亀井 淳三

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研究者氏名
亀井 淳三
 
カメイ ジュンゾウ
所属
星薬科大学
部署
薬物治療学教室
職名
教授
学位
薬学博士(星薬科大学)
その他の所属
星薬科大学応用医療情報研究室

プロフィール

職 歴:昭和58年 4月  星薬科大学助手
    平成 7年 4月  星薬科大学講師
    平成11年 7月  星薬科大学助教授
    平成14年10月  星薬科大学教授      現在に至る

学内役職等:教務部長
      イノベーションセンター長
      先端生命科学研究所生命科学先導研究センター長

学外委員等:
Editorial Board Member of European Journal of Pharmacology
厚生労働省医道審議会専門委員
厚生労働省薬剤師試験委員会委員
日本学術振興会第189委員会委員
日本学術振興会先導的研究開発委員会(食による生体恒常性維持の指標となる未病マーカーの探索戦略)幹事
沖縄新産業研究開発支援事業審査委員会委員
国立精神・神経センター客員研究員
鎮痛薬・オピオイドペプチド研究会世話人(事務局長)
日本咳嗽研究会世話人
日本薬理学会常置委員(編集委員会)・学術評議員・代議員
日本神経精神薬理学会評議員
日本緩和医療薬学会評議員
日本糖尿病・肥満動物学会評議員
日本アロマセラピー学会評議員

所属学会:日本薬学会、日本薬理学会、日本糖尿病学会、日本糖尿病合併症学会、日本肥満学会、日本神経科学会、日本神経精神薬理学会、日本疼痛学会、日本ペインクリニック学会、日本線維筋痛症学会、日本咳嗽研究会、鎮痛薬・オピオイドペプチド研究会、日本糖尿病・肥満動物学会、日本ストレス学会、日本うつ病学会、日本東洋医学会、日本緩和医療薬学会、日本癌治療学会、日本アロマセラピー学会、国際ひびき生命科学学会、Society for Neuroscience、American Diabetes Associationほか

研究テーマ:
1)慢性咳嗽の発症機序および病因の解明
2)糖尿病、肥満、メタボリックシンドロームに伴う中枢および末梢神経系の機能変化とその分子機構の解明

研究分野

 
 

経歴

 
2015年
   
 
星薬科大学 薬学部 教授
 

委員歴

 
 
 - 
現在
日本学術振興会  先導的研究開発委員会(食による生体恒常性維持の指標となる未病マーカーの探索戦略)
 
 
   
 
Editorial Board Member of European Journal of Pharmacology
 
 
   
 
厚生労働省薬剤師試験委員会委員
 
 
   
 
日本学術振興会第189委員会委員
 
 
   
 
沖縄新産業研究開発支援事業審査委員会委員
 
 
   
 
鎮痛薬・オピオイドペプチド研究会世話人(事務局長)
 
 
   
 
日本咳嗽研究会世話人
 
 
   
 
日本薬理学会常置委員会委員(編集委員会)・学術評議員・代議員
 
 
   
 
日本神経精神薬理学会評議員
 
 
   
 
日本緩和医療薬学会評議員
 
 
   
 
日本糖尿病・肥満動物学会評議員
 
 
   
 
日本アロマセラピー学会評議員
 

論文

 
C. Ardianto, N. Yonemochi, S. Yamamoto, L. Yang, F. Takenoya, S. Shioda, H. Nagase, H. Ikeda, J. Kamei
Neuroscience   320 183-193   2016年4月   [査読有り]
© 2016 IBRO. The hypothalamus controls feeding behavior. Since central opioid systems may regulate feeding behavior, we examined the role of μ-, δ- and κ-opioid receptors in the lateral hypothalamus (LH), the hunger center, in feeding behavior of ...
H. Ikeda, C. Ardianto, N. Yonemochi, L. Yang, T. Ohashi, M. Ikegami, H. Nagase, J. Kamei
Neuroscience   311 9-21   2015年12月   [査読有り]
© 2015 IBRO. Opioid receptors, especially μ-opioid receptors, in the ventral tegmental area (VTA) and nucleus accumbens (NAcc) are reported to regulate food motivation. However, the roles of μ-, δ- and κ-opioid receptors are not fully understood. ...
Toshiyuki Iwata, Isao Ito, Akio Niimi, Akio Niimi, Koji Ikegami, Satoshi Marumo, Naoya Tanabe, Hitoshi Nakaji, Yoshihiro Kanemitsu, Hisako Matsumoto, Junzo Kamei, Mitsutoshi Setou, Michiaki Mishima
PLoS ONE   10    2015年11月   [査読有り]
© 2015 Iwata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are c...
Hiroko Ikeda, Megumi Ikegami, Misa Kai, Junzo Kamei
Experimental Neurology   269 233-241   2015年7月   [査読有り]
© 2015 Elsevier Inc. The role of cannabinoid systems in conditioned fear memory was investigated in streptozotocin (STZ)-induced diabetic mice. The cannabinoid receptor agonist WIN-55,212-2 (1mg/kg, i.p.), when injected into normal mice after cond...
Masahiko Funada, Tomohisa Mori, Jun Maeda, Yuko Tsuda, Sachiko Komiya, Norifumi Shimizu, Junzo Kamei, Tsutomu Suzuki
European journal of pharmacology   742 89-93   2014年11月   [査読有り]
Copyright © 2014 Elsevier B.V. All rights reserved. Genetic factors affect the locomotor activity induced by morphine, which mainly depends on the activation of dopaminergic systems, and morphine has distinct pharmacological activities in C57BL/6J...
Takatsune Shimizu, Takatsune Shimizu, Takatsune Shimizu, Eiji Sugihara, Eiji Sugihara, Sayaka Yamaguchi-Iwai, Sayaka Yamaguchi-Iwai, Sakura Tamaki, Yuko Koyama, Walied Kamel, Walied Kamel, Walied Kamel, Arisa Ueki, Tomoki Ishikawa, Tomoki Ishikawa, Tatsuyuki Chiyoda, Satoru Osuka, Nobuyuki Onishi, Hiroko Ikeda, Junzo Kamei, Koichi Matsuo, Yumi Fukuchi, Toshihiro Nagai, Junya Toguchida, Junya Toguchida, Junya Toguchida, Yoshiaki Toyama, Akihiro Muto, Hideyuki Saya, Hideyuki Saya
Cancer Research   74 6531-6541   2014年11月   [査読有り]
© 2014 AACR. Osteosarcoma is a malignant bone tumor in children and adolescents characterized by intrinsic therapeutic resistance. The IGF2 is expressed at elevated levels in osteosarcoma after treatment with chemotherapy, prompting an examination...
Ken Ichiro Tanaka, Ken Ichiro Tanaka, Yuki Nakanishi, Shyota Sekino, Megumi Ikegami, Hiroko Ikeda, Junzo Kamei
European Journal of Pharmacology   733 68-74   2014年6月   [査読有り]
Diabetic neuropathy is one of the most frequent complications of diabetes mellitus. Therefore, the present study was designed to investigate the anti-hyperalgesic mechanism of fentanyl in a mouse model of streptozotocin- induced diabetic neuropath...
Mao Nakayama, Daisuke Iejima, Masakazu Akahori, Junzo Kamei, Asako Goto, Takeshi Iwata
Investigative Ophthalmology and Visual Science   55 6514-6523   2014年1月   [査読有り]
© 2014 The Association for Research in Vision and Ophthalmology, Inc. PURPOSE: We determined the function of ARMS2 and HtrA1 in the choroid and retina using transgenic (Tg) mice and evaluated the effects of mainstream cigarette smoke on these mice...
Fumiaki Sato, Hiroshi Takahashi, Yasuhiko Komatsu, Fumiya Asukabe, Junzo Kamei
Japanese Pharmacology and Therapeutics   42 735-738   2014年1月   [査読有り]
Objective: We examined effect of placenta extract on the proliferation and Type I collagen mRNA expression of human skin fibroblast. Methods: Normal human skin fibroblast were treated with 0.16,0.32, 0.64% placenta extract. After 48 hours, the pro...
M. Ikegami, H. Ikeda, T. Ohashi, M. Ohsawa, Y. Ishikawa, M. Kai, A. Kamei, J. Kamei
Diabetes, Obesity and Metabolism   15 1128-1135   2013年12月   [査読有り]
Aims: To investigate the mechanism of the metabolic disturbance induced by the atypical antipsychotic olanzapine, we examined whether adenosine 5′-monophosphate-activated protein kinase (AMPK) in the hypothalamus and hepatic glucose production are...
Junzo Kamei, Hiroshi Takahasi, Fumiya Asukabe, Katsuya Nagai
Japanese Pharmacology and Therapeutics   41 855-861   2013年11月
Objective: We examined effect of placenta extract on the activities of hepatic sympathetic, adrenal sympathetic, pancreatic sympathetic and gastric vagal nerves in rats. Methods: A polyethylene catheter was inserted into the duodenal cavity for in...
H. Ikeda, M. Ikegami, M. Kai, M. Ohsawa, J. Kamei
Neuroscience   250 446-454   2013年10月   [査読有り]
The role of spinal cannabinoid systems in neuropathic pain of streptozotocin (STZ)-induced diabetic mice was studied. In normal mice, injection of the cannabinoid receptor agonist WIN-55,212-2 (1 and 3μg, i.t.) dose-dependently prolonged the tail-...
Megumi Ikegami, Hiroko Ikeda, Yoko Ishikawa, Masahiro Ohsawa, Takahiro Ohashi, Misa Kai, Atsuko Kamei, Junzo Kamei
European Journal of Pharmacology   718 376-382   2013年9月   [査読有り]
Treatment with atypical antipsychotic drugs is known to increase the risk of glucose intolerance and diabetes. However, the mechanism of this effect is unclear. Since central adenosine 5′-monophosphate-activated protein kinase (AMPK) plays an impo...
H. Ikeda, H. Ikeda, T. Saigusa, T. Saigusa, J. Kamei, N. Koshikawa, N. Koshikawa, A. R. Cools
Neuroscience   241 126-134   2013年6月   [査読有り]
Central dopamine systems are key players in the cerebral organization of behavior and in various neurological and psychiatric diseases. We demonstrate the presence of a neurochemical feed-forward loop characterized by region-specific changes in do...
Junzo Kamei, Yuki Nakanishi, Megumi Asato, Hiroko Ikeda
Cough   9    2013年2月   [査読有り]
Background: Although the mechanism of fentanyl-induced cough is unclear, several lines of evidence suggest that allergic mediators, such as histamine, may play a role in the production of fentanyl-induced coughs. The aim of this study was to explo...
Megumi Ikegami, Hiroko Ikeda, Takahiro Ohashi, Misa Kai, Mamiko Osada, Atsuko Kamei, Junzo Kamei, Junzo Kamei
Neuroendocrinology   98 224-232   2013年1月   [査読有り]
Background/Aims: Atypical antipsychotic drugs such as olanzapine are known to induce metabolic disturbance. We have already shown that olanzapine induces hepatic glucose production through the activation of hypothalamic adenosine 5′-monophosphate-...
Megumi Asato, Hiroko Ikeda, Junzo Kamei
Japanese Journal of Neuropsychopharmacology   32 251-255   2012年11月   [査読有り]
Metabolic disorders, such as diabetes and obesity, have been indicated to disturb the function of the central nervous system (CNS) as well as several peripheral organs. Clinically, it is well recognized that the prevalence of anxiety and depressio...
Hiroko Ikeda, Hiroko Ikeda, Junzo Kamei, Noriaki Koshikawa, Noriaki Koshikawa, Alexander R. Cools
Journal of Pharmacological Sciences   120 152-164   2012年11月   [査読有り]
Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson's disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they intera...
Masahiro Ohsawa, Masahiro Ohsawa, Masahiro Ohsawa, Junpei Mutoh, Megumi Asato, Shohei Yamamoto, Hideki Ono, Hiroaki Hisa, Junzo Kamei
European Journal of Pharmacology   682 56-61   2012年5月   [査読有り]
Carnosine is a biologically active dipeptide that is found in fish and chicken muscle. Recent studies have revealed that carnosine has neuroprotective activity in zinc-induced neural cell apoptosis and ischemic stroke. In the present study, we exa...
Masahiro Ohsawa, Anna Carlsson, Megumi Asato, Takayuki Koizumi, Yuki Nakanishi, Rebecca Fransson, Anja Sandström, Mathias Hallberg, Fred Nyberg, Junzo Kamei
Molecular Pain   7    2011年10月   [査読有り]
Background: Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite substance P1-7 (SP1-7) and its C-terminal amidated congener induced antihyperalgesic effects in diabetic mice. In this stud...
Hiroyasu Sakai, Akiko Fujita, Ayako Watanabe, Yoshihiko Chiba, Junzo Kamei, Miwa Misawa
Journal of Smooth Muscle Research   47 1-10   2011年8月   [査読有り]
Cigarette smoking is one of the main risk factors in the development of chronic obstructive pulmonary disease (COPD). It has been suggested that an augmented agonistinduced, RhoA mediated Ca 2+ sensitization is responsible for the enhanced bronchi...
Shigeo Miyata, Shoko Hirano, Masahiro Ohsawa, Junzo Kamei
Psychopharmacology   213 441-452   2011年2月   [査読有り]
Rationale: The traditional antihistamine chlorpheniramine ameliorates panic attacks, phobias, and lowered mood, and this therapeutic effect is independent of the blockade of histamine H 1 receptors. Since chlorpheniramine inhibits the reuptake of ...
J. Kamei, M. Ohsawa, S. S. Hayashi, Y. Nakanishi
Neuroscience   174 224-233   2011年2月   [査読有り]
Respiratory depression is the most well-known and dangerous side-effect of opioid analgesics. Clinical investigations have revealed that this opioid-induced respiratory depression is less severe in patients with chronic pain, but the mechanisms th...
Junzo Kamei, Yuki Nakanishi, Yoko Ishikawa, Shun Suke Hayashi, Megumi Asato, Masahiro Ohsawa
European Journal of Pharmacology   652 117-120   2011年2月   [査読有り]
We examined the involvement of tetrodotoxin (TTX)-resistant sodium channels in the peripheral mechanisms of the cough reflex in mice. We also examined the possibility of using ambroxol as an effective antitussive agent, and found that it produced ...
Masahiro Ohsawa, Anna Carlsson, Megumi Asato, Takayuki Koizumi, Yuki Nakanishi, Rebecca Fransson, Anja Sandström, Mathias Hallberg, Fred Nyberg, Junzo Kamei
Peptides   32 93-98   2011年1月   [査読有り]
We previously demonstrated that intrathecal treatment with substance P metabolite substance P1-7 induced anti-hyperalgesia in diabetic mice. In the present study, we have used a synthetic analog of this peptide, the substance P1-7 amide, showing h...
Masahiro Ohsawa, Megumi Aasato, Shun Suke Hayashi, Junzo Kamei
Pain   152 114-122   2011年1月   [査読有り]
Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. Several investigations have noted that many factors in the spinal cord are involved in the symptoms of painful diabetic neuropathy, ...
Maki Yoneko, Y. Katayama, N. Moro, J. Kamei, J. Kojima
Methods and Findings in Experimental and Clinical Pharmacology   32 727-731   2010年12月   [査読有り]
Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH). CSW induces excessive natriuresis and osmotic diuresis, reduces total blood volume, aggravates cerebral vasospasm and causes cerebral ischemia after SA...
M. Yoneko, Y. Katayama, T. Igarashi, T. Mori, N. Moro, Y. Kondo, J. Kamei, J. Kojima
Methods and Findings in Experimental and Clinical Pharmacology   32 475-480   2010年12月   [査読有り]
Cerebral salt wasting (CSW) frequently occurs concomitantly with an aneurysmal subarachnoid hemorrhage (SAH). CSW induces excessive natriuresis and osmotic diuresis, and reduces the total volume of blood. We previously reported that a rat model wi...
Masahiro Ohsawa, Junzo Kamei
European Journal of Pharmacology   644 1-4   2010年10月   [査読有り]
Diabetic neuropathy is one of the most common complications in diabetes, and hyperalgesia and allodynia are serious symptoms of diabetic neuropathy. There are few therapeutic options available for the treatment of such diabetic painful neuropathy....
Masahiro Ohsawa, Shun suke Hayashi, Junzo Kamei
European Journal of Pharmacology   641 49-53   2010年9月   [査読有り]
Mechanical allodynia is a major complication in diabetic mellitus. Peripheral Σ1 receptors were shown to be involved in nociceptive perception. We therefore investigated the effect of 1 receptor ligand (+)-pentazocine injected into the dorsal surf...
Anna Carlsson, Masahiro Ohsawa, Mathias Hallberg, Fred Nyberg, Junzo Kamei
European Journal of Pharmacology   626 250-255   2010年1月   [査読有り]
We have recently explored the role of the tachykinin substance P neuroactive fragment substance P1-7 in the mediation of anti-inflammatory effects using a blister model in the rat paw (Wiktelius et al., 2006). We observed that this heptapeptide in...
Junzo Kamei, Shigeo Miyata, Masahiro Ohsawa
Progress in Neuro-Psychopharmacology and Biological Psychiatry   33 1431-1437   2009年11月   [査読有り]
The traditional Japanese Kampo medicine Yokukansan (YKS, Yi-gan san in Chinese) has been demonstrated to improve the behavioral and psychological symptoms of dementia (BPSD), such as anxiety, hallucinations, agitation and irritability. The aim of ...
Noriyuki Ohkura, Masaki Fujimura, Johsuke Hara, Masahiro Ohsawa, Junzo Kamei, Shinji Nakao
Experimental Lung Research   35 296-306   2009年5月   [査読有り]
The aim of the present study was to investigate the relation between bronchoconstriction and cough induced by methacholine (Mch) inhalation and to elucidate the role of C-fibers and rapidly adapting irritant receptors (RARs) in these reactions in ...
Junzo Kamei, Masahiro Ohsawa, Shigeo Miyata, Shun ichi Tanaka
European Journal of Pharmacology   600 83-86   2008年12月   [査読有り]
Sensory abnormality is one of the serious complications in diabetes. Since the effective therapeutic regimen to ameliorate the diabetic sensory abnormality is very few, the present study was then designed to investigate the effect of zinc l-carnos...
Shigeo Miyata, Masahiro Ohsawa, Junzo Kamei
Folia Pharmacologica Japonica   132 213-216   2008年12月   [査読有り]
Junzo Kamei, Masahiro Ohsawa, Shigeo Miyata, Kazuki Endo, Hiroyuki Hayakawa
European Journal of Pharmacology   598 32-36   2008年11月   [査読有り]
Neuropathy accompanied by abnormal sensory perception is the most common complication in insulin-dependent and -independent diabetes mellitus. Since there are very few effective therapeutic regimens for sensory abnormalities in diabetes, we examin...
Junzo Kamei, Shigeo Miyata, Takayuki Sunohara, Atsuko Kamei, Masahiko Shimada, Masahiro Ohsawa
Journal of Pharmacological Sciences   108 381-384   2008年11月   [査読有り]
We examined the effect of the novel atypical antipsychotic drug aripiprazole alone or in combination with the selective serotonin reuptake inhibitor fluoxetine in the mouse tail suspension test. We also investigated the effect of aripiprazole on g...
Kou Takahashi, Akiyoshi Saitoh, Misa Yamada, Yoshiaki Maruyama, Noritaka Hirose, Junzo Kamei, Mitsuhiko Yamada
Journal of Pharmacological Sciences   108 320-334   2008年11月   [査読有り]
We investigated the effects of antidepressants on the gene expression profile and behavior of olfactory-bulbectomized (OBX) rats. Removal of the main olfactory bulbs in rats alters neuronal function in brain areas involved in emotional regulation,...
Junzo Kamei, Shunsuke Hayashi, Masahiro Ohsawa
Folia Pharmacologica Japonica   131 429-433   2008年8月   [査読有り]
Satoshi Sakami, Masayuki Maeda, Koji Kawai, Takumi Aoki, Kuniaki Kawamura, Hideaki Fujii, Hideaki Fujii, Ko Hasebe, Mayumi Nakajima, Takashi Endo, Shinya Ueno, Tsuyoshi Ito, Junzo Kamei, Hiroshi Nagase, Hiroshi Nagase
Journal of Medicinal Chemistry   51 4404-4411   2008年8月   [査読有り]
We have previously reported antitussive effects of naltrindole (NTI), a typical δ opioid receptor antagonist, in a rat model. The ED50 values of NTI by intraperitoneal and peroral injections were 104 μg/kg and 1840 μg/kg, respectively, comparable ...
Masahiro Ohsawa, Shigeo Miyata, Anna Carlsson, Junzo Kamei
European Journal of Pharmacology   588 213-216   2008年7月   [査読有り]
Hypoalgesia is one of the serious complications in diabetes. Since there are few therapeutic treatments for this diabetic hypoalgesia, the present study was designed to examine the effect of acetyl-L-carnitine (ALC) on the changes of nociceptive t...
Akiyoshi Saitoh, Mitsuhiko Yamada, Misa Yamada, Kou Takahashi, Kazumasa Yamaguchi, Hiroyasu Murasawa, Akiko Nakatani, Yoshimi Tatsumi, Noritaka Hirose, Junzo Kamei
Brain Research   1208 160-169   2008年5月   [査読有り]
The responses of olfactory bulbectomized (OBX) rats to antidepressant treatment are similar to those of depressed patients since chronic administration of an antidepressant reverses OBX-induced behavioral and physiological changes. Previously, usi...
Junzo Kamei, Yoshiki Takahashi, Takeshi Itabashi, Shunsuke Hayashi, Ken ichi Kawai
Pulmonary Pharmacology and Therapeutics   21 356-359   2008年4月   [査読有り]
We examined the sensitivity of the cough reflex to inhaled citric acid in guinea pigs that had been actively sensitized with the protein fraction of Aspergillus restrictus strain A-17. The number of coughs elicited by an aerosol of 5% citric acid ...
Tadashi Yamakawa, Keizo Ohnaka, Shun Ichi Tanaka, Hirotoshi Utsunomiya, Junzo Kamei, Kazuaki Kadonosono
Biomedical Research   29 1-8   2008年3月   [査読有り]
Lysophosphatidylcholine (lysoPC) stimulates the release of prostaglandins (PGs) in various cells and tissues. Cyclooxygenase (COX)-2 has recently emerged as a key regulator of PG synthesis. We investigated whether lysoPC regulates COX-2 expression...
Shigeo Miyata, Toshiko Shimoi, Shoko Hirano, Naoko Yamada, Yoko Hata, Naoki Yoshikawa, Masahiro Ohsawa, Junzo Kamei
Journal of Pharmacological Sciences   105 272-278   2007年11月   [査読有り]
Freezing behavior is thought to be a sign of fear in animals. We examined whether the freezing behavior during the elevated open-platform stress, which is a psychological stressor without painful stimulus, is modulated by serotonergic neurotransmi...
M. Yoneko, J. Kamei, C. F. Ito, Jun Kojima, Jun Kojima
Methods and Findings in Experimental and Clinical Pharmacology   29 389-394   2007年7月   [査読有り]
Several experimental chronic renal failure (CRF) models are available for testing new drugs. A CRF model induced by the intravenous injection of 2 mg/kg of doxorubicin (DXR) twice during a 20-day interval reportedly results in pathological charact...
Junzo Kamei, Shun suke Hayashi, Yoshiki Takahashi, Chihiro Nozaki
European Journal of Pharmacology   566 181-184   2007年7月   [査読有り]
The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced ...
Akiyoshi Saitoh, Kazumasa Yamaguchi, Yoshimi Tatsumi, Hiroyasu Murasawa, Akiko Nakatani, Noritaka Hirose, Misa Yamada, Mitsuhiko Yamada, Junzo Kamei
Psychopharmacology   191 857-865   2007年5月   [査読有り]
Rationale: It has been reported that many of the behavioral and serotonergic neuronal changes observed in olfactory bulbectomy (OBX) were improved by subchronic administration of a variety of antidepressants. Objective: We examined the effects of ...
Shoko Hirano, Shigeo Miyata, Kenji Onodera, Junzo Kamei
European Journal of Pharmacology   562 72-76   2007年5月   [査読有り]
It has been reported that chlorpheniramine, a classical antihistamine, has antidepressant-like effects in animal models of depression. In this study, we examined the involvement of dopaminergic (dopamine D1 and dopamine D2 receptors), noradrenergi...
Shigeo Miyata, Naoko Yamada, Shoko Hirano, Shun ichi Tanaka, Junzo Kamei
Brain Research   1147 233-239   2007年5月   [査読有り]
It is well established that diabetes widely affects the functioning of the central nervous system. However, no in vivo study assessed the serotonin (5-HT)-releasing system in the prefrontal cortex (PFC) and amygdala - the crucial regions regulatin...
Chihiro Nozaki, Junzo Kamei
European Journal of Pharmacology   560 160-162   2007年4月   [査読有り]
The effect of naloxonazine, a selective μ1-opioid receptor antagonist, on oxycodone-induced antinociception was examined in streptozotocin-induced diabetic mice. Oxycodone (5 mg/kg, s.c.) induced significant antinociception in both non-diabetic an...
Junzo Kamei, Noritaka Hirose, Takuma Oka, Shigeo Miyata, Akiyoshi Saitoh, Mitsuhiko Yamada
Journal of Pharmacological Sciences   103 175-180   2007年2月   [査読有り]
The most consistent behavioral changes caused by olfactory bulbectomy are hyperemotional responses such as hyperactivity in a novel environment. However, the changes in the emotional behavior of mice after undergoing olfactory bulbectomy have not ...
Shoko Hirano, Shigeo Miyata, Junzo Kamei
Pharmacology Biochemistry and Behavior   86 27-31   2007年1月
We previously reported that streptozotocin (STZ)-induced diabetic mice showed the depressive-like behavior in the tail suspension test. It has also been reported that leptin-deficient obese mice demonstrate the depressive-like behavior. Since STZ-...
Chihiro Nozaki, Junzo Kamei
European Journal of Pharmacology   552 99-104   2006年12月
The involvement of opioid receptor activation in the antinociceptive effect of either fluvoxamine, a selective serotonin reuptake inhibitor, or serotonin (5-HT) on thermal hyperalgesia and mechanical allodynia in a model of neuropathic pain in mic...
Akiyoshi Saitoh, Noritaka Hirose, Mitsuhiko Yamada, Misa Yamada, Chihiro Nozaki, Takuma Oka, Junzo Kamei
Journal of Pharmacological Sciences   102 377-386   2006年12月   [査読有り]
The most consistent behavioral change caused by olfactory bulbectomy (OBX) is a hyperemotional response to novel environmental stimuli. The aim of this study was to characterize the emotional behavior of OBX mice using the hole-board test. After t...
Junzo Kamei, Yoshiki Takahashi
European Journal of Pharmacology   547 160-164   2006年10月   [査読有り]
We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes. Although the inhalation of 0.1 M citric acid by itself produced only a few coughs in guin...
Hajime Kubo, Mai Inoue, Junzo Kamei, Kimio Higashiyama
Biological and Pharmaceutical Bulletin   29 2046-2050   2006年10月   [査読有り]
(-)-Multiflorine isolated from leguminous plants produces a hypoglycemic effect when administered to mice with streptozotocin-induced diabetes. (-)-Multiflorine has an enaminone-type conjugation on the A ring, which is unusual in lupine alkaloids....
Akiyoshi Saitoh, Mitsuhiko Yamada, Misa Yamada, Shinya Kobayashi, Noritaka Hirose, Kazuo Honda, Junzo Kamei
Psychopharmacology   188 1-11   2006年9月   [査読有り]
Rationale: The role of Rho/Rho-associated kinase (ROCK) in regulating dendritic and axonal morphology during development has gained much attention. Very little is known, however, about the role of the Rho/ROCK pathway in emotional behavior. Object...
Shigeo Miyata, Shoko Hirano, Junzo Kamei
Psychopharmacology   186 1-6   2006年5月   [査読有り]
Rationale: We previously reported that the head-twitch responses induced by the 5-HT2 receptor agonist (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) (DOI-HTRs) were decreased in streptozotocin-induced diabetic mice. Objectives: We examined the involve...
Shigeo Miyata, Akiyoshi Saitoh, Shoko Hirano, Junzo Kamei
Japanese Journal of Neuropsychopharmacology   26 83-87   2006年4月   [査読有り]
The prevalence of cognitive disorder, depression, and anxiety is about 2-fold higher in diabetic patients than in the general population. This higher prevalence is also observed in Japanese patients with diabetes. It has been reported that strepto...
Junzo Kamei, Chihiro Nozaki, Akiyoshi Saitoh
European Journal of Pharmacology   536 123-127   2006年4月   [査読有り]
In the present study, we examined the effect of mexiletine on vincristine-induced thermal hyperalgesia in mice. Mice were intraperitoneally treated with vincristine at a dose of 0.05 mg/kg one day after the measurement of the pre-drug latency in t...
Chihiro Nozaki, Akiyoshi Saitoh, Junzo Kamei
European Journal of Pharmacology   535 145-151   2006年3月   [査読有り]
We investigated the antinociceptive efficacy of systemic and centrally injected oxycodone on thermal hyperalgesia in streptozotocin-induced diabetic mice. The antinociceptive response was assessed by recording the latency in the tail-flick test us...
Shoko Hirano, Shigeo Miyata, Kenji Onodera, Junzo Kamei
Pharmacology Biochemistry and Behavior   83 214-220   2006年2月   [査読有り]
We previously reported that streptozotocin-induced diabetic mice showed depressive-like behavior in the tail suspension test. It is well known that the central histaminergic system regulates many physiological functions including emotional behavio...
Yoshihiko Chiba, Masahiko Murata, Hiroko Ushikubo, Yuji Yoshikawa, Akiyoshi Saitoh, Hiroyasu Sakai, Junzo Kamei, Miwa Misawa
American Journal of Respiratory Cell and Molecular Biology   33 574-581   2005年12月   [査読有り]
Cigarette smoking is a risk factor for the development of airway hyperresponsiveness and chronic obstructive pulmonary disease. Little is known concerning the effect of cigarette smoking on the contractility of airway smooth muscle. The current st...
Shigeo Miyata, Shoko Hirano, Junzo Kamei
Pharmacology Biochemistry and Behavior   82 615-620   2005年12月   [査読有り]
We previously reported that streptozotocin (STZ)-induced diabetic mice exhibited depressive-like behavior in the tail suspension test. In this study, we examined the involvement of benzodiazepine receptor functions in this diabetes-induced depress...
Junzo Kamei, Yoshiki Takahashi, Yuji Yoshikawa, Akiyoshi Saitoh
European Journal of Pharmacology   528 158-161   2005年12月   [査読有り]
We examined the effect of inhaled ATP on the chemical irritant-induced coughs to clarify the roles of ionotropic purinergic receptors in these modulations. Although inhalation of 0.1 M citric acid by itself produced only a few coughs in guinea pig...
Akiyoshi Saitoh, Yuji Yoshikawa, Kenji Onodera, Kenji Onodera, Junzo Kamei
Psychopharmacology   182 327-334   2005年11月   [査読有り]
Rationale: Recent studies have shown that endogenous opioid systems are associated with the regulation of emotional responses. In particular, it has been reported that δ-opioid receptors act naturally to inhibit stress and anxiety. Objective: The ...
Chihiro Nozaki, Akiyoshi Saitoh, Naoya Tamura, Junzo Kamei
European Journal of Pharmacology   524 75-79   2005年11月   [査読有り]
The effect of oxycodone on thermal hyperalgesia in streptozotocin-induced diabetic mice was examined. The antinociceptive response was assessed by recording the latency in the tail-flick test using the radiant heat from a 50-W projection bulb on t...
Junzo Kamei, Shigeo Miyata, Masashi Takahashi, Akiyoshi Saitoh
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.   25 221-225   2005年10月   [査読有り]
It is well accepted that diabetes leads to learning and memory impairment in humans and rodents. Because central delta-opioid receptors have important roles in learning processes, we investigated the involvement of delta-opioid receptors in the sp...
Junzo Kamei, Shigeo Miyata, Masashi Takahashi, Akiyoshi Saitoh
Japanese Journal of Neuropsychopharmacology   25 221-225   2005年10月   [査読有り]
It is well accepted that diabetes leads to learning and memory impairment in humans and rodents. Because central δ-opioid receptors have important roles in learning processes, we investigated the involvement of δ-opioid receptors in the spatial le...
Hirotoshi Utsunomiya, Tadashi Yamakawa, Junzo Kamei, Kazuaki Kadonosono, Shun Ichi Tanaka
Biomedical Research   26 193-200   2005年10月   [査読有り]
Dried plums, considered a healthy food in the West and used as medicine in India, contain phenolic compounds with protective actions against age-related diseases. Effects of oral plum ekisu (concentrated juice) on lipid and glucose tolerance were ...
Junzo Kamei, Naoya Tamura, Akiyoshi Saitoh
Pain   117 112-120   2005年9月   [査読有り]
The mechanisms that underlie the development of vincristine-induced painful neuropathy are poorly understood. The nitric oxide (NO)-cGMP pathway has been reported to be involved in the spinal transmission of nociceptive information. In the present...
Masahiro Ohsawa, Masahiro Ohsawa, Junzo Kamei
Journal of Pharmacological Sciences   98 25-32   2005年5月   [査読有り]
The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular...
Kimio Higashiyama, Yosuke Takeuchi, Takayasu Yamauchi, Satoshi Imai, Junzo Kamei, Yoshinori Yajima, Minoru Narita, Tsutomu Suzuki
Biological and Pharmaceutical Bulletin   28 845-848   2005年5月   [査読有り]
We previously reported that either (+)-matrine (matridin-15-one) or (+)-allomatrine (the C-6 epimer of matrine)-induced antinociceptive effect was attenuated by s.c. pretreatment with a κ-opioid receptor (KOR) antagonist nor-binaltorphimine (nor-B...
Junzo Kamei, Shoko Hirano, Shigeo Miyata, Akiyoshi Saitoh, Kenji Onodera
Journal of Pharmacological Sciences   97 266-272   2005年2月   [査読有り]
The second-generation histamine-H1-receptor antagonists, such as epinastine and cetirizine, are used as non-sedating antihistamines for treating allergic symptoms due to their poor ability to penetrate blood-brain barrier. Because it has been repo...
Junzo Kamei, Akiyoshi Saitoh, Takayuki Asano, Rie Nakamura, Hiroyuki Ichiki, Akira Iiduka, Masayoshi Kubo
European Journal of Pharmacology   507 163-168   2005年1月   [査読有り]
We examined the pharmacokinetic and pharmacodynamic properties of liquiritin apioside, a main antitussive component of Glycyrrhizae radix (licorice), with regard to its antitussive effect in guinea pigs. The peak plasma concentration of the unchan...
Junzo Kamei, Kiyotaka Katsuma, Yutaka Kasuya
Naunyn-Schmiedeberg's Archives of Pharmacology   345 203-208   2004年12月   [査読有り]
The effect of pentazocine on the capsaicininduced cough reflex in rats was investigated. Intraperitoneal injection of pentazocine, in doses from 1 to 10 mg/kg, significantly decreased the number of coughs in a dose-dependent manner. The antitussiv...
A. Takahashi, T. Saito, H. Mayanagi, J. Kamei, K. Onodera
Methods and Findings in Experimental and Clinical Pharmacology   26 769-773   2004年12月   [査読有り]
This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histo...
Shigeo Miyata, Shoko Hirano, Junzo Kamei
Psychopharmacology   177 224-229   2004年12月   [査読有り]
Rationale: Clinical studies suggest that the prevalence of psychiatric disorders is higher in diabetic patients than in the general population. It has been reported that central serotonin2A (5-HT2A) receptors may be involved in the pathogenesis an...
Junzo Kamei, Akiyoshi Saitoh, Naoya Tamura
Journal of Pharmacological Sciences   96 280-285   2004年11月   [査読有り]
The effect of mexiletine on the nociceptive behavior induced by the intrathecal injection of fenvalerate, which predominantly activates tetrodotoxin-resistant (TTX-R) sodium channels, was studied in diabetic mice. The intrathecal injection of fenv...
Junzo Kamei, Yasuhiro Matsunawa, Akiyoshi Saitoh
European Journal of Pharmacology   497 233-239   2004年8月   [査読有り]
Several reports have demonstrated that the number of capsaicin-induced coughs is increased in the presence of prostaglandins in the airway. Moreover, it has been reported that the expression of cyclooxygenase-2, which converts arachidonic acid to ...
Akiyoshi Saitoh, Yuji Kimura, Tomohiko Suzuki, Koji Kawai, Hiroshi Nagase, Junzo Kamei
Journal of Pharmacological Sciences   95 374-380   2004年7月   [査読有り]
In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1- piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a non-peptidic selective δ-opioid receptor agonist,...
Junzo Kamei, Yasuhiro Matsunawa, Shigeo Miyata, Shun Ichi Tanaka, Akiyoshi Saitoh
European Journal of Pharmacology   489 77-87   2004年4月   [査読有り]
The effects of nociceptin on the exploratory behavior of mice were examined using an automatic hole-board apparatus. A low dose of nociceptin (0. 01 nmol, i.c.v.) had an anxiolytic effect, as reflected by an increase in head-dipping behavior. Howe...
Shigeo Miyata, Shoko Hirano, Junzo Kamei, Junzo Kamei
Neuropsychopharmacology   29 461-469   2004年3月   [査読有り]
Several lines of evidence have indicated that the prevalence of depression in diabetic subjects is higher than that in the general population, however, little information is available on the effects of antidepressants in diabetes. In the present s...
S. I. Tanaka, S. I. Tanaka, S. I. Tanaka, T. Yamakawa, M. Kimura, I. Aoki, J. Kamei, K. Okuda, C. Mobbs
Diabetes Research and Clinical Practice   63 1-9   2004年1月   [査読有り]
The present study examined the feasibility of liposome-mediated gene transfer via nasal administration, for treating insulin-dependent diabetes mellitus. The rat insulin gene was packed under control of the CMV promoter, complexed with DC-chol/DOP...
Akiyoshi Saitoh, Kayo Morita, Keiichi Ueno, Yoshio Yamaki, Toshio Takizawa, Takahisa Tokunaga, Junzo Kamei
Nippon Nogeikagaku Kaishi   77 1242-1245   2003年12月   [査読有り]
Rosemary, plantago, and tea tree oil have been customarily used for the treatment of the common cold, but the detailed mechanisms of these antitussive effects are not well known. Thus, the aim of this study was to assess the antitussive properties...
Tadashi Yamakawa, Shun Ichi Tanaka, Junzo Kamei, Kazuaki Kadonosono, Kenji Okuda
European Journal of Pharmacology   478 39-46   2003年9月   [査読有り]
Activation of 4E-binding protein 1 (4E-BP1) by growth factors regulates protein synthesis in vascular smooth muscle cells. The interaction between G protein-coupled receptors and activated 4E-BP1 is unclear. We examined phosphadityl inositol (PI) ...
Kayo Morita, Junzo Kamei
European Journal of Pharmacology   474 269-272   2003年8月   [査読有り]
Several lines of evidence indicate that the opioid and cannabinoid systems produce synergistic interactions. The present study examined the opioid receptors involved in the antitussive effect of WIN 55212-2 ((R)-(+)-[2,3- dihydro-5-methyl-3-[4-mor...
Tadashi Yamakawa, Shun ichi Tanaka, Junzo Kamei, Kazuaki Kadonosono, Kenji Okuda
Journal of atherosclerosis and thrombosis   10 37-42   2003年6月   [査読有り]
We recently reported that lysophosphatidylcholine (lysoPC) acts on vascular smooth muscle cells ( VSMCs ) to produce a mitogenic response through the activation of extracellular signal-regulated kinases 1/2 (ERK1/2). In this study, we examined the...
Junzo Kamei, Shigeo Miyata, Kayo Morita, Akiyoshi Saitoh, Hiroshi Takeda
Pharmacology Biochemistry and Behavior   75 247-254   2003年5月   [査読有り]
We examined the effects of fluoxetine and fluvoxamine, selective serotonin reuptake inhibitors (SSRIs), and desipramine, a selective noradrenaline (NA) reuptake inhibitor, given alone or in combination with diazepam on immobility time in the tail ...
Junzo Kamei, Rie Nakamura, Hiroyuki Ichiki, Masayoshi Kubo
European Journal of Pharmacology   469 159-163   2003年5月   [査読有り]
We attempted to elucidate the antitussive principles of Glycyrrhizae radix, a main component of Bakumondo-to (Mai-men-dong-tang). Although the 50% methanol-eluted fraction (100 mg/kg, p.o.) caused a more than 60% reduction in the number of capsaic...
Akiyoshi Saitoh, Kazumasa Yamaguchi, Hiroyasu Murasawa, Junzo Kamei
Japanese Journal of Neuropsychopharmacology   23 75-82   2003年4月   [査読有り]
With the recent appearance of SSRI and SNRI, medication options with respect to depression have broadened. However, patients displaying clear improvement with existing antidepressants still do not exceed about 60 percent of total patients. New typ...
Atsushi Takahashi, Kenji Onodera, Junzo Kamei, Shinobu Sakurada, Hisashi Shinoda, Shuichi Miyazaki, Takashi Saito, Hideaki Mayanagi
Journal Pharmacological Sciences   91 313-318   2003年4月   [査読有り]
We investigated the effects of chronic administration of zonisamide, an antiepileptic agent, on bone metabolism in growing rats. Administration of zonisamide at a dose of 80 mg/kg per day, s.c. for 5 weeks significantly decreased bone mineral dens...
Junzo Kamei, Kayo Morita, Akiyoshi Saitoh, Hiroshi Nagase
European Journal of Pharmacology   467 219-222   2003年4月   [査読有り]
The antitussive effects of endomorphin-1 and endomorphin-2, endogenous μ-opioid receptor agonists, on capsaicin-induced coughs were examined in mice. Endomorphin-2, at doses of 3, 10 and 30 μg, i.c.v., dose-dependently inhibited the number of caps...
Junzo Kamei, Kayo Morita, Shigeo Miyata, Kenji Onodera
Psychopharmacology   166 176-180   2003年3月   [査読有り]
Rationale: Little information is available about the interaction between dihydrocodeine and second-generation antihistamine drugs such as cetirizine and ebastine, with particular reference to the rewarding effect of dihydrocodeine. Objective: The ...
Kazuo Isomae, Shinichi Morimoto, Hiroshi Hasegawa, Kayo Morita, Junzo Kamei
European Journal of Pharmacology   465 97-103   2003年3月   [査読有り]
Effects of 2-[2-(1-benzylpiperidin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo[3,4-b] quinolin-1-one hemifumarate (T-82), a new quinoline derivative, on drug- and basal forebrain lesion-induced amnesia models were examined in rats. Scopolamine (0...
J. Kamei, K. Onodera, M. Kawaguchi, M. Shibata, M. Kagawa, M. Wachi, J. Kojima
Methods and Findings in Experimental and Clinical Pharmacology   24 493-496   2002年10月   [査読有り]
A study of the different volume and infusion rates of a new maintenance fluid, Veen 3G, on the general conditions of rats was investigated during the 14 days after infusion. In Experiment 1, 100 ml/kg and 200 ml/kg of Veen 3G were infused at a rat...
Ko Zushida, Kenji Onodera, Junzo Kamei
European Journal of Pharmacology   453 209-215   2002年10月   [査読有り]
The antinociceptive effects of pinacidil, an adenosine triphosphate (ATP)-sensitive K+i (KATP) channel opener, were examined using the tail-flick test in non-diabetic and diabetic mice. Pinacidil i.c.v. produced dose-dependent antinociception in b...
Junzo Kamei, Emiko Iguchi, Mitsumasa Sasaki, Ko Zushida, Kayo Morita, Shun ichi Tanaka
Brain Research   948 17-23   2002年9月   [査読有り]
We examined the effect of diabetes on the fenvalerate-induced nociceptive response in mice. The intrathecal (i.t.) or intraplantar (i.pl.) injection of fenvalerate, a sodium channel activator, induced a characteristic behavioral syndrome mainly co...
Junzo Kamei, Ko Zushida, Shigeo Miyata
Japanese Journal of Psychopharmacology   22 121-129   2002年8月   [査読有り]
Diabetic neuropathy is a most-convoluted complication. Diabetic gastropathy, ulcers, diarrhea, and bladder dysfunction are the major peripheral neuropathies. Peripheral neuropathies have been the primary neuroscience focus of diabetes research. In...

Misc

 
Junzo Kamei, Akiyoshi Saitoh, Masahiro Ohsawa, Tsutomu Suzuki, Miwa Misawa, Hiroshi Nagase, Yutaka Kasuya
European Journal of Pharmacology   280 347   1995年7月
The antinociceptive potencies of 2-methyl-4aα-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aα-octahydro-quinolino[2,3,3-g]isoquinoline (TAN-67), a non-peptidic δ-opioid receptor agonist, were examined using the acetic acid abdominal constriction test and t...
J. Kamei, N. Kawashima, Y. Iwamoto, T. Suzuki, H. Nagase, M. Misawa, Y. Kasuya
Regulatory Peptides   53    1994年2月
J. Kamei, H. Tanihara, Y. Kasuya
New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914   341   1990年1月
Results of an examination of the effectiveness of the selective opioid agonists for the μ, δ and κ receptors suggest that, 1) antitussive effects are mediated by both μ and κ receptors, and 2) δ receptors may play an inhibitory role in antitussive...

競争的資金等の研究課題

 
糖尿病とオピオイドの薬理作用
咳嗽反射の薬理学的研究