364, Nov 12, 2021 Peer-reviewedLast authorCorresponding author
High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice.

Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka …

Science advances, 7(46) eabl6077, Nov 12, 2021 Peer-reviewed
Identifying Social Withdrawal (Hikikomori) Factors in Adolescents: Understanding the Hikikomori Spectrum

Yukiko Hamasaki, Nancy Pionnié-Dax, Géraldine Dorard, Nicolas Tajan, Takatoshi Hikida

Child Psychiatry & Human Development, 52(5) 808-817, Oct, 2021 Peer-reviewedLast author
Natural and Artificial Intelligence: A brief introduction to the interplay between AI and neuroscience research.

Tom Macpherson, Anne Churchland, Terry Sejnowski, James DiCarlo, Yukiyasu Kamitani, Hidehiko Takahashi, Takatoshi Hikida

Neural networks : the official journal of the International Neural Network Society, 144 603-613, Sep 28, 2021 Peer-reviewedInvitedLast authorCorresponding author
Parallel and hierarchical neural mechanisms for adaptive and predictive behavioral control.

Tom Macpherson, Masayuki Matsumoto, Hiroaki Gomi, Jun Morimoto, Eiji Uchibe, Takatoshi Hikida

Neural networks : the official journal of the International Neural Network Society, 144 507-521, Sep 17, 2021 Peer-reviewedLast authorCorresponding author
Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortex.

Takatoshi Hikida, Shuhei Yao, Tom Macpherson, Ayumi Fukakusa, Makiko Morita, Haruhide Kimura, Keisuke Hirai, Tatsuya Ando, Hiroyoshi Toyoshiba, Akira Sawa

Scientific reports, 10(1) 1838-1838, Feb 4, 2020 Peer-reviewedLead authorCorresponding author
Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice.

Takatoshi Hikida, Makiko Morita, Mahomi Kuroiwa, Tom Macpherson, Takahide Shuto, Naoki Sotogaku, Minae Niwa, Akira Sawa, Akinori Nishi

Neuroscience research, 151 38-45, Feb, 2020 Peer-reviewedLead authorCorresponding author
Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders.

Tom Macpherson, Takatoshi Hikida

Psychiatry and clinical neurosciences, 73(6) 289-301, Jun, 2019 Peer-reviewedInvitedLast authorCorresponding author
Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.

Tom Macpherson, Hiroyuki Mizoguchi, Akihiro Yamanaka, Takatoshi Hikida

Neurochemistry international, 126 11-18, Jun, 2019 Peer-reviewedInvitedLast authorCorresponding author
Nucleus Accumbens Dopamine D1-Receptor-Expressing Neurons Control the Acquisition of Sign-Tracking to Conditioned Cues in Mice.

Tom Macpherson, Takatoshi Hikida

Frontiers in neuroscience, 12 418-418, Jun, 2018 Peer-reviewedLast authorCorresponding author
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M. Guerrini, Yumi Tsutsui, Mikako Maruya, Alexis Vogelzang, Kenji Chamoto, Kurara Honda …

NATURE IMMUNOLOGY, 18(12) 1342-1352, Dec, 2017 Peer-reviewed
Endocytosis following dopamine D-2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFR beta signaling in striatopallidal medium spiny neurons

N. Shioda, Y. Yabuki, Y. Wang, M. Uchigashima, T. Hikida, T. Sasaoka, H. Mori, M. Watanabe, M. Sasahara, K. Fukunaga

MOLECULAR PSYCHIATRY, 22(8) 1205-1222, Aug, 2017 Peer-reviewed
Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning.

Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T

Molecular neuropsychiatry, 2(3) 124-132, Oct, 2016 Peer-reviewedLast authorCorresponding author
Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.

Tom Macpherson, Makiko Morita, Yanyan Wang, Toshikuni Sasaoka, Akira Sawa, Takatoshi Hikida

Learning & memory (Cold Spring Harbor, N.Y.), 23(7) 359-64, Jul, 2016 Peer-reviewedLast authorCorresponding author
Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning

Takatoshi Hikida, Makiko Morita, Tom Macpherson

Neuroscience research, 108 1-5, Jul, 2016 Peer-reviewedInvitedLead authorCorresponding author
Striatal direct and indirect pathways control decision-making behavior.

Tom Macpherson, Makiko Morita, Takatoshi Hikida

Frontiers in psychology, 5 1301-1301, Nov, 2014 Peer-reviewedLast authorCorresponding author
Distinct Roles of Segregated Transmission of the Septo-Habenular Pathway in Anxiety and Fear

Takashi Yamaguchi, Teruko Danjo, Ira Pastan, Takatoshi Hikida, Shigetada Nakanishi

NEURON, 78(3) 537-544, May, 2013 Peer-reviewed
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids

Minae Niwa, Hanna Jaaro-Peled, Stephanie Tankou, Saurav Seshadri, Takatoshi Hikida, Yurie Matsumoto, Nicola G. Cascella, Shin-Ichi Kano, Norio Ozaki, Toshitaka Nabeshima …

Science, 339(6117) 335-339, Jan 18, 2013 Peer-reviewed
Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors

Takatoshi Hikida, Satoshi Yawata, Takashi Yamaguchi, Teruko Danjo, Toshikuni Sasaoka, Yanyan Wang, Shigetada Nakanishi

Proceedings of the National Academy of Sciences of the United States of America, 110(1) 342-347, Jan 2, 2013 Peer-reviewedLead authorCorresponding author
DISC1 as a therapeutic target for mental illnesses

Takatoshi Hikida, Nao J. Gamo, Akira Sawa

EXPERT OPINION ON THERAPEUTIC TARGETS, 16(12) 1151-1160, Dec, 2012 Peer-reviewedInvitedLead authorCorresponding author
Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

Takatoshi Hikida, Kensuke Kimura, Norio Wada, Kazuo Funabiki, Shigetada Nakanishi

NEURON, 66(6) 896-907, Jun, 2010 Peer-reviewedLead author
Modulation of D-serine levels in brains of mice lacking PICK1

Takatoshi Hikida, Asif K. Mustafa, Kazuhisa Maeda, Kumiko Fujii, Roxanne K. Barrow, Masoumeh Saleh, Richard L. Huganir, Solomon H. Snyder, Kenji Hashimoto, Akira Sawa

BIOLOGICAL PSYCHIATRY, 63(10) 997-1000, May, 2008 Peer-reviewedLead author
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

Takatoshi Hikida, Hanna Jaaro-Peled, Saurav Seshadri, Kenichi Oishi, Caroline Hookway, Stephanie Kong, Di Wu, Rong Xue, Manuella Andrade, Stephanie Tankou …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(36) 14501-14506, Sep, 2007 Peer-reviewedLead author
Serine racemase binds to PICK1: potential relevance to schizophrenia

K Fujii, K Maeda, T Hikida, AK Mustafa, R Balkissoon, J Xia, T Yamada, Y Ozeki, R Kawahara, M Okawa …

MOLECULAR PSYCHIATRY, 11(2) 150-157, Feb, 2006 Peer-reviewed
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine

T Hikida, Y Kitabatake, Pastan, I, S Nakanishi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(10) 6169-6173, May, 2003 Peer-reviewedLead author
Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens

T Hikida, S Kaneko, T Isobe, Y Kitabatake, D Watanabe, Pastan, I, S Nakanishi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(23) 13351-13354, Nov, 2001 Peer-reviewedLead author
Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function

S Kaneko, T Hikida, D Watanabe, H Ichinose, T Nagatsu, RJ Kreitman, Pastan, I, S Nakanishi

SCIENCE, 289(5479) 633-637, Jul, 2000 Peer-reviewed

Major Misc.

精神疾患の新しい理解と支援に寄与する最先端神経科学情動・認知学習の神経回路機構の研究から疾患横断的な精神疾患病態を考える

疋田貴俊

精神神経学雑誌, (2019特別号) S572-S572, Jun, 2019
【診断と治療のABC[136]統合失調症】(第2章)病態動物モデル

疋田貴俊

最新医学, 別冊(統合失調症) 79-84, Jul, 2018 Lead authorLast authorCorresponding author
Pathway-specific Modulation of Nucleus Accumbens in Reward and Aversive Learning Behaviors and Drug Addiction via Selective Transmitter Receptors

疋田貴俊

日本神経精神薬理学雑誌, 35(2) 47-48, Apr 25, 2015
神経科学からのトランスレーショナルリサーチ

疋田貴俊

統合失調症研究, 4(1) 61, Mar, 2014
大脳基底核神経回路と意思決定

疋田貴俊

日本生物学的精神医学会誌, 107, 2014

Major Books and Other Publications

精神医学領域の論文を読みこなすキーワード100!

疋田貴俊 (Role: Contributor, 22.大脳基底核、基礎研究、80.モデル動物)

新興医学出版社, Jan, 2023 (ISBN: 9784880028866)
もっとよくわかる!食と栄養のサイエンス : 食行動を司る生体恒常性維持システム

小澤貴明, 疋田貴俊 (Role: Contributor, 第10章食のもたらす快情動の神経メカニズム報酬系の脳内回路)

羊土社, Mar, 2021 (ISBN: 9784758122092)
どうして心臓は動き続けるの？生命をささえるタンパク質のなぞにせまる

疋田貴俊 (Role: Contributor, 15 どうして麻薬にはまるの？)

化学同人, Nov, 2018 (ISBN: 9784759819816)
Annual Review神経2013

疋田貴俊 (Role: Contributor, I. Basic Neuroscience、 1. 神経生理、2) 大脳基底核の直接路と間接路の機能分離)

中外医学社, Jan 25, 2013 (ISBN: 4498128974)

Major Presentations

柔軟な行動のためのドーパミン神経伝達機構

疋田貴俊

細胞間情報伝達研究会, May 23, 2023 Invited
Brain mechanism in decision-making of model mice.

Takatoshi Hikida

Italy-Japan Hikikomori Research Workshop 2023., Apr 28, 2023 Invited
Dopamine neurotransmission mechanisms in the nucleus accumbens for flexible cognitive behavior.

Hikida T, Nishioka T, Macpherson T, Hamaguchi K

Mar 16, 2023 Invited
柔軟な認知行動のための神経回路機構.

疋田貴俊

BPCNPNPPP4学会合同年会, Nov 4, 2022 Invited
Neural mechanisms for the strategy to avoid a choice that leads to negative outcome in visual discrimination learning.

Takatoshi Hikida, Tadaaki Nishioka, Tom Macpherson, Kosuke Hamaguchi

4th International Touchscreen Symposium., Sep 23, 2022 Invited
行動柔軟性における側坐核の並列神経回路機構.

疋田貴俊, マクファーソントム

Neuro2022, Jul 1, 2022 Invited
Homeostatic regulation of neural circuit mechanisms in flexible cognitive behavior and psychiatric disorders.

疋田貴俊

第95回日本薬理学会年会, Mar 9, 2022 Invited
Diverse activity patterns of medium spiny neurons in the nucleus accumbens in reward and aversion.

Mar 9, 2022 Invited
側坐核における報酬・忌避の神経機構.

疋田貴俊, マクファーソントム, 西岡忠昭

2021年度生理学研究所研究会「多様な視点から情動を捉え直す, Sep 15, 2021 Invited
報酬/目的指向行動の神経回路機構.

疋田貴俊

第15回 Motor Control研究会, Sep 10, 2021 Invited
適切な行動選択のための柔軟な脳のしくみ.

疋田貴俊

令和2年度国立大学附置研究所・センター会議第２部会シンポジウム「コロナ新時代における蛋白質科学研究」, Nov 14, 2020 Invited
意思決定における側坐核ネットワークの制御機構.

疋田貴俊

生理学研究所研究会意思決定研究の新展開〜社会共感・主観価値の生成・葛藤に関わる神経メカニズム〜, Sep 14, 2020 Invited
報酬・忌避行動と精神疾患病態における神経回路機構の解析.

疋田貴俊

第5回包括的神経グリア研究会, Jan 10, 2020 Invited
報酬・忌避行動における大脳基底核神経回路

疋田貴俊

第91回日本生理学会大会, Mar 16, 2014, 日本生理学会 Invited
神経科学からのトランスレーショナルリサーチ

疋田貴俊

第9回日本統合失調症学会, Mar 15, 2014, 日本統合失調症学会 Invited
Neural circuit mechanisms in decision-making and emotional behavior

RIKEN BSI Forum, Dec 11, 2013, RIKEN BSI
報酬や侵害刺激による側坐核神経回路の直接路と間接路の機能的可塑性

疋田貴俊

第43回日本神経精神薬理学会シンポジウム「ドーパミン薬理学の新展開」, Oct 26, 2013, 日本神経精神薬理学会 Invited
Distinct roles of direct and indirect pathways in the nucleus accumbens to reward and aversive behavior.

International Symposium on Prediction and Decision Making 2013, Oct 13, 2013, 新学術領域「予測と意思決定の脳内計算機構の解明による人間理解と応用
Dopaminergica regulation of basal ganglia circuit in learning behavior and drug addiction

Takatoshi Hikida

WFSBP2013Kyoto Symposium "Rodent models targeting specific neural circuits for the study of psychiatric disorders, Jun 25, 2013 Invited

Teaching Experience

Professional Memberships

Major Research Projects

Development of multi-dimensional hikikomori support system based on bio-psycho-social understandings

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
食嗜好行動の神経基盤から精神状態を予測する

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jun, 2023 - Mar, 2025

疋田貴俊
戦略的な意思決定の神経機構と精神疾患病態の解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

疋田貴俊

Education

Apr, 1998 - Mar, 2002

Graduate School of Medicine, Kyoto University
Apr, 1991 - Mar, 1997

Faculty of Medicine, Kyoto University

Industrial Property Rights

特許第7012310号精神疾患モデル動物およびその製造方法

岡正啓, 盛山哲嗣, 米田悦啓, 宮本洋一, 辻井聡, 疋田貴俊, 森田真規子
特許第5728471号大脳基底核神経回路の神経伝達を解析する方法

疋田貴俊, 中西重忠
WO2011-135632 大脳基底核神経回路の神経伝達を解析する方法

疋田貴俊, 中西重忠
特表2006-519225 依存症治療用医薬組成物

中西重忠, 疋田貴俊, アイラ・パスタン

Profile Information

Research Interests

Research Areas

Research History

Awards

Major Papers

Major Misc.

Major Books and Other Publications

Major Presentations

Teaching Experience

Professional Memberships

Major Research Projects

Education

Industrial Property Rights

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Coauthors