西原眞杉 (Masugi Nishihara) - マイポータル

基本情報

所属: 東京大学大学院農学生命科学研究科獣医学専攻教授

学位: 農学博士

通称等の別名: 西原真杉
J-GLOBAL ID: 200901012591715760
researchmap会員ID: 1000013132

外部リンク: http://www.vm.a.u-tokyo.ac.jp/seiri/

研究キーワード

研究分野

経歴

学歴

1977年4月 - 1981年3月

東京大学, 大学院農学系研究科, 畜産学専攻
- 1979年

東京大学
1973年4月 - 1977年3月

東京大学, 農学部, 畜産獣医学科
- 1977年

東京大学

論文

Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice

Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara

EXPERIMENTAL GERONTOLOGY 95 1-8 2017年9月査読有り
Molecular species of prostaglandins involved in modulating luteinising hormone pulses of female rats under infectious stress conditions

T. Matsuwaki, M. Komatsuda, A. Fujisawa, M. Doke, K. Yamanouchi, M. Nishihara

JOURNAL OF NEUROENDOCRINOLOGY 29(7) 7 2017年7月査読有り
Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress

Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara

MOLECULAR NEUROBIOLOGY 54(5) 3717-3728 2017年7月査読有り
Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells

Ken-ichi Kawashima, Yuri Ishiuchi, Miki Konnai, Saori Komatsu, Hitoshi Sato, Hideo Kawaguchi, Nobumitsu Miyanishi, Jerome Lamartine, Masugi Nishihara, Taku Nedachi

FEBS OPEN BIO 7(2) 149-159 2017年2月査読有り
Human Crmp4 mutation and disrupted Crmp4 expression in mice associated with ASD characteristics and sexual dimorphism

Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly BJ, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R

Sci Rep 7 16812 2017年査読有り
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes

Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M

Hum Mol Genet 26(969)-988 2017年査読有り
Glucocorticoids suppress the protective effect of cyclooxygenase-2-related signaling on hippocampal neurogenesis under acute stress conditions

Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M

Mol Neurobiol 54 1953-1966 2017年査読有り
Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues

Shiho Takeuchi, Shin-Ichi Nakano, Katsuyuki Nakamura, Atsufumi Ozoe, Peggie Chien, Hidehito Yoshihara, Fumihiko Hakuno, Takashi Matsuwaki, Yasushi Saeki, Shin-Ichiro Takahashi …

EXPERIMENTAL CELL RESEARCH 347(2) 367-377 2016年10月査読有り
Influenza D Virus Infection in Herd of Cattle, Japan

Shin Murakami, Maiko Endoh, Tomoya Kobayashi, Akiko Takenaka-Uema, James K. Chambers, Kazuyuki Uchida, Masugi Nishihara, Benjamin Hause, Taisuke Horimoto

EMERGING INFECTIOUS DISEASES 22(8) 1517-1519 2016年8月査読有り
Lack of estrogen receptor α in astrocytes of progranulin-deficient mice

J Reprod Dev 62 547-551 2016年査読有り
Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb

Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R

J Anat 288 99-108 2016年査読有り
Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells

Nakano S, Nakamura K, Teramoto N, Yamanouchi K, Nishihara M

Ani Sci J 87(1) 108 2016年査読有り
Possible involvement of the cerebellum in motor-function impairment in progranulin-deficient mice

Takashi Matsuwaki, Akira Kobayashi, Kanade Mase, Katsuyuki Nakamura, Shin-Ichi Nakano, Takahiro Miyoshi, Keitaro Yamanouchi, Masugi Nishihara

NEUROREPORT 26(14) 877-881 2015年9月査読有り
Mouse pups lacking collapsin response mediator protein 4 (CRMP4) manifest impaired olfactory ability and hyperactivity in the olfactory bulb

Europ J Neurosci 42 2335-2345 2015年査読有り
Multiple therapeutic effects of progranulin on experimental acute ischemic stroke

Brain 138 1932-1948 2015年査読有り
Progranulin reduction accelerates tau phosphorylation in P301L tau transgenic mice

J Neuropahol Exp Neurol 74 158-165 2015年査読有り
Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells

Kazunori Sato, Yuki Yamanaka, Masaya Ishii, Kazusa Ishibashi, Yurina Ogura, Ritsuko Ohtani-Kaneko, Masugi Nishihara, Taku Nedachi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 78(9) 1495-1503 2014年9月査読有り
Free Access to Running Wheels Abolishes Hyperphagia in Human Growth Hormone Transgenic Rats

Mugiko Komatsuda, Keitaro Yamanouchi, Takashi Matsuwaki, Masugi Nishihara

JOURNAL OF VETERINARY MEDICAL SCIENCE 76(7) 993-999 2014年7月査読有り
Generation of muscular dystrophy model rats with a CRISPR/Cas system

Katsuyuki Nakamura, Wataru Fujii, Masaya Tsuboi, Jun Tanihata, Naomi Teramoto, Shiho Takeuchi, Kunihiko Naito, Keitaro Yamanouchi, Masugi Nishihara

SCIENTIFIC REPORTS 4 5635 2014年7月査読有り
Myotube formation is affected by adipogenic lineage cells in a cell-to-cell contact-independent manner

Yuki Takegahara, Keitaro Yamanouchi, Katsuyuki Nakamura, Shin-ichi Nakano, Masugi Nishihara

EXPERIMENTAL CELL RESEARCH 324(1) 105-114 2014年5月査読有り

もっとみる

MISC

The effect of glucocorticoids on bradykinesia induced by immobilization stress

Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara

HORMONES AND BEHAVIOR 54(1) 41-46 2008年6月
In vivo gene transfer of PPARg is insufficient to induce adipogenesis in skeletal muscle

Ayako BAN, Keitaro YAMANOUCHI, Takashi MATSUWAKI, Masugi NISHIHARA

J Vet Med Sci 70(8) 761-767 2008年
Involvement of 20a-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice

Jae-hyek CHOI, Maho ISHIDA, Takashi MATSUWAKI, Keitaro YAMANOUCHI, Masugi NISHIHARA

J Reprod Dev 54(6) 408-412 2008年
Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene

Yuko Kayasuga, Shuichi Chiba, Masatoshi Suzuki, Takefumi Kikusui, Takashi Matsuwaki, Keitaro Yamanouchi, Hayato Kotaki, Reiko Horai, Yoichiro Iwakura, Masugi Nishihara

BEHAVIOURAL BRAIN RESEARCH 185(2) 110-118 2007年12月
The effects of GABA on embryonic gonadotropin-releasing hormone neurons in rat hypothalamic primary culture

Hitomi FUJIOKA, Keitaro YAMANOUCHI, Tatsuo AKEMA, Masugi NISHIHARA

J Reprod Dev 53(2) 323-331 2007年
Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus

J Reprod Dev 53(2) 297-307 2007年
The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats

Yoshitake Cho, Miyako Ariga, Yasunobu Uchijima, Kumi Kimura, Jeung-Yon Rho, Yasufumi Furuhata, Fumihiko Hakuno, Keitaro Yamanouchi, Masugi Nishihara, Shin-Ichiro Takahashi

ENDOCRINOLOGY 147(11) 5374-5384 2006年11月
Maintenance of gonadotropin secretion by glucocorticoids under stress conditions through the inhibition of prostaglandin synthesis in the brain

T Matsuwaki, Y Kayasuga, K Yamanouchi, M Nishihara

ENDOCRINOLOGY 147(3) 1087-1093 2006年3月
Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats

Hwi-Cheul LEE, Keitaro YAMANOUCHI, Masugi NISHIHARA

J Reprod Dev 52(3) 343-352 2006年
Neuromedin S is a novel anorexigenic hormone

T Ida, K Mori, M Miyazato, Y Egi, S Abe, K Nakahara, M Nishihara, K Kangawa, N Murakami

ENDOCRINOLOGY 146(10) 4217-4223 2005年10月
Modulation of growth hormone pulsatility by sex steroids in female goats

T Yonezawa, K Mogi, JY Li, R Sako, K Yamanouchi, M Nishihara

ENDOCRINOLOGY 146(6) 2736-2743 2005年6月
Expression and possible role of 20a-hydroxysteroid dehydrogenase in the placenta of the goat

J Reprod Dev 51(2) 265-272 2005年

書籍等出版物

Controlling mechanism of GnRH pulse generator activity in the rat. In : Neural Control of the Reproduction : Physiology and Behavior.

Japan Scientific Societies Press/Karger 1997年
In vivo electrophysiological monitoring of the GnRH pulse generator in rats and goats

Pulsatility in Neuroendocrine Systems, Academic Press 1994年

所属学協会

共同研究・競争的資金等の研究課題

新規リソソームタンパク質による神経筋組織の恒常性維持機構の解明

2017年4月 - 2020年3月
脳内成長因子の生理作用と病態に関する研究

2011年4月 - 2016年3月
ステロイド／成長因子システムの中枢作用機構に関する研究

2008年4月 - 2011年3月
ステロイドと成長因子の共役による脳機能の維持と再生

2005年4月 - 2008年3月
性ステロイド中枢作用の分子機構に関する研究

2001年4月 - 2005年3月
Sex steroid actions in the brain, Brain control of growth and metabolism