大西 啓

J-GLOBALへ         更新日: 16/03/28 17:50
 
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研究者氏名
大西 啓
 
オオニシ ヒラク
所属
星薬科大学
部署
医療薬剤学
職名
教授
学位
薬学博士

研究キーワード

 
 

研究分野

 
 

論文

 
Kawano Y, Sasatsu M, Mizutani A, Hirose K, Hanawa T, Onishi H
Chemical & pharmaceutical bulletin      2016年3月   [査読有り]
Onishi H, Sakata O, Yumoto K
Biological & pharmaceutical bulletin   38(6) 919-925   2015年   [査読有り]
Onishi H, Yumoto K, Sakata O
International journal of pharmaceutics   468(1-2) 207-213   2014年7月   [査読有り]
Effect of short-term polyphenol treatment on endothelial dysfunction and thromboxane A2 levels in streptozotocin-induced diabetic mice.
Taguchi K, Hida M, Matsumoto T, Ikeuchi-Takahashi Y, Onishi H, Kobayashi T
Biological & pharmaceutical bulletin   37(6) 1056-1061   2014年   [査読有り]
Chondroitin sulfate-glycyl-prednisolone conjugate as arthritis targeting system: localization and drug release in inflammatory joints.
Onishi H, Yoshida R, Matsuyama M
Biological & pharmaceutical bulletin   37(10) 1641-1649   2014年   [査読有り]
Onishi H, Isoda Y, Matsuyama M
International journal of pharmaceutics   456(1) 113-120   2013年11月   [査読有り]
Ikeuchi-Takahashi Y, Sasatsu M, Onishi H
International journal of pharmaceutics   453(2) 454-461   2013年9月   [査読有り]
Ikeuchi-Takahashi Y, Watanabe N, Sasatsu M, Onishi H
Drug development and industrial pharmacy   39(8) 1254-1261   2013年8月   [査読有り]
Conjugate between chondroitin sulfate and prednisolone with a glycine linker: preparation and in vitro conversion analysis.
Onishi H, Matsuyama M
Chemical & pharmaceutical bulletin   61(9) 902-912   2013年   [査読有り]

Misc

 
Takashi Masutomi, Hiraku Onishi, Yuri Takahashi, Yoshiharu Machida
Current drug delivery   7 447-452   2010年12月
Ovalbumin (OVA) is often used as a model antigen, and its biodistribution is important for the induction of immunization, especially oral immunization. In this study, an allergic substance-detecting kit, Egg Protein ELISA kit, was applied to the i...
Hiraku Onishi, Kennichi Koyama, Osamu Sakata, Yoshiharu MacHida
Drug Development and Industrial Pharmacy   36 879-884   2010年8月
Background: Although lactoferrin (LF) possesses useful functions such as antitumor, antiviral, and anti-inflammatory acitivities, it is subject to gastric digestion, resulting in the reduction of efficacy. Therefore, it is important to develop a s...
H. Onishi
Journal of Drug Delivery Science and Technology   20 15-22   2010年1月
Chitosan microparticles have been actively developed with an emphasis on preparative methods, particle characteristics, release control and in vivo applications. Many types have been produced, including simple microparticles, chemically cross-link...
Osamu Sakata, Hiraku Onishi, Yoshiharu Machida
Yakugaku Zasshi   130 119-125   2010年1月
A semisolid dosage form of clonazepam (CZP), administered to the oral cavity between the lower gum and bottom lip with small volume of saline, was developed to obtain the stable dosage which can replace the injection dosage form. Semisolid dosage ...
Kennichi Ueki, Hiraku Onishi, Masanaho Sasatsu, Yoshiharu Machida
Drug Development Research   70 512-519   2009年12月
Carboxy-polyethylene glycol-poly(DL-lactic acid) block copolymer was synthesized by reductive amination of carboxy-polyethylene glycol-amine and aldehyde-ended poly(DL-lactic acid). The obtained product, PA-PEG-CB, composed of pure carboxy-polyeth...

Works

 
振動写真法による回析強度測定法の開発
1982年
ムーアスパラギナーゼの結晶構造の解析
1981年
フェロセン誘導体の結晶構造の精密化
1980年

競争的資金等の研究課題

 
制癌薬の薬物送達に関する研究
生体適合性高分子を用いた制御放出型製剤の開発研究
高分子を用いた薬物動態制御と薬効の改善
高分子医薬、高分子ナノパーテイクルによる薬物ターゲティング