Tsukasa Seya

Profile Information

Affiliation: Professor, Graduate School of Medicine, Division of Medicine, Aomori University

Degree: Medical Doctor(Hokkaido University)
薬学博士(北海道大学)

J-GLOBAL ID: 200901092226287256
researchmap Member ID: 0000021382

External link: http://www.med.hokudai.ac.jp/~bac-w/

Research Interests

Research Areas

Research History

2019 - Present

Aomori University
2016 - 2019

- 北海道大学大学院医学研究科産業創出分野ワクチン免疫学分野特任教授
2004 - 2016

- 北海道大学大学院医学研究科免疫学分野教授
2006 - 2009

北海道大学先端生命科学研究院教授
2005 - 2007

東京大学医学研究科非常勤講師（併任）講師
2004 - 2007

大阪府立成人病センター研究所研究員
2005 - 2006

Institute for Virus Research, Kyoto University
2003 - 2004

大阪大学医学研究科客員教授教授
2001 - 2004

大阪府立成人病センター研究所所長
1998 - 2004

奈良先端大学院大学客員教授教授
1998 - 2001

大阪府立成人病センター研究所免疫部門部長
1987 - 1998

大阪府立成人病センター研究所免疫部門室長
1984 - 1987

米国ワシントン大学微生物・免疫学講座研究員
1979 - 1984

Faculty of Pharmaceutical Sciences, Hokkaido University
1976 - 1979

北海道大学医学部附属病院1内科医員

Education

Committee Memberships

2008

広報委員, 日本免疫学会

Awards

2015

小島三郎記念医学賞, 黒住財団

瀬谷司
2015

北海道医師会医学賞, 北海道医師会

瀬谷司
2014

北海道科学技術賞, 北海道庁

瀬谷司
2006

武田科学振興財団研究助成金（一般研究奨励）
2005

三菱財団研究奨励賞
2005

Mitsubishi Foundation Princess Takamatsu Cancer Research Fund
2003

高松宮妃がん研究奨励賞

Papers

457

Two Modes of Th1 Polarization Induced by Dendritic-Cell-Priming Adjuvant in Vaccination.

Tsukasa Seya, Masashi Shingai, Tomomi Kawakita, Misako Matsumoto

Cells, 12(11), May 29, 2023
Innate-Acquired Linkage in Immunotherapy.

Tsukasa Seya

Cells, 12(3), Jan 19, 2023
Toward Establishing an Ideal Adjuvant for Non-Inflammatory Immune Enhancement.

Tsukasa Seya, Megumi Tatematsu, Misako Matsumoto

Cells, 11(24), Dec 11, 2022
Prophylactic Vaccine Targeting TLR3 on Dendritic Cells Ameliorates Eosinophilic Pneumonia in a Mouse SARS-CoV Infection Model.

Naoko Iwata-Yoshikawa, Noriyo Nagata, Hiromi Takaki, Misako Matsumoto, Tadaki Suzuki, Hideki Hasegawa, Tsukasa Seya

ImmunoHorizons, 6(4) 275-282, Apr 27, 2022
Hepatitis B virus genomic nucleic acid in the activation and maturation of bone marrow-derived dendritic cells

Chean Ring Leong, Tsukasa Seya, Woei Yenn Tong, Wen-Nee Tan

Asia Pacific Journal of Molecular Biology and Biotechnology, 109-119, Dec 30, 2021
Targeting Toll-like receptor 3 in dendritic cells for cancer immunotherapy.

Misako Matsumoto, Yohei Takeda, Tsukasa Seya

Expert opinion on biological therapy, 20(8) 1-10, Apr 7, 2020 Peer-reviewed
Correction to: Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.

Olga Romanets-Korbut, Larysa M Kovalevska, Tsukasa Seya, Svetlana P Sidorenko, Branka Horvat

Cellular & molecular immunology, 17(3) 300-301, Mar, 2020
Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells.

Wang G, Kouwaki T, Mugikura K, Okamoto M, Takaki H, Funami K, Seya T, Oshiumi H

The Journal of biological chemistry, 294(50) 18969-18979, Dec, 2019 Peer-reviewed
A Toll-like receptor 3 (TLR3) agonist ARNAX for therapeutic immunotherapy.

Seya T, Takeda Y, Matsumoto M

Advanced drug delivery reviews, 147 37-43, Jul, 2019 Peer-reviewed
Glycan vaccine

Tsukasa Seya, Sho Yamasaki, Koichi Fukase

Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG), 179-187, Jan 1, 2019
Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy.

Yoshida S, Shime H, Matsumoto M, Kasahara M, Seya T

Frontiers in immunology, 10 671-671, 2019 Peer-reviewed
Vaccine adjuvant ARNAX promotes mucosal IgA production in influenza HA vaccination.

Takeda Y, Takaki H, Fukui-Miyazaki A, Yoshida S, Matsumoto M, Seya T

Biochemical and biophysical research communications, 506(4) 1019-1025, Dec, 2018 Peer-reviewed
The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells.

Takeda Y, Azuma M, Hatsugai R, Fujimoto Y, Hashimoto M, Fukase K, Matsumoto M, Seya T

Innate immunity, 24(5) 323-331, Jul, 2018 Peer-reviewed
Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models.

Takeda Y, Yoshida S, Takashima K, Ishii-Mugikura N, Shime H, Seya T, Matsumoto M

Cancer science, 109(7) 2119-2129, Jul, 2018 Peer-reviewed
Mucosal Immune Response in Nasal-Associated Lymphoid Tissue upon Intranasal Administration by Adjuvants.

Takaki H, Ichimiya S, Matsumoto M, Seya T

Journal of innate immunity, 10(5-6) 1-7, Jun, 2018 Peer-reviewed
TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells.

Takashima K, Oshiumi H, Matsumoto M, Seya T

Biochemical and biophysical research communications, 499(4) 985-991, May, 2018 Peer-reviewed
Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model.

Yoshida S, Shime H, Takeda Y, Nam JM, Takashima K, Matsumoto M, Shirato H, Kasahara M, Seya T

Cancer science, 109(4) 956-965, Apr, 2018 Peer-reviewed
DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70

Ken Takashima, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya

Journal of Innate Immunity, 10(1) 44-55, Feb 1, 2018 Peer-reviewed
Toll-like receptor 3 in nasal CD103 + dendritic cells is involved in immunoglobulin A production

H. Takaki, S. Kure, H. Oshiumi, Y. Sakoda, T. Suzuki, A. Ainai, H. Hasegawa, M. Matsumoto, T. Seya

Mucosal Immunology, 11(1) 82-96, Jan 1, 2018 Peer-reviewed
Extracellular RNA Sensing by Pattern Recognition Receptors.

Megumi Tatematsu, Kenji Funami, Tsukasa Seya, Misako Matsumoto

Journal of innate immunity, 10(5-6) 398-406, 2018

Misc.

133

腫瘍抗原特異的CTLの誘導・活性化維持を軸とした複合免疫療法

Yohei Takeda, Misako Matsumoto, Tsukasa Seya

Cancer Immunotherapy, 2(2) 50-52, Sep, 2018 Invited
A safe way for insulting antigen with adjuvant without cytokine toxicity in vaccines

Tsukasa Seya

CYTOKINE, 100 56-57, Dec, 2017
炎症毒性のない抗がん免疫アジュバントの開発へ向けて (第二回)

瀬谷司, 松本美佐子, 武田洋平

The Lung perspectives, 25(3) 87-93, Aug, 2017 Invited
炎症毒性のない抗がん免疫アジュバントの開発へ向けて (第一回)

瀬谷司, 松本美佐子, 武田洋平

The Lung perspectives, 25(2) 78-83, May, 2017 Invited
Tumor cell death by pattern-sensing of exogenous RNA: Tumor cell TLR3 directly induces necroptosis by poly(I:C) in vivo, independent of immune effector-mediated tumor shrinkage

Hiromi Takaki, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya

ONCOIMMUNOLOGY, 6(10), 2017
Priming adjuvant for evoking antitumor immunity

256(7) 811-816, Feb 13, 2016
Tumor vaccines with dsRNA adjuvant ARNAX induces antigen-specific tumor shrinkage without cytokinemia

Tsukasa Seya, Yohei Takeda, Misako Matsumoto

ONCOIMMUNOLOGY, 5(2), 2016
ヒト初代B細胞におけるHCVcc感染

中井正人, 伊藤淳, 常松聖司, 佐藤史幸, 佃曜子, 寺下勝巳, 荘拓也, 須田剛生, 夏井坂光輝, 小川浩司 …

日本消化器病学会雑誌, 112(臨増総会) A354-A354, Mar, 2015
アダプタータイプTIRドメインの溶液構造

久米田博之, 榎園能章, 狩野裕孝, 堀内正隆, 小椋賢治, 瀬谷司, 稲垣冬彦

Abstracts. Annual Meeting of the NMR Society of Japan, 54th, 2015
Inflammation and immunity in cancer

Tsukasa Seya, Misako Matsumoto, Keiko Udaka, Noriyuki Sato

Inflammation and Immunity in Cancer, 1-268, Jan 1, 2015
Regulatory mechanism of RIG-I signaling by NS3-4A protease of hepatitis C virus

62(3) 262-267, Sep, 2014
Regulatory mechanism of RIG-I signaling by ubiquitin ligases

62(1) 111-119, Jul, 2014
dsRNA induces conversion of immunosuppressive TAMs and MDSCs to cells with antitumor activity

61(6) 613-620, Jun, 2014
RNA Response in Tumor-infiltrating Macrophages

33(12) 1242-1246, 2014
INAMはpolyI:C治療によるメラノーマの抗肺転移活性に必須である

笠松純, 押海裕之, 松本美佐子, 瀬谷司

日本生体防御学会学術総会講演抄録集, 25th 20, 2014
INAM plays a critical role in rapid NK-accessory cell interaction leading to IFN .GAMMA. induction

KASAMATSU Jun, OSHIUMI Hiroyuki, EBIHARA Takashi, MATSUMOTO Misako, SEYA Tsukasa

日本免疫学会総会・学術集会記録, 42(Proceedings) 83-83, Nov 18, 2013
Regulation of Tregs by TLR stimulation

246(10) 871-878, Sep 7, 2013
Toll-like receptor in tumor immunity

12(2) 196-203, Aug, 2013
TLR3シグナル経路の活性化は腫瘍内ミエロイド系細胞を癌攻撃型エフェクターに転換する

志馬寛明, 松本美佐子, 押海裕之, 田中伸哉, 中根明夫, 岩倉洋一郎, 田原秀晃, 井上徳光, 瀬谷司

北海道醫學雜誌 = Acta medica Hokkaidonensia, 88(2) 81-81, Apr 1, 2013
Poly(I:C)はCD8^+DCのTLR3/TICAM-1経路を介して抗腫瘍CTLを誘導する

東正大, 海老原敬, 押海裕之, 松本美佐子, 瀬谷司

北海道醫學雜誌 = Acta medica Hokkaidonensia, 88(2) 97-97, Apr 1, 2013

Teaching Experience

Professional Memberships

Works

21世紀COEプログラム＜バイオとナノを融合する新生命科学拠点＞シンポジウム「創薬を目指したケミカルバイオロジー研究の最前線」（札幌）：合成ワクチンアジュバントによる樹状細胞の機能分化（特別講演）

2005

Research Projects

Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2016

HATAKEYAMA Masanori, TANIGUCHI Tadatsugu, SEYA Tsukasa, OSHIMA Masanobu, MATSUOKA Masao, SHIMOTOHNO Kunitada, AZUMA Takeshi, AKIYOSHI Kazunari
液性メディエーターとしてのnon-coding RNA

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, Apr, 2014 - Mar, 2015

瀬谷司
感染発がんを変調する宿主炎症応答機構

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Jun, 2010 - Mar, 2015

瀬谷司, 松本美佐子, 櫨木薫, 志馬寛明, PENMETCHA Kumar
An alternative interferon inducing pathway predicted through phylogenetic analyses

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SEYA Tsukasa
Molecular mechanisms of dendritic cell maturation in response to pattern sensing

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

SEYA Tsukasa, MATSUMOTO Misako, OSHIUMI Hiroyuki, SHIME Hiroaki
The role of innate immune signals in controlling regulatory T cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

SAYURI Yamazaki, SEYA Tsukasa
Spatiotemporal regulation of nucleic acid uptake and signaling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

MATSUMOTO Misako, SEYA Tsukasa
Molecular mechanism by which extracellular RNA activates Toll-like receptor 3

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project), Japan Society for the Promotion of Science, 2009 - 2011

MATSUMOTO Misako, SEYA Tsukasa
ウイルス感染樹状細胞のエフェクター誘導の多指向性

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2009 - 2010

瀬谷司
Mechanism of nucleic acid recognition by endosomal Toll-like receptor 3

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

MATSUMOTO Misako, SEYA Tsukasa
トール受容体の発がん制御機構の解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

瀬谷司
Pattern-recognition receptors in dendritic cells evoke cellular immunity in response to viral RNA patterns

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2007 - 2009

SEYA Tsukasa, MATSUMOTO Misako, AKAZAWA Takashi
ウイルス感染のRNA応答

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2007 - 2008

瀬谷司, 松本美佐子, 押海裕之, 海老原敬
サカナの自然免疫:がん、感染症に関与する環境因子探索のモデル系の構築

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2005 - 2006

瀬谷司
Functional analysis of the surface proteins (F, G and SH proteins) of human metapneumovirus and its clinical application

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

ISHIGURO Nobuhisa, SEYA Tsukasa
Pattern recognition receptors on human dendritic cells that induce specific effector responses depending on microbes.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2004 - 2005

SEYA Thukasa, MATSUMOTO Misako, HAZEKI Kaoru
Molecular mechanism whereby Type I interferon is induced in host immune cells by measles virus infection : possible involvement of Toll-like receptors (TLRs)

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2005

SEYA Tsukasa, MATSUMOTO Misako
自然免疫の活性化による抗がん免疫療法

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2004 - 2004

瀬谷司, 松本美佐子, 赤澤隆
Recognition of dsRNA by Toll-like receplor 3

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

MATSUMOTO Misako, SEYA Tsukasa
Innate immunityの活性化による抗がん免疫療法

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2003 - 2003

瀬谷司, 赤澤隆

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