Shin'ichi TAKEDA

Profile Information

Affiliation: National Center of Neurology and Psychiatry
: Visiting Professor, Tokushima University
: Invited lecturer, Toho University School of Medicine
: Invited lecturer, Tohoku University School of Medicine

Degree: M.D., Ph.D.(Guraduate School Shinshu University)

J-GLOBAL ID: 200901030897807569
researchmap Member ID: 0000041707

Research Interests

Research Areas

Life sciences / Neurology /

Research History

Apr, 2020 - Present

名誉所長・顧問, 国立精神・神経医療研究センター神経研究所
Apr, 2018 - Present

理事, 国立精神・神経医療研究センター
Apr, 2015 - Mar, 2018

Director-General, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Oct, 2000 - Mar, 2018

Director, Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Oct, 2008 - Mar, 2015

Director, Translational Medical Center, National Center of Neurology and Psychiatry
Apr, 2000 - Sep, 2000

Section Chief, Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Oct, 1995 - Mar, 2000

Section chief, Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Sep, 1992 - Sep, 1995

Section chief, Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Aug, 1987 - Aug, 1992

Postdoctoral Researcher, Département de Biologie Moléculaire, Unité de Biochimie, Institut Pasteur, Paris, France
1984 - 1987

Research associate, Department of 3rd Internal Medicine, Shinshu University School of Medicine

Education

- 1981

Graduate School, Shinshu University
- 1977

Faculty of Medicine, Akita University School of Medicine

Committee Memberships

- Present

評議員, 日本神経学会
- Present

理事長, 日本筋学会
- Present

理事, 日仏医学会
- Present

Associate editor, Am J Pathol
- Present

Associate editor, J Neuromuscular Diseases
- Present

Muscle subcommittee member, 米国遺伝子細胞治療学会
- Present

評議員, 日本遺伝子治療学会
- Present

評議員, 日本炎症再生医学会
- Present

Member of muscle subcommittee, American Society of Gene and Cell Therapy
- Present

Councillor, Japanese Society of Gene Therapy
- Present

Councillor, Japanese Society of Inflammation and Regeneration
Treasurer, Asian Oceanian Myology Center

Awards

Papers

385

The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function

Michihiro Imamura, Hirokazu Matsumoto, Hideyuki Mannen, Shin’ichi Takeda, Yoshitsugu Aoki

In Vitro Cellular & Developmental Biology - Animal, Apr 1, 2024
Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle

Tsukasa Tominari, Masaru Takatoya, Toshiya Matsubara, Michio Matsunobe, Daichi Arai, Chiho Matsumoto, Michiko Hirata, Shosei Yoshinouchi, Chisato Miyaura, Yoshifumi Itoh …

International Journal of Molecular Sciences, 25(1) 303-303, Dec 25, 2023 Peer-reviewedInvitedCorresponding author
Memories of Professor François Gros

Shin’ichi Takeda

Comptes Rendus. Biologies, 346(S2) 1-5, Dec 19, 2023 Peer-reviewedInvited
【デュシェンヌ型筋ジストロフィー(DMD)診療の最前線】疫学研究世界のDMDの疫学研究

野上健一郎, 中村治雅, 武田伸一

Progress in Medicine, 43(11) 1005-1010, Nov, 2023
Antioxidants restore store-operated Ca2+ entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein.

Fusako Sakai-Takemura, Fumiaki Saito, Ken'ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Kiichiro Matsumura, Shin'ichi Takeda, Yoshitsugu Aoki, Yuko Miyagoe-Suzuki

FASEB bioAdvances, 5(11) 453-469, Nov, 2023
Antioxidants restore store-operated Ca²⁺ entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein

Fusako Sakai-Takemura, Fumiaki Saito, Ken'ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Kiichiro Matsumura, Shin'ichi Takeda, Yoshitsugu Aoki, Yuko Miyagoe-Suzuki

FASEB BioAdvances, 5(11) 453-469, Nov, 2023
Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide.

Watanabe N, Tone Y, Nagata T, Masuda S, Saito T, Motohashi N, Takagaki K, Aoki Y, Takeda S

Molecular therapy. Nucleic acids, 34 102034-102034, Sep, 2023
Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, an antisense oligonucleotide with a novel connected-sequence design

Naoki Watanabe, Yuichiro Tone, Tetsuya Nagata, Satoru Masuda, Takashi Saito, Norio Motohashi, Kazuchika Takagaki, Yoshitsugu Aoki, Shin’ichi Takeda

Feb 23, 2023
Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy.

Yasumasa Hashimoto, Hiroshi Kuniishi, Kazuhisa Sakai, Yuta Fukushima, Xuan Du, Kunihiko Yamashiro, Kei Hori, Michihiro Imamura, Mikio Hoshino, Mitsuhiko Yamada …

Progress in neurobiology, 216 102288-102288, May 30, 2022
Duchenne muscular dystrophy diagnosis using fibroblast‐derived myotube cells

Yuki Okada, Michinori Funato, Shin'ichi Takeda, Hideo Kaneko

Pediatrics International, 64(1), Jan, 2022 Peer-reviewedCorresponding author
Mesenchymal stem cells derived from human induced pluripotent stem cells improve the engraftment of myogenic cells by secreting urokinase-type plasminogen activator receptor (uPAR)

Ahmed Elhussieny, Ken’ichiro Nogami, Fusako Sakai-Takemura, Yusuke Maruyama, Natsumi Takemura, Wael Talaat Soliman, Shin’ichi Takeda, Yuko Miyagoe-Suzuki

Stem Cell Research & Therapy, 12(1), Dec, 2021 Peer-reviewedCorresponding author
Muscle pathophysiology in mouse models of musculocontractural Ehlers-Danlos syndrome due to CHST14 mutations (mcEDS-CHST14), generated through CRISPR/Cas9-mediated genomic editing

Yuko Nitahara-Kasahara, Shuji Mizumoto, Yukiko U. Inoue, Shota Saka, Guillermo Posadas-Herrera, Aki Nakamura-Takahashi, Yuki Takahashi, Ayana Hashimoto, Kohei Konishi, Shinji Miyata …

Disease Models & Mechanisms, 14(12), Dec 1, 2021 Peer-reviewedCorresponding author
Exon-Skipping in Duchenne Muscular Dystrophy

Shin’ichi Takeda, Paula R. Clemens, Eric P. Hoffman

Journal of Neuromuscular Diseases, 8(s2) S343-S358, Nov 30, 2021
LC-MSによるヒト骨格筋ジストロフィンの高精度タンパク質定量法の開発

富成司, 松延道生, 高戸谷賢, 平田美智子, 武田伸一, 青木吉嗣, 稲田全規

日本筋学会学術集会プログラム・抄録集, 7回 95-95, Nov, 2021
国内初のデュシェンヌ型筋ジストロフィーに対する核酸医薬品の開発

永田哲也, 渡辺直樹, 武田伸一

日本核酸医薬学会誌, 25(1) 5-15, Jun, 2021
Development of outcome measures according to dystrophic phenotypes in X-linked muscular dystrophy in Japan

Mutsuki Kuraoka, Yoshitsugu Aoki, Shin'ichi Takeda

Exp Anim, 70(4) 419-430, Jun, 2021 Peer-reviewedLast author
Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice

Ken'ichiro Nogami, Yusuke Maruyama, Fusako Sakai-Takemura, Norio Motohashi, Ahmed Elhussieny, Michihiro Imamura, Satoshi Miyashita, Megumu Ogawa, Satoru Noguchi, Yuki Tamura …

Human Molecular Genetics, 30(11) 1006-1019, May 31, 2021
Periostin Is Required for the Maintenance of Muscle Fibers during Muscle Regeneration

Naoki Ito, Yuko Miyagoe-Suzuki, Shin’ichi Takeda, Akira Kudo

International Journal of Molecular Sciences, 22(7) 3627-3627, Mar 31, 2021
Improved transduction of canine X-linked muscular dystrophy with rAAV9-microdystrophin via multipotent MSC pretreatment.

Hiromi Hayashita-Kinoh, Posadas-Herrera Guillermo, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Hironori Okada, Tomoko Chiyo, Shin'ichi Takeda, Takashi Okada

Molecular therapy. Methods & clinical development, 20 133-141, Mar 12, 2021
Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides

Yuichiro Tone, Kamel Mamchaoui, Maria K. Tsoumpra, Yasumasa Hashimoto, Reiko Terada, Rika Maruyama, Michael J. Gait, Andrey A. Arzumanov, Graham McClorey, Michihiro Imamura …

Nucleic Acid Therapeutics, Feb 9, 2021

Misc.

387

Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment

Hiromi Hayashita-Kinoh, Posadas Herrera-Guillermo, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 30(4) 494-494, Apr, 2022
Anti-Inflammatory Properties of IL-10-Expressing Multipotent Mesenchymal Stromal Cells for Duchenne Muscular Dystrophy

Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 30(4) 490-490, Apr, 2022
Improved Transduction of DMD Dog with rAAV-Microdystrophin via Multipotent Mesenchymal Cell Pretreatment

Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 29(4) 287-288, Apr, 2021
LC-MSによるヒト骨格筋ジストロフィンの高精度タンパク質定量法の開発

富成司, 松延道生, 松延道生, 高戸谷賢, 平田美智子, 武田伸一, 青木吉嗣, 稲田全規

日本筋学会学術集会プログラム・抄録集, 7th, 2021
Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment

Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Kazuhiro Takao, Tsutomu Igarashi, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 28(4) 327-327, Apr, 2020
デュシェンヌ型筋ジストロフィー(DMD)治療の新たな展開-ビルトラルセンへの期待-5.新規DMD治療薬ビルトラルセンの特徴 1)エクソン・スキップ治療とは何か

永田哲也, 武田伸一

Progress in Medicine, 40(10), 2020
Muscular dystrophy

青木吉嗣, 武田伸一

生体の科学, 71(5), 2020
筋小胞体カルシウムポンプSERCAの活性化による,Duchenne型筋ジストロフィーモデルマウスの病態改善

野上健一郎, 丸山友輔, 竹村英子, 本橋紀夫, ELHUSSIENY Ahmed, 今村道博, 宮下聡, 小川恵, 野口悟, 三宅克也 …

日本筋学会学術集会プログラム・抄録集, 6th, 2020
プロスタグランジンE2による筋管形成の促進作用

富成司, 篠崎靖子, 平田美智子, 青木吉嗣, 武田伸一, 宮浦千里, 稲田全規

日本筋学会学術集会プログラム・抄録集, 6th, 2020
スパイクインアプローチによるジストロフィンタンパク質の定量方法

高戸谷賢, 富成司, 松延道生, 松延道生, 平田美智子, 宮浦千里, 武田伸一, 青木吉嗣, 稲田全規

日本筋学会学術集会プログラム・抄録集, 6th, 2020
STIM1細胞質ドメインに変異を持つTAM患者由来のiPS細胞の樹立と筋分化誘導及びカルシウム動態解析

竹村英子, 斉藤史明, 野上健一郎, 野上健一郎, 丸山友輔, 丸山友輔, 武田伸一, 鈴木友子, 青木吉嗣

日本筋学会学術集会プログラム・抄録集, 6th, 2020
CXMDJにおいて二重PPMOの併用処理はmulti-exon skippingとジストロフィン発現を推進する(Dual PPMO combinations drive multi-exon skipping and dystrophin expression in CXMDJ)

Tsoumpra Maria K., Roux Loiec, McClorey Graham, Kuraoka Mutsuki, Arima Sayuri, Mizobe Yoshitaka, Hara Yuko, Arzumanov Andrey A., Gait Michael J., Kimura Koichi …

日本筋学会学術集会プログラム・抄録集, 5回 74-74, Aug, 2019
筋ジストロフィー犬の血清で増加するmiR-188の筋分化に関する機能的解析

有馬さゆり, 柴崎浩之, 今村道博, 谷端淳, 倉岡睦季, 松坂恭成, 内海文彰, 田沼靖一, 武田伸一

日本筋学会学術集会プログラム・抄録集, 5回 129-129, Aug, 2019
ジストロフィーの犬における運動機能の加速度計による評価結果(Accelerometric outcomes of motor function in dystrophic dogs)

Kuraoka Mutsuki, Kasahara Yuko, Tachimori Hisateru, Kato Naohiro, Shibasaki Hiroyuki, Shin Akihiko, Aoki Yoshitsugu, Kimura En, Takeda Shin'ichi

Experimental Animals, 68(Suppl.) S167-S167, Jul, 2019
筋肉の発生と再生，そして臨床応用へ

野上健一郎, 鈴木友子, 武田伸一

THE BONE 特集, 33(1) 87-92, May, 2019 Invited
骨格筋の質的可塑性を調節する分子メカニズム

谷端淳, 武田伸一

実験医学増刊, 37(7) 96-102, May, 2019 Invited
骨格筋量制御におけるKLF15の機能の解析

平田悠, 野村和弘, 千賀陽子, 岡田裕子, 小林憲太, 岡本士毅, 箕越靖彦, 今村道博, 武田伸一, 小田崇弘 …

糖尿病, 62(Suppl.1) S-149, Apr, 2019
Systemic Treatment with Dental Pulp-Derived Stem Cells for Muscle Dysfunction in Dystrophic Muscle

Yuko Nitahara Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Yuki Oda, Aki Nakamura Takahashi, Chiaki Masuda, Posadas Herrera Guillermo, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 27(4) 381-381, Apr, 2019
イヌ筋ジストロフィーモデルの歩様における加速度アウトカムの検討

倉岡睦季, 倉岡睦季, 笠原優子, 笠原優子, 立森久照, 加藤直広, 柴崎浩之, 柴崎浩之, シン明彦, 青木吉嗣 …

日本実験動物学会総会講演要旨集(Web), 66th, 2019
筋ジストロフィーを対象とした核酸医薬開発におけるヒト化マウスの必要性

越後谷裕介, R.Q. Lim Kenji, NHU Triu, 谷端淳, 青木吉嗣, 武田伸一, 横田俊文

日本獣医学会学術集会講演要旨集, 162nd, 2019

Books and Other Publications

理科年表2020、第93冊、生物部

武田伸一 (Role: Joint author, 健康寿命と老化)

丸善出版㈱, Nov, 2019
実験医学（増刊）超高齢社会に挑む骨格筋のメディカルサイエンス

武田伸一 (Role: Supervisor (editorial))

㈱羊土社, Apr, 2018
Muscle Cell and Tissue

Nogami K, Blanc M, Takemura F, Takeda S, Miyagoe-Suzuki Y (Role: Joint author, Making skeletal muscle from human pluripotent stem cells.)

IntechOpen, London, 2018
Methods in molecular biology

Miyatake S, Mizobe Y, Takizawa H, Hara Y, Yokota T, Takeda S, Aoki Y (Role: Joint author, Exon Skipping Therapy Using Phosphorodiamidate Morpholino Oligomers in the mdx52 Mouse Model of Duchenne Muscular Dystrophy)

2017
先端治療技術の実用化と開発戦略

滝澤歩武, 青木吉嗣, 武田伸一 (Role: Joint author, アンチセンス核酸医薬の特徴と研究動向と安全性評価)

株式会社技術情報協会, 2017 (ISBN: 9784861046506)
アクチュアル脳・神経疾患の臨床

溝部吉高, 青木吉嗣, 武田伸一 (Role: Joint author, デュシェンヌ型筋ジストロフィーのエクソン・スキップ治療．神経疾患治療ストラテジー既存の治療・新規治療・今後の治療と考え方)

株式会社中山書店, 2017
筋疾患の遺伝子・再生治療神経・筋疾患の最新医療

先端医療技術研究所 pp241-246, 2001
筋肉細胞

遺伝子治療開発ハンドブック pp474-479, 1999
遺伝子治療筋ジストロフィーはここまでわかったPart2

筋ジストロフィー研究連絡協議会 pp205-216, 1999
治療〔ミオパチー総論〕≪最新内科学体系≫第71巻ミオパチー

中山書店東京 pp105-113, 1996
Duchenne型筋ジストロフィーの遺伝子治療臨床遺伝学 VI遺伝子治療と予防

診断と治療社東京 pp286-303, 1995
ジストロフィー鶏筋の構造蛋白、筋ジストロフィー、江橋節郎編

野々村, 武田

東京大学出版会pp117-126, 1982
Nonomura Y, Takeda S: Structural proteins of dystrophic chicken muscles Muscular dystrophy, ed by Ebashi S

University Tokyo Press, Tokyo, pp117-126, 1982

Presentations

クリニカル・イノベーション・ネットワークのあゆみ

武田伸一

第１回国際レジストリフォーラム, Dec 12, 2019 Invited
Antisense treatment to correct dystrophin-deficiency in the brain.

Shin'ichi TAKEDA

European Nuero Muscular Centre (ENMC),, Nov 30, 2019 Invited
エクソン・スキップ治療薬（NS-065/NCNP-01）の開発

武田伸一

2019年日本製薬工業協会医薬品評価委員会総会シンポジウム「医薬品の新規モダリティ」, Nov 25, 2019 Invited
遺伝性疾患における遺伝子治療の現状と今後の展望

武田伸一

第61回歯科基礎医学会学術大会、メインシンポジウム3「骨と筋の遺伝性疾患の遺伝子治療：現状と今後の展望」, Oct 14, 2019 Invited
宇宙空間と筋萎縮

武田伸一

徳島大学大学院2019年度「宇宙と栄養・医学概論」特別講義, Sep 11, 2019 Invited
筋ジストロフィーに対する治療法の進歩

武田伸一

一般社団法人埼玉県筋ジストロフィー協会特別講演, Aug 31, 2019 Invited
遺伝性疾患における遺伝子治療の現状と今後の展望

武田伸一

第450回東京歯科大学大学院セミナー, Aug 19, 2019 Invited
核酸医薬による筋ジストロフィー治療の現状と課題

武田伸一

第35回日本DDS学会学術集会、シンポジウム3「核酸医薬とDDS」, Jul 4, 2019 Invited
筋ジストロフィーに対する遺伝子治療

武田伸一

信州大学医学部第三内科同窓会特別講演, Jun 15, 2019 Invited
クリニカルイノベーションネットワークの目指すところ

武田伸一

医療ビッグデータ・コンソーシアム第3回ライフサイエンス部会会議, May 19, 2019 Invited
筋ジストロフィーに対する遺伝子治療

武田伸一

第30回日本医学会総会2019中部、セッション1-2-4, Apr 28, 2019 Invited
筋ジストロフィーに対するエクソン・スキップを含む遺伝子治療の進歩

武田伸一

第83回日本循環器学会、モーニングレクチャー「遺伝子治療の新展開」, Mar 31, 2019 Invited
Therapeutic approaches to muscle diseases.

Shin'ichi TAKEDA

Gill’s day at the Myology Institute,, Mar 29, 2019 Invited
筋ジストロフィーに対する再生医療のUPDATES

武田伸一

第18回日本再生医療学会総会、シンポジウム「整形外科領域の再生医療の現状と展開」, Mar 22, 2019 Invited
デュシェンヌ型筋ジストロフィーに対するエクソン53スキップ治療薬による早期探索的臨床試験

武田伸一

2018年度AMED公開シンポジウム、「オールジャパンでの医薬品創出プロジェクト～革新的な新薬抄出への挑戦」, Mar 4, 2019 Invited
クリニカルイノベーションネットワーク難病プラットフォームへの期待

武田伸一

第1回AMED難病プラットフォーム公開シンポジウム, Mar 2, 2019 Invited
核酸医薬を用いた筋ジストロフィーの治療

武田伸一

第36回日本神経治療学会学術集会、シンポジウム「難治性神経筋疾患で始まった核酸医薬による原因治療」, Nov 24, 2018 Invited
Current advances for DMD gene therapy.

Shin'ichi TAKEDA

Neurology Times Annual meeting,, Nov 18, 2018 Invited
筋ジストロフィーに治療の最新の進歩

武田伸一

第5回筋ジストロフィー医療研究会、シンポジウム「基礎と臨床をつなぐ」, Oct 26, 2018 Invited
遺伝性疾患における遺伝子治療の現状と今後の展望

武田伸一

第61回歯科基礎医学会学術大会、メインシンポジウム3「骨と筋の遺伝性疾患の遺伝子治療：現状と今後の展望」, Oct 14, 2018 Invited

Professional Memberships

Research Projects

Development of DMD exon 3-9 skipping therapy using iPSc

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Nakamura Akinori
Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Tanihata Jun
application of induced mesenchymal stem cells from human iPS cells to cell therapy in muscular dystrophy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Suzuki Yuko, Takemura Fusako
Exon 45 skipping theraphy using iPS cells deleted exons 46-55 in the DMD gene

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Akinori Nakamura
Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Sawada Yasuhiro, TAKEDA Shin'ichi
Development of rAAV-mediated brain transduction with transient ultrasound-mediated modulation of the blood-brain interface in adult common marmoset toward modeling epilepsy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Okada Hironori, OKADA Takashi, TAKEDA Shinichi, KINOH Hiromi, KASAHARA Yuko
Establishment of chemical RNA editing method for genetic code resoration therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Tsukahara Toshifumi, Takada Shin'ichi
Development of Antisense Mediated Therapy for Exons Duplication in Duchenne Muscular Dystrophy.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

SAITO Takashi, NAGATA Tetsuya, TAKEDA Shin'ichi, AOKI Yoshitsugu, TANIHATA Jun, NAKAMURA Akinori, MASUDA Satoru, MOTOHASHI Yuko, YOKOTA Toshifumi
Elucidation of the mechanisms of skeletal muscle hypertrophy by intracellular calcium concentration.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

TAKEDA SHIN'ICHI, SUZUKI YUUKO, AOKI YOSHITSUGU
Induction of transplantable myogenic cells from pluripotent stem cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SUZUKI Yuko, TAKEDA Shin'ichi
Molecular characterization of a HECT-type E3 ubiquitin ligase that is encoded in the WWP1 gene responsible for chicken muscular dystrophy.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

IMAMURA Michihiro, TAKEDA Shin'ichi
Molecular signaling in neuromuscular synaptogenesis and myasthenia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

YAMANASHI Yuji, TEZUKA Tohru, NUREKI Osamu, NATSUME Tohru, TAKEDA Shin'ICHI, MOTOMURA Masakatsu
Study on Mechano-Sensing Channel in muscular dystrophic dog

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

NAGATA Tetsuya, TAKEDA Shin'ichi, IWATA Yuko
Molecular pathogenesis of neonatal fulminant dystrophic dog and fetal therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2012

NAKAMURA Akinori, TAKEDA Shin'ichi
The elucidation of the molecular mechanisms of NO-mediated muscle atrophy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

TAKEDA Shin ichi, SUZUKI Yuuko, IMAMURA Michihiro
Study on molecular regulation of muscle regeneration by mesenchymal cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

SUZUKI Yuko, TAKEDA Shin'ichi
Molecular mechanism of selective degeneration of Purkinje fibers in dystrophic dog

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

NAKAMURA Akinori, TAKEDA Shin'ichi
Analysis of the roles of POMGnT1 in development and maintenance of certral nervous system and skeletal muscle

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

SUZUKI Yuko, TAKEDA Shinichi, ENDO Tamao
Analysis of roles for osteopontin in muscle regeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

SUZUKI Yuko, TAKEDA Shinichi
THE RELEVANCE OF THE SELECTIVE DAMAGE OF PURKINJE FIBER AND THE ABNORMAL ELECTROCARDIOGRAM IN CANINE X-LINKED MUSCLAR DYSTROPHY

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

SHIMATSU Yoshiki, KUWAHARA Masayoshi, WAKAO Yoshito, TAKEDA Shin'ichi

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短縮型ジストロフィン特許出願日：平成10年5月8日特許出願公開番号：特開平11-318467号特許出願公開日：平成11年11月24日

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