Hidenori NISHIHARA

Profile Information

Affiliation: Associate Professor, Faculty of Agriculture, Department of Advanced Bioscience, Kindai University

Degree: 博士（理学）(東京工業大学)

J-GLOBAL ID: 200901047302507885
researchmap Member ID: 5000040089

External link: http://kaken.nii.ac.jp/ja/r/10450727

脊椎動物の進化多様性、特に哺乳類のゲノム進化機構に関して、分子生物学と生物情報学の両面から研究しています。

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Kindai University
Apr, 2016 - Mar, 2023

School of Life Science and Technology, Tokyo Institute of Technology
Dec, 2007 - Mar, 2016

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Apr, 2007 - Dec, 2007

Mathematical and Computing Sciences, Information Science and Engineering, Tokyo Institute of Technology
Aug, 2006 - Mar, 2007

Research Organization of Information and Systems
Apr, 2006 - Jul, 2006

Research Organization of Information and Systems
- Sep, 2005

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

Awards

Sep, 2020

研究奨励賞, 哺乳類の転移因子に関するゲノム進化学的研究, 日本進化学会

西原秀典
Sep, 2017

-, Vertebrate phylogenomics and genome-scale evolutionary analysis of transposable elements

Hidenori NISHIHARA
Feb, 2010

手島精一記念研究賞研究論文賞, Retroposon analysis and recent geological data suggest near-simultaneous divergence of the three superorders of mammals

西原秀典

Papers

A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception.

Hidenori Nishihara, Yasuka Toda, Tae Kuramoto, Kota Kamohara, Azusa Goto, Kyoko Hoshino, Shinji Okada, Shigehiro Kuraku, Masataka Okabe, Yoshiro Ishimaru

Nature ecology & evolution, Dec 13, 2023 Peer-reviewedLead authorCorresponding author
Functional divergence in solute permeability between ray-finned fish-specific paralogs of aqp10.

Genki Imaizumi, Kazutaka Ushio, Hidenori Nishihara, Ingo Braasch, Erika Watanabe, Shiori Kumagai, Tadaomi Furuta, Koji Matsuzaki, Michael F Romero, Akira Kato …

Genome biology and evolution, Dec 1, 2023 Peer-reviewed
Kangaroo endogenous retrovirus (KERV) forms megasatellite DNA with a simple repetition pattern in which the provirus structure is retained.

Akihiko Koga, Hidenori Nishihara, Hideyuki Tanabe, Rieko Tanaka, Rika Kayano, Shinya Matsumoto, Taiki Endo, Kornsorn Srikulnath, Rachel J O'Neill

Virology, 586 56-66, Sep, 2023 Peer-reviewed
Na+/Cl- cotransporter 2 is not fish-specific and is widely found in amphibians, non-avian reptiles, and select mammals.

Toya Motoshima, Ayumi Nagashima, Chihiro Ota, Haruka Oka, Kohei Hosono, Ingo Braasch, Hidenori Nishihara, Akira Kato

Physiological genomics, 55(3) 113-131, Mar 1, 2023 Peer-reviewed
Splashed E-box and AP-1 motifs cooperatively drive regeneration response and shape regeneration abilities.

Teruhisa Tamaki, Takafumi Yoshida, Eri Shibata, Hidenori Nishihara, Haruki Ochi, Atsushi Kawakami

Biology open, 12(2), Feb 15, 2023 Peer-reviewed
Marsupial genome analysis suggests that satellite DNA formation from walb endogenous retrovirus is an event specific to the red-necked wallaby.

Akihiko Koga, Kenji Hashimoto, Yusuke Honda, Hidenori Nishihara

Genes to cells : devoted to molecular & cellular mechanisms, 28(2) 149-155, Feb, 2023 Peer-reviewed
T1R2-mediated sweet sensing in a lizard.

Qiaoyi Liang, Meng-Ching Ko, Nathaniel S R Ng, Borja Reh, Jessica G H Lee, Atsuko Yamashita, Hidenori Nishihara, Yasuka Toda, Maude W Baldwin

Current biology : CB, 32(23) R1302-R1303, Dec 5, 2022 Peer-reviewed
Paleogenomics reveals independent and hybrid origins of two morphologically distinct wolf lineages endemic to Japan

Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayako Kohno, Yuichiro Kudo, Ayumi Akiyoshi, Jiaqi Wu, Fuyuki Tokanai, Minoru Sakamoto, Naoki Kohno …

Current Biology, 32(11) 2494-2504, May, 2022 Peer-reviewedLast authorCorresponding author
Maelstrom functions in the production of Siwi-piRISC capable of regulating transposons in Bombyx germ cells.

Yurika Namba, Yuka W Iwasaki, Kazumichi M Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C Siomi

iScience, 25(3) 103914-103914, Mar 18, 2022 Peer-reviewed
Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2-PTEN-AKT Pathway and Placental Cell Proliferation.

Beni Lestari, Satomi Naito, Akinori Endo, Hidenori Nishihara, Akira Kato, Erika Watanabe, Kimitoshi Denda, Masayuki Komada, Toshiaki Fukushima

Molecular biology and evolution, 39(2), Feb 3, 2022 Peer-reviewed
Replacement of owl monkey centromere satellite by a newly evolved variant was a recent and rapid process

Hidenori Nishihara, Roscoe Stanyon, Hideyuki Tanabe, Akihiko Koga

Genes to Cells, 26(12) 979-986, Dec, 2021 Peer-reviewedLead author
Ancient DNA reveals multiple origins and migration waves of extinct Japanese brown bear lineages

Takahiro Segawa, Takahiro Yonezawa, Hiroshi Mori, Ayumi Akiyoshi, Morten E. Allentoft, Ayako Kohno, Fuyuki Tokanai, Eske Willerslev, Naoki Kohno, Hidenori Nishihara

Royal Society Open Science, 8(8) 210518-210518, Aug, 2021 Peer-reviewedLast authorCorresponding author
Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation.

Kyoko Ishino, Hidetoshi Hasuwa, Jun Yoshimura, Yuka W Iwasaki, Hidenori Nishihara, Naomi M Seki, Takamasa Hirano, Marie Tsuchiya, Hinako Ishizaki, Harumi Masuda …

Nucleic Acids Research, 49(5) 2700-2720, Mar 18, 2021 Peer-reviewed
Comparative genomic analyses illuminate the distinct evolution of megabats within Chiroptera

Masato Nikaido, Shinji Kondo, Zicong Zhang, Jiaqi Wu, Hidenori Nishihara, Yoshihito Niimura, Shunta Suzuki, Kazushige Touhara, Yutaka Suzuki, Hideki Noguchi …

DNA Research, 27(4), Aug 1, 2020 Peer-reviewed
The CENP-B box, a nucleotide motif involved in centromere formation, has multiple origins in New World monkeys

Ratchaphol Thongchum, Hidenori Nishihara, Kornsorn Srikulnath, Hirohisa Hirai, Akihiko Koga

Genes & Genetic Systems, 94(6) 301-306, Dec 1, 2019 Peer-reviewed
Retrotransposons spread potential cis-regulatory elements during mammary gland evolution

Hidenori Nishihara

Nucleic Acids Research, 47(22) 11551-11562, Oct 23, 2019 Peer-reviewedLead authorCorresponding author
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex

Yoko Arai, Andrzej W. Cwetsch, Eva Coppola, Sara Cipriani, Hidenori Nishihara, Hiroaki Kanki, Yoann Saillour, Betty Freret-Hodara, Annie Dutriaux, Norihiro Okada …

Cell Reports, 29(3) 645-658, Oct, 2019 Peer-reviewed
Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka, Hidenori Nishihara, Hidehiro Toh, Luis Augusto Eijy Nagai, Kosuke Hashimoto, Sung-Joon Park, Aoi Shibuya, Ana Maria Suzuki, Yujiro Tanaka, Kenta Nakai …

Developmental Cell, 51(1) 21-34, Oct, 2019 Peer-reviewed
Evolutionary origin of OwlRep, a megasatellite DNA associated with adaptation of owl monkeys to nocturnal lifestyle

Hidenori Nishihara, Roscoe Stanyon, Junko Kusumi, Hirohisa Hirai, Akihiko Koga

Genome Biology and Evolution, 10(1) 157-165, Jan 1, 2018 Peer-reviewed
Phylogenetic analysis of proteins involved in the stringent response in plant cells

Doshun Ito, Yuta Ihara, Hidenori Nishihara, Shinji Masuda

JOURNAL OF PLANT RESEARCH, 130(4) 625-634, Jul, 2017 Peer-reviewed

Misc.

SINEs as Credible Signs to Prove Common Ancestry in the Tree of Life: A Brief Review of Pioneering Case Studies in Retroposon Systematics

Masato Nikaido, Hidenori Nishihara, Norihiro Okada

Genes, 13(6) 989, May 31, 2022 Peer-reviewed
Transposable elements as genetic accelerators of evolution: contribution to genome size, gene regulatory network rewiring and morphological innovation

Hidenori Nishihara

Genes & Genetic Systems, 94(6) 269-281, Dec 1, 2019 Peer-reviewedLead authorCorresponding author
Evolution of transposable elements and evolution of eukaryote genomes mediated by transposable elements

Hidenori Nishihara

Genes & Genetic Systems, 94(6) 231-231, Dec 1, 2019 Corresponding author
哺乳類の転移因子とゲノム進化研究

西原秀典

遺伝子医学, 9(2) 143-149, Apr, 2019 InvitedLead authorLast authorCorresponding author
Persistence of massive standing genetic variation in East African cichlids illuminated by genomewide SINE insertion analyses

樋口拓人, 西原秀典, 梶谷嶺, 豊田敦, 伊藤武彦, 岡田典弘, 二階堂雅人

日本進化学会大会プログラム・講演要旨集(Web), 21st, 2019
東アフリカ産シクリッドの全ゲノムを対象にした祖先多型遺伝子座の網羅的探索

樋口拓人, 西原秀典, 梶谷嶺, 伊藤武彦, 二階堂雅人

日本進化学会大会プログラム・講演要旨集(Web), 20th, 2018
Mechanism of genome diversification by amplification of SINEs with the CTCF binding site

Takahiro Tsukui, Ken Kurokawa, Hidenori Nishihara, Mika Hirakawa, Norihiro Okada

GENES & GENETIC SYSTEMS, 90(6) 407-407, Dec, 2015
トランスポゾンがもたらす進化 SINEに由来するエンハンサーが寄与した哺乳類の進化

西原秀典, 岡田典弘

生物科学, 67(1) 2-9, Dec 1, 2015
シーラカンスゲノム中の反復配列の特徴

西原秀典, 岡田典弘

生物の科学遺伝, 68(3) 267-273, May, 2014
生物の系統と新しい分類体系[第8回]哺乳類―レトロポゾン法によって明らかになった哺乳類の進化

岡田典弘, 西原秀典

生物の科学遺伝, 67(2) 119-126, Mar 1, 2013
地球生命興亡史―顕生代における放散と絶滅【Part2:中生代の始まり―約2億5,200万年前】大陸移動と哺乳類の進化

西原秀典, 丸山茂徳, 岡田典弘

生物の科学遺伝, 66(5) 531-537, Sep 1, 2012
SINE由来配列は間脳のFgf8エンハンサーの活性を視床下部に限定する

中西晶子, 小林直樹, 鈴木(平野)明日香, 西原秀典, 佐々木剛, 佐々木剛, 平川美夏, 平川美夏, 隅山健太, 下郡智美 …

日本進化学会大会プログラム・講演要旨集(Web), 14th, 2012
脳梁進化に関与したSINE由来エンハンサー

西原秀典, TEISSIER Anne, 小林直樹, 田代賢祐, 中西晶子, 佐々木剛, 伊澤和輝, YAN Kuo, TARABYKIN Victor, 隅山健太 …

日本進化学会大会プログラム・講演要旨集(Web), 14th, 2012
Characterization of the Fgf8 cis-regulatory elements derived from a SINE and possibility of participation in the mammal-specific brain formation

中西晶子, 佐々木剛, 小林直樹, 西原秀典, 隅山健太, 斉藤成也, 岡田典弘

日本分子生物学会年会講演要旨集, 32nd(Vol.4), 2009

Professional Memberships

Research Projects

Mechanism of lineage-specific gene regulation by retrotransposons

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
グアニン四重鎖によるレトロトランスポゾン転移制御メカニズムの解明

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

塩田倫史, 西原秀典
絶滅動物の進化ダイナミクス研究の革新的展開に向けた堆積物古代DNA解析法の確立

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

瀬川高弘, 甲能直樹, 西原秀典
The way of life in the Pleistocene extinct mammals elucidated by ancient DNA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2023
脊椎動物における味覚受容体TAS1Rの新規レパートリーの機能解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2022

西原秀典
Exploration of gene regulatory systems rewired by mammalian transposable elements.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2022

Nishihara Hidenori
冥王代類似環境微生物

科学研究費補助金(新学術領域研究(研究領域提案型)), 文部科学省, 2014 - 2018

鎌形洋一
大進化の分子機構の解明

科学研究費補助金(基盤研究(B)), 文部科学省, 2014 - 2017

岡田典弘
レトロポゾンが関与する脳梁形成メカニズムの解明

科学研究費補助金(若手研究(B)), 文部科学省, 2014 - 2017

西原秀典
新種の出現:種分化と大進化の分子機構

科学研究費補助金(基盤研究(S)), 文部科学省, 2009 - 2013

岡田典弘
大脳新皮質形成に関わる発現制御機構

科学研究費補助金(新学術領域研究(研究領域提案型)), 文部科学省, 2011 - 2012

西原秀典
Phylogenetic origin of Passeriformes, Falconiformes and Gruiformes based on retroposon insertions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

NISHIHARA Hidenori
生物多様性獲得の分子機構

科学研究費補助金(基盤研究(A)), 基盤研究(A), 文部科学省, 2009 - 2009

岡田典弘
Inferring Molecular Phylogenies in the Post-genomic Era

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

ADACHI Jun, CAO Ying, HASEGAWA Masami, NISHIHARA Hidenori, MATSUI Atsushi, YONEZAWA Takahiro
全ゲノムデータを基盤とする大規模な遺伝子情報を指標とした霊長類の系統的起源の解明

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2007 - 2007

西原秀典
レトロポゾンの挿入を指標とした霊長類の系統的起源の解明

科学研究費補助金(若手研究(B)), 若手研究(B), 文部科学省, 2007 - 2007

西原秀典
散在性反復配列SINEの挿入を指標としたAfrotheria内部の系統解析

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2003 - 2004

西原秀典

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