Takanobu Nakazawa

Last updated: 11/12/07 16:43

Name	Takanobu Nakazawa
E-mail	takanobunakazawa-tkyumin.ac.jp

Research Keywords

miRNA(12)

Research Areas

Biological science / Molecular biology(2571) /
Neuroscience / Neuroscience in general(1513) /

Career

Plain Text

Jun 2011

Today

特任講師, 東京大学大学院医学系研究科　神経生理学分野

Dec 2007

May 2011

助教, 東京大学医科学研究所　癌細胞シグナル分野

Apr 2007

Nov 2007

特任助教, 東京大学医科学研究所

Feb 2005

Mar 2007

特任助手, 東京大学医科学研究所

Papers

Plain Text

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases.

Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Nakazawa T, Yamamoto T, Jackson MF, MacDonald JF.

The EMBO Journal in press 2012 [Refereed]

NYAP: a phosphoprotein family that links PI3K to WAVE1 signaling in neurons.

Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T.

The EMBO Journal 30 4739-4754 Dec 2011 [Refereed]

Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.

Chen C, Ito K, Takahashi A, Wang G, Suzuki T, Nakazawa T, Yamamoto T, Yokoyama K.

Biochemical and biophysical research communications 411 360-364 2011 [Refereed]

Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain.

Katano T, Nakazawa T, Nakatsuka T, Watanabe M, Yamamoto T, Ito S.

Neuropharmacology 60 609-616 2011 [Refereed]

NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala

Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T# (# Corresponding author)

Molecular Brain 3 37 Dec 2010 [Refereed]

Receptor tyrosine phosphatase sigma (RPTPsigma) regulates, p250GAP, a novel substrate that attenuates Rac signaling

Chagnon MJ, Wu CL, Nakazawa T, Yamamoto T, Noda M, Blanchetot C, Tremblay ML

Cellular Signaling 22 1626-1633 2010 [Refereed]

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.

Taniguchi S*, Nakazawa T*#, Tanimura A*, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T (* co-1st author, # Corresponding author)

The EMBO journal 28 3717-3729 Dec 2009 [Refereed]

Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning.

Isosaka T, Hattori K, Kida S, Kohno T, Nakazawa T, Yamamoto T, Yagi T, Yuasa S

The European journal of neuroscience 28 973-981 Sep 2008 [Refereed]

Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.

Goto J, Tezuka T, Nakazawa T, Sagara H, Yamamoto T

Molecular and cellular neurosciences 38 203-212 Jun 2008 [Refereed]

Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.

Nakazawa T, Kuriu T, Tezuka T, Umemori H, Okabe S, Yamamoto T

Journal of neurochemistry 105 1384-1393 May 2008 [Refereed]

Neurotensin type 2 receptor is involved in fear memory in mice.

Yamauchi R, Wada E, Kamichi S, Yamada D, Maeno H, Delawary M, Nakazawa T, Yamamoto T, Wada K

Journal of neurochemistry 102 1669-1676 Sep 2007 [Refereed]

microRNA modulation of circadian-clock period and entrainment.

Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K

Neuron 54 813-829 Jun 2007 [Refereed]

Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans.

Delawary M, Nakazawa T, Tezuka T, Sawa M, Iino Y, Takenawa T, Yamamoto T

Biochemical and biophysical research communications 357 377-382 Jun 2007 [Refereed]

Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene.

Kawa S, Ito C, Toyama Y, Maekawa M, Tezuka T, Nakamura T, Nakazawa T, Yokoyama K, Yoshida N, Toshimori K, Yamamoto T

Proceedings of the National Academy of Sciences of the United States of America 103 19344-19349 Dec 2006 [Refereed]

Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases.

Yokoyama K, Tezuka T, Hoshina N, Nakazawa T, Yamamoto T

Biochemical and biophysical research communications 349 1401-1405 Nov 2006 [Refereed]

Brain-derived neurotrophic factor rapidly increases NMDA receptor channel activity through Fyn-mediated phosphorylation.

Xu F, Plummer MR, Len GW, Nakazawa T, Yamamoto T, Black IB, Wu K

Brain research 1121 22-34 Nov 2006 [Refereed]

Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.

Liu H*, Nakazawa T*, Tezuka T, Yamamoto T (* co-1st author)

The Journal of biological chemistry 281 23611-23619 Aug 2006 [Refereed]

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.

Nakazawa T*, Komai S*, Watabe AM*, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T

The EMBO journal 25 2867-2877 Jun 2006 [Refereed]

Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.

Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S

The European journal of neuroscience 22 1445-1454 Sep 2005 [Refereed]

Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling.

Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T

Genes to cells : devoted to molecular & cellular mechanisms 9 219-232 Mar 2004 [Refereed]

Altered gene expression in the adult brain of fyn-deficient mice.

Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T

Cellular and molecular neurobiology 24 149-159 Feb 2004 [Refereed]

p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.

Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T

Molecular biology of the cell 14 2921-2934 Jul 2003 [Refereed]

p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.

Taniguchi S, Liu H, Nakazawa T, Yokoyama K, Tezuka T, Yamamoto T

Biochemical and biophysical research communications 306 151-155 Jun 2003 [Refereed]

Tyrosine dephosphorylation and ethanol inhibition of N-Methyl-D-aspartate receptor function.

Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD

The Journal of biological chemistry 278 11020-11025 Mar 2003 [Refereed]

[Regulation of NMDA receptor function by Fyn-mediated tyrosine phosphorylation]

Nakazawa T, Tezuka T, Yamamoto T

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 22 165-167 Oct 2002 [Refereed]

Differential effects of hypoxia-ischemia on subunit expression and tyrosine phosphorylation of the NMDA receptor in 7- and 21-day-old rats.

Gurd JW, Bissoon N, Beesley PW, Nakazawa T, Yamamoto T, Vannucci SJ

Journal of neurochemistry 82 848-856 Aug 2002 [Refereed]

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang DM

Journal of neurochemistry 80 589-597 Feb 2002 [Refereed]

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRepsilon2 (NR2B) subunit of the N-methyl-D-aspartate receptor.

Nakazawa T, Komai S, Tezuka T, Hsatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T

The Journal of Biological Chemistry 276 693-699 2001 [Refereed]

Cloning and characterization of EPD2, a gene required for efficient pseudohyphal formation of a dimorphic yeast, Candida maltosa.

Nakazawa T, Takahashi M, Horiuchi H, Ohta A, Takagi M

Bioscience, Biotechnology, and Biochemistry 64 369-377 2000 [Refereed]

Isolation and characterization of EPD1, an essential gene for pseudohyphal growth of a dimorphic yeast, Candida maltosa.

Nakazawa T, Horiuchi H, Ohta A, Takagi M

Journal of Bacteriology 180 2079-2086 1998 [Refereed]

Evidence that part of a centromeric DNA region induces pseudohyphal growth in a dimorphic yeast, Candida maltosa.