Yu Hirano

Profile Information

J-GLOBAL ID: 200901031203125977
researchmap Member ID: 5000086777

External link: http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=Y19551032

Research Areas

Life sciences / Applied biochemistry /

Papers

Synthesis of Crosslinked 2′‐OMe RNA Duplexes Using 2‐Amino‐6‐Vinylpurine and Their Application for Effective Inhibition of miRNA Function

Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura, Yasuo Komatsu, Fumi Nagatsugi

Current Protocols, 2(3) e386, Mar, 2022
Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes

Yu Hirano, Yasuo Komatsu

RSC Advances, 2022
Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation

Sho Okumura, Yu Hirano, Yasuo Komatsu

Scientific Reports, 11(1), Dec, 2021
Facile control of surface crystallographic orientation of anodized nanoporous gold catalyst and its application for highly efficient hydrogen evolution reaction

Yasuhiro Mie, Haruka Takayama, Yu Hirano

JOURNAL OF CATALYSIS, 389 476-482, Sep, 2020
Inhibition of breast cancer cell proliferation with anti-microRNA oligonucleotides flanked by interstrand cross-linked duplexes

Sho Okumura, Yu Hirano, Yasuo Komatsu

Nucleosides, Nucleotides & Nucleic Acids, 39(1-3) 225-235, Feb 20, 2020
Adsorptive Stripping Voltammetry for the Determination of Dissolved Oxygen Using a Mesoporous Pt Microelectrode

Ikegami, Masiki, Hirano, Yu, Mie, Yasuhiro, Komatsu, Yasuo

JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 166(6) B542-B546, Apr, 2019 Peer-reviewed
Synthesis and Application of Interstrand Cross-Linked Duplexes by Covalently Linking a Pair of Abasic Sites

Current Protocols in Nucleic Acid Chemistry, Dec, 2018 Peer-reviewed
Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

Mie, Yasuhiro, Hirano, Yu, Kowata, Keiko, Nakamura, Akiyoshi, Yasunaga, Mayu, Nakajima, Yoshihiro, Komatsu, Yasuo

MOLECULAR THERAPY-NUCLEIC ACIDS, 10 64-74, Mar, 2018 Peer-reviewed
Analysis of time-course drug response in rat cardiomyocytes cultured on a pattern of islands

Sho Okumura, Yu Hirano, Yoshiyuki Maki, Yasuo Komatsu

The Analyst, 2018 Peer-reviewed
Bienzyme reactions on cross-linked DNA scaffolds for electrochemical analysis

Yu Hirano, Masiki Ikegami, Keiko Kowata, Yasuo Komatsu

BIOELECTROCHEMISTRY, 113 15-19, Feb, 2017 Peer-reviewed
Fabrication and characterization of nanoporous gold on microelectrode

Ikegami, Masiki, Hirano, Yu, Mie, Yasuhiro, Komatsu, Yasuo

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 783 188-191, Dec, 2016 Peer-reviewed
Analysis of beat fluctuations and oxygen consumption in cardiomyocytes by scanning electrochemical microscopy

Yu Hirano, Mikie Kodama, Masahiro Shibuya, Yoshiyuki Maki, Yasuo Komatsu

ANALYTICAL BIOCHEMISTRY, 447 39-42, Feb, 2014 Peer-reviewed
Development of a scanning electrochemical microscopy-based micropipette and its application to analysis of topographic change of single-cell

Yu Hirano, Keiko Kowata, Mikie Kodama, Yasuo Komatsu

BIOELECTROCHEMISTRY, 92 1-5, Aug, 2013 Peer-reviewed
Direct Electrochemistry of Microsomal Human Flavin-containing Monooxygenases 1 and 3 on Naphthalenethiol Thin Films

Ikegami, Masiki, Mie, Yasuhiro, Hirano, Yu, Komatsuz, Yasuo

ECS ELECTROCHEMISTRY LETTERS, 2(12) G5-G7, 2013 Peer-reviewed
Interstrand cross-link of DNA by covalently linking a pair of abasic sites

Kohei Ichikawa, Naoshi Kojima, Yu Hirano, Toshie Takebayashi, Keiko Kowata, Yasuo Komatsu

CHEMICAL COMMUNICATIONS, 48(15) 2143-2145, 2012 Peer-reviewed
Improvement of Detectable Sensitivity for Enzyme Reaction by Scanning Electrochemical Microscopy with Distance Control System for Immunosensing

Yu Hirano, Tomoyuki Yasukawa, Yoshiaki Mase, Daisuke Oyamatsu, Hitoshi Shiku, Fumio Mizutani, Tomokazu Matsue

ELECTROCHEMISTRY, 80(1) 30-32, Jan, 2012 Peer-reviewed
Size-controlled fabrication of gold nanodome arrays and its application to enzyme electrodes

Ikegami, Masiki, Mie, Yasuhiro, Hirano, Yu, Suzuki, Masaaki, Komatsu, Yasuo

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 384(1-3) 388-392, Jul, 2011 Peer-reviewed
Preparation of Immunosensors Using a Microfluidic Device with an Interdigitated Array Electrode Modified with Antibodies

Yu Hirano, Tomoyuki Yasukawa, Yoshihiro Sawayashiki, Hitoshi Shiku, Fumio Mizutani, Tomokazu Matsue

ELECTROCHEMISTRY, 78(2) 175-177, Feb, 2010 Peer-reviewed
6. New technologies developed for the practical use of antifreeze protein

Cryobiology, Dec, 2009 Peer-reviewed
Construction of Time-Lapse Scanning Electrochemical Microscopy with Temperature, Control and Its Application To Evaluate the Preservation Effects of Antifreeze Proteins on Living Cells

Yu Hirano, Yoshiyuki Nishimiya, Keiko Kowata, Fumio Mizutani, Sakae Tsuda, Yasuo Komatsu

ANALYTICAL CHEMISTRY, 80(23) 9349-9354, Dec, 2008 Peer-reviewed

Misc.

クロスリンク2本鎖構造によるanti-miRNAオリゴの細胞内局在への影響

平野悠, 平野悠, 扇谷仁希, 千高佐知子, 三重安弘, 小松康雄, 小松康雄

日本核酸医薬学会年会講演要旨集, 5th, 2019
走査型電気化学顕微鏡用の白金/金コンポジット微細構造電極の開発

池上真志樹, 平野悠, 三重安弘, 小松康雄

応用物理学会春季学術講演会講演予稿集(CD-ROM), 65th, 2018
クロスリンク2本鎖構造を有するanti-miRNAオリゴ核酸の細胞内動態

平野悠, 平野悠, 扇谷仁希, 三重安弘, 小綿恵子, 小松康雄, 小松康雄

日本核酸医薬学会年会講演要旨集, 4th, 2018
アノード溶解によるナノポーラスゴールド形成の電極サイズ依存性

池上真志樹, 平野悠, 三重安弘, 小松康雄

応用物理学会春季学術講演会講演予稿集(CD-ROM), 64th, 2017
架橋化構造を有するanti-miRNAオリゴによる神経膠芽腫細胞の増殖抑制効果

三重安弘, 平野悠, 小綿恵子, 小松康雄

日本核酸医薬学会年会講演要旨集, 3rd, 2017
ナノ構造の導入による電気化学顕微鏡用マイクロ電極の高感度化

池上真志樹, 平野悠, 三重安弘, 小松康雄

応用物理学会春季学術講演会講演予稿集(CD-ROM), 63rd, 2016
クロスリンク2本鎖構造を有するanti-miRNAオリゴ核酸の構造とmiRNA阻害活性との相関

三重安弘, 平野悠, 小綿恵子, 中村彰良, 安永茉由, 中島芳浩, 小松康雄

日本核酸医薬学会年会講演要旨集, 2nd, 2016
クロスリンク2本鎖を有する核酸のmiRNA阻害効果と構造の相関性

小綿恵子, 三重安弘, 平野悠, 中村彰良, 安永茉由, 中島芳浩, 小松康雄

日本薬学会年会要旨集(CD-ROM), 136th, 2016
2′-O-Methyl RNA2本鎖の分子内架橋化反応とmiRNA阻害核酸への展開

三重安弘, 平野悠, 小綿恵子, 小松康雄

日本RNA学会年会要旨集, 17th, 2015
架橋化2′-O-Methyl RNA2本鎖を有する核酸のmiRNA阻害効果

三重安弘, 平野悠, 小綿恵子, 中村彰良, 安永茉由, 中島芳浩, 小松康雄

日本核酸医薬学会年会講演要旨集, 1st, 2015
フラビン含有モノオキシゲナーゼを用いた酵素固定化電極

池上真志樹, 三重安弘, 平野悠, 小松康雄

応用物理学会春季学術講演会講演予稿集(CD-ROM), 61st, 2014
ナノドーム型微細構造を有する酵素固定化電極の開発

池上真志樹, 三重安弘, 平野悠, 小松康雄

応用物理学関係連合講演会講演予稿集(CD-ROM), 58th, 2011
2本鎖構造の安定化を目的とした架橋化試薬の開発

市川康平, 小島直, 竹林知志恵, 平野悠, 小綿恵子, 小松康雄

アンチセンスシンポジウム講演要旨集, 20th 31, 2010
611 Fabrication of ordered Au nanocorn using a nanoporous alumina template

IKEGAMI Masiki, HIRANO Yu, MIE Yasuhiro, KOMATSU Yasuo

2009(48) 195-196, Nov 28, 2009
509 Characteristics of Interferometric Nanoporous Biosensor

IKEGAMI Masiki, HIRANO Yu, MIE Yasuhiro, Suzuki MASAAKI, KOMATSU Yasuo

2008(47) 129-130, Sep 27, 2008
Hypothermic preservation of cultured cells with using fish type III antifreeze protein from Noched-fin eelpout.

Warashina, A, Hirano, Y, Takamichi, M, Nishimiya, Y, Kondo, H, Tsuda, S

Cryobiology and Cryotechnology, 54(2) 93-96., 2008
ポーラスアルミナを用いた光干渉型バイオセンサの反応速度特性

池上真志樹, 平野悠, 三重安弘, 鈴木正昭

応用物理学会学術講演会講演予稿集, 68th(3), 2007
国産魚類からの不凍タンパク質の探索と機能解析

西宮佳志, 近藤英昌, 三重安弘, 平野悠, 宇梶愼子, 佐藤涼子, 野呂奈津子, 安井雅範, 高道学, 三浦愛 …

マリンバイオテクノロジー学会大会講演要旨集, 10th, 2007
電気化学酵素免疫測定法によるナトリウム利尿ペプチドホルモン検出

三重安弘, 大須賀友美佳, 平野悠

Proceedings of the Chemical Sensor Symposium, 41 127-129, Apr, 2006
シアフォース電気化学・近接場光学顕微鏡の開発とバイオイメージングへの応用

高橋康史, 平野悠, 安川智之, 珠玖仁, 末永智一

化学とマイクロ・ナノシステム研究会講演要旨集, 13th, 2006

Research Projects

Analysis of beat fluctuations in cardiomyocytes by scanning electrochemical microscopy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Hirano Yu
Development of anti-miRNA oligonucleotides with stable duplexes to control cardiac diseases.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Komatsu Yasuo

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