岡本宏 (Hiroshi Okamoto) - マイポータル

基本情報

所属: 東北大学大学院医学系研究科・医学部医科学専攻名誉教授

J-GLOBAL ID: 200901007115758309
researchmap会員ID: 1000003935

外部リンク: http://db.tohoku.ac.jp/whois/detail/f3431c410316984fa67d7813d3feba70.html

研究キーワード

研究分野

学歴

- 1969年3月

京都大学, 医学研究科, 生理系
- 1964年3月

金沢大学, 医学部, 医学科

受賞

論文

179

Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells

Haruhiro Higashida, Sarah E. H. Bowden, Shigeru Yokoyama, Alla Salmina, Minako Hashii, Naoto Hoshi, Jia-Sheng Zhang, Rimma Knijnik, Mami Noda, Zen-Guo Zhong …

NEUROSCIENCE RESEARCH 57(3) 339-346 2007年3月査読有り
CD38 is critical for social behaviour by regulating oxytocin secretion

Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike …

NATURE 446(7131) 41-45 2007年3月査読有り
Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine

T. Ose, Y. Kadowaki, H. Fukuhara, H. Kazumori, S. Ishihara, J. Udagawa, H. Otani, S. Takasawa, H. Okamoto, Y. Kinoshita

ONCOGENE 26(3) 349-359 2007年1月査読有り
REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy

Satoru Motoyama, Toshihiro Sugiyama, Yasuharu Ueno, Hiroshi Okamoto, Shin Takasawa, Hiroshi Nanjo, Hitoshi Watanabe, Kiyotomi Maruyama, Manabu Okuyama, Jun-ichi Ogawa

ANNALS OF SURGICAL ONCOLOGY 13(12) 1724-1731 2006年12月査読有り
Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFN beta

R. Planas, A. Alba, J. Carrillo, M. C. Puertas, R. Ampudia, X. Pastor, H. Okamoto, S. Takasawa, W. Gurr, R. Pujol-Borrell …

DIABETOLOGIA 49(10) 2379-2387 2006年10月査読有り
RAGE control of diabetic nephropathy in a mouse model - Effects of RAGE gene disruption and administration of low-molecular weight heparin

Khin-Mar Myint, Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Ai Harashima, Hideto Yonekura, Takuo Watanabe, Harumichi Shinohara, Masayoshi Takeuchi, Koichi Tsuneyama …

DIABETES 55(9) 2510-2522 2006年9月査読有り
Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas

YR Lu, A Ponton, H Okamoto, S Takasawa, PL Herrera, JL Liu

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 291(1) E50-E58 2006年7月査読有り
Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis

Martin H. Bluth, Sameer A. Patel, Brian K. Dieckgraefe, Hiroshi Okamoto, Michael E. Zenilman

WORLD JOURNAL OF GASTROENTEROLOGY 12(28) 4511-4516 2006年7月査読有り
Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression

A Harashima, Y Yamamoto, CM Cheng, K Tsuneyama, KM Myint, A Takeuchi, K Yoshimura, H Li, T Watanabe, S Takasawa …

BIOCHEMICAL JOURNAL 396(1) 109-115 2006年5月査読有り
A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice

R Inagi, Y Yamamoto, M Nangaku, N Usuda, H Okamato, K Kurokawa, CV de Strihou, H Yamamoto, T Miyata

DIABETES 55(2) 356-366 2006年2月査読有り
Cyclin D1 activation through ATF-2 in reg-induced pancreatic beta-cell regeneration

S Takasawa, T Ikeda, T Akiyama, K Nata, K Nakagawa, NJ Shervani, N Noguchi, S Murakami-Kawaguchi, A Yamauchi, Takahashi, I …

FEBS LETTERS 580(2) 585-591 2006年1月査読有り
Interleukin-8 regulates expression of reg protein in Helicobacter pylori-infected gastric mucosa

N Yoshino, S Ishihara, MAK Rumi, CF Ortega-Cava, T Yuki, H Kazumori, S Takazawa, H Okamoto, Y Kadowaki, Y Kinoshita

AMERICAN JOURNAL OF GASTROENTEROLOGY 100(10) 2157-2166 2005年10月査読有り
Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6

T Nakazawa, S Takasawa, N Noguchi, K Nata, A Tohgo, M Mori, K Nakagawara, T Akiyama, T Ikeda, A Yamauchi …

GENE 360(1) 55-64 2005年10月査読有り
Activation of regenerating gene Reg in rat and human hearts in response to acute stress

T Kiji, Y Dohi, S Takasawa, H Okamoto, A Nonomura, S Taniguchi

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 289(1) H277-H284 2005年7月査読有り
Receptor for advanced glycation end products is a promising target of diabetic nephropathy.

Yamamoto Yasuhiko, Doi Toshio, Kato Ichiro, Shinohara Harumichi, Sakurai Shigeru, Yonekura Hideto, Watanabe Takuo, Myint Kihn Mar, Harashima Ai, Takeuchi Masayoshi …

Ann N Y Acad Sci 1043 562-566 2005年6月査読有り
Expression of Reg/PAP family members during motor nerve regeneration in rat

K Namikawa, M Fukushima, K Murakami, A Suzuki, S Takasawa, H Okamoto, H Kiyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 332(1) 126-134 2005年6月査読有り
Identification of islet-type ryanodine receptor and its cyclic ADP-ribose-induced intracellular Ca2+ mobilization.

Takasawa Shin, Nata Koji, Noguchi Naoya, Ikeda Takayuki, Yamauchi Akiyo, Takahashi Iwao, Yoshikawa Takeo, Okamoto Hiroshi

Diabetes 54 A406-A406 2005年4月査読有り
Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.

Nata Koji, Ikeda Takayuki, Noguchi Naoya, Yamauchi Akiyo, Takahashi Iwao, Yoshikawa Takeo, Onogawa Tohru, Takasawa Shin, Okamoto Hiroshi

Diabetes 54 A392-A392 2005年4月査読有り
Pancreatic Beta-cell regeneration by Regenerating gene (Reg) and a possible therapeutic use of Reg gene and/or Reg protein in diabetes treatment.

Okamoto Hiroshi, Takasawa Shin, Nata Koji, Noguchi Naoya, Ikeda Takayuki, Yamauchi Akiyo, Takahashi Iwao, Yoshikawa Takeo

Int J Artificial Organs 28(4) 329-330 2005年4月査読有り
REG I alpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer

A Sekikawa, H Fukui, S Fujii, J Takeda, A Nanakin, H Hisatsune, H Seno, S Takasawa, H Okamoto, T Fujimori …

GASTROENTEROLOGY 128(3) 642-653 2005年3月査読有り

もっとみる

MISC

Recent advances in physiological and pathological significance of NAD(+) metabolites: roles of poly(ADP-ribose) and cyclic ADP-ribose in insulin secretion and diabetogenesis. (Nutrition Research Reviews)

Okamoto H, Takasawa S

Nutrition Research Reviews 16(2) 253-266 2003年4月
Recent advances in physiological and pathological significance of tryptophan-NAD+ metabolites: lessons from insulin-producing pancreatic beta-cells. (Adv Exp Med Biol)

Okamoto Hiroshi

Adv Exp Med Biol 527 243-252 2003年4月
Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells. (Diabetes)

Okamoto Hiroshi, Takasawa Shin

Diabetes 51 Suppl 3 S462-73 2002年12月
Pancreatic β-cell death, regeneration and insulin secretion: Roles of poly(ADP-ribose) polymerase and cyclic ADP-ribose

Shin Takasawa, Hiroshi Okamoto

International Journal of Experimental Diabetes Research 3(2) 79-96 2002年
Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system. (Chem Immunol)

Okamoto H, Takasawa S, Nata K, Kato I, Tohgo A, Noguchi N

Chem Immunol 75 121-145 2000年4月
The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells. (J Hepatobiliary Pancreat Surg)

Okamoto H

J Hepatobiliary Pancreat Surg 6(3) 254-262 1999年4月
The CD38-cyclic ADP-ribose signaling system in insulin secretion. (Mol Cell Biochem)

Okamoto H

Mol Cell Biochem 193(1月2日) 115-118 1999年3月
Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene. (J Mol Med)

Okamoto H

J Mol Med 77(1) 74-78 1999年1月
The CD38-cyclic ADP-ribose signalling system in insulin secretion: molecular basis and clinical implications. (Diabetologia)

Okamoto H, Takasawa S, Nata K

Diabetologia 40(12) 1485-1491 1997年12月
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38: inhibition of hydrolysis by ATP and physiological significance. (Methods Enzymol)

Okamoto H, Takasawa S, Tohgo A, Nata K, Kato I, Noguchi N

Methods Enzymol 280 306-318 1997年4月
New aspects to the functioning and regeneration of pancreatic beta-cells. Cyclic ADP-ribose and Reg gene. (Adv Exp Med Biol)

Okamoto H

Adv Exp Med Biol 426 301-311 1997年4月
New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose. (Biochimie)

Okamoto H, Takasawa S, Tohgo A

Biochimie 77(5) 356-363 1995年4月
Islet beta-cell regeneration and reg genes. (Adv Exp Med Biol)

Unno M, Itoh T, Watanabe T, Miyashita H, Moriizumi S, Teraoka H, Yonekura H, Okamoto H

Adv Exp Med Biol 321 61-66 1992年4月
[reg (regenerating gene) : structure and tissue specific expression] (Nippon Rinsho)

Yonekura H, Watanabe T, Terazono K, Yamamoto H, Okamoto H, Yonemura Y, Itoh T, Tsuzuki H, Teraoka H, Yoshida N

Nippon Rinsho 49 Suppl 752-759 1991年2月
Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter. (Ann N Y Acad Sci)

Yamagami T, Ohsawa K, Nishizawa M, Inoue C, Gotoh E, Yanaihara N, Yamamoto H, Okamoto H

Ann N Y Acad Sci 527 87-102 1988年4月
The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration. (Biomed Biochim Acta)

Okamoto H

Biomed Biochim Acta 44(1) 15-20 1985年4月
MOLECULAR-BASIS OF EXPERIMENTAL DIABETES - DEGENERATION, ONCOGENESIS AND REGENERATION OF PANCREATIC B-CELLS OF ISLETS OF LANGERHANS (Bioessays)

Okamoto H

Bioessays 2(1) 15-21 1985年1月
[Vasoactive intestinal polypeptide(VIP)- and insulin-producing cells--molecular biology, physiology and pathology] (Nippon Naibunpi Gakkai Zasshi)

Okamoto H

Nippon Naibunpi Gakkai Zasshi 60(12) 1449-1463 1984年12月20日
Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes. (Mol Cell Biochem)

Okamoto H

Mol Cell Biochem 37(1) 43-61 1981年6月9日

所属学協会

日本学術会議(2005/10-)