Kazushige Kuroha

Profile Information

Affiliation: School of Medicine Medical Course , Histology and Cell Biology, Yokohama City University

Degree: 博士（理学）(名古屋大学)

J-GLOBAL ID: 201101092212606730
researchmap Member ID: 6000029620

External link: http://db.tohoku.ac.jp/whois/detail/29c473119f059757dc5fef7ab35d0165.html

真核生物における翻訳制御と品質管理機構。
精子幹細胞において分化誘導の鍵となるゲノム修飾酵素群の翻訳制御機構。

Research Interests

Research Areas

Research History

Apr, 2019 - Present

Assistant Professor, School of Medicine, Yokohama City University
Apr, 2013 - Mar, 2019

Postdoctoral fellow, SUNY Downstate Medical Center
Apr, 2010 - Mar, 2013

Researcher, Tohoku University Graduate School of Pharmaceutical Sciences

Papers

Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC.

Anna Miścicka, Alexander G Bulakhov, Kazushige Kuroha, Alexandra Zinoviev, Christopher U T Hellen, Tatyana V Pestova

Nucleic acids research, Feb 15, 2024 Peer-reviewed
Tsga8 is required for spermatid morphogenesis and male fertility in mice.

Yuki Kobayashi, Shin-Ichi Tomizawa, Michio Ono, Kazushige Kuroha, Keisuke Minamizawa, Koji Natsume, Selma Dizdarević, Ivana Dočkal, Hiromitsu Tanaka, Tatsukata Kawagoe …

Development (Cambridge, England), 148(8), Apr 15, 2021 Peer-reviewed
Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice.

Kuniko Nakajima, Michio Ono, Uroš Radović, Selma Dizdarević, Shin-Ichi Tomizawa, Kazushige Kuroha, Go Nagamatsu, Ikue Hoshi, Risa Matsunaga, Takayuki Shirakawa …

Disease models & mechanisms, 12(11), Nov 12, 2019 Peer-reviewed
Two classes of EF1-family translational GTPases encoded by giant viruses

Zinoviev, Alexandra, Kuroha, Kazushige, Pestova, Tatyana, Hellen, Christopher

Nucleic Acids Research, 47(11) 5761-5776, Apr, 2019 Peer-reviewed
Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1.

Kuroha K, Zinoviev A, Hellen CUT, Pestova TV

Molecular cell, 72(2) 286-302.e8, Oct, 2018 Peer-reviewedLead authorCorresponding author
The Upf factor complex interacts with aberrant products derived from mRNAs containing a premature termination codon and facilitates their proteasomal degradation.

Kazushige Kuroha, Koji Ando, Reiko Nakagawa, Toshifumi Inada

The Journal of biological chemistry, 288(40) 28630-40, Oct 4, 2013 Peer-reviewed
Roles of Dom34:Hbs1 in Nonstop Protein Clearance from Translocators for Normal Organelle Protein Influx

Toshiaki Izawa, Tatsuhisa Tsuboi, Kazushige Kuroha, Toshifumi Inada, Shuh-ichi Nishikawa, Toshiya Endo

CELL REPORTS, 2(3) 447-453, Sep, 2012 Peer-reviewed
Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3 ' End of Aberrant mRNA

Tatsuhisa Tsuboi, Kazushige Kuroha, Kazuhei Kudo, Shiho Makino, Eni Inoue, Isao Kashima, Toshifumi Inada

MOLECULAR CELL, 46(4) 518-529, May, 2012 Peer-reviewed
Receptor for activated C kinase 1 stimulates nascent polypeptide-dependent translation arrest

Kazushige Kuroha, Mayuko Akamatsu, Lyudmila Dimitrova, Takehiko Ito, Yuki Kato, Katsuhiko Shirahige, Toshifumi Inada

EMBO REPORTS, 11(12) 956-961, Dec, 2010 Peer-reviewed
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1 alpha complex

Kan Kobayashi, Izumi Kikuno, Kazushige Kuroha, Kazuki Saito, Koichi Ito, Ryuichiro Ishitani, Toshifumi Inada, Osamu Nureki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(41) 17575-17579, Oct, 2010 Peer-reviewed
Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome

Kazushige Kuroha, Tsuyako Tatematsu, Toshifumi Inada

EMBO REPORTS, 10(11) 1265-1271, Nov, 2009 Peer-reviewed
Analysis of nonstop mRNA translation in the absence of tmRNA in Escherichia coli

Kazushige Kuroha, Nobuo Horiguchi, Hiroji Aiba, Toshifumi Inada

GENES TO CELLS, 14(6) 739-749, Jun, 2009 Peer-reviewed
Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein Degradation by the Proteasome

Lyudmila N. Dimitrova, Kazushige Kuroha, Tsuyako Tatematsu, Toshifumi Inada

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(16) 10343-10352, Apr, 2009 Peer-reviewedLead author
Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeast

Sayoko Ito-Harashima, Kazushige Kuroha, Tsuyako Tatematsu, Toshifumi Inada

GENES & DEVELOPMENT, 21(5) 519-524, Mar, 2007 Peer-reviewed

Misc.

未成熟終止コドンを含むmRNA由来のタンパク質分解機構の解析

安藤功穣, 黒羽一誠, 中川れい子, 稲田利文

日本RNA学会年会要旨集, 16th 235, Jul 23, 2014
未成熟終止コドンを含むmRNA由来のタンパク質分解促進機構の解析

安藤功穣, 黒羽一誠, 中川れい子, 稲田利文

日本蛋白質科学会年会プログラム・要旨集, 14th 134, May 26, 2014
オルガネラタンパク質の膜輸送システムおけるDom34:Hbs1複合体の役割

井澤俊明, 黒羽一誠, 稲田利文, 西川周一, 遠藤斗志也

日本蛋白質科学会年会プログラム・要旨集, 12th 61, May 31, 2012
翻訳アレストおよびNGDにおけるRACK1の機能解析

池内健, 黒羽一誠, 鹿島勲, 稲田利文

日本分子生物学会年会プログラム・要旨集(Web), 34th, 2011
Twelve basic amino acids in a row tend to induce translation arrest, followed by endonucleolytic cleavage and proteasome-mediated nascent peptide degradation in yeast

L. Dimitrova, K. Kuroha, T. Tatematsu, T. Inada

FEBS JOURNAL, 275 146-146, Jun, 2008

Professional Memberships

Research Projects

精子幹細胞の運命決定に関わるエピジェネティクス因子群の転写後制御機構

内藤記念科学奨励金・研究助成, 公益財団法人内藤記念科学振興財団, Sep, 2021 - Sep, 2023
Post-transcriptional control of spermatogonial stem cell self-renewal and differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
精子幹細胞の運命決定に関わるH3K9メチル基転移酵素の時期特異的発現を規定する翻訳制御機構の解析

ビジョナリーリサーチ助成(スタート), 武田科学振興財団, 2021 - 2023
精子幹細胞の運命決定に関わるエピジェネティクス関連分子の翻訳制御機構

わかば助成金, 一般財団法人横浜総合医学振興財団, Aug, 2021 - Aug, 2022
精子幹細胞における分化開始と共役したエピジェネティック因子群の翻訳制御機構

研究活動スタート支援, 横浜市立大学, Aug, 2019 - Mar, 2021

黒羽一誠
Mechanism of translation arrest and degradation of aberrant products in mRNA quality control systems

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

KUROHA Kazushige
新生ポリペプチド鎖依存的な翻訳アレストとそれに伴うmRNA分解機構

研究活動スタート支援, 研究活動スタート支援, 東北大学, 2010 - 2011

黒羽一誠
プロテアソームによる異常mRNA由来の異常タンパク質分解機構の解析

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2008 - 2010

黒羽一誠

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Research Interests

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Research History

Papers

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