岡部勝 (Masaru Okabe) - マイポータル

基本情報

所属: 大阪大学微生物病研究所遺伝子機能解析分野教授,施設長

学位: 薬学博士(大阪大学)

J-GLOBAL ID: 200901000229664288
researchmap会員ID: 1000031460

研究キーワード

研究分野

経歴

委員歴

論文

NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility

Daiji Kiyozumi, Taichi Noda, Ryo Yamaguchi, Tomohiro Tobita, Takafumi Matsumura, Kentaro Shimada, Mayo Kodani, Takashi Kohda, Yoshitaka Fujihara, Manabu Ozawa …

Science 368(6495) 1132-1135 2020年6月5日査読有り
Reduction in BDNF from inefficient precursor conversion influences nest building and promotes depressive-like behavior in mice

Masami Kojima, Hikari Otabi, Haruko Kumanogoh, Atsushi Toyoda, Masahito Ikawa, Masaru Okabe, Toshiyuki Mizui

International Journal of Molecular Sciences 21(11) 2020年6月1日査読有り
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.

Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T …

Biology of reproduction 101(2) 501-511 2019年8月1日査読有り
Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies

Naoki Aoyama, Hiroyuki Miyoshi, Hitoshi Miyachi, Masahiro Sonoshita, Masaru Okabe, Makoto Mark Taketo

Genes to Cells 23(7) 580-589 2018年7月1日査読有り
The mechanics clarifying counterclockwise rotation in most IVF eggs in mice

Kenta Ishimoto, Masahito Ikawa, Masaru Okabe

Scientific Reports 7 43456 2017年3月3日査読有り
A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats^†

Ayako Isotani, Takafumi Matsumura, Masaki Ogawa, Takahiro Tanaka, Kazuo Yamagata, Masahito Ikawa, Masaru Okabe

Biology of Reproduction 97(1) 61-68 2017年査読有り
STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation

Ken Takashima, Yohei Takeda, Hiroyuki Oshiumi, Hiroaki Shime, Masaru Okabe, Masahito Ikawa, Misako Matsumoto, Tsukasa Seya

Biochemical and Biophysical Research Communications 478(4) 1764-1771 2016年9月30日査読有り
The behavior and acrosomal status of mouse spermatozoa in vitro, and within the oviduct during fertilization after natural mating

Toshiaki Hino, Yuko Muro, Miwa Tamura-Nakano, Masaru Okabe, Hiroyuki Tateno, Ryuzo Yanagimachi

Biology of Reproduction 95(3) 2016年9月1日査読有り
Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice

Masamichi Ishizuka, Eri Ohtsuka, Atsuto Inoue, Mirei Odaka, Hirotaka Ohshima, Norihisa Tamura, Kaoru Yoshida, Norihisa Sako, Tadashi Baba, Shin ichi Kashiwabara …

Development Growth and Differentiation 58(7) 600-608 2016年9月1日査読有り
Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naïve from primed pluripotent stem cells

Shin Kobayashi, Yusuke Hosoi, Hirosuke Shiura, Kazuo Yamagata, Saori Takahashi, Yoshitaka Fujihara, Takashi Kohda, Masaru Okabe, Fumitoshi Ishino

Development (Cambridge) 143(16) 2958-2964 2016年8月15日査読有り
Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice

Haruhiko Miyata, Julio M. Castaneda, Yoshitaka Fujihara, Zhifeng Yu, Denise R. Archambeault, Ayako Isotani, Daiji Kiyozumi, Maya L. Kriseman, Daisuke Mashiko, Takafumi Matsumura …

Proceedings of the National Academy of Sciences of the United States of America 113(28) 7704-7710 2016年7月12日査読有り
Behavior of mouse spermatozoa in the female reproductive tract from soon after mating to the beginning of fertilization

Yuko Muro, Hidetoshi Hasuwa, Ayako Isotani, Haruhiko Miyata, Kazuo Yamagata, Masahito Ikawa, Ryuzo Yanagimachi, Masaru Okabe

Biology of Reproduction 94(4) 1-7 2016年4月査読有り
Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities

N. Tatsumi, N. Hojo, O. Yamada, M. Ogawa, Y. Katsura, S. Kawata, E. Morii, H. Sakamoto, R. Inaba, A. Tsuda …

Oncogene 35(8) 1003-1014 2016年2月25日査読有り
Impaired female fertility in tubulointerstitial Antigen-Like 1-Deficient mice

Akihito Takahashi, Ajalli Rahim, Miki Takeuchi, Emiko Fukui, Midori Yoshizawa, Kuniaki Mukai, Makoto Suematsu, Hidetoshi Hasuwa, Masaru Okabe, Hiromichi Matsumoto

Journal of Reproduction and Development 62(1) 43-49 2016年2月20日査読有り
The acrosome reaction: A historical perspective

Masaru Okabe

Advances in Anatomy Embryology and Cell Biology 220 2016年査読有り
Calreticulin is required for development of the cumulus oocyte complex and female fertility

Keizo Tokuhiro, Yuhkoh Satouh, Kaori Nozawa, Ayako Isotani, Yoshitaka Fujihara, Yumiko Hirashima, Hiroyuki Matsumura, Kazuhiro Takumi, Takashi Miyano, Masaru Okabe …

Scientific Reports 5 14254 2015年9月21日査読有り
Mechanisms of fertilization elucidated by gene-manipulated animals

Masaru Okabe

Asian Journal of Andrology 17(4) 646-652 2015年7月査読有り
DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka, Masaru Okabe, Misako Matsumoto, Tsukasa Seya

Cell Reports 11(8) 1193-1207 2015年5月26日査読有り
A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis

Hidenobu Okuda, Hiroshi Kiuchi, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, Haruhiko Miyata, Masaru Okabe, Masahito Ikawa, Yoshitaka Kawakami …

PLoS ONE 10(4) e0124293 2015年4月査読有り
Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron

Mariko Umemura, Kanako Tsunematsu, Yusuke I. Shimizu, Haruo Nakano, Shigeru Takahashi, Yasutomo Higashiura, Masaru Okabe, Yuji Takahashi

Bioscience, Biotechnology and Biochemistry 79(7) 1082-1089 2015年査読有り

もっとみる

MISC

322

Haprin-deficient spermatozoa are incapable of in vitro fertilization

Yusuke Aoki, Akira Tsujimura, Kazuhiro Kaseda, Masaru Okabe, Keizo Tokuhiro, Tomoe Ohta, Moira K. O'Bryan, Hidenobu Okuda, Kouichi Kitamura, Yukiko Ogawa …

Molecular Reproduction and Development 87(5) 534-541 2020年5月1日
Beware of memes in the interpretation of your results – lessons from gene-disrupted mice in fertilization research

Masaru Okabe

FEBS Letters 592(16) 2673-2679 2018年8月
Sperm-egg interaction and fertilization: Past, present, and future

Masaru Okabe

Biology of Reproduction 99(1) 134-146 2018年
Erratum: Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein (FEBS Lett. (1999) 449 (277-283))

Tomoko Nakanishi, Masahito Ikawa, Shuichi Yamada, Martti Parvinen, Tadashi Baba, Yoshitake Nishimune, Masaru Okabe

FEBS Letters 589(20) 3220-3220 2015年10月7日
Mechanism of fertilization: A modern view

Masaru Okabe

Experimental Animals 63(4) 357-365 2014年
Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes

Susumu Mitsutake, Kota Zama, Hazuki Yokota, Tetsuya Yoshida, Miki Tanaka, Masaru Mitsui, Masahito Ikawa, Masaru Okabe, Yoshikazu Tanaka, Tadashi Yamashita …

Journal of Biological Chemistry 286(32) 28544-28555 2011年8月12日
Mechanisms of fertilization - A view from the study of gene-manipulated mice

Yuko Muro, Masaru Okabe

Journal of Andrology 32(3) 218-225 2011年5月
A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice

Chikara Kokubu, Kyoji Horie, Koichiro Abe, Ryuji Ikeda, Sumi Mizuno, Yoshihiro Uno, Sanae Ogiwara, Masato Ohtsuka, Ayako Isotani, Masaru Okabe …

Nature Genetics 41(8) 946-952 2009年8月
Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration

Makoto Nishizuka, Keishi Kishimoto, Ayumi Kato, Masahito Ikawa, Masaru Okabe, Ryuichiro Sato, Hiroyuki Niida, Makoto Nakanishi, Shigehiro Osada, Masayoshi Imagawa

Experimental Cell Research 315(5) 809-819 2009年3月10日
Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration

Makoto Nishizuka, Keishi Kishimoto, Ayumi Kato, Masahito Ikawa, Masaru Okabe, Ryuichiro Sato, Hiroyuki Niida, Makoto Nakanishi, Shigehiro Osada, Masayoshi Imagawa

EXPERIMENTAL CELL RESEARCH 315(5) 809-819 2009年3月
Genetic loss of Faah compromises male fertility in mice

Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J. Kingsley, Lawrence J. Marnett, Benjamin F. Cravatt, Sudhansu K. Dey

Biology of Reproduction 80(2) 235-242 2009年2月
Genetic Loss of Faah Compromises Male Fertility in Mice

Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J. Kingsley, Lawrence J. Marnett, Benjamin F. Cravatt, Sudhansu K. Dey

BIOLOGY OF REPRODUCTION 80(2) 235-242 2009年2月
Putative sperm fusion protein IZUMO and the role of N-glycosylation

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Biochemical and Biophysical Research Communications 377(3) 910-914 2008年12月19日
Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus

Dong-Ye Youn, Dong-Hyoung Lee, Mi-Hyun Lim, Jung-Sook Yoon, Ji Hee Lim, Seung Eun Jung, Chung Eun Yeum, Cheol Whee Park, Ho-Joong Youn, Jae-Seon Lee …

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 295(6) E1349-E1357 2008年12月
Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus

Dong Ye Youn, Dong Hyoung Lee, Mi Hyun Lim, Jung Sook Yoon, Hee Lim Ji, Eun Jung Seung, Eun Yeum Chung, Whee Park Cheol, Ho Joong Youn, Jae Seon Lee …

American Journal of Physiology - Endocrinology and Metabolism 295(6) E1349-E1357 2008年12月
Putative sperm fusion protein IZUMO and the role of N-glycosylation

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377(3) 910-914 2008年12月
Differential human serum-mediated neutralization of PERV released from pig cells transfected with variants of hDAF

Eiji Okura, Aiko Ishimaru, Aki Yamamoto, Shino Nakatsu, Ryota Shirakura, Masaru Okabe, Yoshiki Sawa, Masahiro Fukuzawa, Meinoshin Okumura, Shuji Miyagawa

Xenotransplantation 15(6) 365-373 2008年11月
Differential human serum-mediated neutralization of PERV released from pig cells transfected with variants of hDAF

Eiji Okura, Aiko Ishimaru, Aki Yamamoto, Shino Nakatsu, Ryota Shirakura, Masaru Okabe, Yoshiki Sawa, Masahiro Fukuzawa, Meinoshin Okumura, Shuji Miyagawa

XENOTRANSPLANTATION 15(6) 365-373 2008年11月
The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice

Kenji Miyado, Keiichi Yoshida, Kazuo Yamagata, Keiichi Sakakibara, Masaru Okabe, Xiaobiao Wang, Kiyoko Miyamoto, Hidenori Akutsu, Takahiko Kondo, Yuji Takahashi …

Proceedings of the National Academy of Sciences of the United States of America 105(35) 12921-12926 2008年9月2日
The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice

Kenji Miyado, Keiichi Yoshida, Kazuo Yamagata, Keiichi Sakakibara, Masaru Okabe, Xiaobiao Wang, Kiyoko Miyamoto, Hidenori Akutsu, Takahiko Kondo, Yuji Takahashi …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(35) 12921-12926 2008年9月

もっとみる

書籍等出版物

顕微鏡活用なるほどQ&A(共著)

羊土社 2009年 (ISBN: 9784758107310)
精子の受精能(共著)

改訂3版対外受精Update 2001年
遺伝子の発現と機能を解析する方法(共著)

臨床消化器内科6 消化器疾患の分子医学 2001年
精子学(共著)

東京大学出版会 1992年

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

相同組換えによる遺伝子改変動物の作製と疾患モデルマウスの作製

その他の研究制度
疾患モデル動物の作成

科学研究費補助金
受精のメカニズムに関する研究

科学研究費補助金
Production of model animals for human diseases

Grant-in-Aid for Scientific Research
Study on Fertilization Mechanism

Grant-in-Aid for Scientific Research

岡部勝

基本情報

研究キーワード

研究分野

経歴

委員歴

論文

MISC

書籍等出版物

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

産業財産権

メニュー