Naoki Sasaki

Profile Information

Affiliation: Professor, College of Science Department of Chemistry, Rikkyo University

Degree: Ph.D(Mar, 2007, The University of Tokyo)

Researcher number: 30462691
ORCID ID: https://orcid.org/0000-0003-1267-1744
J-GLOBAL ID: 200901009732887380
researchmap Member ID: 6000002032

External link: https://www2.rikkyo.ac.jp/web/n_sasaki/

Naoki SASAKI received B. Eng. (2002), M. Eng. (2004) and PhD in Engineering (2007) degrees (Applied Chemistry) from the University of Tokyo. After working as a Special Postdoctoral Researcher at RIKEN in 2007 – 2010 and as an Assistant Professor at Japan Women’s University in 2010 – 2013, he served as an Associate Professor (PI) at Toyo University. In 2020, he moved to Rikkyo University as an Associate Professor (PI), and he promoted to Full Professor (PI) in 2023. His current research interests include microfluidic systems for bioanalysis and artificial life.

Research Interests

Research Areas

Research History

Apr, 2024 - Present

Rikkyo University
Apr, 2024 - Present

Saitama University
Apr, 2023 - Present

Professor, College of Science Department of Chemistry, Rikkyo University
Sep, 2022 - Present

非常勤講師, 理学部, 日本女子大学
Apr, 2022 - Mar, 2024

Rikkyo University
Apr, 2020 - Mar, 2023

Associate professor, Department of Chemistry, College of Science, Rikkyo University
Jun, 2021 - Sep, 2021

Faculty of Science, Ochanomizu University
Apr, 2016 - Mar, 2020

Associate professor, Department of Applied Chemistry, Faculty of Science and Engineering, Toyo University
Apr, 2013 - Mar, 2016

Associate professor, Department of Applied Chemistry, Faculty of Science and Engineering, Toyo University
Apr, 2010 - Mar, 2013

Assistant professor, Faculty of Science, Japan Women's University
Apr, 2007 - Mar, 2010

Special postdoctoral researcher, RIKEN

Education

Apr, 2004 - Mar, 2007

The University of Tokyo
Apr, 2002 - Mar, 2004

The University of Tokyo
Apr, 1998 - Mar, 2002

Department of Applied Chemistry, The Faculty of Engineering, The University of Tokyo

Committee Memberships

May, 2022 - Present

専門調査員, 文部科学省科学技術・学術政策研究所
2020 - 2023

Technical Program Committee, MicroTAS
Apr, 2019 - Mar, 2022

編集委員, 化学とマイクロ・ナノシステム学会会誌「化学とマイクロ・ナノシステム」
Apr, 2018 - Mar, 2022

代議員, 日本分析化学会
Apr, 2016 - Mar, 2020

「分析化学」編集委員, 日本分析化学会
Aug, 2019 - Aug, 2019

オーガナイザー, 第32回バイオメディカル分析科学シンポジウム若手シンポジウム
Apr, 2015 - Mar, 2018

幹事, 日本分析化学会関東支部
May, 2016 - May, 2016

第76回分析化学討論会討論主題オーガナイザ『分析化学を支える「マイクロ・ナノ」～「マイクロ・ナノ」を基盤技術とした分析化学の新潮流と将来展望』, 日本分析化学会

Awards

Sep, 2023

RSC Tokyo International Conference 2023 "Digital Discovery" Poster Prize, Development of a microfluidic platform to evaluate nanoparticle uptake by tumor cells in the presence of M2 macrophages

Risa Hatsuta, Yiting Zhang, Naoki Sasaki
Nov, 2019

第9回CSJ化学フェスタ2019 優秀ポスター発表賞, 二方向観察可能な膜集積マイクロ流体デバイスを用いる角化細胞層の透過性評価, 日本化学会

杉本茉莉花、佐々木直樹
Sep, 2019

学生ポスター賞, 無細胞マイクロ血管モデルを用いる腫瘍細胞の血管外遊出アッセイ, 日本分析化学会第68年会

浅海裕一郎, 佐々木直樹
Dec, 2016

Hot article award, "A Membrane-Integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines", Analytical Sciences

Naoki SASAKI, Mariko TATANOU, Tomoko SUZUKI, Yasutaka ANRAKU, Akihiro KISHIMURA, Kazunori KATAOKA, Kae SATO
Sep, 2015

Award for Young Researchers, Development of micro bioanalytical devices based on deductive and constitutive approaches, The Japan Society for Analytical Chemistry

Naoki SASAKI
Oct, 2012

優秀ポスター発表賞, 「リンパ管内皮細胞のマイクロデバイス培養と細胞間接着分子の観察」, 第2回CSJ化学フェスタ2012

佐藤美和, 佐々木直樹, 平川聡史, 佐藤香枝
Sep, 2012

Poster Presentation Award, "Microchip-based in situ Padlock/RCA system for single DNA counting in a cell", RSC Tokyo International Conference 2012

Arisa Kuroda, Reina Ishii, Naoki Sasaki, Mats Nilsson, Kae Sato
Jun, 2012

Hot article award, ”Photochemical immobilization of cells onto a glass substrate for in situ DNA analysis”, Analytical Sciences

Naoki SASAKI, Anri ISU, Reina ISHII, Kae SATO

Papers

Bead-Based Padlock Rolling Circle Amplification under Molecular Crowding Conditions: The Effects of Crowder Charge and Size

Naoki SASAKI, Chikako Kase, Kae SATO

Analytical Sciences, 37(5) 727-732, May, 2021 Peer-reviewedLead authorCorresponding author
Fabrication of a T-Shaped Microfluidic Channel Using a Consumer Laser Cutter and Application to Monodisperse Microdroplet Formation

Naoki Sasaki, Eisuke Sugenami

Micromachines, 12(2) 160-160, Feb 5, 2021 Peer-reviewedLead authorCorresponding author
Photolithography-free Vessel-on-a-chip to Simulate Tumor Cell Extravasation

Yuichiro Asaumi, Naoki Sasaki

Sensors and Materials, 33(1) 241-241, Jan 22, 2021 Peer-reviewedLast authorCorresponding author
Mechanistic investigation of bead-based padlock rolling circle amplification under molecular crowding conditions

Naoki Sasaki, Chikako Kase, Masaki Chou, Genki Nakazato, Kae Sato

Analytical Biochemistry, 593 113596-113596, Mar, 2020 Peer-reviewed
Photoactivatable hydrogel interfaces for resolving the interplay of chemical, mechanical, and geometrical regulation of collective cell migration

Shota Yamamoto, Kei Okada, Naoki Sasaki, Alice Chinghsuan Chang, Kazuo Yamaguchi, Jun Nakanishi

Langmuir, 35(23) 7459-7468, Jun, 2019 Peer-reviewed
Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness.

Hiroyoshi Y Tanaka, Kentaro Kitahara, Naoki Sasaki, Natsumi Nakao, Kae Sato, Hirokazu Narita, Hiroshi Shimoda, Michiya Matsusaki, Hiroshi Nishihara, Atsushi Masamune …

Biomaterials, 192 355-367, Feb, 2019 Peer-reviewed
Photolithography-free Skin-on-a-chip for Parallel Permeation Assays

Naoki Sasaki, Kimiaki Tsuchiya, Hironori Kobayashi

Sensors and Materials, 31(1) 107-115, Jan, 2019 Peer-reviewed
Label-free rapid separation and enrichment of bone marrow-derived mesenchymal stem cells from a heterogeneous cell mixture using a dielectrophoresis device

Junya Yoshioka, Yu Ohsugi, Toru Yoshitomi, Tomoyuki Yasukawa, Naoki Sasaki, Keitaro Yoshimoto

Sensors (Switzerland), 18(9) 3007, Sep 8, 2018 Peer-reviewed
Fabrication of Microfluidic Cell Culture Devices Using a Consumer Laser Cutter

Naoki SASAKI, Tomomi HAYASHI, Nanako INOUE, Masahiro ONISHI

BUNSEKI KAGAKU, 67(7) 379-386, Jul, 2018 Peer-reviewed
Molecular crowding improves bead-based padlock rolling circle amplification

Naoki Sasaki, Yoshitaka Gunji, Chikako Kase, Kae Sato

ANALYTICAL BIOCHEMISTRY, 519 15-18, Feb, 2017 Peer-reviewed
A Membrane-integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines

Naoki Sasaki, Mariko Tatanou, Tomoko Suzuki, Yasutaka Anraku, Akihiro Kishimura, Kazunori Kataoka, Kae Sato

ANALYTICAL SCIENCES, 32(12) 1307-1314, Dec, 2016 Peer-reviewed
Analytical applications of microfluidic vascular models

Naoki Sasaki, Kae Sato

Bunseki Kagaku, 65(5) 241-247, 2016 Peer-reviewed
Patterned Co-culture of Live Cells on a Microchip by Photocrosslinking with Benzophenone

Kiichi Sato, Sayaka Kikuchi, Eri Yoshida, Reina Ishh, Naoki Sasaki, Kin-ichi Tsunoda, Kae Sato

ANALYTICAL SCIENCES, 32(1) 113-116, Jan, 2016 Peer-reviewed
Alternating Current Cloud Point Extraction on a Microfluidic Chip: the Use of Ferrocenyl Surfactants

Yuya Usui, Naoki Sasaki

ANALYTICAL SCIENCES, 32(1) 109-111, Jan, 2016 Peer-reviewed
Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability

Miwa Sato, Naoki Sasaki, Manabu Ato, Satoshi Hirakawa, Kiichi Sato, Kae Sato

PLOS ONE, 10(9) e0137301, Sep, 2015 Peer-reviewed
Alternating current cloud point extraction on a microchip: The effect of electrode geometry

Naoki Sasaki, Chisaki Maekawa, Kae Sato

ELECTROPHORESIS, 36(3) 424-427, Feb, 2015 Peer-reviewed
AC electrokinetics for bioanalysis on a microchip

Naoki Sasaki

Bunseki Kagaku, 64(1) 1-8, 2015 Peer-reviewed
Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device

Naoki Sasaki, Jun-Ichiro Jo, Ichio Aoki, Kae Sato

ANALYTICAL BIOCHEMISTRY, 458 72-74, Aug, 2014 Peer-reviewed
Microfluidics for nano-pathophysiology

Kae Sato, Naoki Sasaki, Helene Andersson Svahn, Kiichi Sato

ADVANCED DRUG DELIVERY REVIEWS, 74 115-121, Jul, 2014
Bead-based padlock rolling circle amplification for single DNA molecule counting

Kae Sato, Reina Ishii, Naoki Sasaki, Kiichi Sato, Mats Nilsson

ANALYTICAL BIOCHEMISTRY, 437(1) 43-45, Jun, 2013 Peer-reviewed

Misc.

先んずる者として

佐々木直樹

ぶんせき, (1) 33, Jan, 2024 Invited
Skin-on-a-chipの研究動向

杉本茉莉花, 佐々木直樹

化学とマイクロ・ナノシステム, 18(2), Oct, 2019 Peer-reviewedInvited
粒ぞろいの細胞もどきを作る

佐々木直樹

ぶんせき, (6) 215-215, Jun, 2016 Peer-reviewedInvited
光誘起動電現象で生体分子を濃縮する

佐々木直樹

ぶんせき, (7) 361, 2010

Presentations

160

マイクロ液滴内相分離の酵素反応による制御

藤田夏葉, 章逸汀, 佐々木直樹

第13回CSJ化学フェスタ2023, Oct 19, 2023
多孔膜垂直配置マイクロ腫瘍モデルにおける細胞共培養法の検討

初田理紗, 章逸汀, 佐々木直樹

第13回CSJ化学フェスタ2023, Oct 19, 2023
血管新生実験に応用可能な並行多孔膜組み込みマイクロデバイスの開発

加藤はる香, 章逸汀, 佐々木直樹

第13回CSJ化学フェスタ2023, Oct 19, 2023
Spontaneous dynamic microcompartmentation in cell-sized microdroplets

Naoki Sasaki, Sakurako Kojima

The 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2023), Oct 16, 2023
Development of a microfluidic platform to evaluate nanoparticle uptake by tumor cells in the presence of M2 macrophages

Risa Hatsuta, Yiting Zhang, Naoki Sasaki

RSC Tokyo International Conference 2023, Sep 8, 2023
Angiogenesis model on a microfluidic device with vertically aligned porous membranes

Yiting Zhang, Haruka Kato, Naoki Sasaki

RSC Tokyo International Conference 2023, Sep 8, 2023
Microfluidic fabrication of cell-sized gelatin microparticles

Miki Takagi, Yiting Zhang, Naoki Sasaki

RSC Tokyo International Conference 2023, Sep 8, 2023
細胞様液滴における分子・粒子の局在化と液滴のアレイ化

小嶋櫻子, 坂上欧介, 佐々木直樹

第83回分析化学討論会, May 21, 2023
多孔膜垂直配置マイクロ流体デバイスによる血管新生モデルの構築

加藤はる香, 佐々木直樹

化学とマイクロ・ナノシステム学会第47回研究会, May 14, 2023
民生用レーザー加工機によるマイクロ液滴形成・アレイ化デバイスの作製

坂上欧介, 小嶋櫻子, 佐々木直樹

化学とマイクロ・ナノシステム学会第47回研究会, May 14, 2023
Organ-on-a-Chip with vertically arranged porous membranes

Naoki Sasaki

Pittcon 2023, Mar 21, 2023 Invited
自然乳化と水性二相系を利用するマイクロ液滴内相分離

小嶋櫻子, 佐々木直樹

化学とマイクロ・ナノシステム学会第46回研究会, Nov 15, 2022
自然乳化を利用したマイクロ液滴内相分離

小嶋櫻子, 佐々木直樹

第12回CSJ化学フェスタ2022, Oct 19, 2022
細胞共培養のための多孔膜垂直配置マイクロ流体デバイスの開発

初田理紗, 佐々木直樹

第12回CSJ化学フェスタ2022, Oct 19, 2022
温度相転移を利用するマイクロ液滴・微粒子形成システムの構築

高木美紀, 佐々木直樹

第12回CSJ化学フェスタ2022, Oct 19, 2022
マイクロ流体デバイスを用いる細胞様液滴の形成

二宮駿斗, 黒須梨沙, 杉井菜々花, 佐々木直樹

日本分析化学会第71年会, Sep 16, 2022
22世紀の機器分析

佐々木直樹

第34回環境工学連合講演会, May 31, 2022 Invited
Padlock/RCA法と金ナノ粒子を利用する目視核酸検出

佐々木直樹, 寺澤菜都

第82回分析化学討論会, May 14, 2022
マイクロ液滴形成デバイス

佐々木直樹

令和3年度分析イノベーション交流会, Jan 26, 2022
二方向観察可能なskin-on-a-chipによる抗炎症剤評価（3）：免疫細胞の遊走評価への応用

杉本茉莉花, 安藤直子, 佐々木直樹

第81回分析化学討論会, May 23, 2021

Teaching Experience

Sep, 2023 - Present

科学英語 (立教大学)
Sep, 2022 - Present

分析化学II (日本女子大学)
2022 - Present

自然科学の探求 (立教大学)
2020 - Present

化学実験C (立教大学)
2020 - Present

化学実験B (立教大学)
2020 - Present

化学実験A (立教大学)
2020 - Present

化学の最前線 (立教大学)
2020 - Present

分析化学応用特論１ (立教大学)
2020 - Present

分析化学１ (立教大学)
2021

専門化学実験III (お茶の水女子大学)
Apr, 2013 - Mar, 2020

先端化学 (東洋大学)
Apr, 2013 - Mar, 2020

物理化学II (東洋大学)
Apr, 2013 - Mar, 2020

物理化学I (東洋大学)
Apr, 2013 - Mar, 2020

化学実験 (東洋大学)
Apr, 2018 - Mar, 2019

物理化学III (東洋大学)
Apr, 2016 - Mar, 2019

ナノサイエンス (東洋大学)
Apr, 2013 - Mar, 2018

安全化学 (東洋大学)
Apr, 2013 - Mar, 2016

化学II (東洋大学)
Apr, 2010 - Mar, 2013

物理化学実験 (日本女子大学)
Apr, 2010 - Mar, 2013

化学概論実験 (日本女子大学)

Professional Memberships

Research Projects

非腫瘍細胞を有するマイクロ腫瘍組織モデルの構築

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

佐々木直樹, 岸村顕広
Microfluidic tumor model for nanomedicine development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Sasaki Naoki
White box testing of nanomedicines on a microfluidic device

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Sasaki Naoki
Rapid, sensitive, and on-site detection of bacteria using DNA amplidication on an electrode-integrated microfluidic device

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

SASAKI Naoki
Microfluidic device for stem cell communication analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

SASAKI Naoki
微細加工技術を駆使した細胞質注入による体細胞リプログラミング法の確立

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2009

伊藤嘉浩, 細川和生, 佐々木直樹

Industrial Property Rights

特開2020-028270 細胞遊走アッセイデバイス

佐々木直樹
特開2020-028962 膜組み込みマイクロ流体デバイスの製造方法

佐々木直樹
特開2013-212059 光架橋反応を利用したガラス基板への細胞固定化法

佐藤香枝, 佐々木直樹
特許4590558 流体混合装置

北森武彦, 金幸夫, 佐々木直樹
特許4590557 マイクロミキサーおよび流体の撹拌方法並びに流体の混合方法

北森武彦, 金幸夫, 佐々木直樹
特開2008-062190 マイクロミキサーおよび流体の撹拌方法並びに流体の混合方法

北森武彦, 金幸夫, 佐々木直樹