安光 英太郎

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アバター
研究者氏名
安光 英太郎
 
ヤスミツ ヒデタロウ
eメール
hyasumityokohama-cu.ac.jp
URL
http://www-user.yokohama-cu.ac.jp/~hyasumit/
学位
薬学博士(東京大学)

研究分野

 
 

学歴

 
 
 - 
1983年3月
東京大学 大学院薬学研究科 博士課程修了 
 

論文

 
Fujii Y, Dohmae N, Takio K, Kawsar SM, Matsumoto R, Hasan I, Koide Y, Kanaly RA, Yasumitsu H, Ogawa Y, Sugawara S, Hosono M, Nitta K, Hamako J, Matsui T, Ozeki Y
The Journal of biological chemistry      2012年10月   [査読有り]
Fine bubble mixing (FBM) culture of E. coli: a highly cost-effective middle scale-size culture system.
Yasumitsu H, Tajima H, Isobe M, Kutsuna S, Kawsar SM, Fujii Y, Kanaly RA, Ozeki Y, Yokotaa E
Protein and peptide letters      2012年8月   [査読有り]
Matsumoto R, Fujii Y, Kawsar SM, Kanaly RA, Yasumitsu H, Koide Y, Hasan I, Iwahara C, Ogawa Y, Im CH, Sugawara S, Hosono M, Nitta K, Hamako J, Matsui T, Ozeki Y
Toxins   4 323-338   2012年5月   [査読有り]
Fujii Y, Sugawara S, Araki D, Kawano T, Tatsuta T, Takahashi K, Kawsar SM, Matsumoto R, Kanaly RA, Yasumitsu H, Ozeki Y, Hosono M, Miyagi T, Hakomori SI, Takayanagi M, Nitta K
The protein journal   31(1) 15-26   2012年1月   [査読有り]
Yasumitsu H, Mochida K, Yasuda C, Isobe M, Kawsar SM, Fujii Y, Matsumoto R, Kanaly RA, Ozeki Y
In vitro cellular & developmental biology. Animal   47 728-734   2011年12月   [査読有り]
Kawsar SM, Matsumoto R, Fujii Y, Matsuoka H, Masuda N, Chihiro I, Yasumitsu H, Kanaly RA, Sugawara S, Hosono M, Nitta K, Ishizaki N, Dogasaki C, Hamako J, Matsui T, Ozeki Y
The protein journal   30(7) 509-519   2011年10月   [査読有り]
Matsumoto R, Shibata TF, Kohtsuka H, Sekifuji M, Sugii N, Nakajima H, Kojima N, Fujii Y, Kawsar SM, Yasumitsu H, Hamako J, Matsui T, Ozeki Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   158 266-273   2011年4月   [査読有り]
Fujii Y, Kawsar SM, Matsumoto R, Yasumitsu H, Ishizaki N, Dogasaki C, Hosono M, Nitta K, Hamako J, Taei M, Ozeki Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   158(1) 30-37   2011年1月   [査読有り]
Yasumitsu H, Ozeki Y, Kawsar SM, Toda T, Kanaly R
Analytical biochemistry   406(1) 86-88   2010年11月   [査読有り]
Yasumitsu H, Ozeki Y, Kawsar SM, Fujii Y, Sakagami M, Matuo Y, Toda T, Katsuno H
Electrophoresis   31(12) 1913-1917   2010年6月   [査読有り]
Production of active MMP7 in E. coli and its application for metalloproteinase inhibitors screening.
Katsuno H, Shirakawa R, Miyazaki K, Ozeki Y, Yasumitsu H
Protein and peptide letters   17 568-572   2010年5月   [査読有り]
Purification and biochemical characterization of a D-galactose binding lectin from Japanese sea hare (Aplysia kurodai) eggs.
Kawsar SM, Matsumoto R, Fujii Y, Yasumitsu H, Dogasaki C, Hosono M, Nitta K, Hamako J, Matsui T, Kojima N, Ozeki Y
Biochemistry. Biokhimiia   74 709-716   2009年7月   [査読有り]
Kawsar SM, Takeuchi T, Kasai K, Fujii Y, Matsumoto R, Yasumitsu H, Ozeki Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   152(4) 382-389   2009年4月   [査読有り]
Glycan-binding profile and cell adhesion activity of American bullfrog (Rana catesbeiana) oocyte galectin-1.
Kawsar SM, Matsumoto R, Fujii Y, Yasumitsu H, Uchiyama H, Hosono M, Nitta K, Hamako J, Matsui T, Kojima N, Ozeki Y
Protein and peptide letters   16 677-684   2009年   [査読有り]
Kawsar SM, Fujii Y, Matsumoto R, Ichikawa T, Tateno H, Hirabayashi J, Yasumitsu H, Dogasaki C, Hosono M, Nitta K, Hamako J, Matsui T, Ozeki Y
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology   150(4) 349-357   2008年8月   [査読有り]
Morita A, Miyagi E, Yasumitsu H, Kawasaki H, Hirano H, Hirahara F
Proteomics   6 5880-5890   2006年11月   [査読有り]
Udagawa K, Yasumitsu H, Esaki M, Sawada H, Nagashima Y, Aoki I, Jin M, Miyagi E, Nakazawa T, Hirahara F, Miyazaki K, Miyagi Y
Placenta   23 145-153   2002年2月   [査読有り]
Jin M, Udagawa K, Miyagi E, Nakazawa T, Hirahara F, Yasumitsu H, Miyazaki K, Nagashima Y, Aoki I, Miyagi Y
Gynecologic oncology   83 325-333   2001年11月   [査読有り]
Tsubota Y, Mizushima H, Hirosaki T, Higashi S, Yasumitsu H, Miyazaki K
Biochemical and biophysical research communications   278(3) 614-620   2000年11月   [査読有り]
Miyata S, Koshikawa N, Yasumitsu H, Miyazaki K
The Journal of biological chemistry   275(7) 4592-4598   2000年2月   [査読有り]
Sato J, Hasegawa S, Akaogi K, Yasumitsu H, Yamada S, Sugahara K, Miyazaki K
Journal of cellular biochemistry   75(2) 187-195   1999年11月   [査読有り]
Goto S, Miyazaki K, Funabiki T, Yasumitsu H
Analytical biochemistry   272(2) 135-142   1999年8月   [査読有り]
Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture.
Miyata S, Koshikawa N, Higashi S, Miyagi Y, Nagashima Y, Yanoma S, Kato Y, Yasumitsu H, Miyazaki K
Journal of biochemistry   125 1067-1076   1999年6月   [査読有り]
Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells.
Miyata S, Miyagi Y, Koshikawa N, Nagashima Y, Kato Y, Yasumitsu H, Hirahara F, Misugi K, Miyazaki K
Clinical & experimental metastasis   16 613-622   1998年10月   [査読有り]
Koshikawa N, Hasegawa S, Nagashima Y, Mitsuhashi K, Tsubota Y, Miyata S, Miyagi Y, Yasumitsu H, Miyazaki K
The American journal of pathology   153 937-944   1998年9月   [査読有り]
Elevated expression of membrane-type 1 and 3 matrix metalloproteinases in rat vascular smooth muscle cells activated by arterial injury.
Shofuda K, Nagashima Y, Kawahara K, Yasumitsu H, Miki K, Miyazaki K
Laboratory investigation; a journal of technical methods and pathology   78 915-923   1998年8月   [査読有り]
Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells.
Shofuda K, Moriyama K, Nishihashi A, Higashi S, Mizushima H, Yasumitsu H, Miki K, Sato H, Seiki M, Miyazaki K
Journal of biochemistry   124 462-470   1998年8月   [査読有り]
Production of trypsins by human gastric cancer cells correlates with their malignant phenotype.
Kato Y, Nagashima Y, Koshikawa N, Miyagi Y, Yasumitsu H, Miyazaki K
European journal of cancer (Oxford, England : 1990)   34 1117-1123   1998年6月   [査読有り]
Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization.
Udagawa K, Miyagi Y, Hirahara F, Miyagi E, Nagashima Y, Minaguchi H, Misugi K, Yasumitsu H, Miyazaki K
Placenta   19 217-223   1998年3月   [査読有り]
Hirahara F, Miyagi E, Nagashima Y, Miyagi Y, Yasumitsu H, Koshikawa N, Nakatani Y, Nakazawa T, Udagawa K, Kitamura H, Minaguchi H, Miyazaki K
Gynecologic oncology   68 162-165   1998年2月   [査読有り]
cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells.
Yamakawa T, Miyata S, Ogawa N, Koshikawa N, Yasumitsu H, Kanamori T, Miyazaki K
Biochimica et biophysica acta   1395 202-208   1998年1月   [査読有り]
Identification of integrin-dependent and -independent cell adhesion domains in COOH-terminal globular region of laminin-5 alpha 3 chain.
Mizushima H, Takamura H, Miyagi Y, Kikkawa Y, Yamanaka N, Yasumitsu H, Misugi K, Miyazaki K
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research   8 979-987   1997年9月   [査読有り]
Nagashima Y, Hasegawa S, Koshikawa N, Taki A, Ichikawa Y, Kitamura H, Misugi K, Kihira Y, Matuo Y, Yasumitsu H, Miyazaki K
International journal of cancer. Journal international du cancer   72(3) 441-445   1997年7月   [査読有り]
Koshikawa N, Nagashima Y, Miyagi Y, Mizushima H, Yanoma S, Yasumitsu H, Miyazaki K
FEBS letters   409(3) 442-448   1997年6月   [査読有り]
Shofuda K, Yasumitsu H, Nishihashi A, Miki K, Miyazaki K
The Journal of biological chemistry   272(15) 9749-9754   1997年4月   [査読有り]
Yasumitsu H, Shofuda K, Nishihashi A, Eki T, Koshikawa N, Mizushima H, Miyazaki K
DNA research : an international journal for rapid publication of reports on genes and genomes   4(1) 77-79   1997年2月   [査読有り]
Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors.
Mizushima H, Miyagi Y, Kikkawa Y, Yamanaka N, Yasumitsu H, Misugi K, Miyazaki K
Journal of biochemistry   120 1196-1202   1996年12月   [査読有り]
Synergistic growth stimulation of mouse fibroblasts by tumor-derived adhesion factor with insulin-like growth factors and insulin.
Akaogi K, Sato J, Okabe Y, Sakamoto Y, Yasumitsu H, Miyazaki K
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research   7 1671-1677   1996年12月   [査読有り]
Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6.
Miyagi Y, Yasumitsu H, Mizushima H, Koshikawa N, Matsuda Y, Itoh H, Hori TA, Aoki I, Misugi K, Miyazaki K
DNA and cell biology   15 947-954   1996年11月   [査読有り]
Akaogi K, Okabe Y, Sato J, Nagashima Y, Yasumitsu H, Sugahara K, Miyazaki K
Proceedings of the National Academy of Sciences of the United States of America   93(16) 8384-8389   1996年8月   [査読有り]
Miyagi Y, Yasumitsu H, Eki T, Miyata S, Kkawa N, Hirahara F, Aoki I, Misugi K, Miyazaki K
Genomics   35(1) 267-268   1996年7月   [査読有り]
Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells.
Koshikawa N, Nakamura T, Tsuchiya N, Isaji M, Yasumitsu H, Umeda M, Miyazaki K
Journal of biochemistry   119 334-339   1996年2月   [査読有り]
Hirahara F, Miyagi Y, Miyagi E, Yasumitsu H, Koshikawa N, Nagashima Y, Kitamura H, Minaguchi H, Umeda M, Miyazaki K
International journal of cancer. Journal international du cancer   63(2) 176-181   1995年10月   [査読有り]
[TIMPs (tissue inhibitors of metalloproteinases): their species, functions and effects on tumor metastasis].
Yasumitsu H, Wakabayashi E, Kitajima H, Sakamoto Y, Miyazaki K
Nihon rinsho. Japanese journal of clinical medicine   53 1798-1804   1995年7月   [査読有り]
Characterization of matrix-degrading proteinases and their inhibitors secreted by human gynecological carcinoma cells.
Miyagi E, Yasumitsu H, Hirahara F, Minaguchi H, Koshikawa N, Miyazaki K, Umeda M
Japanese journal of cancer research : Gann   86 568-576   1995年6月   [査読有り]
Marked induction of gelatinases, especially type B, in host fibroblasts by human ovarian cancer cells in athymic mice.
Miyagi E, Yasumitsu H, Hirahara F, Nagashima Y, Minaguchi H, Miyazaki K, Umeda M
Clinical & experimental metastasis   13 89-96   1995年3月   [査読有り]
cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2.
Miyagi Y, Koshikawa N, Yasumitsu H, Miyagi E, Hirahara F, Aoki I, Misugi K, Umeda M, Miyazaki K
Journal of biochemistry   116 939-942   1994年11月   [査読有り]
Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line.
Koshikawa N, Yasumitsu H, Nagashima Y, Umeda M, Miyazaki K
The Biochemical journal   303 ( Pt 1) 187-190   1994年10月   [査読有り]
Akaogi K, Okabe Y, Funahashi K, Yoshitake Y, Nishikawa K, Yasumitsu H, Umeda M, Miyazaki K
Biochemical and biophysical research communications   198(3) 1046-1053   1994年2月   [査読有り]
Miyazaki K, Kikkawa Y, Nakamura A, Yasumitsu H, Umeda M
Proceedings of the National Academy of Sciences of the United States of America   90(24) 11767-11771   1993年12月   [査読有り]
Synthetic peptide-generated monoclonal antibodies to transforming growth factor-beta 1.
Tahara N, Yasumitsu H, Umeda M
Hybridoma   12 441-453   1993年8月   [査読有り]
Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein.
Miyazaki K, Funahashi K, Numata Y, Koshikawa N, Akaogi K, Kikkawa Y, Yasumitsu H, Umeda M
The Journal of biological chemistry   268 14387-14393   1993年7月   [査読有り]
Yasumitsu H, Seo N, Misugi E, Morita H, Miyazaki K, Umeda M
In vitro cellular & developmental biology. Animal   29A(5) 403-407   1993年5月   [査読有り]
Morita H, Yasumitsu H, Watanabe Y, Miyazaki K, Umeda M
Cell structure and function   18(1) 61-72   1993年2月   [査読有り]
Multiple secretion of matrix serine proteinases by human gastric carcinoma cell lines.
Koshikawa N, Yasumitsu H, Umeda M, Miyazaki K
Cancer research   52 5046-5053   1992年9月   [査読有り]
Miyazaki K, Umenishi F, Funahashi K, Koshikawa N, Yasumitsu H, Umeda M
Biochemical and biophysical research communications   185(3) 852-859   1992年6月   [査読有り]
Comparison of extracellular matrix-degrading activities between 64-kDa and 90-kDa gelatinases purified in inhibitor-free forms from human schwannoma cells.
Yasumitsu H, Miyazaki K, Umenishi F, Koshikawa N, Umeda M
Journal of biochemistry   111 74-80   1992年1月   [査読有り]
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.
Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M
Cancer research   50 7758-7764   1990年12月   [査読有り]
Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin.
Umenishi F, Yasumitsu H, Ashida Y, Yamauti J, Umeda M, Miyazaki K
Journal of biochemistry   108 537-543   1990年10月   [査読有り]
Kan M, Huang JS, Mansson PE, Yasumitsu H, Carr B, McKeehan WL
Proceedings of the National Academy of Sciences of the United States of America   86(19) 7432-7436   1989年10月   [査読有り]
The androgen-dependent rat prostate protein, probasin, is a heparin-binding protein that co-purifies with heparin-binding growth factor-1.
Matuo Y, Adams PS, Nishi N, Yasumitsu H, Crabb JW, Matusik RJ, McKeehan WL
In vitro cellular & developmental biology : journal of the Tissue Culture Association   25 581-584   1989年6月   [査読有り]
Establishment of a human glioma cell line bearing a homogeneously staining chromosomal region and releasing alpha- and beta-type transforming growth factors.
Kanno H, Kuwabara T, Shinonaga M, Chang CC, Tanaka Y, Sugio Y, Morita H, Yasumitsu H, Umeda M, Nagashima Y
Acta neuropathologica   79 30-36   1989年   [査読有り]
Morita H, Yasumitsu H, Harada H, Umeda M, Takaoka T
Cell structure and function   13(6) 481-493   1988年12月   [査読有り]
Transforming growth factors in urine from patients with primary brain tumors.
Kanno H, Kuwabara T, Yasumitsu H, Umeda M
Journal of neurosurgery   68 775-780   1988年5月   [査読有り]
High level of beta-type transforming growth factor activity in human urine obtained from cancer patients.
Nishimura R, Okumura H, Noda K, Yasumitsu H, Umeda M
Japanese journal of cancer research : Gann   77 560-567   1986年6月   [査読有り]
Fujita T, Ohno S, Yasumitsu H, Taniguchi T
Cell   41(2) 489-496   1985年6月   [査読有り]
Yasumitsu H, Hanaoka F, Yasuda H, Murakami Y, Enomoto T, Yamada M
Cell structure and function   10(1) 79-88   1985年3月   [査読有り]
Fuse A, Fujita T, Yasumitsu H, Kashima N, Hasegawa K, Taniguchi T
Nucleic acids research   12(24) 9323-9331   1984年12月   [査読有り]

Misc

 
安光英太郎、他:TIMP
安光 英太郎
(1995)キーワード'95-96「癌」. 186-187   
安光英太郎、他:マトリックスプロテアーゼと癌転移
安光 英太郎
(1999)Surgery Frontier. 6: 148-158   
安光英太郎、他:メタロプロテアーゼインヒビターTIMPと癌の浸潤・転移
安光 英太郎
(1994)血液・腫瘍科. 29:245-250   
安光英太郎、他:癌の悪性伸展に関連するメタロプロテアーゼインヒビター(TIMPs)の種類と役割
安光 英太郎
(1995)日本臨床. 53: 1798-1804   
安光英太郎、他:細胞外マトリックスと癌転移
安光 英太郎
(1992)代謝. 29: 25-33   

書籍等出版物

 
癌細胞が分泌するタンパク質の機能解析
現代化学増刊 「病態プロテオミクス」   2002年   

競争的資金等の研究課題

 
癌の増殖・転移にかかわる蛋白質性因子の解析
共同研究
研究期間: 1988年   
動物細胞の分化に関わる分泌性蛋白質因子の解析
共同研究
研究期間: 1997年