Uchimoto Kazuhiro

Profile Information

Degree: M.D.

J-GLOBAL ID: 201301023893218166
researchmap Member ID: B000228874

臨床で用いられる全身麻酔薬が高次脳機能に及ぼす影響をテーマに、主に動物モデルを用いて、行動学的、電気生理学的、生体分子的な側面から解析を行っています。

Research Interests

Research Areas

Research History

Assistant Professor, Yokohama City University School of Medicine

Papers

Exploratory analyses of postanesthetic effects of desflurane using behavioral test battery of mice.

Ryo Niikura, Tomoyuki Miyazaki, Kumiko Yonezaki, Kazuhiro Uchimoto, Kenkichi Takase, Takahisa Goto

Behavioural pharmacology, 31(7) 597-609, May 25, 2020 Peer-reviewed
Automated assessment of pain in rats using a voluntarily accessed static weight-bearing test

Hung Tae Kim, Kazuhiro Uchimoto, Tyler Duellman, Jay Yang

PHYSIOLOGY & BEHAVIOR, 151 139-146, Nov, 2015 Peer-reviewed
A pilot study of tele-anaesthesia by virtual private network between an island hospital and a mainland hospital in Japan

Tetsuya Miyashita, Yusuke Mizuno, Yo Sugawara, Yusuka Nagamine, Yukihide Koyama, Tomoyuki Miyazaki, Kazuhiro Uchimoto, Yasuhiro Iketani, Kentaro Tojo, Takahisa Goto

JOURNAL OF TELEMEDICINE AND TELECARE, 21(2) 73-79, Mar, 2015 Peer-reviewed
Postanesthetic Effects of Isoflurane on Behavioral Phenotypes of Adult Male C57BL/6J Mice

Kumiko Yonezaki, Kazuhiro Uchimoto, Tomoyuki Miyazaki, Ayako Asakura, Ayako Kobayashi, Kenkichi Takase, Takahisa Goto

PLOS ONE, 10(3) e0122118, Mar, 2015 Peer-reviewed
The efficacy of lidocaine to prevent laryngospasm in children: a systematic review and meta-analysis

T. Mihara, Kazuhiro Uchimoto, S. Morita, T. Goto

ANAESTHESIA, 69(12) 1388-1396, Dec, 2014 Peer-reviewed
Isoflurane Impairs Learning and Hippocampal Long-term Potentiation via the Saturation of Synaptic Plasticity

Kazuhiro Uchimoto, Tomoyuki Miyazaki, Yoshinori Kamiya, Takahiro Mihara, Yukihide Koyama, Masataka Taguri, Gaku Inagawa, Takuya Takahashi, Takahisa Goto

ANESTHESIOLOGY, 121(2) 302-310, Aug, 2014 Peer-reviewed
Effect of lidocaine on preventing laryngospasm during general anaesthesia in children: a systematic review and meta-analysis

T. Mihara, Kazuhiro Uchimoto, T. Goto

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 31 1-1, Jun, 2014
Very short exposure of volatile anesthetics induces long-term learning deficit in young adult male rats

Kazuhiro Uchimoto, H. Fujimoto, K. Yonezaki, T. Miyazaki, T. Ando, T. Goto

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 31 121-121, Jun, 2014
Role of nerve growth factor-tyrosine kinase receptor A signaling in paclitaxel-induced peripheral neuropathy in rats

Yusuke Nakahashi, Yoshinori Kamiya, Kengo Funakoshi, Tomoyuki Miyazaki, Kazuhiro Uchimoto, Kentaro Tojo, Kenichi Ogawa, Tetsuo Fukuoka, Takahisa Goto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 444(3) 415-419, Feb, 2014 Peer-reviewed
Bumetanide, an inhibitor of cation-chloride cotransporter isoform 1, inhibits ?-aminobutyric acidergic excitatory actions and enhances sedative actions of midazolam in neonatal rats

Yukihide Koyama, Tomio Andoh, Yoshinori Kamiya, Satoshi Morita, Tomoyuki Miyazaki, Kazuhiro Uchimoto, Takahiro Mihara, Takahisa Goto

Anesthesiology, 119(5) 1096-1108, Nov, 2013 Peer-reviewed
Reevaluation of the Effectiveness of Ramosetron for Preventing Postoperative Nausea and Vomiting: A Systematic Review and Meta-Analysis

Takahiro Mihara, Kentaro Tojo, Kazuhiro Uchimoto, Satoshi Morita, Takahisa Goto

ANESTHESIA AND ANALGESIA, 117(2) 329-339, Aug, 2013 Peer-reviewed
Comparison of postoperative learning deficit due to isoflurane exposure or propofol infusion

Kazuhiro Uchimoto, Tomoyuki Miyazaki, Yosiyuki Kamiya, Yosuke Tominaga, Takahisa Goto

European Journal of Anaesthesiology, 30 109-110, Jun, 2013
Effects of volatile anesthetics on the circadian rhythms of rat hippocampal acetylcholine release and locomotor activity

T. Kikuchi, H. Tan, T. Mihara, Kazuhiro Uchimoto, D. Mitsushima, K. Takase, S. Morita, T. Goto, T. Andoh, Y. Kamiya

Neuroscience, 237 151-160, May 1, 2013 Peer-reviewed
Day or Night Administration of Ketamine and Pentobarbital Differentially Affect Circadian Rhythms of Pineal Melatonin Secretion and Locomotor Activity in Rats

Takahiro Mihara, Tatsuaki Kikuchi, Yoshinori Kamiya, Motokazu Koga, Kazuhiro Uchimoto, Kiyoyasu Kurahashi, Takahisa Goto

ANESTHESIA AND ANALGESIA, 115(4) 805-813, Oct, 2012 Peer-reviewed

Misc.

A Case of Combined Spinal-Epidural Anesthesia for Cesarean Section in a Patient with Right Heart Failure due to Supravalvular Pulmonary Stenosis after Jatene Operation

月永晶人, 入江友哉, 内本一宏, 宮下徹也, 後藤隆久

麻酔, 65(10) 1031‐1033-1033, Oct 10, 2016 Peer-reviewed
開腹手術におけるIV‐PCAとPCEAによる術後鎮痛の有用性の比較検討

内本一宏, 栗原理恵子, 宮下徹也, 菊地龍明, 後藤隆久

J Anesth, 22(Supplement (CD-ROM)) P2-71-05, 2008

Presentations

Very short exposure of volatile anesthetics induces long-term learning deficit in young adult male rats

Uchimoto K

ESA2014, Jun 2, 2014
単純開腹疼痛が海馬認知記憶能に与える影響

内本一宏

日本麻酔科学会第61回学術集会, Jun, 2014
全身麻酔薬が認知記憶に及ぼす影響～成体ラットモデルを中心に

内本一宏, 後藤隆久

日本麻酔科学会第61回学術集会, Jun, 2014 Invited
Effect of lidocaine on preventing laryngospasm during general anaesthesia in children: a systematic review and meta-analysis

Mihara T, Uchimoto K, Goto T

ESA2014, May 1, 2014
Propofol Did Not Affect Contextual Learning After Intraperitoneal Administration in Adult Rats

Uchimoto K

ASA2013, Oct 15, 2013
Comparison of post-anesthetic learning deficit due to isoflurane exposure or propofol infusion

Uchimoto K

ESA2013, Jun 2, 2013
術後認知記憶障害のメカニズムの解明

内本一宏

日本麻酔科学会第60回学術集会, Jun, 2013
Isoflurane causes postanesthesia learning disturbances in adult rats by interfering with trafficking of GluA1-containing AMPA receptors in the hippocampus

Uchimoto K

ASA2012, Oct 15, 2012
幼若ラットへのイソフルラン暴露による中枢神経毒性に対してエリスロポチエンに保護作用はあるか

内本一宏

日本麻酔科学会第59回学術集会, Jun, 2012
イソフルラン暴露24時間後のラットの行動学的記憶学習に対する概日リズムの影響

内本一宏

日本麻酔科学会第58回学術集会, Jun, 2011
イソフルラン暴露後のラットの空間認知記憶学習に対する概日リズムの影響

内本一宏

日本麻酔科学会第57回学術集会, Jun, 2010

Professional Memberships

Research Projects

ARDSに伴う肺胞上皮細胞死はアポトーシスなのか，ネクローシスなのか？

基盤 C, 日本学術振興会基盤, Apr, 2017 - Mar, 2020

内本一宏
Identification of the neural circuit and mechanism underlying sevoflurane-induced antidepressant effect

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

goto takahisa, Goshima Yoshio
吸入麻酔薬曝露後の記憶学習能に関するメカニズムの網羅的解析

基盤 C, 日本学術振興会, Apr, 2015 - Mar, 2018

伊奈川岳
超短時間麻酔薬曝露モデルによる成体ラットの認知記憶障害の検討

若手 B, 日本学術振興会, Apr, 2014 - Mar, 2016

内本一宏
成体ラット開腹手術モデルを用いた急性侵害性疼痛による記憶学習能への影響の検討

基盤 C, 日本学術振興会, Apr, 2013 - Mar, 2016

小川賢一
網羅的行動テストバッテリーを用いた麻酔薬の新規効能探索

基盤 B, 日本学術振興会, Apr, 2013 - Mar, 2016

後藤隆久
全身麻酔後の記憶学習能変化とＡＭＰＡ型グルタミン酸受容体の関与に関する研究

基盤 C, 日本学術振興会, Apr, 2012 - Mar, 2015

伊奈川岳
Protective potentials of mannitol-erythropoietin against neurotoxicityof general anesthesia on immature brain.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2012 - Mar, 2014

MAESHIMA Hanae, UCHIMOTO Kazuhiro, ANDOH Tomio

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