渡辺 雅彦


渡辺 雅彦

J-GLOBALへ         更新日: 15/05/22 10:24
 
アバター
研究者氏名
渡辺 雅彦
URL
http://www.hucc.hokudai.ac.jp/~e20704/
所属
北海道大学
部署
大学院医学研究科
職名
教授
学位
博士(医学)(筑波大学)

プロフィール

昭和59年3月 東北大学医学部卒
昭和63年3月 筑波大学大学院医学研究科博士課程修了、医学博士
昭和63年4月 金沢大学医学部助手(解剖学第1講座)
平成2年1月 東北大学医学部助手(解剖学第2講座)
平成4年2月 北海道大学医学部助教授(解剖学第1講座)
(平成5年10月〜平成6年7月 文部省在外研究員として米国ノースカロライナ大学
「相同組み替えによる実験モデル動物の作成と解析に関する研究」)
平成10年11月 北海道大学大学院医学研究科教授、現在に至る

研究専門分野:分子神経解剖学

担当学部教育:解剖学実習(6単位)、解剖発生学(2単位)、神経解剖学(1単位)

研究分野

 
 

経歴

 
2008年
 - 
2009年
北海道大学 医学(系)研究科(研究院) 教授
 
2007年
   
 
北海道大学 医学(系)研究科(研究院)・医学研究科・医学研究院・医学部 大学院・教授
 
2006年
   
 
北海道大学 医学(系)研究科(研究院)・大学院医学研究科・医学研究科 教授
 
2005年
   
 
北海道大学 医学(系)研究科(研究院)・医学研究科 大学院・教授
 
2004年
   
 
北海道大学 医学(系)研究科(研究院)・大学院医学研究科・医学研究科 大学院・教授
 

論文

 
Yoneda, T. and Kameyama, K. and Esumi, K. and Daimyo, Y. and Watanabe, M. and Hata, Y.
Plos One   8(1)    2013年   [査読有り]
The mammalian visual system exhibits significant experience-induced plasticity in the early postnatal period. While physiological studies have revealed the contribution of the CB1 cannabinoid receptor (CB1) to developmental plasticity in the prima...
Yan, Dan and Yamasaki, Miwako and Straub, Christoph and Watanabe, Masahiko and Tomita, Susumu
Neuron   78(4) 687-699   2013年   [査読有り]
Shi, T. J. S. and Zhang, M. D. and Zeberg, H. and Nilsson, J. and Grunler, J. and Liu, S. X. and Xiang, Q. and Persson, J. and Fried, K. J. and Catrina, S. B. and Watanabe, M. and Arhem, P. and Brismar, K. and Hokfelt, T. G. M.
Proceedings of the National Academy of Sciences of the United States of America   110(2) 690-695   2013年   [査読有り]
Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes. Here we studied some phenotypic features of a well-established animal model of type 2 diabetes, the leptin receptor-deficient db(-)/db(-) mous...
Sakagami, H. and Katsumata, O. and Hara, Y. and Tamaki, H. and Watanabe, M. and Harvey, R. J. and Fukaya, M.
Journal of Comparative Neurology   521(4) 860-876   2013年   [査読有り]
The BRAG/IQSEC is a family of guanine nucleotide exchange factors for ADP ribosylation factors, small GTPases that regulate membrane trafficking and actin cytoskeleton, and comprises three structurally related members (BRAG13) generated from diffe...
Mizukoshi, K. and Sasaki, M. and Izumi, Y. and Miura, M. and Watanabe, M. and Amaya, F.
Neuroscience   234 77-87   2013年   [査読有り]
Kawakita, I. and Uchigashima, M. and Konno, K. and Miyazaki, T. and Yamasaki, M. and Watanabe, M.
European Journal of Neuroscience   37(4) 532-543   2013年   [査読有り]
Postnatal expression of the type 2K+Cl cotransporter (KCC2) in neurons lowers the Cl equilibrium potential to values that are more negative than the resting potential, thereby converting the action of Cl-permeable GABAA and glycine receptors from ...
Kano, Masanobu and Nakayama, Hisako and Hashimoto, Kouichi and Kitamura, Kazuo and Sakimura, Kenji and Watanabe, Masahiko
Journal of Physiology-London   591(13) 3151-3158   2013年   [査読有り]
Indriati, D. W. and Kamasawa, N. and Matsui, K. and Meredith, A. L. and Watanabe, M. and Shigemoto, R.
Journal of Neuroscience   33(8) 3668-+   2013年   [査読有り]
P/Q-type voltage-dependent calcium channels play key roles in transmitter release, integration of dendritic signals, generation of dendritic spikes, and gene expression. High intracellular calcium concentration transient produced by these channels...
Hozumi, Yasukazu and Matsui, Hirooki and Sakane, Fumio and Watanabe, Masahiko and Goto, Kaoru
Journal of Histochemistry & Cytochemistry   61(6) 462-476   2013年   [査読有り]
Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits
Hoshina, Naosuke and Tanimura, Asami and Yamasaki, Miwako and Inoue, Takeshi and Fukabori, Ryoji and Kuroda, Teiko and Yokoyama, Kazumasa and Tezuka, Tohru and Sagara, Hiroshi and Hirano, Shinji and Kiyonari, Hiroshi and Takada, Masahiko and Kobayashi, Kazuto and Watanabe, Masahiko and Kano, Masanobu and Nakazawa, Takanobu and Yamamoto, Tadashi
Neuron   78(5) 839-854   2013年   [査読有り]
Brumovsky, Pablo R. and Seal, Rebecca P. and Lundgren, Kerstin H. and Seroogy, Kim B. and Watanabe, Masahiko and Gebhart, G. F.
Journal of Urology   189(6) 2342-2349   2013年   [査読有り]
The interaction of the cannabinoidergic and serotonergic system modulating synaptic transmission in the basal amygdala
Yoshida, T. and Izumi, T. and Ohmura, Y. and Watanabe, M. and Yoshioka, M.
Journal of Pharmacological Sciences   118 179P-179P   2012年   [査読有り]
Yaguchi, Hiroaki and Okumura, Fumihiko and Takahashi, Hidehisa and Kano, Takahiro and Kameda, Hiroyuki and Uchigashima, Motokazu and Tanaka, Shinya and Watanabe, Masahiko and Sasaki, Hidenao and Hatakeyama, Shigetsugu
Journal of Biological Chemistry   287(15) 12050-12059   2012年   [査読有り]
Tripartite motif (TRIM)-containing proteins, which are defined by the presence of a common domain structure composed of a RING finger, one or two B-box motifs and a coiled-coil motif, are involved in many biological processes including innate immu...
Tanimura, A. and Uchigashima, M. and Yamazaki, M. and Uesaka, N. and Mikuni, T. and Abe, M. and Hashimoto, K. and Watanabe, M. and Sakimura, K. and Kano, M.
Proceedings of the National Academy of Sciences of the United States of America   109(30) 12195-12200   2012年   [査読有り]
Takeuchi, Y. and Yamasaki, M. and Nagumo, Y. and Imoto, K. and Watanabe, M. and Miyata, M.
Journal of Neuroscience   32(20) 6917-6930   2012年   [査読有り]
Shikanai, H. and Yoshida, T. and Konno, K. and Yamasaki, M. and Izumi, T. and Ohmura, Y. and Watanabe, M. and Yoshioka, M.
Journal of Neuroscience   32(41) 14415-14426   2012年   [査読有り]
The serotonergic (5-HTergic) system arising from the dorsal raphe nucleus (DRN) is implicated in various physiological and behavioral processes, including stress responses. The DRN is comprised of several subnuclei, serving specific functions with...
Padgett, Claire L. and Lalive, Arnaud L. and Tan, Kelly R. and Terunuma, Miho and Munoz, Michaelanne B. and Pangalos, Menelas N. and Martinez-Hernandez, Jose and Watanabe, Masahiko and Moss, Stephen J. and Lujan, Rafael and Luescher, Christian and Slesinger, Paul A.
Neuron   73(5) 978-989   2012年   [査読有り]
Oshima, S. and Watanabe, M.
European Journal of Oral Sciences   120(5) 386-394   2012年   [査読有り]
Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia
Okubo, Y. and Mashimo, M. and Yamazawa, T. and Yamasaki, M. and Watanabe, M. and Murayama, T. and Lino, M.
Journal of Pharmacological Sciences   118 102P-102P   2012年   [査読有り]
Nishizawa, K. and Fukabori, R. and Okada, K. and Kai, N. and Uchigashima, M. and Watanabe, M. and Shiota, A. and Ueda, M. and Tsutsui, Y. and Kobayashi, K.
Journal of Neuroscience   32(39) 13421-13432   2012年   [査読有り]
The dorsal striatum, which contains the dorsolateral striatum (DLS) and dorsomedial striatum (DMS), integrates the acquisition and implementation of instrumental learning in cooperation with the nucleus accumbens (NAc). The dorsal striatum regulat...
Nakayama, Hisako and Miyazaki, Taisuke and Kitamura, Kazuo and Hashimoto, Kouichi and Yanagawa, Yuchio and Obata, Kunihiko and Sakimura, Kenji and Watanabe, Masahiko and Kano, Masanobu
Neuron   74(2) 384-396   2012年   [査読有り]
Functional neural circuit formation during development involves massive elimination of redundant synapses. In the cerebellum, one-to-one connection from excitatory climbing fiber (CF) to Purkinje cell (PC) is established by elimination of early-fo...
Miyazaki, Taisuke and Yamasaki, Miwako and Hashimoto, Kouichi and Yamazaki, Maya and Abe, Manabu and Usui, Hiroshi and Kano, Masanobu and Sakimura, Kenji and Watanabe, Masahiko
Journal of Neuroscience   32(4) 1311-1328   2012年   [査読有り]
In the adult cerebellum, each Purkinje cell (PC) is innervated by a single climbing fiber (CF) in proximal dendrites and 10(5)-10(6) parallel fibers (PFs) in distal dendrites. This organized wiring is established postnatally through heterosynaptic...
Matsumoto, H. and Shibasaki, K. and Uchigashima, M. and Koizumi, A. and Kurachi, M. and Moriwaki, Y. and Misawa, H. and Kawashima, K. and Watanabe, M. and Kishi, S. and Ishizaki, Y.
Plos One   7(8)    2012年   [査読有り]
Martinez-Turrillas, R. and Puerta, E. and Chowdhury, D. and Marco, S. and Watanabe, M. and Aguirre, N. and Perez-Otano, I.
Neurobiology of Disease   48(3) 290-298   2012年   [査読有り]
Excitotoxicity due to excessive activation of glutamate receptors is a primary mediator of cell death in acute and chronic neurological disorders, and NMDA-type glutamate receptors (NMDARs) are thought to be involved. NMDARs assemble from heterome...
Kudo, T. and Uchigashima, M. and Miyazaki, T. and Konno, K. and Yamasaki, M. and Yanagawa, Y. and Minami, M. and Watanabe, M.
Journal of Neuroscience   32(50) 18035-18046   2012年   [査読有り]
Dopaminergic (DAergic) neurons in the ventral tegmental area (VTA) play crucial roles in motivational control of behaviors, and their activity is regulated directly or indirectly via GABAergic neurons by extrinsic afferents from various sources, i...
Kakizawa, Sho and Yamazawa, Toshiko and Chen, Yili and Ito, Akihiro and Murayama, Takashi and Oyamada, Hideto and Kurebayashi, Nagomi and Sato, Osamu and Watanabe, Masahiko and Mori, Nozomu and Oguchi, Katsuji and Sakurai, Takashi and Takeshima, Hiroshi and Saito, Nobuhito and Iino, Masamitsu
Embo Journal   31(2) 417-428   2012年   [査読有り]
Mobilization of intracellular Ca2+ stores regulates a multitude of cellular functions, but the role of intracellular Ca2+ release via the ryanodine receptor (RyR) in the brain remains incompletely understood. We found that nitric oxide (NO) direct...
Iwakura, A. and Uchigashima, M. and Miyazaki, T. and Yamasaki, M. and Watanabe, M.
Journal of Neuroscience   32(27) 9438-9448   2012年   [査読有り]
Ito-Ishida, A. and Miyazaki, T. and Miura, E. and Matsuda, K. and Watanabe, M. and Yuzaki, M. and Okabe, S.
Neuron   76(3) 549-564   2012年   [査読有り]
Differentiation of pre- and postsynaptic sites is coordinated by reciprocal interaction across synaptic clefts. At parallel fiber (PF)-Purkinje cell (PC) synapses, dendritic spines are autonomously formed without PF influence. However, little is k...
Hrabovszky, E. and Molnar, C. S. and Robert, N. and Vida, B. and Borsay, B. A. and Racz, K. and Laszlo, H. and Watanabe, M. and Imre, K. and Liposits, Z.
Endocrinology   153(6) 2766-2776   2012年   [査読有り]
Holderith, N. and Lorincz, A. and Katona, G. and Rozsa, B. and Kulik, A. and Watanabe, M. and Nusser, Z.
Nature Neuroscience   15(7) 988-997   2012年   [査読有り]
Gregg, L. C. and Jung, K. M. and Spradley, J. M. and Nyilas, R. and Suplita, R. L. and Zimmer, A. and Watanabe, M. and Mackie, K. and Katona, I. and Piomelli, D. and Hohmann, A. G.
Journal of Neuroscience   32(28) 9457-9468   2012年   [査読有り]
Fukabori, Ryoji and Okada, Kana and Nishizawa, Kayo and Kai, Nobuyuki and Kobayashi, Kenta and Uchigashima, Motokazu and Watanabe, Masahiko and Tsutsui, Yuji and Kobayashi, Kazuto
European Journal of Neuroscience   35(5) 784-797   2012年   [査読有り]
Derks, N. M. and Pinter, O. and Zuure, W. and Ledent, C. and Watanabe, M. and Molnar, C. S. and Wei, Y. and Roubos, E. W. and Wu, S. and Hrabovszky, E. and Zelena, D. and Kozicz, T.
Journal of Neuroendocrinology   24(11) 1447-1461   2012年   [査読有り]
Neurones in the centrally projecting EdingerWestphal nucleus (EWcp) are the main site of urocortin 1 (Ucn1) synthesis in the mammalian brain, and are assumed to play a role in the stress response of the animal. Because endocannabinoid signalling h...
Cserep, C. and Szabadits, E. and Szonyi, A. and Watanabe, M. and Freund, T. F. and Nyiri, G.
Plos One   7(5)    2012年   [査読有り]
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease
Chiodi, Valentina and Uchigashima, Motokazu and Beggiato, Sarah and Ferrante, Antonella and Armida, Monica and Martire, Alberto and Potenza, Rosa Luisa and Ferraro, Luca and Tanganelli, Sergio and Watanabe, Masahiko and Domenici, Maria Rosaria and Popoli, Patrizia
Neurobiology of Disease   45(3) 983-991   2012年   [査読有り]
Cannabinoid CB1 receptors (CB1Rs) are known to be downregulated in patients and in animal models of Huntington's disease (HD). However, the functional meaning of this reduction, if any, is still unclear. Here, the effects of the cannabinoid recept...
Baseer, N. and Polgar, E. and Watanabe, M. and Furuta, T. and Kaneko, T. and Todd, A. J.
Journal of Neuroscience   32(34) 11854-11863   2012年   [査読有り]
Ballesteros-Merino, C. and Lin, M. and Wu, W. W. and Ferrandiz-Huertas, C. and Cabanero, M. J. and Watanabe, M. and Fukazawa, Y. and Shigemoto, R. and Maylie, J. and Adelman, J. P. and Lujan, R.
Hippocampus   22(6) 1467-1480   2012年   [査読有り]
Brumovsky PR, Seroogy KB, Lundgren KH, Watanabe M, Hökfelt T, Gebhart GF
Experimental neurology   230(2) 258-272   2011年8月   [査読有り]
Hida Y, Fukaya M, Hagiwara A, Deguchi-Tawarada M, Yoshioka T, Kitajima I, Inoue E, Watanabe M, Ohtsuka T
Journal of biochemistry   149(6) 693-700   2011年6月   [査読有り]
Allen D, Bond CT, Luján R, Ballesteros-Merino C, Lin MT, Wang K, Klett N, Watanabe M, Shigemoto R, Stackman RW Jr, Maylie J, Adelman JP
Nature neuroscience   14(6) 744-749   2011年6月   [査読有り]
Hashimoto K, Tsujita M, Miyazaki T, Kitamura K, Yamazaki M, Shin HS, Watanabe M, Sakimura K, Kano M
Proceedings of the National Academy of Sciences of the United States of America   108(24) 9987-9992   2011年6月   [査読有り]
Allen D, Nakayama S, Kuroiwa M, Nakano T, Palmateer J, Kosaka Y, Ballesteros C, Watanabe M, Bond CT, Luján R, Maylie J, Adelman JP, Herson PS
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism      2011年6月   [査読有り]
Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M
Journal of neuroscience research   89(5) 773-790   2011年5月   [査読有り]
Stanić D, Mulder J, Watanabe M, Hökfelt T
The Journal of comparative neurology   519(7) 1219-1257   2011年5月   [査読有り]
Suzuki S, Tamai K, Watanabe M, Kyuuma M, Ono M, Sugamura K, Tanaka N
Biochemical and biophysical research communications   408(4) 582-588   2011年5月   [査読有り]
Uchigashima M, Yamazaki M, Yamasaki M, Tanimura A, Sakimura K, Kano M, Watanabe M
The Journal of neuroscience : the official journal of the Society for Neuroscience   31(21) 7700-7714   2011年5月   [査読有り]
Polgár E, Sardella TC, Watanabe M, Todd AJ
The Journal of comparative neurology   519(6) 1007-1023   2011年4月   [査読有り]
Mulder J, Zilberter M, Pasquaré SJ, Alpár A, Schulte G, Ferreira SG, Köfalvi A, Martín-Moreno AM, Keimpema E, Tanila H, Watanabe M, Mackie K, Hortobágyi T, de Ceballos ML, Harkany T
Brain : a journal of neurology   134 1041-1060   2011年4月   [査読有り]
Szabadits E, Cserép C, Szonyi A, Fukazawa Y, Shigemoto R, Watanabe M, Itohara S, Freund TF, Nyiri G
The Journal of neuroscience : the official journal of the Society for Neuroscience   31(16) 5893-5904   2011年4月   [査読有り]
Katano T, Nakazawa T, Nakatsuka T, Watanabe M, Yamamoto T, Ito S
Neuropharmacology   60(4) 609-616   2011年3月   [査読有り]
Fukaya M, Kamata A, Hara Y, Tamaki H, Katsumata O, Ito N, Takeda S, Hata Y, Suzuki T, Watanabe M, Harvey RJ, Sakagami H
Journal of neurochemistry   116(6) 1122-1137   2011年3月   [査読有り]
Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BD
Nature neuroscience   14(3) 338-344   2011年3月   [査読有り]
Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
Biochemical and biophysical research communications   406(4) 627-632   2011年3月   [査読有り]
Yamasaki M, Miyazaki T, Azechi H, Abe M, Natsume R, Hagiwara T, Aiba A, Mishina M, Sakimura K, Watanabe M
The Journal of neuroscience : the official journal of the Society for Neuroscience   31(9) 3362-3374   2011年3月   [査読有り]
Kobayashi K, Masuda T, Takahashi M, Miyazaki J, Nakagawa M, Uchigashima M, Watanabe M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K
The European journal of neuroscience   33 612-621   2011年2月   [査読有り]
Yoshida T, Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M
Proceedings of the National Academy of Sciences of the United States of America   108(7) 3059-3064   2011年2月   [査読有り]
Miyazaki T, Yamasaki M, Uchigashima M, Matsushima A, Watanabe M
The European journal of neuroscience   33 82-94   2011年1月   [査読有り]
Yoshida, T. and Uchigashima, M. and Yamasaki, M. and Katona, I. and Yamazaki, M. and Sakimura, K. and Kano, M. and Yoshioka, M. and Watanabe, M.
Proceedings of the National Academy of Sciences of the United States of America   108(7) 3059-3064   2011年   [査読有り]
2-Arachidonoylglycerol (2-AG) is the endocannabinoid that mediates retrograde suppression of synaptic transmission in the brain. 2-AG is synthesized in activated postsynaptic neurons by sn-1-specific diacylglycerol lipase (DGL), binds to presynapt...
Yamasaki, M. and Miyazaki, T. and Azechi, H. and Abe, M. and Natsume, R. and Hagiwara, T. and Aiba, A. and Mishina, M. and Sakimura, K. and Watanabe, M.
Journal of Neuroscience   31(9) 3362-3374   2011年   [査読有り]
The number of synaptic AMPA receptors (AMPARs) is the major determinant of synaptic strength and is differently regulated in input pathway-dependent and target cell type-dependent manners. In cerebellar Purkinje cells (PCs), the density of synapti...
MOP Reduction During Long-Term Methamphetamine Withdrawal was Restored by Chronic Post-Treatment with Fluoxetine
Yamamoto, H. and Takamatsu, Y. and Imai, K. and Kamegaya, E. and Hagino, Y. and Watanabe, M. and Yamamoto, T. and Sora, I. and Koga, H. and Ikeda, K.
Current Neuropharmacology   9(1) 73-78   2011年   [査読有り]
Previously, we found fluoxetine reduces methamphetamine preference in mice. However, effects of fluoxetine on developed methamphetamine preference and on methamphetamine induced gene expression changes have been largely unknown. The present study ...
Watanabe, M. and Kano, M.
European Journal of Neuroscience   34(10) 1697-1710   2011年   [査読有り]
Innervation of Purkinje cells (PCs) by multiple climbing fibers (CFs) is refined into mono-innervation during the first three postnatal weeks of rodents lives. In this review article, we will integrate the current knowledge on developmental proces...
Uchigashima, M. and Yamazaki, M. and Yamasaki, M. and Tanimura, A. and Sakimura, K. and Kano, M. and Watanabe, M.
Journal of Neuroscience   31(21) 7700-7714   2011年   [査読有り]
2-Arachidonoylglycerol (2-AG) is the endocannabinoid that mediates retrograde suppression of neurotransmission in the brain. In the present study, we investigated the 2-AG signaling system at mossy cell (MC)-granule cell (GC) synapses in the mouse...
Tiong, S. Y. X. and Polgar, E. and van Kralingen, J. C. and Watanabe, M. and Todd, A. J.
Molecular Pain   7    2011年   [査読有り]
Background: Inhibitory interneurons constitute 30-40% of neurons in laminae I-III and have an important anti-nociceptive role. However, because of the difficulty in classifying them we know little about their organisation. Previous studies have id...
Szabadits, E. and Cserep, C. and Szonyi, A. and Fukazawa, Y. and Shigemoto, R. and Watanabe, M. and Itohara, S. and Freund, T. F. and Nyiri, G.
Journal of Neuroscience   31(16) 5893-5904   2011年   [査読有り]
GABAergic inhibition plays a central role in the control of pyramidal cell ensemble activities; thus, any signaling mechanism that regulates inhibition is able to fine-tune network patterns. Here, we provide evidence that the retrograde nitric oxi...
Suzuki, S. and Tamai, K. and Watanabe, M. and Kyuuma, M. and Ono, M. and Sugamura, K. and Tanaka, N.
Biochemical and Biophysical Research Communications   408(4) 582-588   2011年   [査読有り]
Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. AMSH (associated molecule with the SH3 domain of STAM) is a deubiquitination enzyme that participates in the endosomal ...
Straub, C. and Hunt, D. L. and Yamasaki, M. and Kim, K. S. and Watanabe, M. and Castillo, P. E. and Tomita, S.
Nature Neuroscience   14(7) 866-U83   2011年   [査読有り]
Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) have a unique brain distribution, which has been historically defined...
Stanic, D. and Mulder, J. and Watanabe, M. and Hokfelt, T.
Journal of Comparative Neurology   519(7) 1219-1257   2011年   [査読有り]
Neuropeptide Y (NPY) is widely expressed in the brain and its biological effects are mediated through a variety of receptors. We examined, using immunohistochemistry, expression of the Y2 receptor (R) protein in the adult mouse brain and its assoc...
Sardella, T. C. P. and Polgar, E. and Watanabe, M. and Todd, A. J.
Neuroscience   192 708-720   2011年   [査読有り]
Nitric oxide produced by neuronal nitric oxide synthase (nNOS) in the spinal cord is required for development of hyperalgesia in inflammatory and neuropathic pain states. nNOS is expressed by some dorsal horn neurons, and an early study that used ...
Sardella, T. C. P. and Polgar, E. and Garzillo, F. and Furuta, T. and Kaneko, T. and Watanabe, M. and Todd, A. J.
Molecular Pain   7    2011年   [査読有り]
Background: The opioid peptide dynorphin is expressed by certain neurons in the superficial dorsal horn of the spinal cord, but little is known about the types of cell that contain dynorphin. In this study, we have used an antibody against the dyn...
Polgar, E. and Sardella, T. C. P. and Watanabe, M. and Todd, A. J.
Journal of Comparative Neurology   519(6) 1007-1023   2011年   [査読有り]
Between 25-40% of neurons in laminae I-III are GABAergic, and some of these express neuropeptide Y (NPY). We previously reported that NPY-immunoreactive axons form numerous synapses on lamina III projection neurons that possess the neurokinin 1 re...
Mulder, J. and Zilberter, M. and Pasquare, S. J. and Alpar, A. and Schulte, G. and Ferreira, S. G. and Kofalvi, A. and Martin-Moreno, A. M. and Keimpema, E. and Tanila, H. and Watanabe, M. and Mackie, K. and Hortobagyi, T. and de Ceballos, M. L. and Harkany, T.
Brain   134 1041-1060   2011年   [査読有り]
Retrograde messengers adjust the precise timing of neurotransmitter release from the presynapse, thus modulating synaptic efficacy and neuronal activity. 2-Arachidonoyl glycerol, an endocannabinoid, is one such messenger produced in the postsynaps...
Miyazaki, T. and Yamasaki, M. and Uchigashima, M. and Matsushima, A. and Watanabe, M.
European Journal of Neuroscience   33(1) 82-94   2011年   [査読有り]
Secretogranin II (SgII), or chromogranin C, is thought to participate in the sorting and packaging of peptide hormones and neuropeptides into secretory granules and large dense-core vesicle (LDCVs), and also functions as a precursor of neuropeptid...
Miyazaki, T. and Watanabe, M.
Anatomical Science International   86(1) 10-18   2011年   [査読有り]
In the adult cerebellum, a single climbing fiber (CF) innervates proximal dendrites of Purkinje cells (PCs). This monoinnervation is established by the developmental elimination of surplus CFs through homosynaptic competition among multiply innerv...
Ludanyi, A. and Hu, S. J. and Yamazaki, M. and Tanimura, A. and Piomelli, D. and Watanabe, M. and Kano, M. and Sakimura, K. and Magloczky, Z. and Mackie, K. and Freund, T. F. and Katona, I.
Neuroscience   174 50-63   2011年   [査読有り]
Clinical and experimental evidence demonstrates that endocannabinoids play either beneficial or adverse roles in many neurological and psychiatric disorders. Their medical significance may be best explained by the emerging concept that endocannabi...
Larsen, R. S. and Corlew, R. J. and Henson, M. A. and Roberts, A. C. and Mishina, M. and Watanabe, M. and Lipton, S. A. and Nakanishi, N. and Perez-Otano, I. and Weinberg, R. J. and Philpot, B. D.
Nature Neuroscience   14(3) 338-344   2011年   [査読有り]
Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked ...
Kobayashi, K. and Masuda, T. and Takahashi, M. and Miyazaki, J. and Nakagawa, M. and Uchigashima, M. and Watanabe, M. and Yaginuma, H. and Osumi, N. and Kaibuchi, K.
European Journal of Neuroscience   33(4) 612-621   2011年   [査読有り]
Cranial motor neurons, which are divided into somatic motor (SM), branchiomotor (BM) and visceral motor (VM) neurons, form distinct axonal trajectories to innervate their synapse targets. Rho GTPase regulates various neuronal functions through one...
Kato, S. and Kuramochi, M. and Kobayashi, K. and Fukabori, R. and Okada, K. and Uchigashima, M. and Watanabe, M. and Tsutsui, Y.
Journal of Neuroscience   31(47) 17169-17179   2011年   [査読有り]
The dorsal striatum receives converging excitatory inputs from diverse brain regions, including the cerebral cortex and the intralaminar/midline thalamic nuclei, and mediates learning processes contributing to instrumental motor actions. However, ...
Katano, T. and Nakazawa, T. and Nakatsuka, T. and Watanabe, M. and Yamamoto, T. and Ito, S.
Neuropharmacology   60(4) 609-616   2011年   [査読有り]
Previously we demonstrated that phosphorylation of NR2B subunits of the N-methyl-D-aspartate (NMDA) glutamate receptor at Tyr1472 is increased in a neuropathic-pain model and that this phosphorylation is required for the maintenance of neuropathic...
Quantitative Detection of mu Opioid Receptor: Western Blot Analyses Using mu Opioid Receptor Knockout Mice
Kasai, S. and Yamamoto, H. and Kamegaya, E. and Uhl, G. R. and Sora, I. and Watanabe, M. and Ikeda, K.
Current Neuropharmacology   9(1) 219-222   2011年   [査読有り]
Increasing evidence suggests that mu opioid receptor (MOP) expression is altered during the development of and withdrawal from substance dependence. Although anti-MOP antibodies have been hypothesized to be useful for estimating MOP expression lev...
Karlocai, M. R. and Toth, K. and Watanabe, M. and Ledent, C. and Juhasz, G. and Freund, T. F. and Magloczky, Z.
Plos One   6(11)    2011年   [査読有り]
The endocannabinoid system plays a central role in retrograde synaptic communication and may control the spread of activity in an epileptic network. Using the pilocarpine model of temporal lobe epilepsy we examined the expression pattern of the Ty...
Joo, J. Y. and Lee, S. J. and Uemura, T. and Yoshida, T. and Yasumura, M. and Watanabe, M. and Mishina, M.
Biochemical and Biophysical Research Communications   406(4) 627-632   2011年   [査読有り]
Trans-synaptic interaction of postsynaptic glutamate receptor 62 and presynaptic neurexins (NRXNs) through cerebellin precursor protein (Cbln) 1 mediates synapse formation in the cerebellum [T. Uemura, S.J. Lee, M. Yasumura, T. Takeuchi, T. Yoshid...
Izumi, T. and Boku, S. and Shinmin, W. and Inoue, T. and Konno, K. and Yamaguchi, T. and Yoshida, T. and Matsumoto, M. and Watanabe, M. and Koyama, T. and Yoshioka, M.
Journal of Neuroscience Research   89(5) 773-790   2011年   [査読有り]
The amygdala is one of the crucial brain structures for conditioned fear, in which conditioned stimuli are received by the basolateral nucleus of the amygdala (BLA), inducing a fear reaction via the central nucleus of the amygdala (CeA). Whereas B...
Ichikawa, R. and Yamasaki, M. and Miyazaki, T. and Konno, K. and Hashimoto, K. and Tatsumi, H. and Inoue, Y. and Kano, M. and Watanabe, M.
Journal of Neuroscience   31(47) 16916-16927   2011年   [査読有り]
In early postnatal development, perisomatic innervation of cerebellar Purkinje cells (PCs) switches from glutamatergic climbing fibers (CFs) to GABAergic basket cell fibers (BFs). Here we examined the switching process in C57BL/6 mice. At postnata...
Hondo, M. and Furutani, N. and Yamasaki, M. and Watanabe, M. and Sakurai, T.
Plos One   6(9)    2011年   [査読有り]
Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood. We confirmed...
Hida, Y. and Fukaya, M. and Hagiwara, A. and Deguchi-Tawarada, M. and Yoshioka, T. and Kitajima, I. and Inoue, E. and Watanabe, M. and Ohtsuka, T.
Journal of Biochemistry   149(6) 693-700   2011年   [査読有り]
The planar cell polarity (PCP) protein, Prickle (Pk), is conserved in invertebrates and vertebrates, and regulates cellular morphogenesis and movement. Vertebrate Pk consists of at least two family members, Pk1 and Pk2, both of which are expressed...
Hashimoto, K. and Tsujita, M. and Miyazaki, T. and Kitamura, K. and Yamazaki, M. and Shin, H. S. and Watanabe, M. and Sakimura, K. and Kano, M.
Proceedings of the National Academy of Sciences of the United States of America   108(24) 9987-9992   2011年   [査読有り]
Neural circuits are initially redundant but rearranged through activity-dependent synapse elimination during postnatal development. This process is crucial for shaping mature neural circuits and for proper brain function. At birth, Purkinje cells ...
Fukaya, M. and Kamata, A. and Hara, Y. and Tamaki, H. and Katsumata, O. and Ito, N. and Takeda, S. and Hata, Y. and Suzuki, T. and Watanabe, M. and Harvey, R. J. and Sakagami, H.
Journal of Neurochemistry   116(6) 1122-1137   2011年   [査読有り]
P>SynArfGEF, also known as BRAG3 or IQSEC3, is a member of the brefeldin A-resistant Arf-GEF/IQSEC family and was originally identified by screening for mRNA species associated with the post-synaptic density fraction. In this study, we demonstrate...
Fernandez-Alacid, L. and Watanabe, M. and Molnar, E. and Wickman, K. and Lujan, R.
European Journal of Neuroscience   34(11) 1724-1736   2011年   [査読有り]
G protein-gated inwardly-rectifying K+ (GIRK/family 3 of inwardly-rectifying K+) channels are coupled to neurotransmitter action and can play important roles in modulating neuronal excitability. We investigated the temporal and spatial expression ...
Brumovsky, P. R. and Seroogy, K. B. and Lundgren, K. H. and Watanabe, M. and Hokfelt, T. and Gebhart, G. F.
Experimental Neurology   230(2) 258-272   2011年   [査読有り]
Glutamate is the main excitatory neurotransmitter in the nervous system, including in primary afferent neurons. However, to date a glutamatergic phenotype of autonomic neurons has not been described. Therefore, we explored the expression of vesicu...
Brumovsky, P. R. and Robinson, D. R. and La, J. H. and Seroogy, K. B. and Lundgren, K. H. and Albers, K. M. and Kiyatkin, M. E. and Seal, R. P. and Edwards, R. H. and Watanabe, M. and Hokfelt, T. and Gebhart, G. F.
Journal of Comparative Neurology   519(16) 3346-3366   2011年   [査読有り]
Vesicular glutamate transporters (VGLUTs) have been extensively studied in various neuronal systems, but their expression in visceral sensory and autonomic neurons remains to be analyzed in detail. Here we studied VGLUTs type 1 and 2 (VGLUT(1) and...
Arora, D. and Hearing, M. and Haluk, D. M. and Mirkovic, K. and Fajardo-Serrano, A. and Wessendorf, M. W. and Watanabe, M. and Lujan, R. and Wickman, K.
Journal of Neuroscience   31(34) 12251-12257   2011年   [査読有り]
Enhanced glutamatergic neurotransmission in dopamine (DA) neurons of the ventral tegmental area (VTA), triggered by a single cocaine injection, represents an early adaptation linked to the more enduring effects of abused drugs that characterize ad...
Allen, D. and Nakayama, S. and Kuroiwa, M. and Nakano, T. and Palmateer, J. and Kosaka, Y. and Ballesteros, C. and Watanabe, M. and Bond, C. T. and Lujan, R. and Maylie, J. and Adelman, J. P. and Herson, P. S.
Journal of Cerebral Blood Flow and Metabolism   31(12) 2302-2312   2011年   [査読有り]
In mouse hippocampal CA1 pyramidal neurons, the activity of synaptic small-conductance Ca(2+)-activated K(+) channels type 2 (SK2 channels) provides a negative feedback on N-methyl-D-aspartate receptors (NMDARs), reestablishing Mg(2+) block that r...
Allen, D. and Bond, C. T. and Lujan, R. and Ballesteros-Merino, C. and Lin, M. T. and Wang, K. and Klett, N. and Watanabe, M. and Shigemoto, R. and Stackman, R. W. and Maylie, J. and Adelman, J. P.
Nature Neuroscience   14(6) 744-U344   2011年   [査読有り]
SK2-containing channels are expressed in the postsynaptic density (PSD) of dendritic spines on mouse hippocampal area CA1 pyramidal neurons and influence synaptic responses, plasticity and learning. The Sk2 gene (also known as Kcnn2) encodes two i...
Farkas I, Kalló I, Deli L, Vida B, Hrabovszky E, Fekete C, Moenter SM, Watanabe M, Liposits Z
Endocrinology   151 5818-5829   2010年12月   [査読有り]
Yang JH, Wada A, Yoshida K, Miyoshi Y, Sayano T, Esaki K, Kinoshita MO, Tomonaga S, Azuma N, Watanabe M, Hamase K, Zaitsu K, Machida T, Messing A, Itohara S, Hirabayashi Y, Furuya S
The Journal of biological chemistry   285(53) 41380-41390   2010年12月   [査読有り]
Parajuli LK, Fukazawa Y, Watanabe M, Shigemoto R
The Journal of comparative neurology   518(21) 4362-4374   2010年11月   [査読有り]
Mashimo M, Okubo Y, Yamazawa T, Yamasaki M, Watanabe M, Murayama T, Iino M
The European journal of neuroscience   32 1668-1677   2010年11月   [査読有り]
Miyazaki T, Yamasaki M, Takeuchi T, Sakimura K, Mishina M, Watanabe M
The Journal of neuroscience : the official journal of the Society for Neuroscience   30(45) 15196-15209   2010年11月   [査読有り]
Ciruela F, Fernández-Dueñas V, Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R
The European journal of neuroscience   32 1265-1277   2010年10月   [査読有り]

Misc

 
山嶋哲盛, 渡辺雅彦, 塚田和幸
Neuropathology : official journal the Japanese Society of Neuropathology   22    2002年5月
高橋幸利, 坂口直美, 渡辺雅彦, 森寿, 三品昌美, 愛波秀男, 斎藤義朗, 内田靖, 松尾直樹, 服部里美, 近藤直実
日本てんかん学会プログラム・予稿集   (35)    2001年9月

書籍等出版物

 
Neural circuit development and plasticity shaped by glutamate transporters. In: Molecular Imaging for Integrated Medical Therapy and Drug Development. (eds. Tamaki N, Kuge Y)
渡辺 雅彦
Springer   2013年   
Synaptogenesis and synapse elimination. In: Handbook of the Cerebellum and Cerebellar Disorders. (eds, Manto M, Gruol DL, Schmahmann N, Koibuchi N, Rossi F)
渡辺 雅彦 (担当:分担執筆, 範囲:pp281-299)
Springer   2013年   
Cerebellar circuits. In: Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Healthy and Diseased Brain, volume 3 (eds, Rubenstein JL, Rakic P)
渡辺 雅彦 (担当:分担執筆, 範囲:pp.75-93)
Elsevier   2013年   
大脳の構造と機能、「脳卒中理学療法の理論と技術」(原寛美、吉尾雅春編集)
渡辺 雅彦 (担当:分担執筆, 範囲:2-24頁)
Medical View   2013年   
脳幹の構造と機能、「脳卒中理学療法の理論と技術」(原寛美、吉尾雅春編集)
渡辺 雅彦 (担当:分担執筆, 範囲:25-46頁)
Medical View   2013年   

担当経験のある科目

 
 

競争的資金等の研究課題

 
高次脳領域におけるシナプス伝達制御機構の分子形態学的研究
日本学術振興会: 科学研究費補助金 基盤研究(S)
研究期間: 2012年4月 - 2017年3月    代表者: 渡辺 雅彦
包括型脳科学研究推進支援ネットワーク
文部科学省科学研究費補助金: 新学術領域研究(研究領域提案型)
研究期間: 2010年4月 - 2015年3月    代表者: 木村實
競合的シナプス回路成熟の構造基盤と分子基盤
文部科学省科学研究費補助金: 新学術領域研究(統合脳:代表丹治順)
研究期間: 2005年4月 - 2010年3月    代表者: 渡辺 雅彦
活動依存的カルシウム流入による競合的シナプス回路発達の共通原理の解明
日本学術振興会: 科学研究費補助金 基盤研究(S)
代表者: 渡辺 雅彦