Etsuo Yonemochi

Profile Information

Affiliation: Professor, School of Pharmacy and Pharmaceutical Sciences, Hoshi University

Degree: Ph. D.
(BLANK)

J-GLOBAL ID: 200901091872911204
researchmap Member ID: 1000010754

External link: https://jupiter.hoshi.ac.jp/lab/bukka/

Research Interests

Research Areas

Life sciences / Pharmaceuticals - analytical and physicochemistry /

Research History

Apr, 2013 - Present

Professor, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
Jul, 1998 - Mar, 2013

Faculty of Pharmaceutical Sciences, Toho University
Mar, 1997 - Jun, 1998

文部省在外研究員, ロンドン大学薬学部
1992 - 1997

Faculty of Pharmaceutical Sciences, Chiba University
1987 - 1991

Faculty of Pharmaceutical Sciences, Chiba University

Education

- 1987

Chiba University
- 1985

Faculty of Pharmaceutical Sciences, Chiba University

Committee Memberships

Apr, 2023 - Present

副会頭（年会担当）, (公社)日本薬学会
May, 2022 - Present

理事, (公社)日本薬剤学会
Apr, 2022 - Present

評議員, (一財)新製剤技術とエンジニアリング振興基金
Apr, 2022 - Present

薬剤師国家試験試験委員, 厚生労働省
Jun, 2021 - Present

会長, (一社)製剤機械技術学会
Apr, 2016 - Present

日本薬局方原案検討委員会国際調和委員会委員, (独)医薬品医療機器総合機構
Apr, 2016 - Present

日本薬局方原案検討委員会総合委員会委員, (独)医薬品医療機器総合機構
Apr, 2016 - Present

日本薬局方原案検討委員会物性試験法委員会座長, (独)医薬品医療機器総合機構
Apr, 2009 - Present

試験委員会委員, (公財)医薬品情報担当者教育センター
Apr, 2017 - Mar, 2023

関東支部幹事, (公社)日本薬学会

Awards

Papers

264

Crystal Polymorph Search in the NPT Ensemble via a Deposition/Sublimation Alchemical Path

Aaron J. Nessler, Okimasa Okada, Yuya Kinoshita, Koki Nishimura, Hiroomi Nagata, Kaori Fukuzawa, Etsuo Yonemochi, Michael J. Schnieders

Crystal Growth & Design, Apr 17, 2024
The Development and Characterization of Novel Ionic Liquids Based on Mono- and Dicarboxylates with Meglumine for Drug Solubilizers and Skin Permeation Enhancers

Takayuki Furuishi, Sara Taguchi, Siran Wang, Kaori Fukuzawa, Etsuo Yonemochi

Pharmaceutics, Feb 26, 2024
The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles

Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi …

Pharmaceutics, Jan, 2024
Novel method for the accurate calculation of Drucker–Prager cap model parameters and reduction of experimental time and effort

Tsubasa Sato, Naoto Morita, Etsuo Yonemochi, Kozo Takayama

Advanced Powder Technology, Jan, 2024
Prediction of Binding Pose and Affinity of SARS-CoV-2 Main Protease and Repositioned Drugs by Combining Docking, Molecular Dynamics, and Fragment Molecular Orbital Calculations

Yuma Handa, Koji Okuwaki, Yusuke Kawashima, Ryo Hatada, Yuji Mochizuki, Yuto Komeiji, Shigenori Tanaka, Takayuki Furuishi, Etsuo Yonemochi, Teruki Honma …

Jul 25, 2023
脂質ナノ粒子の脂質組成と形態が免疫刺激特性に関与する(Lipid composition and morphology of lipid nanoparticle contributed to its immunostimulatory properties)

アニンディタ・ジェシカ, 田中浩揮, 植田圭祐, 東顕二郎, 森部久仁一, 佐々木香純, 米持悦生, 櫻井遊, 秋田英万

日本DDS学会学術集会プログラム予稿集, 39回 185-185, Jul, 2023
Optimization and Advantages of Molded Tablets Using Trehalose as a Binder

Yuki Takahashi, Takayuki Furuishi, Etsuo Yonemochi

Chemical and Pharmaceutical Bulletin, 71(6) 416-423, Jun 1, 2023
Characterization of Co-amorphous Carvedilol–Maleic Acid System Prepared by Solvent Evaporation

Takayuki Furuishi1, Nanami Sato-Hata, Kaori Fukuzawa, Etsuo Yonemochi

Pharmaceutical Development and Technology, 1-13, Mar 22, 2023
Promoting Activity of Terpenes on Skin Permeation of Famotidine

Qihui Xu, Yifan Wu, Hiroki Saito, Yuki Ofuchi, Haruna Setoyama, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi, Yasuko Obata

Chemical and Pharmaceutical Bulletin, 71(2) 111-119, Feb 1, 2023
Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.

Hiroki Tanaka, Shinya Hagiwara, Daiki Shirane, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Miho Hishinuma, Katsuyuki Chida, Kasumi Sasaki …

ACS nano, 17(3) 2588-2601, Jan 31, 2023
【薬剤学で切り拓く創薬モダリティの未来】薬剤学で切り拓く創薬モダリティの未来 In silico技術を用いた処方設計

古石誉之, 米持悦生, 山下富義, 室篤志, 荒井宏明

薬剤学: 生命とくすり, 83(1) 10-13, Jan, 2023
Physicochemical Properties and Transdermal Absorption of a Flurbiprofen and Lidocaine Complex in the Non-Crystalline Form

Qihui Xu, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi

Pharmaceutics, 15(2) 318, Jan, 2023 Peer-reviewed
Robustness assessment of cation-exchange chromatography with in-silico peak deconvolution in monoclonal antibody purification

Ryunosuke Kitamura, Takaki Aiso, Kosaku Kawatsu, Yumiko Masuda, Takefumi Kawabe, Koichi Nonaka, Etsuo Yonemochi

Journal of Chromatography Open, 2 100060, Nov, 2022 Peer-reviewedCorresponding author
Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage

Yuto Kawano, Yoshiharu Tanaka, Nanami Hata, Yuki Yoshiike, Masato Nakajima, Etsuo Yonemochi, Nobuhiro Ishihara

Crystals, Oct 8, 2022
Evaluating the correlation of binding affinities between isothermal titration calorimetry and fragment molecular orbital method of estrogen receptor beta with diarylpropionitrile (DPN) or DPN derivatives.

Chiaki Handa, Yuki Yamazaki, Shigeru Yonekubo, Noritaka Furuya, Takaki Momose, Tomonaga Ozawa, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi

The Journal of steroid biochemistry and molecular biology, 222 106152-106152, Sep, 2022
Study of Orally Disintegrating Tablets Using Erythritol as an Excipient Produced by Moisture-Activated Dry Granulation (MADG)

Mizuki Yamada, Agata Ishikawa, Shun Muramatsu, Takayuki Furuishi, Yoshinori Onuki, Kaori Fukuzawa, Etsuo Yonemochi

Pharmaceuticals, 15(8) 1004-1004, Aug 15, 2022
Chitosan film containing antifungal agent-loaded SLNs for the treatment of candidiasis using a Box-Behnken design

Pakorn Kraisit, Etsuo Yonemochi, Takayuki Furuishi, Jongjan Mahadlek, Sontaya Limmatvapirat

CARBOHYDRATE POLYMERS, 283 119178-119178, May, 2022
Non-Effective Improvement of Absorption for Some Nanoparticle Formulations Explained by Permeability under Non-Sink Conditions

Kazuya Sugita, Noriyuki Takata, Etsuo Yonemochi

Pharmaceutics, 14(4) 816-816, Apr 7, 2022
Formulation of Biopharmaceutical Dry Powder Inhaler Using the Void Forming Index (VFI) to Detect and Avoid Powder Caking in Dry Powder Inhaler Formulations

Sunao Maruyama, Makoto Miyajima, Etsuo Yonemochi

CHEMICAL & PHARMACEUTICAL BULLETIN, 70(4) 245-253, Apr, 2022
アルギニンベースのイオン液体を用いたフィルム製剤の開発(Development of oral thin film formulation using arginine-based ionic liquids)

Xu Qihui, 古石誉之, 福澤薫, 米持悦生

日本薬学会年会要旨集, 142年会 28F-pm01S, Mar, 2022

Misc.

986

Structure and interaction evaluation of ssPalm lipid nanoparticle using computational chemistry

小浪なおこ, 氏家かれん, 佐々木香純, 奥脇弘次, 田中浩揮, 秋田英万, 古石誉之, 福澤薫, 福澤薫, 米持悦生

日本薬学会年会要旨集(Web), 143rd, 2023
Application of in silico simulation to evaluation of hygroscopic behavior of solid dispersion formulations

米持悦生, 松本穂香, 奥脇弘次, 古石誉之, 福澤薫, 福澤薫

日本薬学会年会要旨集(Web), 143rd, 2023
Evaluation of the applicability of molecular complex of arginine and asparagine as binding agents for pharmaceutical tablets

佐藤瑠莉, 村松駿, 加藤里佳, 小川紗季, 古石誉之, 米持悦生

日本薬学会年会要旨集(Web), 143rd, 2023
Study of granules for tableting using moisture activate of granulation (MADG) method with twin-screw granulator

古石誉之, 村松駿, 齋藤紘輝, 礒貝渉, 米持悦生

日本薬学会年会要旨集(Web), 143rd, 2023
Characterization of lipid nanoparticle-nucleic acid complexes by experimental methods and molecular simulations

佐々木香純, 奥脇弘次, 古石誉之, 東顕二郎, 福澤薫, 福澤薫, 米持悦生

日本薬学会年会要旨集(Web), 143rd, 2023
処方設計への応用に向けた計算科学を用いたイオン性脂質ナノ粒子の構造予測

小倉由未佳, 奥脇弘次, 古石誉之, 山下雄史, 米持悦生, 福澤薫

製剤と粒子設計シンポジウム講演要旨集, 40th, 2023
Study on Qualification Evaluation of Powder Flowability Data by “Shear Cell Mthod” and its Application to Manufacturing Process Development

米持悦生, 宮崎玉樹

医薬品医療機器レギュラトリーサイエンス, 54(3), 2023
Molecular dynamic simulation and fragment molecular orbital methods on the inclusion complexation of norephedrine enantiomers with β-cyclodextrin

奈良友里衣, 古石誉之, 奥脇弘次, 遠藤朋宏, 福澤薫, 福澤薫, 米持悦生

シクロデキストリンシンポジウム講演要旨集, 39th, 2023
イオン化脂質のプロトン化による脂質ナノ粒子の構造変化に関する研究

小倉由未佳, 奥脇弘次, 古石誉之, 福澤薫, 米持悦生

日本DDS学会学術集会プログラム予稿集, 39th, 2023
トルブタミドとメグルミンからなるイオン液体含有口腔内崩壊フィルム製剤の開発

古石誉之, 古石誉之, 土井優月, 福澤薫, 米持悦生

日本DDS学会学術集会プログラム予稿集, 39th, 2023
Structural evaluation of ionizable lipid nanoparticles using experimental methods and molecular simulations

小倉由未佳, 奥脇弘次, 古石誉之, 福澤薫, 米持悦生

日本薬剤学会年会講演要旨集(CD-ROM), 38th, 2023
Citric acid/Arginine ionic liquid: Characterization and drug solubilization

古石誉之, 岡部華奈, 田中菜緒, 福澤薫, 米持悦生

日本薬剤学会年会講演要旨集(CD-ROM), 38th, 2023
Structure and interaction analysis of ssPalm lipid nanoparticle containing nucleic acids using computational chemistry

小浪なおこ, 氏家かれん, 佐々木香純, 奥脇弘次, 田中浩揮, 秋田英万, 古石誉之, 福澤薫, 福澤薫, 米持悦生

日本薬剤学会年会講演要旨集(CD-ROM), 38th, 2023
Mechanism of functional expression and conditions for formulation optimization of molecular complexes of arginine and asparagine as binder for formulation

加藤里佳, 佐藤瑠莉, 村松駿, 古石誉之, 福澤薫, 米持悦生

日本薬剤学会年会講演要旨集(CD-ROM), 38th, 2023
Improvement of Drug Solubility and Stabilization of Polymeric Drugs Using Ionic Liquids

古石誉之, 米持悦生

Drug Delivery System, 38(3), 2023
Investigation of the interaction between cyclodextrin and norephedrine enantiomer using surface plasmon resonance method and quantum chemical calculation

古石誉之, 大橋玲子, 伊野希, 奈良友里衣, 奥脇弘次, 奥脇弘次, 福澤薫, 遠藤朋宏, 米持悦生

日本薬学会年会要旨集(Web), 142年会 26L-pm04, Mar, 2022
Dynamical FMO analysis for RNA sequence specificity of eIF4A-inhibitor complex

半田佑磨, 川嶋裕介, 古石誉之, 米持悦生, 伊藤拓宏, 斉藤大寛, 斉藤大寛, 岩崎信太朗, 岩崎信太朗, 加藤幸一郎 …

日本薬学会年会要旨集(Web), 142年会 27C-am11S, Mar, 2022
Relationship between the lipid lamellar structure and ceramide chirality

荒井梨絵, 古石誉之, 福澤薫, 米持悦生, 石田賢哉, 小幡誉子

日本薬学会年会要旨集(Web), 142年会 28C-am02S, Mar, 2022
Formulation design of oral disintegrating tablets by moisture activated dry granulation using low substituted hydroxypropyl cellulose

村松駿, 古石誉之, 福澤薫, 米持悦生

日本薬学会年会要旨集(Web), 142年会 28F-am04S, Mar, 2022
アルギニンベースのイオン液体を用いたフィルム製剤の開発(Development of oral thin film formulation using arginine-based ionic liquids)

Xu Qihui, 古石誉之, 福澤薫, 米持悦生

日本薬学会年会要旨集, 142年会 28F-pm01S, Mar, 2022

Major Books and Other Publications

固体医薬品の物性評価第2版

米持, 悦生, 日本薬剤学会物性FG (Role: Editor)

じほう, Aug, 2018 (ISBN: 9784840751070)
レファレンス物理化学

米持, 悦生, 近藤, 伸一, 山中, 淳平, 内海, 美保

廣川書店, Apr, 2017 (ISBN: 9784567223706)

Professional Memberships

Research Projects

Study on solid formulation of lipoplex using ionic liquid

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Yonemochi Etsuo, HATTORI Yoshiyuki, KAWANO Kumi
Analysis of Molecular Interactions in Solid Pharmaceuticals

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1995 - 1996

YAMAMOTO Keiji, YONEMOCHI Etsuo, OGUCHI Toshio, NAKAJIMA Shinichiro
医薬品-多孔性医薬品添加剤混合系に関する製剤学的研究

科学研究費助成事業奨励研究(A), 奨励研究(A), 日本学術振興会, 1992 - 1992

米持悦生
A Study of Mechanochemical Effects on the Solid Dispersion of Pharmaceuticals and Molecular Interactions

Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1991 - 1992

YAMAMOTO Keiji, YONEMOCHI Etsuo, OGUCHI Toshio
医薬品製剤の物性評価
医薬品の製剤化、特にPAT(Process Analytical Technology)に関する研究
医薬品原薬の探索からプレフォーミュレーションまでの物性評価に関する研究
医薬品光学異性体の物理化学的性質の検討
密封加熱によるクロデキストリン包接化合物の調製
製剤添加剤との混合粉砕による医薬品の分子状態の検討
Physicochemical properties of enantiotropic drugs.
New methods of preparing cyclodextrin inclusion compounds by sealed-heating
Molecular behavior of medicinals in ground mixture with pharmaceutical additives

Industrial Property Rights

特開2013-043886 アシクロビル改変組成物及びその製造方法

寺田勝英, 米持悦生, 吉橋秦生, 増田孝明
特開2001-278812 錠剤用崩壊剤及びこれを用いた錠剤

深見仁一, 山口寿, 寺田勝英, 米持悦生, 吉橋泰生
特開2001-106522 酸処理ケイ酸カルシウム粒子、およびその製造方法

吉橋泰生, 藤森順也, 米持悦生, 牧田みどり, 寺田勝英, 中島新一郎, 花輪剛久
Acid-treated calcium silicate particles and theirmanufacture
Tablets containing glycine as a disintegrator
Tablets containing glycine as a disintegrant
Acid-treated Calcium silicate particles and their manufacture

Profile Information

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Research History

Education

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Awards

Papers

Misc.

Major Books and Other Publications

Professional Memberships

Research Projects

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