SHIRATO Kazuya

Last updated: Sep 1, 2015 at 16:02
 
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Name
SHIRATO Kazuya
Affiliation
National Institute of Infectious Diseases
Section
Laboratory of Acute Respiratory Viral Diseases and Cytokines, Department of Virology III
Job title
Senior Researcher
Degree
Doctor of Philosophy in Veterinary Medical Science(Hokkaido University)

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
Apr 2009
   
 
Senior Researcher, Laboratory of Acute Respiratory Viral Diseases and Cytokines, Department of Virology III, National Institute of Infectious Diseases
 
Apr 2005
 - 
Mar 2009
Researcher, Laboratory of Acute Respiratory Viral Diseases and Cytokines, Department of Virology III, National Institute of Infectious Diseases
 

Education

 
Apr 1996
 - 
Mar 2002
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
 
Apr 2002
 - 
Mar 2005
Graduate School of Veterinary Medicine, Hokkaido University
 

Published Papers

 
Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus
Kazuya Shirato*, Makoto Ujike, Miyuki Kawase and Shutoku Matsuyama
Virus Research   210 213-226   2015   [Refereed]
Middle East respiratory syndrome coronavirus infection not found in camels in Japan
Shirato K*, Azumano A, Nakao T, Hagihara D, Ishida M, Tamai K, Yamazaki K, Kawase M, Okamoto Y, Kawakami S, Okada N, Fukshima K, Nakajima K, and Matsuyama S
Japanese Journal of Infectious Diseases   68(3) 256-258   2015   [Refereed]
The host protease TMPRSS2 plays a major role for in vivo replication of emerging H7N9 and seasonal influenza viruses
Kouji Sakai, Yasushi Ami, Maino Tahara, Toru Kubota, Masaki Anraku, Masako Abe, Noriko Nakajima, Tsuyoshi Sekizuka, Kazuya Shirato, Yuriko Suzaki, Akira Ainai, Yuichiro Nakatsu, Kazuhiko Kanou, Kazuya Nakamura, Tadaki Suzuki, Katsuhiro Komase, Eri Nobusaw
Journal of Virology   88(10) 5608-5616   2014   [Refereed]
Detection of Middle East respiratory syndrome coronavirus using reverse transcription oop-mediated isothermal amplification (RT-LAMP)
Kazuya Shirato*, Takuya Yano, Syouhei Senba, Shigehiro Akachi, Takashi Kobayashi, Takamichi Nishinaka, Tsugunori Notomi and Shutoku Matsuyama
Virology Journal   11 139   2014   [Refereed]
Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease
Kazuya Shirato, Yoshio Imada, Miyuki Kawase, Keiko Nakagaki, Shutoku Matsuyama, and Fumihiro Taguchi*
Journal of Medical Virology   DOI: 10.1002/jmv.23950   2014   [Refereed]
Neuropathogenesis of a mouse-adapted porcine epidemic 1 diarrhea virus infection in suckling mice
Osamu Kotani, Kazuya Shirato, Noriyo Nagata, Hidetoshi Ikeda, Kimimasa Takahashi, Fumihiro Taguchi*
Journal of General Virology   94(4) 831-836   2013   [Refereed]
TMPRSS2 is an activating protease for respiratory parainfluenza viruses
Masako Abe, Maino Tahara, Kouji Sakai, Hiromi Yamaguchi, Kazuhiko Kanou, Kazuya Shirato, Miyuki Kawase, Masahiro Noda, Hirokazu Kimura, Shutoku Matsuyama, Hideo Fukuhara, Katsumi Mizuta, Katsumi Maenaka, Yasushi Ami, Mariko Esumi, Atsushi Kato, and Makoto Takeda*
Journal of Virology   87(21) 11930-11935   2013   [Refereed]
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Mediated by the Transmembrane Serine Protease TMPRSS2
Kazuya Shirato, Miyuki Kawase, and Shutoku Matsuyama*
Journal of Virology   87(23) 12552-12561   2013   [Refereed]
Increased replication of respiratory syncytial virus in the presence of cytokeratin 8 and 18
Kazuya Shirato*, Makoto Ujike, Miyuki Kawase, and Shutoku Matsuyama
Journal of Medical Virology   84(2) 365-370   2012   [Refereed]
The differences in neutralizing antigenicity between laboratory and clinical isolates of HCoV-229E isolated in Japan in 2004-2008 depend on the S1 region sequence of spike protein
Kazuya Shirato, Miyuki Kawase, Oshi Watanabe, Chika Hirokawa, Shutoku Matsuyama, Hidekazu Nishimura, and Fumihiro Taguchi*
Journal of General Virology   93(9) 1908-1917   2012   [Refereed]
Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents SARS coronavirus entry
Miyuki Kawase, Kazuya Shirato, Lia van der Hoek, Fumihiro Taguchi, and Shutoku Matsuyama*
Journal of Virology   86(12) 6537-6545   2012   [Refereed]
Two palmitylated cysteine residues of the severe acute respiratory syndrome coronavirus spike protein are critical for S-incorporation into virus-like particles, but not for M-S co-localization
Makoto Ujike*, Cheng Huang, Kazuya Shirato, Shutoku Matsuyama, Shinji Makino, and Fumihiro Taguchi
Journal of General Virology   93(4) 823-828   2012   [Refereed]
Role of proteases in the release of porcine epidemic diarrhea virus from infected cells. Journal of Virology
Kazuya Shirato, Shutoku Matsuyama, Makoto Ujike, and Fumihiro Taguchi*
Journal of Virology   85(15) 7872-7880   2011   [Refereed]
Kazuya Shirato, Madoka Maejima, Shutoku Matsuyama, Makoto Ujike, Ayako Miyazaki, Natsumi Takeyama, Hidetoshi Ikeda, and Fumihiro Taguchi*
Virus Research   161(2) 188-193   2011   [Refereed]
Detection of bat coronaviruses from Miniopterus fuliginosus in Japan
Kazuya Shirato, Ken Maeda, Shumpei Tsuda, Kazuo Suzuki, Shumpei Watanabe, Hiroshi Shimoda, Naoya Ueda, Koichiro Iha, Satoshi Taniguchi, Shigeru Kyuwa, Daiji Endoh, Shutoku Matsuyama, Ichiro Kurane, Masayuki Saijo, Shigeru Morikawa, Yasuhiro Yoshikawa, Hiroomi Akashi, Tetsuya Mizutani*
Virus Genes   DOI; 10.1007/s11262-011-0661-1   2011   [Refereed]
Kazuya Shirato, Madoka Maejima, Asuka Hirai, Yasushi Ami, Natsumi Takeyama, Kotaro Tsuchiya, Kouich Kusanagi, Tetsuo Nunoya and Fumihiro Taguchi*
Archives of Virology   155(12) 1989-1995   2010   [Refereed]
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2
Shutoku Matsuyama*, Noriyo Nagata, Kazuya Shirato, Miyuki Kawase, Makoto Takeda, and Fumihiro Taguchi.
Journal of Virology   84(24) 12658-12664   2010   [Refereed]
Kazuya Shirato*, and Fumihiro Taguchi
Virology   386(1) 88-93   2009   [Refereed]
Yasushi Ami, Noriyo Nagata, Kazuya Shirato, Rie Watanabe, Naoko Iwata, Keiko Nakagaki, Shuetsu Fukushi, Masayuki Saijo, Shigeru Morikawa, Fumihiro Taguchi*
Microbiology and Immunology   52(2) 118-127   2008   [Refereed]
Rie Watanabe, Shutoku Matsuyama, Kazuya Shirato, Masami Maejima, Shuetsu Fukushi, Shigeru Morikawa and Fumihiro Taguchi*
Journal of Virology   82(23) 11985-11991   2008   [Refereed]
Tumor necrosis factor alpha is not a pathogenic determinant in acute lethal encephalitis induced by a highly neurovirulent strain of mouse hepatitis virus.
Kazuya Shirato, Eiichi Momotani, Masuhiro Takata, Kenji Sekikawa, and Takahide Taniguchi*
Archives of Virology   153(3) 549-553   2008   [Refereed]
Protease-Mediated Entry via the Endosome of Human Coronavirus 229E
Miyuki Kawase, Kazuya Shirato, Shutoku Matsuyama, and Fumihiro Taguchi*
Journal of Virology   83(2) 712-721   2008   [Refereed]
Diagnosis of human respiratory syncytial virus infection using reverse transcription loop-mediated isothermal amplification.
Kazuya Shirato*, Hidekazu Nishimura, Masayuki Saijo, Michiko Okamoto, Masahiro Noda, Masato Tashiro, and Fumihiro Taguchi
Journal of Virological Methods.   139, 78-84    2007
Rapid genome sequencing of RNA viruses
Tetsuya Mizutani, Daiji Endoh, Michiko Okamoto, Kazuya Shirato, Hiroyuki Shimizu, Minetaro Arita, Shuetsu Fukushi, Masayuki Saijo, Koji, Sakai, Chang Kwang Limn, Mikako Ito, Reiko Nerome, Tomohiko Takasaki, Koji Ishii, Tetsuro Suzuki, Ichiro Kurane, Shigeru Morikawa* and Hidekazu Nishimura
Emerging infectious diseases   13(2) 322-324   2007   [Refereed]
The kinetics of proinflammatory cytokines in murine peritoneal macrophages infected with envelope protein-glycosylated or non-glycosylated West Nile virus.
Kazuya shirato, Hirotsugu Miyoshi, Hiroaki Kariwa, Ikuo Takashima*
Virus Research   121(1), 11-16    2006   [Refereed]
Detection of West Nile virus and Japanese encephalitis virus using real-time PCR with a probe common to both viruses.
Kazuya Shirato, Hirotsugu Miyoshi, Hiroaki Kariwa, Ikuo Takashima*
Journal of Virological Methods   126, 119-125    2005   [Refereed]
Different chemokine expression in lethal and non-lethal murine West Nile virus infection
Kazuya Shirato, Takashi Kimura, Tetsuya Mizutani, Hiraki Kariwa, and Ikuo Takashima*
Journal of Medical Virology   74, 507-513    2004   [Refereed]
Kazuya Shirato, Hirotsugu Miyoshi, Akiko Goto, Yoshihiko Ako, Tomotaka Ueki, Hiroaki Kariwa, and Ikuo Takashima*
Journal of General Virlogy   85(12) 3637-3645   2004   [Refereed]
Discrimination of West Nile virus and Japanese encephalitis virus strains using RT-PCR RFLP analysis.
Kazuya Shirato, Tetsuya Mizutani, Hiroaki Kariwa, and Ikuo Takashima*
Microbiology and Immunology   47(6), 439-445    2003   [Refereed]
Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus
Tetsuya Mizutani*, Masayuki Kobayashi, Yuki Eshita, Kazuya Shirato, Takashi Kimura, Yoshihiko Ako, Hirotsugu Miyoshi, Tomohiko Takasaki, Ichiro Kurane, Hiroaki Kariwa, Takashi Umemura, and Ikuo Takashima.
Insect Molecular Biology   12(5) 491-499   2003   [Refereed]

Misc

 
Tumor necrosis factor and carcinoma by hepatitis B and C virus infection.
Kazuya Shirato, and Tetsuya Mizutani*
Tumor Necrosis Factor, Toma P. Rossard (ed.), Nova Science Publishers, Inc.   205-219   2009
Replication, Transcription, and Translation of Coronaviruses
Kazuya Shirato, and Tetsuya Mizutani*
Viral Genomes: Diversity, Properties and Parameters, Zhi Feng and Ming Long (ed.), Nova Science Publishers, Inc.   159-167   2009
Viral proteins, host cell proteins, and manipulation of the cell cycle by viruses.
Kazuya Shirato, and Tetsuya Mizutani*
Progress in Cell Growth Research. Takumi Hayashi (ed.), Nova Science Publishers, Inc.   135-147   2008
Tumor necrosis factor and carcinoma by hepatitis B and C virus infection.
Kazuya Shirato, and Tetsuya Mizutani*
Oncogene Proteins: New Research. Artur H. Malloy and Earl C. Carson (ed.), Nova Science Publishers, Inc.   273-287   2008
SARS as an emerging disease
Kazuya Shirato, Makoto Ujike, Rie Watanabe, Tetsuya Mizutani*
SARS, Mizutani (ed.), SARS,Transworld Research Network, Kerala, India.   17-27   2006

Research Grants & Projects

 
15fk0108013h0101
Japan Agency for Medical Research and Development: Research Program on Emerging and Re-emerging Infectious Diseases
Project Year: Apr 2015 - Mar 2018    Investigator(s): Makoto Takeda
Studies on the influence of isolation and passage of virus on viral original entry system
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (C)
Project Year: 2014 - 2016    Investigator(s): Kazuya Shirato
Identification of viral receptor for porcine epidemic diarrhea virus
The Ito foundation: Grant for Research
Project Year: 2014       Investigator(s): Kazuya Shirato
Identification of the host factors that relates replication of RSV using MDCK cells and cDNA libraries
Kawano Masanori Memorial Foundation for Promotion of Pediatrics: Grant-in-aid for young scientists
Project Year: 2013       Investigator(s): Kazuya Shirato
Identification of the host factors that relates infection and replication of RSV
Japan Society for the Promotion of Science: Grant-in-Aid for Young Scientists (B)
Project Year: 2011 - 2013    Investigator(s): Kazuya Shirato