SUGIURA Kikuya

J-GLOBAL         Last updated: Jul 26, 2017 at 15:23
 
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Name
SUGIURA Kikuya
Affiliation
Osaka Prefecture University
Section
Graduate School of Life and Environmental Sciences, Division of Veterinary Sciences
Job title
Professor
Degree
Doctor(Medicine)(Kansai Medical University)

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
Oct 2001
 - 
Mar 2017
Associate Professor, Osaka Prefecture University
 
Jun 1999
 - 
Sep 2001
Asistant Professor, Kansai Medical University
 
Apr 1984
 - 
May 1999
Research Associate, Kansai Medical University
 
 
   
 
(Fuculty of Medicine)
 
 
   
 
(Fuculty of Medicine)
 

Education

 
 
 - 
1984
Veterinary Medicine, Graduate School, Division of Agriculture, Yamaguchi University
 
 
 - 
1982
Veterinary Madicine, Faculty of Agriculture, Yamaguchi University
 

Awards & Honors

 
1994
Inoue Research Award for Youg Scientists
 

Misc

 
Feeder-independent canine induced pluripotent stem cells maintained under serum-free conditions.
Nishimura T, Hatoya S, Kanegi R, Wijesekera DPH, Sanno K, Tanaka E, Sugiura K, Hiromitsu Tamada NK, Imai H, Inaba T.
Mol. Reprod. Dev   84(4) 329-339   Apr 2017
Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy.
Koyama Y, Ito T, Hasegawa A, Eriguchi M, Inaba T, Ushigusa T, Sugiura K.
Biotechnol. Lett.   38(11) 1857-1866   Nov 2016
Production of feline leukemia inhibitory factor with biological activity in Escherichia coli.
Kanegi R, Hatoya S, Tsujimoto Y, Takenaka S, Nishimura T, Wijewardana V, Sugiura K, Takahashi M, Kawate N, Tamada H, Inaba T.
Theriogenology   86(2) 604-611   Jul 2016
pH-sensitive polymer-liposome-based antigen delivery systems potentiated with interferon-γ gene lipoplex for efficient cancer immunotherapy.
Yuba E, Kanda Y, Yoshizaki Y, Teranishi R, Harada A, Sugiura K, Izawa T, Yamate J, Sakaguchi N, Koiwai K, Kono K.
Biomaterials   67 214-224   Oct 2015
Effect of ovarian hormones on maturation of dendritic cells from peripheral blood monocytes in dogs.
Wijewardana V, Sugiura K*, Wijesekera DPH, Hatoya S, Nishimura T, Kanegi R, Ushigusa T, Inaba T.
J. Vet. Med. Sci.   77(7) 771-775   Jul 2015
High effective non-viral antitumor gene therapy system comprised of biocompatible small plasmid complex particles consisting of pDNA, anionic plysaccharide, and fully deproteced linear polyethylenimine.
Koyama Y, Sugiura K, Yoshihira C, Inaba T. Ito T.
Pharmaceutics   7(3) 152-164   Jul 2015
Development of a dendritic cell-targeting lipopeptide as an immunoadjuvant that inhibits tumor growth without inducing local inflammation.
Akazawa T, Ohashi T, Nakajima H, Nishizawa Y, Kodama K, Sugiura K, Inaba T, Inoue N.
Int. J. Cancer.   135(12) 2847-2856   Dec 2014
Enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a novel type synthetic vector.
Wijesekera DP, Sugiura K, Yuba E, Ueda K, Wijewardana V, Kanegi R, Nishimura T, Ushigusa T, Hatoya S, Kono K, Inaba T.
Vet. Immunol. Immunopathol.   162(1) 59-64   Nov 2014
Evaluation of serum phosphotylated neurofilament subunit NF-H as a prognostic biomarker in dogs with thoracolumbar intervertebral disc herniation.
Nishida H, Nakayama M, Tanaka H, Kamishima H, Izawa T, Hatoya S, Sugiura K, Ide C, Inaba T.
Vet. Surg.   43(3) 286-293   Mar 2014
Production of canine soluble CD40 ligand to induce maturation of monocyte derived dendritic cells for cancer immunotherapy.
Wijewardana V, Sugiura K, Yahata M, Akazawa T, Wijesekera DPH, Imamoto S, Hatoya S, Inoue N, Inaba T.
Vet. Immunol. Immunopathol.   156(1) 121-127   Nov 2013
Generation of functional platelets from canine induced pluripotent stem cells.
Nishimura T, Hatoya S, Kanegi R, Sugiura K, Wijewardana V, Kuwamura M, Tanaka M, Yamate J, Izawa T, Takahashi M, Kawate N, Tamada H, Imai H, Inaba T.
Stem Cells Dev.   22(14) 2026-2035   Jul 2013
Evaluation of methods for cell harvesting and the biological properties at successive passages of canine bone marrow stromal cells.
Nishida H, Shoji Y, Nakamura M, Hatoya S, Sugiura K, Yamate J, Kuwamura M, Kotani T, Nakayama M, Suzuki Y, Ide C, Inaba T
Am J Vet Res   73(11) 1832-1840   Nov 2012
Three cases of idiopathic sterile pyogranulomatous inflammation of epidural fat in Miniature Dachshunds.
Nishida H, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Inaba T, Nakayama M
J Vet Med Sci   74(8) 1071-1074   Aug 2012
Safety of autologous bone marrow stromal cell transplantation in dogs with acute spinal cord injury.
Nishida H, Nakayama M, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Harada Y, Suzuki Y, Ide C, Inaba T.
Vet. Surg.   41(4) 437-442   Mar 2012
Evaluation of transplantation of autologous bone marrow stromal cells into the cerebrospinal fluid for treatment of chronic spinal cord injury in dogs.
Nishida H, Nakayama M, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Suzuki Y, Ide C, Inaba T.
Am. J. Vet Res.   72(8) 1118-1123   Aug 2011
Induction of fertile oestrus in dioestrous bitches using prostaglandin F2α and a GnRH agonist.
Ohmura M, Torii R, Hatoya S, Sugiura K, Tamada H, Kawate N, Takahashi M, Sawada T, Inaba T.
Vet. Rec.   168(23) 667-669   Jun 2011
Successful Management with CHOP for Pulmonary Lymphomatoid Granulomatosis in a Dog.
Hatoya S, Kumagai D, Takeda S, Yamamoto E, Nakanishi M, Kuwamura M, Sugiura K, Sasai H, Yamate J, Inaba T.
J. Vet. Med. Sci.   73(4) 527-530   Apr 2011
Effect of IL-12 on canine dendritic cell maturation following differentiation induced by granulocyte-macrophage CSF and IL-4.
Sugiura K., Wijewardana V., Fujimoto M., Akazawa T., Yahata M., Mito K., Hatoya S., Inoue N., Inaba T.
Vet. Immunol. Immunopathol.   137(3) 322-326   Oct 2010
IFNγ markedly cooperates with intratumoral dendritic cell vaccine in dog tumor madels.
Mito K., Sugiura K., Ueda K., Hori T., Akazawa T., Yamate J., Nakagawa H., Hatoya S., Inaba M., Inoue N., Ikehara S., Inaba T.
Cancer Res.   70(18) 7093-7101   Sep 2010
Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions.
Yamamoto E., Izawa T., Juniantito V., Kuwamura M., Sugiura K., Takeuchi T., Yamate J
Histol. Histopathol.   25(8) 995-1007   Aug 2010
Canine oocyte maturation in culture: Significance of estrogen and EGF receptor gene expression in cumulus cells.
Hatoya S., Sugiyama Y., Nishida H., Okuno T., Torii R., Sugiura K., Kida K., Kawate N., Tamada H., Inaba T.
Theriogenology   71(4) 560-567   Mar 2009
Construction of an expression vector for improved secretion of canine IL-18
Sugiura K., Akazawa T., Fujimoto M., Wijewardana V., Mito K., Hatoya S., Taketani S., Komori M., Inoue N., Inaba T.
Vet. Immunol. Immunopathol.   126(3) 388-391   Dec 2008
Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-sever combined immunodeficiency mice.
Sugiura K., Taketani S., Yoshimura T., Nishino T., Nishino N., Fujisawa J., Hisha T., Inaba T., Ikehara S.
Cytokine   37(3) 218-226   Mar 2007
Reduction of mucin-1 gene expression associated with increased Escherichia coli adherence in the canine uterus in the early stage of dioestrus.
Ishigro K., Baba E., Torii R., Tamada H., Kawate N., Hatoya S., Wijewardana V., Kumagai D., Sugiura K., Sawada T., Inaba T.
Vet. J.   173(2) 325-332   Mar 2007
Isolation and characterization of hematopoietic progenitor cells in canine bone marrow.
Wijewardana V, Sugiura K, Shigeyama N, Moriguchi M, Tsunoda S, Ikehara S, Inaba T.
Vet. Immunol. Immunopathol.   115(3) 230-238   Feb 2007
Generation of canine dendritic cells from peripheral blood monocytes without using purified cytokines.
Wijewardana V., Sugiura K, Oichi T., Fujimoto M., Akazawa T., Hatoya S., Inaba M., Ikehara S., Thotawaththege S.P.J, Inaba T.
Vet. Immunol. Immunopathol.   114(1) 37-48   Nov 2006
Effect of co-culturing with embryonic fibroblasts on IVM, IVF and IVC of canine oocytes.
Hatoya S., Sugiyama Y., Torii R., Wijewardana V., Kumagai D., Sugiura K., Kida K., Kawate K., Tamada H., Sawada T. Inaba T.
Theriogenology   66(5) 1083-1090   Sep 2006
Lactoferrin expression in canine uterus during the estrus cycle and with pyometra.
Kida K., Baba E., Torii R., Kawate N., Hatoya S., Wijewardana V., Sugiura K., Sawada T., Tamada H., Inaba T.
Theriogenology   66(5) 1325-1333   Sep 2006
Induction of fertile oestrus in bitches by an intranasal spray of gonadotrophin-releasing hormone agonist.
Hatoya S., Torii R., Wijewardana V., Kumagai D., Sugiura K., Kawate N., Tamada H., Sawada T., Inaba M.
Vet. Rec.   158(11) 378-379   Mar 2006
Isolation and characterization of embryonic stem cells from canine blastocysts.
Hatoya S., Tirii R., Kondo Y., Okuno T., Kobayashi K., Wijewardana V., Kawate N., Tamada H., Sawada T., Kumagai D., Sugiura K., Inaba T.
Mol. Reprod. Dev.   73(3) 298-305   Mar 2006
Effect of ovarian hormones on periodical changes in immune resistance associated with estrous cycle in the beagle bitch.
Sugiura K., Nishikawa M., Ishiguro K., Tajima T., Inaba M., Torii R., Hatoya S., Wijewardana V., Kumagai D., Tamada H., Sawada T., Ikehara S., Inaba T.
Immunobiol.   209(8) 619-627   Dec 2004
Induction of tolerance in quadruple chimeric mice.
Fan T.-X., Hisha H., Jin T.-N., Sugiura K., Inaba M., Yang G.-X., Li Q., YeSong C., Cui Y.-Z., Li Q., Zhang Y., Zhang X.-G., Fan H.-X., Ikehara S.
Stem Cells   22(5) 683-695   Sep 2004
Enhancement of allogeneic hematopoietic stem cell engraftment and prevention of GvHD by intra-bone marrow transplantation plus donor lymphocyte infusion.
Nakamura K., Inaba M., Sugiura K., Yoshimura T., Kown A-H., Kamiyama Y., Ikehara S
Stem Cells   22(2) 125-134   Mar 2004
Expression of estrogen receptor alpha and beta genes in the mediobasal hypothalamus, pituitary and ovary during the canine estrous cycle.
Hatoya S., Torii R., Kumagai D., Sugiura K., Kawate N., Tamada T., Sawada T., Inaba T.
Neurosci Lett   347(2) 131-135   Aug 2003
Analyses of dendritic cell subsets in pregnancy.
Yoshimura T., Inaba M., Sugiura K., Nakajima T., Ito T., Nakamura K., Kanzaki H., Ikehara S.
Am J Reprod Immunol   50(2) 137-145   Aug 2003
Correlation between accelerated presbycusis and decreased immune functions.
Iwai H., Lee S., Inaba M., Sugiura K., Baba S., Tomoda K., Yamashita T., Ikehara S.
Exp Gerontol   38(3) 319-325   Mar 2003
Enhancement of aromatase gene expression in the mediobasal hypothalamus during anestrus in the beagle bitch.
Inaba T., Namura T., Tani H., Matsuyama S., Torii R., Kawate N., Tamada T., Hatoya S., Kumagai D., Sugiura K., Sawada T.
Neurosci. Lett.   33(2) 319-326   Nov 2002
Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-Taiho-To): stimulatory effects of its fatty acids on hemopoiesis in patients.
Hisha H., Kohdera U., Hirayama M., Yamada H., Iguchi-Uehara T., Fan T., Cui Y., Yang G., Li Y., Sugiura K., Inaba M., Kobayashi Y., Ikehara S.
Stem Cells   20(4) 311-319   Jul 2002
A mouse model for the equilibration interaction between the host immune system and HTLV-1 gene expression.
Furuta. R. A, Sugiura. K, Kawakita. S, Inada. T, Ikehara. S, Matsuda. T, Fujisawa. J.
J. Virol.   76(6) 2703-2713   Mar 2002
Comparision of bone marrow cells harvested from bones of cynomolgus monkeys at various ages by perfusion or aspiration methods: a preclinical study for human BMT.
Kushida T., Inaba M., Ikebukuro K., Ichioka N., Esumi T., Oyaizu H., Yoshimura T., Nagahama T., Nakamura K., Ito T., Hisha H., Sugiura K., Yasumizu Y., Iida H., Ikehara S.
Stem Cells   20(2) 155-164   Mar 2002
Marked increase in number of dendritic cells in autoimmune-prone (NZW×BXSB)Fi mice with age.
Adachi. Y, Taketani. S, Toki. J, Ikebukuro. K, Sugiura. K, Oyaizu. H, Yasumizu. R, Tomita. M, Kaneda. H, Amoh. Y, Ito. T, Okigaki. M, Inaba. M, Ikehara. S
Stem Cells   20(2) 61-72   Mar 2002
New method for thyroid transplantation across major histocompatibility complex barriers using allogeneic bone marrow transplantation.
Lee. S, Sugiura. K, Nagahama. T, Iwai. H, Yamashita. T, Ikehara. S.
Transplantation   72(6) 1144-1149   Sep 2001
A new method for tolerance induction: busulfan administration followed by intravenous injection of neuraminidase-treated donor bone marrow.
Nagahama. T, Sugiura. K, Lee. S, Morita. H, Adachi. Y, Kwon. A-H, Kamiyama. Y, Ikehara. S.
Stem Cells   19(5) 425-436   Sep 2001
Prevention of accelated presbycusis by bone marrow transplantation in senescence-accelated mice.
Iwai. H, Lee. S, Inaba. M, Sugiura. K, Tomoda. K, Yamashita. T, Ikehara. S.
Bone Marrow Transplant.   28(4) 323-328   Aug 2001
A novel strategy for organ allografts using sublethal (7Gy) irradiation fpllowed by injection of donor bone marrow cells via portal vein .
Jin. T, Toki. J, Inaba. M, Sugiura. K, Fan. T, Yu. C, Lian. Z, Takase. K, Feng. B, Ito. T, Cui. Y, Yang. G, Ikehara. S.
Transplantation   71(12) 1725-1731   Jun 2001
Tolerance induction across Mls and minor histocompatibility complex by inhibiting activation of T helper type 1 in early period.
Sugiura. K, Lee. S, Nagahama. T, Adachi. Y, Ishikawa. J, Ikehara. S.
Immunol. Lett.   77(1) 25-30   May 2001
A 4-month-old infant showing anemia, granulocytopenia and thrombocytopenia probably due to autoeactive IgG.
Adachi. Y, Kohdera. U, Sugiura. K, Shinohara. A, Inaba. M, Ikebukuro. K, Oyaizu. H, Genba. H, Kobayashi. Y, Ikehara. S.
Pediatr. Int.   43(1) 91-94   Feb 2001
Major histocompatibility complex restriction between hematopoietic stem cells and stromal cells in vitro.
Sugiura. K, Hisha. H, Ishikawa. J, Adachi. Y, Taketani. S, Lee. S, Nagahama. T, Ikehara. S.
Stem Cells   19(1) 46-58   Jan 2001
A nwemethod for bone marrow cell harvesting.
Kushida. T, Inaba. M, Ikebukura. K, Nagahama. T, Oyaizu. H, Lee. S, Ito. T, Ichioka. N, Hisha. H, Sugiura. K, Miyashima. S, Ageyama. N, Ono. F, Iida. H, Ogawa. R, Ikehara. S.
Stem Cells   18(6) 453-456   Nov 2000
Prevention of autoimmune hearing loss in MRL/lpr mice by bone marrow transplantation.
Lee. S, Iwai. H, Sugiura. K, Takeuchi. K, Kushida. T, Inaba. M, Ikehara. S.
Bone Marrow Transplant.   26(8) 887-892   Oct 2000
Promotive effect of a silk film on epidermal recovery from full-thickness skin wounds.
Sugihara. A, Sugiura. K, Morit.a H, Ninagawa. T, Tubouchi. K, Tobe. R, Izumiya. M, Horio. T, Abraham. N.G, Ikehara S.
Proc. Soc. Exp. Bio. Med.   225(1) 58-64   Oct 2000
Long-term (>1 year) analysis of chimerism and tolerance in mixed allogeneic chimeric mice using normal mouse combinations.
Hayashi. H, Toki. J, Zhexiong. L, Sugiura. K, Inoue. K, Ikehara. S.
Stem Cells   18(4) 273-280   Jul 2000
Acceptance of skin xenografts (from gunea pig to mice) by portal venous and intravenous injection of donor hematolymphoid cells.
Morita. H, Sugiura. K, Nagahama. T, Sasakura. Y, Tu. W, Oda. M, Inoue. H, Taketani. S, Kamiyama. Y, Ikehara. S.
Transplant. Proc.   32(2) 293-294   Mar 2000
Treatment of intractable autoimmune diseases in MRL/lpr mice using a new strategy for allogeneic bone marrow transplantation.
Kushida. T, Inaba. M, Takeuchi. K, Sugiura. K, Ogawa. R, Ikehar. S.
Blood   95(5) 1862-1868   Mar 2000
T cells infiltrating from the systemic circulation proliferate in the endolymphatic sac.
Iwai. H, Tomoda. K, Sugiura. K, Inaba. M, Ikehara. S, Yamashita. T.
Ann. Otol. Rhinol. Laryngol.   108(12) 1146-1150   Dec 1999
Experimental autoimmune thyroiditis induced by thyroglobulin-pulsed dendritic cells.
Watanabe. H, Inaba. M, Adachi. Y, Sugiura. K, Hisha. H, Iguchi. T, Yasumizu. R, Inaba. K, Yamashita. T, Ikehara S.
Autoimmunity   31(4) 273-282   Nov 1999
Age-dependent abnormarities of hematopoietic stem cells in (NZW×BXSB)F1 Mice.
Sugihara. H, Adachi. Y, Inaba. M, Hisha. H, Sugiura. K, Miyashima. S, Amoh. Y, Taketani. S, Oyaizu. H, Ikebukuro. K, Kawamura. M, Genb.a H, Horio. T, Ikehara. S.
Stem Cells   17(6) 357-365   Nov 1999
Acceptance of skin allografts in pigs by portal venous injection of donor bone marrow cells.
Morita. M, Nakamura. N, Sugiura. K, Satoi. S, Sakakura. Y, Tu. W, Yoshida. K, Oda. M, Inoue. T, Inui. H, Nagahama. T, Kamiyama. Y, Ikehara. S.
Ann. Surg.   230(1) 114-119   Jul 1999
Persistent tolerance induced after portal venous injection of allogeneic cells plus cyclophosphamide treatment.
Jin. T, Sugiura. K, Ishikawa. J, Lee. S, Morita. H, Nagahama. T, Ikehara. S.
Immunobiology   200(2) 215-226   Jan 1999
c-kit low pluripotent hematopoietic stem cells from CFU-S on day
Lian. Z, Feng. B, Sugiura. K, Inaba. M, Yu. C, Jin. T, Fan. T, Cui. Y, Yasumizu. R, Toki. J, Adach. Y, Hisha. H, Ikehara. S.
Stem Cells   17(1) 39-44   Jan 1999
A New strategy for organ allografts without using immunosuppressants and irradiation.
Morita. H, Sugiura. K, Inaba. M, Jin. T, Ishikawa. J, Lian. Z, Adachi. Y, Sogo. S, Yamanishi. K, Taki. H, Adachi. M, Noumi. T, Kamiyama. Y, Good. R.A, Ikehara S.
Proc. Natl. Acad. Sci.   95(12) 6947-6952   Jun 1998
Characterization of natural suppressor cells in human bone marrow.
Sugiura. K, Pahwa. S, Yamamoto. Y, Borizov. K, Pahwa. R, Nerson. R.P, Ishikawa. J, Oyaizu. N, Iguchi. T, Good. R.A, Ikehara. S.
Stem Cells   16(2) 99-106   Mar 1998
Effects of administration of monoclonal antibodies (anti-CD4 or anti-CD8) on development of autoimmune disease in (NZW×BXSB)F1 mice.
Adachi. Y, Inaba. M, Sugihara. A, Koshiji. M, Sugiura. K, Amoho. Y, Mori .S, Kamiya. T, Genba. H, Ikehara. S.
Immunobiology   198(4) 451-464   Feb 1998
Granulocyte-macrophage colony -stimulating factor expressed in T cells mediates protective immunity against herpes simplex virus type 1 encephalitis.
Tuboi. K, Kimura. T, Sugiura. K, Hashimoto. I, Nishikawa. M, Uyama. M, Fujisawa. J.
J. Infect. Dis.   178(1) 16-26   Jan 1998
Induction of donor-specific T cell anergy by portal venous injection of allogeneic cells.
Sugiura. K, Kato. K, Hashimoto. F, Jin. T, Amoh. Y, Yamamoto. Y, Morita. H, Okumura. K, Ikehara. S.
Immunobiology   197(5) 460-477   Nov 1997
Requirement of major histocompatibility complex-compatible microenvironment for spleen colony formation
Sugiura. K, Inaba. M, Hisha. H, Borizov. K, Sardin_. E.E, Good. R.A, Ikehara. S.
Stem Cells   15(6) 461-468   Nov 1997
Intrathymically injected hematopoietic stem cells can differentiate into all lineage cells in thymus: Difference between c-kit+ cells and c-kit<low cells.
Lian. Z, Toki. J, Yu. C, Hayashi. H, Yasumizu. R, Sugiura. K, Jin. T, Inaba. M, Hisha. H, Li. Y, Yu. W, Fan. H, Ikehara. S.
Stem Cells   15(6) 430-436   Nov 1997
Major histocompatibility complex restriction between hematopoietic stem cells and stromal cells in vivo.
Hashimoto. F, Sugiura. K, Inoue. K, Ikehara S.
Blood   89(1) 49-54   Jan 1997
Development of insulin-dependent diabetes millitus in [(NOD+BALB/c)]→NOD] mixed allogeneic bone marrow chimeras.
Takao. F, Yasumizu. R, Than. S, Ohnishi-Inoue. Y, Sugiura. K, Inab.a M, Ikehara. S.
Immunobioloy   194(1) 376-389   Nov 1995
Abnormalities of B cells and dendritic cells in SAMP1 mice.
Haruna. H, Inaba. M, Inaba. K, Taketani. S, Sugiura. K, Fukuba. Y, Doi. H, Tokunaga. R, Ikehara. S.
Eur. J. Immunol.   l.25(5) 1319-1325   Sep 1995
Repair mechanism of lupus nephritis in (NZBXNZW)F1 mice by allogeneic bone marrow transplantation.
Nishioka. N, Toki. J, Cherry, Sugiura. K, Than. S. Yasumizu R, Inaba. M, Nishimura. M, Ikehara S.
Immunobiology   192(2) 279-296   May 1995
Enhancing effect of cyclosporin A on hematopoietic progenitors: Possible role on CD8+ T cells as negative regulators.
Hashimoto. F, Sugiura. K, Inoue. K, Ikehara. S.
Exp. Hematol.   22(10) 947-953   Sep 1994
Fate of allogeneic or syngeneic cells in intravenous or portal vein injection: Possible explanation for the mechanism of tolerance induction by portal vein injection.
Zhang. Y, Yasumizu. R, Sugiura. K, Hashimoto. F, Amoh. Y, Lian. Z, Cherry, Nishio. N, Ikehara. S.
Eur. J. Immunol.   24(7) 1558-1565   Jul 1994
Autoimmune disease as stem cell disorder.
Ikehara S., Inaba M., Yasumizu R., Nagata N., Toki J., Hisha H., Sugiura S., Oyaizu N., Kawamura M., Soe Tan, Takao F., Adachi Y., Nishimura M., Nishioka N., Mizutani H., Kurata Y., Good R.A.
Tohoku J. Exp. Med.   173(1) 141-155   May 1994
Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune disease in MRL/MP-lpr/lpr mice by tranplantation of bone marrow plus bones (stromal cells)
Ishida. T, Inaba. M, Hishia. H, Sugiura. K, Adachi. Y, Nagata. N, Ogawa. R, Good. R.A, Ikehara. S.
J. Immunol.   152(6) 3119-3127   Mar 1994
Focal segmental glomerular sclerosi, a type of intractable chronic glomerulonephritis, is a stem cell disorder.
Nishimura. M, Toki. J, Sugiura. K, Hashimot.o F, Tomita. T, Fujishima. H, Hiramatsu. Y, Nishioka .N, Nagata. N, Takahashi. Y, Ikehara. S.
J. Exp. Med.   179(3) 1053-1058   Mar 1994
Analysis of origin of mechanisms of arthritis by allogeneic bone marrow transplantation.
Kitagawa. H, Toki. J, Inaba. M, Sugiura. K, Ogawa. R, Ikehara. S.
Immunobiology   188(1) 99-122   Jun 1993
Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of lymph node stromal cells in lpr- lymphadenopathy.
Ohnishi-Inoue. Y, Yasumizu. R, Sugiura. K, Nagata. N, Fan. H, Oyaizu. N, Inaba. M, Toki. J, Ikehara. S.
Immunobiology   186(5) 449-465   Nov 1992
Effect of human mmunodeficiency virus -1 envelope glycoprotein on in vitro hematopoiesis of umbilical cord blood.
Sugiura. K, Oyaizu. N, Pahwa. R, Kalyanaraman. V.S, Pahwa. S.
Blood   80(6) 1463-1469   Sep 1992
Enrichiment of natural suppressor activity in the fraction of hematopoietic progrnitors with interleukin 3 receptor associated antigen.
Sugiura. K, Ikehara. S, Inaba. M, Haraguchi. S, Ogata. H, Sardin_. E.E, Sugawara. M, Ohta. Y, Good. R.A.
Exp. Hematol.   20(2) 256-263   Feb 1992
Long-term immunologic tolerance induction in chimeric mice after bone marrow transplantation across major histocompatibility barriers. Persistent or redeveloping immunologic responsiveness after prolonged survival.
Sugiura K., Yasumizu R., Iwai H., Inaba M., Toki J., Ogura M., Hara I., Good R.A., Ikehara S.
Thymus   18(3) 137-153   Nov 1991
Transplantation of wheat germ agglutinin-positive hematopoietic cells to prevent or induce systemic autoimmume disease.
Sardi?a E.E., Sugiura K., Ikehara S., Good R.A.
Proc. Natl. Acad. Sci.   88(8) 3218-3222   1991
Organ spesific and systemic autoimmune disease originate from defects in hematopoietic stem cells.
Ikehara. S, Kawamura. M, Takao. F, Inaba. M, Yasumizu. R, Than. S, Hishia. H, Sugiura. K, Koide. Y, Yoshida. T, Ida. T, Imura. H, Good. R.A.
Proc. Natl. Acad. Sci.   87(21) 8341-8344   Nov 1990
Analysis of development of insulitogenic T lymphocyte in NOD mice by transplantation of bone marrow, thymus, and pancreas.
Ida T., Yasumizu R., Ohonish Y., Fan H, Oyaizu Y., Than S., Sugiura K., Inaba M., Kuzuya H., Makino S., Ikehara S., Imura H.
Tlansplantation   49(5) 976-982   May 1990
Inhibition of tumor cell proliferation by natural suppressor cells present in murine bone marrow.
Sugiura. K, Inaba. M, Ogata. H, Yasumizu. R, Sardin_. E.E, Inaba. K, Good. R.A, Ikehara. S.
Cancer Res.   50(9) 2582-2586   May 1990
Allogeneic bone marrow-plus-liver transplantation in the C57/KsJ SPM/SPM mouse, an animal model of nieman-pick disease.
Yasumizu R., Miyawaki S., Sugiura K., Nakamura T., Ohnishi Y., Good R.A., Hamashima Y., Ikehara S.
Transplantation   49(4) 759-764   Apr 1990
Histogenesis of hematopoietic bone marrow in adult mice.
Fan H, Yasumizu Y., Sugiura K., Oyaizu Y., Ohnishi Y., Takao F., Inaba M., Liu J,. Ikehara S.
Exp.Hematol.   18(3) 159-166   Mar 1990
Enrichment of natural suppressor activity in a wheat germ agglutinins positive, hematopoietic progenitor enriched fraction of monkey bone marrow.
Sugiura K., Ikehara S., Gengozian N., Inaba M., Sardi?a E.E., Ogata H., Seong SM., Good RA.
Blood   75(5) 1125-1131   Mar 1990
Rationale for transplantation of both allogeneic bone marrow and stromal cells in the treatment of autoimmune disease. New Strategies in Bone Marrow Transplantation.
Ikehara, S., Inaba, M., Ishida, S., Ogata、 H., Hisha、 H., Yasumizu, R., Oyaizu, N., Sugiura, K., Toki, J., Takao, F., Soe, Than, Kawamura, M., Nishioka, N., Nagata, N., Good, R.A.
New Strategies in Bone Marrow Transplantation   251-257   1990
Long-term observation of autoimmune-prone mice treated for autoimmune disease by allogeneic bone marrow transplantation.
Ikehara. S, Yasumizu. R, Inaba. M, Izui. S, Hayakawa. K, Sekita. K, Toki. J, Sugiura. K, Iwai. H, Nakamura. T, Muso. E, Hamashima. Y, Good. R.A.
Proc. Natl. Acad. Sci.   86 3306-3310   May 1989
Development of donor-derived hymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice.
Yasumizu R., Hiai H., Sugiura K., Oyaizu N., Hongxue F., Ohnishi Y., Iwai H., Inaba M., Kakinuma M., Onoe K., Good R.A., Ikehara S.
J. Immunol.   141(6) 2181-2186   Sep 1988
Sugiura. K, Inaba. M, Ogata. H, Yasumizu. R, Inab.a K, Good. R.A, Ikehara. S.
Proc. Natl. Acad. Sci.   85 4824-4826   Jul 1988
Successful pancreatic allografts in combination with bone marrow transplantation in mice.
Iwai H., Yasumizu R., Sugiura K., Inaba M., Kumazawa T, Good R.A., Ikehara S.
Immunology   69(3) 457-462   Nov 1987
Isolation of murine pluripotent hemopoietic stem cells in the Go phase
Inaba M., Ogata H., Toki J., Kuma S., Sugiura K., Yasumizu R., Ikehara S.
Biochem. Biophys. Res. Commun.   147(2) 687-694   Sep 1987
Treatment of type I diabetes mellitus in NOD mice by transplantation of allogeneic bone marrow and pancreatic tissue.
Yasumizu. R, Sugiura. K, Iwai. H, Inaba. M, Makino. S, Ida. T, Imura. H, Hamashima. Y, Good. R.A, Ikehara. S.
Proc. Natl. Acad. Sci.   84 6555-6557   Sep 1987
Reduction of autoantibody-production by allogeneic bone marrow transplantation. Mixed connective tissue disease and anti-nuclear antibodies.
Ikehara, S., Sekita, K., Izui, S., Yasumizu, R., Inaba, M., Nakamura, T., Toki, J., Sugiura, K., Iwai, H., Hamashima, Y. Good, R.A.
Mixed conective tissue disease and anti-nuclear antibodies   139-144   May 1987
Thymic rudiments are responsible for induction of functional T-cells in nu/nu mice.
Ikehara S., Shimizu J., Yasumizu R., Nakamura T., Inaba M., Inoue S., Oyaizu N., Sugiura K., Hamashima Y. Good R.A.
Thymus   10(3) 193-205   Mar 1987
Role of the thymus and the stem cells in the differentiation of T-cells.
Ikehara, S., Yasumizu, R., Nakamura, T., Sekita, K., Muso, E., Ohtsuki, H., Ogura, M., Toki, J., Inoue, N., Sugiura, K., Iwai, H., Shintaku, M., Ihara, N., Hamashima, Y.
5th Int. Workshop on Immune Deficient Animals, Copenhagen   69-75   Jan 1987
A new rat model for dermatitis: Constitutional abnormalities evidenced by hematological and serum protein determinants.
Ihara N., Sugiura K.
Exp. Anim.   35(2) 139-148   Apr 1986
Dense line cisterna of rough-surface endoplasmic reticulum of hepatocytes of the rat perfused with saponin solution.
Makita T., Sugiura K.
Cell Biol. Int. Rep.   9(7) 607-612   Jun 1985

Research Grants & Projects

 
A Fundamental study of hematopoitic stem cell transplantation for application in veterinary medicine
Project Year: 2002 - 2005
A study for dendritic cell-based cancer immunotherapy in small animal
Project Year: 2005