Hideaki Mizuno

Profile Information

Affiliation: Discovery Technology Research, Chugai Pharmaceutical Co., Ltd.

Degree: Ph.D.

ORCID ID: https://orcid.org/0000-0002-7246-2576
J-GLOBAL ID: 201101050076332642
Researcher ID: A-4702-2012
researchmap Member ID: B000001899

External link: http://dna00.bio.kyutech.ac.jp/mizuno/research.html

Research Interests

Research Areas

Research History

2002 - Present

Discovery science & Technology Department, Chugai Pharmaceutical
2009 - 2010

The Simons Center for Systems Biology, Institute for Advanced Study
2000 - 2002

Department of Genome Science, Nippon Roche
1999 - 2000

Tsukuba Life Science Center, RIKEN

Awards

Dec, 2021

優秀研究賞, ヘビからカエルへの遺伝子水平伝播：脊椎動物間水平伝播の地理的特異性と発生様式に関する新知見, 日本DNA多型学会

倉林敦, 神林千晶, 掛橋竜祐, 水野英明, 大島一彦, 田辺秀之, 細将貴, ミゲル = ベンセス

Papers

Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments

Hironori Fukuda, Kosuke Arai, Hideaki Mizuno, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa …

Cancer Science, Mar 25, 2024
Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer.

Kana Ohashi, Yukari Nishito, Hironori Fukuda, Ryoichi Sadahiro, Yukihiro Yoshida, Shun-Ichi Watanabe, Noriko Motoi, Yukiko Sonobe, Hideaki Mizuno, Hiroyuki Tsunoda …

Scientific reports, 14(1) 429-429, Jan 3, 2024
Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations.

Kazunori Aoki, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, Eri Hashimoto, Mina Takahashi …

Cancer research communications, 3(6) 1026-1040, Jun, 2023 Peer-reviewed
Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion.

Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno …

mAbs, 15(1) 2253570-2253570, 2023
Digital workflows for pathological assessment of rat estrous cycle stage using images of uterine horn and vaginal tissue

Onishi, S., Egami, R., Nakamura, Y., Nagashima, Y., Nishihara, K., Matsuo, S., Murai, A., Hayashi, S., Uesumi, Y., Kato, A. …

Journal of Pathology Informatics, 13 100120-100120, Jun, 2022 Peer-reviewedLast authorCorresponding author
Geography-Dependent Horizontal Gene Transfer from Vertebrate Predators to Their Prey.

Chiaki Kambayashi, Ryosuke Kakehashi, Yusuke Sato, Hideaki Mizuno, Hideyuki Tanabe, Andolalao Rakotoarison, Sven Künzel, Nobuaki Furuno, Kazuhiko Ohshima, Yoshinori Kumazawa …

Molecular biology and evolution, 39(4), Apr 10, 2022 Peer-reviewed
Molecular basis of immune suppressive microenvironment specified by cancer-associated fibroblasts in pancreatic cancer

Hideaki Mizuno

Cancer Science, 2022
Anti-GPRC5D/CD3 bispecific T cell-redirecting antibody for the treatment of multiple myeloma.

Kodama T, Kochi Y, Nakai W, Mizuno H, Baba T, Habu K, Sawada N, Tsunoda H, Shima T, Miyawaki K …

Molecular cancer therapeutics, 18(9) 1555-1564, Jul, 2019 Peer-reviewed
ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor

Yoshito Nakanishi, Hideaki Mizuno, Hitoshi Sase, Toshihiko Fujii, Kiyoaki Sakata, Nukinori Akiyama, Yuko Aoki, Masahiro Aoki, Nobuya Ishii

MOLECULAR CANCER THERAPEUTICS, 14(12) 2831-2839, Dec, 2015 Peer-reviewed
The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC

Y. Takahashi, P. Sheridan, A. Niida, G. Sawada, R. Uchi, H. Mizuno, J. Kurashige, K. Sugimachi, S. Sasaki, Y. Shimada …

ANNALS OF ONCOLOGY, 26(5) 935-942, May, 2015 Peer-reviewed
The PFA-AMeX method achieves a good balance between the morphology of tissues and the quality of RNA content in DNA microarray analysis with laser-capture microdissection samples

Takeshi Watanabe, Atsuhiko Kato, Hiromichi Terashima, Koichi Matsubara, Yu Jau Chen, Kenji Adachi, Hideaki Mizuno, Masami Suzuki

JOURNAL OF TOXICOLOGIC PATHOLOGY, 28(1) 41-47, Jan, 2015 Peer-reviewed
Topological analysis of gene expression arrays identifies high risk molecular subtypes in breast cancer

Javier Arsuaga, Nils A. Baas, Daniel DeWoskin, Hideaki Mizuno, Aleksandr Pankov, Catherine Park

APPLICABLE ALGEBRA IN ENGINEERING COMMUNICATION AND COMPUTING, 23(1-2) 3-15, Apr, 2012 Peer-reviewed
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

William A. Freed-Pastor, Hideaki Mizuno, Xi Zhao, Anita Langerod, Sung-Hwan Moon, Ruth Rodriguez-Barrueco, Anthony Barsotti, Agustin Chicas, Wencheng Li, Alla Polotskaia …

CELL, 148(1-2) 244-258, Jan, 2012 Peer-reviewed
Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

Hirokazu Okayama, Takashi Kohno, Yuko Ishii, Yoko Shimada, Kouya Shiraishi, Reika Iwakawa, Koh Furuta, Koji Tsuta, Tatsuhiro Shibata, Seiichiro Yamamoto …

CANCER RESEARCH, 72(1) 100-111, Jan, 2012 Peer-reviewed
Molecular classification of prostate cancer using curated expression signatures

Elke K. Markert, Hideaki Mizuno, Alexei Vazquez, Arnold J. Levine

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(52) 21276-21281, Dec, 2011 Peer-reviewed
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

Hideaki Mizuno, Benjamin T. Spike, Geoffrey M. Wahl, Arnold J. Levine

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(52) 22745-22750, Dec, 2010 Peer-reviewedLead author
Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome

Hideaki Mizuno, Gurinder Atwal, Haijian Wang, Arnold J. Levine, Alexei Vazquez

BMC GENETICS, 11 27, Apr, 2010 Peer-reviewedLead author
PrognoScan: a new database for meta-analysis of the prognostic value of genes

Hideaki Mizuno, Kunio Kitada, Kenta Nakai, Akinori Sarai

BMC MEDICAL GENOMICS, 2 18, Apr, 2009 Peer-reviewedLead author
A signature-based method for indexing cell cycle phase distribution from microarray profiles

Hideaki Mizuno, Yoshito Nakanishi, Nobuya Ishii, Akinori Sarai, Kunio Kitada

BMC GENOMICS, 10 137, Mar, 2009 Peer-reviewedLead author
Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma

Hidemi Saito, Yukiko Inagaki, Toshiaki Tsunenari, Masako Ura, Hideaki Mizuno, Kaori Fujimoto-Ouchi, Etsuro Onuma, Koh Sato, Etsuro Ogata, Hisafumi Yamada-Okabe

CANCER SCIENCE, 98(10) 1563-1569, Oct, 2007 Peer-reviewed

Misc.

Molecular Subtypes of Lung Adenocarcinoma Present Distinct Immune Tumor Microenvironments

Kosuke Arai, Kazunori Aoki, Hironori Fukuda, Noriko Motoi, Yasuhito Arai, Akiyosi Hirayama, Hideaki Mizuno, Yukari Nisito, Hiroyuki Tsunoda

Sep, 2023
Identification of two immune subtypes in pancreatic ductal adenocarcinoma with characteristic signaling pathways

Hideaki Mizuno

Cancer Science, 2023
Precise profiling of TILs defines three immune subtypes of NSCLC with distinct signaling pathways

Hideaki Mizuno

Cancer Science, 2023
Exploration of novel targets for the development of lung cancer immunotherapy based on the immune tumor microenvironment

Kazunori Aoki, Yukari Nishito, Hideaki Mizuno, Hiroyuki Tsunoda, Atsushi Ochiai

Jul, 2022
Abstract 6145: Increased PD-L1 expression levels were observed on both tumor cells and macrophages by tocilizumab plus gemcitabine/nab-paclitaxel treatment in gemcitabine/nab-paclitaxel-refractory metastatic pancreatic cancer patients

Kyoko Yamaguchi, Etsuko Fujii, Shuichi Mitsunaga, Noriaki Sawada, Masafumi Ikeda, Takashi Fujitomo, Hideaki Mizuno, Yoko Kayukawa, Mayu Makikawa, Kazunori Aoki …

Cancer Research, 82(12_Supplement) 6145-6145, Jun 15, 2022
Abstract CT565: Clinical and translational results of a phase I study, tocilizumab plus gemcitabine/nab-paclitaxel in patient with gemcitabine/nab-paclitaxel-refractory metastatic pancreatic cancer

Shuichi Mitsunaga, Masafumi Ikeda, Kazunori Aoki, Kyoko Yamaguchi, Noriaki Sawada, Etsuko Fujii, Masanobu Nishidate, Takashi Fujitomo, Hideaki Mizuno, Yoko Kayukawa …

Cancer Research, 82(12_Supplement) CT565-CT565, Jun 15, 2022
AI 画像解析プラットフォーム IBM® Visual Insights を用いたラット性周期自動分類モデルの構築

大西慎一, 江上陸, 長島慶宜, 中村祐哉, 西原香織, 松尾沙織, 村井厚子, 林修次, 山崎雅輝, 水野英明 …

第38回日本毒性病理学会講演要旨集, Jan, 2022
Neutrophil-lymphocyte ratio is a useful predictor of postoperative recurrence in squamous cell lung cancer

Hideaki Mizuno

Cancer Science, 2022
CAFs recruit a specific subset of MDSCs for constructing immune suppressive microenvironment of pancreatic cancer.

Hironori Fukuda, Kazunori Aoki, Makiko Yamashita, Aya Hirata, Shigehisa Kitano, Yasuhito Arai, Tatsuhiro Shibata, Nobuyoshi Hiraoka, Hideaki Mizuno, Yukari Nishito …

Oct, 2021
Proposal for novel immunological classification of lung cancer based on tumor-infiltrating lymphocytes of tumor microenvironment

Kazunori Aoki, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Yukari Nishito, Yukiko Sonobe, Yoko Kayukawa, Toru Maruyama, Osamu Natori, Noriaki Sawada …

Sep, 2021
Abstract 1886: Anti -GPRC5D/CD3 T cell-redirecting bispecific antibody with potent in vitro and in vivo antitumor efficacy against multiple myeloma

Tatsushi Kodama, Yu Kochi, Waka Nakai, Hideaki Mizuno, Takeshi Baba, Kiyoshi Habu, Noriaki Sawada, Hiroyuki Tsunoda, Takahiro Shima, Kohta Miyawaki …

Cancer Research, 81(13_Supplement) 1886-1886, Jul 1, 2021
Proposal for novel immunological classification of lung cancer based on the molecular basis of tumor microenvironment

Kazunori Aoki, Yukari Nishito, Hideaki Mizuno, Atsushi Ochia

Proceedings. Annual Meeting of the Japanese Cancer Association, Oct, 2020
ヘビからカエルへの遺伝子水平伝播:起源系統とその伝播メカニズム

神林千晶, 掛橋竜祐, 佐藤祐輔, 古野伸明, 水野英明, 大島一彦, 熊澤慶伯, NAGY Zoltan, 森哲, ALLISON Allen, DONNELLAN Stephen, 太田英利, 細将貴, 柳田哲矢, 佐藤宏, VENCES Miguel, 倉林敦

日本爬虫両棲類学会第57回大会プログラム, 2019(1), May, 2019
Abstract 3028: ERK signal suppression and sensitivity to CH5183284/Debio 1347, a selective FGFR inhibitor

Yoshito Nakanishi, Hideaki Mizuno, Hitoshi Sase, Toshihiko Fujii, Kiyoaki Sakata, Nukinori Akiyama, Yuko Aoki, Masahiro Aoki, Nobuya Ishii

Cancer Research, 76(14_Supplement) 3028-3028, Jul 15, 2016
Abstract 123: Mechanism of oncogenic signal activation by the novel fusion kinase FGFR3-BAIAP2L1

Yoshito Nakanishi, Nukinori Akiyama, Toshiyuki Tsukaguchi, Toshihiko Fujii, Yasuko Satoh, Hideaki Mizuno, Nobuya Ishii, Masahiro Aoki

Cancer Research, 75(15_Supplement) 123-123, Aug 1, 2015
Abstract A41: Pre-clinical investigation of predictive biomarkers for drug candidates using a molecularly profiled large cancer cell line panel.

Satoshi Aida, Hideaki Mizuno, Hiroshi Sakamoto, Yoshito Nakanishi, Hironori Mutoh, James Cai, Helmut Burtscher, Masahiro Aoki, Yuko Aoki, Nobuya Ishii

Molecular Cancer Therapeutics, 12(11_Supplement) A41-A41, Nov 1, 2013
カエル亜目におけるSINE(short interspersed nuclear element)の発見と系統的分布

倉林敦, 古野伸明, 住田正幸, 水野英明, 大島一彦, Miguel Vences

日本爬虫両棲類学会第52回大会プログラム, Nov, 2013
PFA-AMeX法における組織形態保持と核酸品質の関係： LCM / DNA microarray analysisへの応用

加藤淳彦, 渡邉剛, Chen Yu, 芦原基起, 寺島弘道, 水野英明, 加藤千恵, 三好昌夫, 林修次, 足立健児, 伊藤恒夫, 松原亨一, 鈴木雅実

第29回日本毒性病理学会講演要旨集, Jan, 2013
癌マイクロアレイデータ解析に向けたマイニング技術の開発

水野英明

九州工業大学博士学位論文, Mar, 2011
PrognoScan: a new database for meta-analysis of the prognostic value

Proceedings. Annual Meeting of the Japanese Cancer Association, Aug, 2010

Books and Other Publications

革新的AI創薬

小長谷明彦 (Role: Contributor, 中外製薬におけるAI創薬の取り組み)

エヌ・ティー・エス, Jul, 2022 (ISBN: 9784860437886)

Presentations

多層的オミックスデータベース構築による肺がん免疫システムの解明

水野英明

Dialogue Webinar, Dec 17, 2021, ダイアローグ株式会社
多層的オミックスデータベース構築による腫瘍免疫システムの解明と医薬品開発への応用

水野英明

ゲノム創薬・創発フォーラム第５回シンポジウム, Jan 13, 2021, ゲノム創薬・創発フォーラム
製薬企業研究員のキャリアパス

水野英明

第2回生命医薬情報学連合大会, Oct 30, 2013, 日本バイオインフォマティクス学会
ハプロタイプエントロピー法を用いたヒトゲノム中の人種特異的連鎖不平衡領域の高解像度検出

水野英明

IPA UGM 2012, Aug 2, 2012, トミーデジタルバイオロジー株式会社
PrognoScan: a new database for meta-analysis of the prognostic value of genes

Hideaki Mizuno

The 2010 Annual Conference of the Japanese Society for Bioinformatics, Dec 14, 2010, The Japanese Society for Bioinformatics

Professional Memberships

Works

ENIGMA

水野英明

Apr, 2010 Database
PrognoScan: a new database for meta-analysis of the prognostic value of genes

Hideaki Mizuno

Apr, 2009 Database
ORI-GENE: A Tool for Gene Classi cation Based on Evolutional Tree

Hideaki Mizuno

Feb, 2001 Software

Committee Memberships

2012 - 2015

Board Member, Japanese Society for Bioinformatics

Industrial Property Rights

WO2009078386A1 NOVEL METHOD FOR SPECIMEN PREPARATION, WHICH ENSURES PRESERVATION OF TISSUE MORPHOLOGY AND NUCLEIC ACID QUALITY.

Takeshi Watanabe, Fang Yanting, Masami Suzuki, Hiromichi Terashima, Hideaki Mizuno
WO2020189748A1 ANTIGEN-BINDING MOLECULE CONTAINING ANTIGEN-BINDING DOMAIN OF WHICH BINDING ACTIVITY TO ANTIGEN IS CHANGED DEPENDING ON MTA, AND LIBRARY FOR OBTAINING SAID ANTIGEN-BINDING DOMAIN

MIZUNO, Hideaki, SAKA, Koichiro, KAWAUCHI, Hiroki, KATO, Kuniyasu, SAITO, Ryoichi, IGAWA, Tomoyuki, OHARA, Kazuhiro, OKUDE, Junya

Profile Information

Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Works

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