NAKAYAMA YOSHIAKI

Profile Information

Affiliation: Faculty of Pharmacy, Kobe Pharmaceutical University

Degree: 京都大学博士（薬学）

J-GLOBAL ID: 201001003339416581
researchmap Member ID: 6000023904

External link: https://www.kobepharma-u.ac.jp/micro-s/index.html

京都大学大学院薬学研究科博士課程修了。千葉科学大学薬学部、京都産業大学総合生命科学部を経て、現在、神戸薬科大学准教授。免疫学・分子生物学の研究を行う。

Research Interests

Research Areas

Research History

Apr, 2018 - Present

Kobe Pharmaceutical University
Sep, 2014 - Mar, 2018

Faculty of Pharmacy, Kobe Pharmaceutical University
2010 - Sep, 2014

Faculty of Life Sciences, Kyoto Sangyo University
2008 - 2009

:千葉科学大学薬学部助教

Education

- 2008

Kyoto University
- 2003

Faculty of Pharmaceutical Sciences, Kyoto University

Papers

A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling.

Yoshiaki Nakayama, Yuki Masuda, Takehiro Mukae, Tadahisa Mikami, Ryohei Shimizu, Naoto Kondo, Hiroshi Kitagawa, Nobuyuki Itoh, Morichika Konishi

Communications biology, 7(1) 129-129, Jan 25, 2024
Maitake α-glucan promotes differentiation of monocytic myeloid-derived suppressor cells into M1 macrophages.

Yuki Masuda, Yoshiaki Nakayama, Ryohei Shimizu, Kenta Naito, Eri Miyamoto, Akihiro Tanaka, Morichika Konishi

Life sciences, 317 121453-121453, Mar 15, 2023
Neudesin, A Secretory Protein, Suppresses Cytokine Production in Bone Marrow-Derived Dendritic Cells Stimulated by Lipopolysaccharide

Naoto Kondo, Yuki Masuda, Yoshiaki Nakayama, Ryohei Shimizu, Takumi Tanigaki, Yuri Yasui, Nobuyuki Itoh, Morichika Konishi

BPB Reports, 6(5) 155-162, 2023
Activation of macrophages mediates dietary restriction-induced splenic involution.

Kei Nakayama, Takeshi Yoshida, Yoshiaki Nakayama, Noriaki Iguchi, Yuta Namba, Morichika Konishi, Hiroshi Hasegawa

Life sciences, 310 121068-121068, Dec 1, 2022
Social stress alters sleep in FGF21-deficient mice.

Saori Hokari, Sachiko Chikahisa, Tetsuya Shiuchi, Yoshiaki Nakayama, Morichika Konishi, Seiji Nishino, Nobuyuki Itoh, Hiroyoshi Séi

Brain research bulletin, 191 40-47, Dec, 2022
Maturation of dendritic cells by maitake α-glucan enhances anti-cancer effect of dendritic cell vaccination.

Yuki Masuda, Yoshiaki Nakayama, Takehiro Mukae, Akihiro Tanaka, Kenta Naito, Morichika Konishi

International immunopharmacology, 67 408-416, Feb, 2019 Peer-reviewed
Fgf21 regulates T-cell development in the neonatal and juvenile thymus.

Yoshiaki Nakayama, Yuki Masuda, Hiroya Ohta, Tomohiro Tanaka, Miwa Washida, Yo-Ichi Nabeshima, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi

Scientific reports, 7(1) 330-330, Mar 23, 2017 Peer-reviewed
Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor.

Yuki Masuda, Yoshiaki Nakayama, Akihiro Tanaka, Kenta Naito, Morichika Konishi

PloS one, 12(3) e0173621, 2017 Peer-reviewed
Enhancing Study Motivation and Efficacy among First-year Students Using Minute Papers in the Interdisciplinary Subject of Yakugaku Nyumon.

Kouya Yamaki, Koji Ikeda, Kumiko Ueda, Yasushi Habu, Yoshiaki Nakayama, Norihiko Takeda, Kensuke Moriwaki, Akimori Wada, Junko Koyama, Noriko Kodama …

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 137(10) 1285-1299, 2017 Peer-reviewed
[Secreted factor, FGF21, regulates diverse biological processes].

Morichika Konishi, Yoshiaki Nakayama, Yuki Masuda

Seikagaku. The Journal of Japanese Biochemical Society, 88(1) 86-93, Feb, 2016 Peer-reviewed
Interdisciplinary Subject "Yakugaku Nyumon" for First-year Students Constructed with Lectures and Problem-based Learning.

Kouya Yamaki, Masafumi Ueda, Kumiko Ueda, Noriaki Emoto, Nobuaki Mizutani, Koji Ikeda, Keiko Yagi, Masafumi Tanaka, Yasushi Habu, Yoshiaki Nakayama …

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 136(7) 1051-64, 2016 Peer-reviewed
Roles of FGF Signals in Heart Development, Health, and Disease.

Nobuyuki Itoh, Hiroya Ohta, Yoshiaki Nakayama, Morichika Konishi

Frontiers in cell and developmental biology, 4 110-110, 2016 Peer-reviewed
Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease.

Nobuyuki Itoh, Yoshiaki Nakayama, Morichika Konishi

Frontiers in cell and developmental biology, 4 30-30, 2016 Peer-reviewed
Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity.

Yuki Masuda, Daiki Nawa, Yoshiaki Nakayama, Morichika Konishi, Hiroaki Nanba

Journal of leukocyte biology, 98(6) 1015-25, Dec, 2015 Peer-reviewed
O-glycosylation in development of zebrafish

Akira Kurosaka, Yoshiaki Nakayama, Naosuke Nakamura

Glycoscience: Biology and Medicine, 833, Jan 1, 2015 Peer-reviewed
Expression of Fgf23 in activated dendritic cells and macrophages in response to immunological stimuli in mice.

Yuki Masuda, Hiroya Ohta, Yumiko Morita, Yoshiaki Nakayama, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi

Biological & pharmaceutical bulletin, 38(5) 687-93, 2015 Peer-reviewed
Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.

Paitoon Srimontri, Shogo Endo, Toshiro Sakamoto, Yoshiaki Nakayama, Akira Kurosaka, Shigeyoshi Itohara, Yoshio Hirabayashi, Keiko Kato

Journal of neurochemistry, 131(5) 675-87, Dec, 2014 Peer-reviewed
Identification and expression analysis of zebrafish polypeptide α-N-acetylgalactosaminyltransferase Y-subfamily genes during embryonic development.

Yoshiaki Nakayama, Naosuke Nakamura, Tamiko Kawai, Eiichi Kaneda, Yui Takahashi, Ayumi Miyake, Nobuyuki Itoh, Akira Kurosaka

Gene expression patterns : GEP, 16(1) 1-7, Sep, 2014 Peer-reviewed
A rapid and efficient method for neuronal induction of the P19 embryonic carcinoma cell line.

Yoshiaki Nakayama, Ayumi Wada, Rei Inoue, Kazuya Terasawa, Ikuo Kimura, Naosuke Nakamura, Akira Kurosaka

Journal of neuroscience methods, 227 100-6, Apr 30, 2014 Peer-reviewed
Fgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain.

Ayumi Miyake, Tatsuya Chitose, Eriko Kamei, Atsuko Murakami, Yoshiaki Nakayama, Morichika Konishi, Nobuyuki Itoh

PloS one, 9(10) e110836, 2014 Peer-reviewed

Misc.

分泌タンパク質neudesinは炎症性マクロファージに作用しJak/Stat/iNOS経路を抑制する

森本優樹, 中山喜明, 増田有紀, 清水涼平, 伊藤信行, 小西守周

日本薬学会年会要旨集, 142年会 26PO5-03S, Mar, 2022
Fgf21は胸腺髄質上皮細胞の分化成熟を促進し、樹状細胞への組織特異的自己抗原の移行を誘導することで、中枢性免疫寛容に貢献する

安田奨, 岡優希, 増田有紀, 清水涼平, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 142年会 28PO6-01S, Mar, 2022
食餌性肥満とニコチンによって誘発される筋萎縮と代謝変化におけるFgf21の生理的意義

藤本祥文, 薦田哲志, 増田有紀, 清水涼平, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 142年会 28PO9-03S, Mar, 2022
炎症時のマクロファージにおける分泌因子Neudesinの役割の検討

西山侑志, 稲岡浩輝, 上村祐毅, 米田茉希子, 中山喜明, 増田有紀, 伊藤信行, 小西守周

日本薬学会年会要旨集, 141年会 29P01-088S, Mar, 2021
分泌因子Neudesinは樹状細胞の活性を抑制することで、がんの成長を促進する

谷垣拓海, 高間哲也, 村田亜津紀, 松前憲幸, 阿部佑亮, 増田有紀, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 141年会 29P01-089S, Mar, 2021
分泌因子Neudesinは抗原提示細胞の活性を抑制することで、がんの成長を促進する

松前憲幸, 阿部佑亮, 図師まゆ香, 豊田祥恵, 増田有紀, 迎武紘, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 140年会 28Q-pm035S, Mar, 2020
分泌因子Neudesinはマクロファージによる老化赤血球貪食を調節する

米田茉希子, 阿部栞里, 上村祐毅, 立川奈都季, 中野絵梨香, 迎武紘, 増田有紀, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 140年会 28Q-pm036S, Mar, 2020
Fgf21は胸腺樹状細胞を介して中枢性免疫寛容を維持することで、自己免疫疾患の発症を抑制する

荒畠志帆, 岡龍太郎, 松田貴史, 増田有紀, 迎武紘, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 140年会 28Q-pm037S, Mar, 2020
がん組織内マクロファージを標的とするセラノスティクスを指向した蛍光色素標識酸化鉄ナノ粒子の開発

鳥井みよ, 佐野紘平, 片岡若菜, 中山喜明, 小西守周, 宗兼将之, 山崎俊栄, 向高弘

日本DDS学会学術集会プログラム予稿集, 36th 204-204, 2020
Refeeding時の肝臓におけるFgf21の意義

濱本あかり, 吉野美波, 岡田瞳美, 迎武紘, 増田有紀, 中山喜明, 小西守周

日本栄養・食糧学会大会講演要旨集, 73回 284-284, Apr, 2019
低タンパク質栄養状態におけるFGF21の創傷治癒に及ぼす影響

金野凌介, 土居史佳, 岩槻健, 中山喜明, 小西守周, 大石祐一, 山根拓実

アミノ酸研究, 12(2) 121-122, Mar, 2019
分泌因子Neudesinのがん免疫抑制作用について

図師まゆ香, 豊田祥恵, 長久保智希, 中村祐馬, 増田有紀, 迎武紘, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 139年会(3) 99-99, Mar, 2019
Refeeding時の肝臓におけるFgf21の意義

吉野美波, 濱本あかり, 岡田瞳美, 迎武紘, 増田有紀, 中山喜明, 伊藤信行, 小西守周

日本薬学会年会要旨集, 139年会(3) 142-142, Mar, 2019
創傷治癒を補助する細胞療法 FGF21が創傷治癒に及ぼす影響

金野凌介, 土居史佳, 岩槻健, 中山喜明, 小西守周, 大石祐一, 山根拓実

日本創傷治癒学会プログラム・抄録集, 48回 104-104, Nov, 2018
分泌型ヘムタンパク質Neudesinによる赤血球恒常性維持機構の解析

中山喜明, 土居晃平, 楢林桃子, 岩崎駿, 迎武紘, 増田有紀, 伊藤信行, 小西守周

日本薬学会年会要旨集(CD-ROM), 138th(3) ROMBUNNO.26PA‐pm090-173, 2018
Production of double mutants that lack paralogue enzyme genes for mucin-type glycan biosynthesis

Nakamura Naosuke, Tsukada Kasumi, Tsujimoto Yuki, Nakayama Yoshiaki, Konishi Morichika, Kurosaka Akira

GLYCOBIOLOGY, 27(12) 1195-1196, Dec, 2017 Peer-reviewed
分野横断的統合型初年次導入科目「薬学入門」へのミニッツペーパー導入が生み出す学習意欲と学習効果

八巻耕也, 池田宏二, 上田久美子, 土生康司, 中山喜明, 武田紀彦, 森脇健介, 和田昭盛, 小山淳子, 児玉典子 …

薬学雑誌, 137(10) 1285-1299, Oct, 2017
液性因子noudesinによるエネルギー代謝調節機構の解明

太田紘也, 太田紘也, 小西守周, 中山喜明, 中尾一和, 菅波孝祥, 木村郁夫, 伊藤信行

日本内分泌学会雑誌, 93(1) 331-331, Apr 1, 2017
ゲノム編集技術を用いたムチン型糖鎖合成酵素をコードするパラログ遺伝子の二重変異体作製

中村直介, 塚田かすみ, 辻本優季, 中山喜明, 小西守周, 黒坂光

日本生化学会大会(Web), 90th ROMBUNNO.2P‐0012 (WEB ONLY)-0012], 2017
新規肥満症鍵分子neudesinの寒冷ストレス暴露による発現変化および機能解析

迎武紘, 太田紘也, 山田祐維, 中山喜明, 増田有紀, 木村郁夫, 伊藤信之, 小西守周

日本生化学会大会(Web), 90th ROMBUNNO.2P‐1039 (WEB ONLY)-1039], 2017

Books and Other Publications

enetic Diseases Associated with Protein Glycosylation Disorders in Mammals

Nakayama, Y, Nakamura, N, Tsuji, D, Itoh, K, Kurosaka, A

2013
The FGF Family in Humans, Mice, and Zebrafish: Development, Physiology, and Pathophysiology

Human Genetic Diseases, 2011

Professional Memberships

Research Projects

分泌型ヘムタンパク質によるマクロファージの貪食抑制機構の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

中山喜明, 小西守周, 野中元裕
Functional analysis of orphan glycosyltransferases involved in mucin-type O-glycosylation in the brain

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

KUROSAKA Akira
Clarification of molecular mechanisms that are involved in onset of epilepsy, depression, and anxiety.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

KATO Keiko, FURUKAWA Jyunichi
The novel roles of O-glycans in hypothalamus-pituitary axis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Nakayama Yoshiaki
Functional analysis of macropinocytosis in cancer cells under poor nutrientional status

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

YOSHIAKI Nakayama, KUROSAKA Akira, NAKAMURA Naosuke
神経回路形成におけるムチン型糖鎖による新たな膜輸送制御システムの解析

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2012 - Mar, 2014

中山喜明
Studying on ppGalNAcT with focus on the roles of mucin-type carbohydrates in the retinal development.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

NAKAYAMA Yoshiaki, KUROSAKA Akira, NAKAMURA Naosuke, ITOH Nobuyuki, MIYAKE Ayumi
Functional of a brain-specific mucin-type carbohydrate glycosyltransferase involved in neural development and apoptosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

KUROSAKA Akira, TERACHI Toru, SEO Misuzu, NAKAMURA Naosuke, NAKAYAMA Yoshiaki

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