Hidenori Ichijo

Profile Information

Affiliation: 教授 (創薬機構長), 大学院薬学系研究科細胞情報学教室, 東京大学

Degree: Ph.D.(Tokyo Medical and Dental University)

J-GLOBAL ID: 200901099281210828
researchmap Member ID: 1000240551

External link: https://saijyou.f.u-tokyo.ac.jp/index.html

Research Interests

Research Areas

Research History

Sep, 2002 - Present

Professor, Graduate School of Farmaceutical Sciences, The University of Tokyo
Apr, 2000 - Mar, 2003

Professor, Graduate School of Medical and Dental Sciences,, Tokyo Medica and Dentall University
Feb, 1998 - Mar, 2000

Professor, Faculty of Dentistry, Tokyo Medica and Dentall University
May, 1997 - Jan, 1998

Senior Researcher, Biochemistry, The Cancer Institute of Jpanese Foundation for Cancer Research
Apr, 1995 - Apr, 1997

Researcher, Biochemistry, The Cancer Institute of Jpanese Foundation for Cancer Research
Apr, 1992 - Mar, 1995

Tokyo Medica and Dentall University
Apr, 1990 - Mar, 1993

Researcher, Uppsala Branch, Ludwig Cancer Research

Education

Apr, 1986 - Mar, 1990

Doctoral course, Graduate School of Dental Sciences, Tokyo Medical and Dental University
Apr, 1979 - Mar, 1985

Faculty of Dentistry, Tokyo Medical and Dental University

Committee Memberships

Awards

Papers

252

Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP

Yuki Hayashi, Hidenori Ichijo

Autophagy, Apr 10, 2024
TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins.

Yuki Hayashi, Sho Takatori, Waleed Y Warsame, Taisuke Tomita, Takao Fujisawa, Hidenori Ichijo

The EMBO journal, e114272, Nov 6, 2023
Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.

Shoko Ito, Keisuke Kuromiya, Miho Sekai, Hiroaki Sako, Kazuhito Sai, Riho Morikawa, Yohei Mukai, Yoko Ida, Moe Anzai, Susumu Ishikawa …

Proceedings of the National Academy of Sciences of the United States of America, 120(43) e2307118120, Oct 24, 2023
Zinc controls histone acetyltransferase KAT7 activity to maintain cellular zinc homeostasis

Takao Fujisawa, Satoshi Takenaka, Lila Maekawa, Toshiyuki Kowada, Toshitaka Matsui, Shin Mizukami, Isao Naguro, Hidenori Ichijo

Oct 19, 2023
Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress

Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo

May 23, 2023
Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response.

Kazuhiro Morishita, Kengo Watanabe, Isao Naguro, Hidenori Ichijo

Cell reports, 112315-112315, Mar 29, 2023
DNA damage response signaling to mitochondria drives senescence

Shota Yamauchi, Yuki Sugiura, Junji Yamaguchi, Xiangyu Zhou, Takeru Odawara, Shunsuke Fukaya, Isao Naguro, Yasuo Uchiyama, Hidenori Ichijo

Sep 22, 2022
NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress.

Takuto Nishida, Isao Naguro, Hidenori Ichijo

Cell death discovery, 8(1) 195-195, Apr 11, 2022
mTOR-AKT Signaling in Cellular Clock Resetting Triggered by Osmotic Stress.

Hikari Yoshitane, Kiyomichi Imamura, Takenori Okubo, Yuta Otobe, Satoshi Kawakami, Shunsuke Ito, Toru Takumi, Kazuki Hattori, Isao Naguro, Hidenori Ichijo …

Antioxidants & redox signaling, Mar 18, 2022
ASK1 signaling regulates phase-specific glial interactions during neuroinflammation

Xiaoli Guo, Atsuko Kimura, Kazuhiko Namekata, Chikako Harada, Nobutaka Arai, Kohsuke Takeda, Hidenori Ichijo, Takayuki Harada

Proceedings of the National Academy of Sciences of the United States of America, 119(6), Feb 8, 2022 Peer-reviewed
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo

Nature Communications, 12(1), Dec, 2021
ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes.

Saki Takayanagi, Kengo Watanabe, Takeshi Maruyama, Motoyuki Ogawa, Kazuhiro Morishita, Mayumi Soga, Tomohisa Hatta, Tohru Natsume, Tomoya Hirano, Hiroyuki Kagechika …

Scientific reports, 11(1) 22009-22009, Nov 10, 2021
Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.

Haruka Matsui, Takayuki Iriyama, Seisuke Sayama, Naoko Inaoka, Kensuke Suzuki, Midori Yoshikawa, Mari Ichinose, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu …

Placenta, 115 60-69, Nov, 2021
Functional cooperation between ASK1 and p21^Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Carlo De Blasio, Nagendra Verma, Marta Moretti, Samantha Cialfi, Azzurra Zonfrilli, Matteo Franchitto, Federica Truglio, Enrico De Smaele, Hidenori Ichijo, Isao Naguro …

Cell Death Discovery, 7(1), Jun, 2021
Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis.

Kazuki Kojima, Hidenori Ichijo, Isao Naguro

Journal of biochemistry, 169(4) 395-407, Apr 29, 2021
FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

Motoyuki Ogawa, Yosuke Kawarazaki, Yasuyuki Fujita, Isao Naguro, Hidenori Ichijo

Current Biology, 31(5) 1048-1057.e5, Mar 8, 2021
ASK1 suppresses NK cell‐mediated intravascular tumor cell clearance in lung metastasis

Makoto Fujimoto, Miki Kamiyama, Kosuke Fuse, Hiroki Ryuno, Takeru Odawara, Natsuki Furukawa, Yasuhiro Yoshimatsu, Tetsuro Watabe, Michaela Prchal‐Murphy, Veronika Sexl …

Cancer Science, Mar 6, 2021
The mitochondrial Ca²⁺ uptake regulator, MICU1, is involved in cold stress-induced ferroptosis

Toshitaka Nakamura, Motoyuki Ogawa, Kazuki Kojima, Saki Takayanagi, Shunya Ishihara, Kazuki Hattori, Isao Naguro, Hidenori Ichijo

EMBO Reports, 2021
The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression.

Taku Ito-Kureha, Takahisa Miyao, Saori Nishijima, Toru Suzuki, Shin-Ichi Koizumi, Alejandro Villar-Briones, Akinori Takahashi, Nobuko Akiyama, Masahiro Morita, Isao Naguro …

Nature communications, 11(1) 6169-6169, Dec 2, 2020
ASK1 promotes uterine inflammation leading to pathological preterm birth

Midori Yoshikawa, Takayuki Iriyama, Kensuke Suzuki, Seisuke Sayama, Tetsushi Tsuruga, Keiichi Kumasawa, Takeshi Nagamatsu, Kengo Homma, Isao Naguro, Yutaka Osuga …

Scientific Reports, 10(1), Dec 1, 2020

Misc.

129

Cell competition induced by Scribble deficiency in cultured mammalian cells

小川基行, 名黒功, 一條秀憲

医学のあゆみ, 274(5), 2020
Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews …

Cell Death and Differentiation, 25(3) 486-541, Mar 1, 2018
ASK1キナーゼによるレドックスシグナル制御−多彩な翻訳後修飾を介したシASK1キナーゼによるレドックスシグナル制御−多彩な翻訳後修飾を介したシグナル制御とその破綻による疾患

松沢厚, 一條秀憲

実験医学増刊「レドックス疾患学」, 36(5) 692-698, 2018
Foreword

Hidenori Ichijo

Advances in Biological Regulation, 66 1, Dec 1, 2017
プロテインキナーゼ:生理機能へのアプローチとリン酸化解析の統合ストレスシグナルを概日時計に入力するストレス応答性キナーゼASK

今村聖路, 吉種光, 服部一輝, 名黒功, 一條秀憲, 深田吉孝

生命科学系学会合同年次大会, 2017年度 [2PW15-2(3P, Dec, 2017
Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice.

Maruoka S, Gon y, Mizumura K, Okamoto S, Tsuya K, Shikano S, Soda K, Naguro I, Ichijo H, Hashimoto S

Allergol International, 2017
Mitogen-activated protein kinases as key players in osmotic stress signaling

Xiangyu Zhou, Isao Naguro, Hidenori Ichijo, Kengo Watanabe

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1860(9) 2037-2052, Sep, 2016
AS K1 regulates tumor lung metastasis and platelet functions

M. Kamiyama, I. Naguro, H. Ichijo

THROMBOSIS RESEARCH, 140 S182-S182, Apr, 2016
概日時計は細胞ストレスに応答する

今村聖路, 吉種光, 服部一輝, 山口光男, 名黒功, 一條秀憲, 深田吉孝

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.3P‐0374 (WEB ONLY), 2016
Roquin‐2によるASK1の活性制御を介した免疫応答の調節

工藤勇気, 平田祐介, 野口拓也, 一條秀憲, 松沢厚

日本生化学会大会(Web), 88th 4T6L-04(3P0224) (WEB ONLY)-04(3P0224)], Dec, 2015
RING型ユビキチンリガーゼTRIM48によるストレス応答キナーゼASK1の活性制御機構の解明

森下徹, 平田祐介, 野口拓也, 一條秀憲, 松沢厚

日本生化学会大会(Web), 88th 4T17L-01(3P0392) (WEB ONLY)-01(3P0392)], Dec, 2015
東京大学創薬機構の取り組み (創刊50周年記念号) -- (記念特集医薬品開発における産官学連携の展望)

小島宏建, 岡部隆義, 一條秀憲

医薬ジャーナル, 51(10) 81-88, Oct, 2015
Research supporting platform for academic drug discovery in Japan

Hirotatsu Kojima, Takayoshi Okabe, Hidenori Ichijo, Tetsuo Nagano

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 250, Aug, 2015
Mitochondrial proteolysis: Its emerging roles in stress responses

Shiori Sekine, Hidenori Ichijo

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1850(2) 274-280, Feb, 2015
Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015

L. Galluzzi, J. M. Bravo-San Pedro, I. Vitale, S. A. Aaronson, J. M. Abrams, D. Adam, E. S. Alnemri, L. Altucci, D. Andrews, M. Annicchiarico-Petruzzelli …

Cell Death and Differentiation, 22(1) 58-73, Jan 1, 2015
ASK1 is involved in tumor lung metastasis through regulation of platelet functions

Miki Kamiyama, Isao Naguro, Hidenori Ichijo

CANCER RESEARCH, 75(1), Jan, 2015
The function of ASK1 that responds to oxidative stress and its involvement in diseases

247(9) 746-752, Nov 30, 2013
The Role of Zinc and ER Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis

TSUBURAYA Naomi, HOMMA Kengo, NISHITOH Hideki, ICHIJO Hidenori

Biomedical research on trace elements, 23(1) 14-23, Apr 27, 2012
Oxidative stress-induced diseases via the ASK1 signaling pathway

Mayumi Soga, Atsushi Matsuzawa, Hidenori Ichijo

International Journal of Cell Biology, 2012
Dysregulation of Stress-Responsive Kinase Signaling Pathway and Disease

松沢厚, 一條秀憲

細胞工学, 31(2) 138-143, 2012

Professional Memberships

Jun, 1985 - Present

口腔病学会
Jun, 1989 - Present

日本癌学会
Jul, 1993 - Present

歯科基礎医学会
May, 1995 - Present

日本生化学会
Oct, 1997 - Present

日本分子生物学会
Dec, 2002 - Present

日本薬学会
Apr, 2003 - Present

日本口腔科学会
Dec, 2003 - Present

日本薬理学会
Dec, 2005 - Present

日本臨床ストレス応答学会
Jun, 2009 - Present

日本がん分子標的治療学会
Jan, 2010 - Present

日本Cell Death学会
Oct, 2011 - Present

日本学術会議

Research Projects

幹細胞、細胞死、細胞老化に着目した生体内微小環境ネットワーク解析

ムーンショット型研究開発制度, 内閣府, 2020 - 2025

一條秀憲
Elucidation of a novel lysosomal degradation pathway for aberrant membrane proteins at the endoplasmic reticulum

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2021 - 2024
物理化学的ストレスに起因する老化制御シグナル伝達機構

老化メカニズムの解明・制御プロジェクト, 日本医療研究開発機構, 2017 - 2021

一條秀憲
Elucidation of the ASK family-regulated mechanism of cancer metastasis and search for inhibitors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

Ichijo Hidenori
Molecular understanding of osmotic stress sensing and response

Grant-in-Aid for Scientific Research(A), JSPS, 2018 - 2020

Hidenori Ichijo
International netoworking on cell competition for the next generation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Nov, 2015 - Mar, 2019

Fujita Yasuyuki, Tada Masazumi, Levayer Romain, Dahmann Christian, Toyama Yusuke, Hyman Anthony, Yan Yan, Bach Erika, Vittelo Elisa, Elleni Bali
Cell competition: a mechanism for survival of the fittest in the multi-cellular community

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019

Fujita Yasuyuki
Post-translational modifications of a mitochondria-resident protein and its role in systemic regulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

ICHIJO Hidenori
Generation of a marmoset model of normal tension glaucoma and investigation into neuroprotection and neuroregeneration for glaucoma therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

HARADA Takayuki, SASAKI Erika, ISHIDA Susumu, MITAMURA Yoshinori, ICHIJO Hidenori, TOKUNO Hironobu, NAMEKATA Kazuhiko
Exploring stress-responsive molecules involved in cell competition

Grant-in-Aid for Scientific Research on Innovative Areas, MEXT, 2014 - 2018

ICHIJO Hidenori
Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development

Grant-in-Aid for Scientific Research(S), JSPS, 2013 - 2017

ICHIJO Hidenori
A novel purification method for endogenous protein using ASKA technique

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

ICHIJO Hidenori
ストレスシグナルによる炎症制御と炎症慢性化機構の解明

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2013 - Mar, 2014

一條秀憲
生涯に亘って心身の健康を支える脳の分子基盤、環境因子、その失調の解明

脳科学研究戦略推進プログラム, 文部科学省, 2010 - 2014

一條秀憲
Involvement of lipid-metabolizing enzymes in stress response

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

ICHIJO Hidenori
小胞体ストレス-ASK1経路を標的とした筋萎縮性側索硬化症治療薬の基盤開発

保健医療分野における基礎研究推進事業, 医薬基盤研究所, 2008 - 2012

一條秀憲
Drug development by the molecular mechanism-based analysis of stress signaling

Grant-in-Aid for Scientific Research(S), JSPS, 2008 - 2012

ICHIJO Hidenori
RNAiスクリーニングによる浸透圧応答性キナーゼの活性制御因子群の探索

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2008 - 2009

一條秀憲
ストレス応答の分子機構〜結合タンパク質群によるASKファミリー活性制御の構造的分子基盤〜

ターゲットタンパクプログラム, 文部科学省, 2007 - 2009

一條秀憲
Regulation of cell proliferation and cell death by stress signaling in cancer

Grant-in-Aid for Scientific Research on Innovative Areas(2), Grant-in-Aid for Scientific Research on Priority Areas, MEXT, 2005 - 2009

ICHIJO Hidenori

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