村上良子 (Yoshiko Murakami) - マイポータル

基本情報

所属: 大阪大学微生物病研究所籔本難病解明寄附研究部門教授

学位: 医学博士

J-GLOBAL ID: 200901011838632580
researchmap会員ID: 1000282465

外部リンク

研究キーワード

研究分野

経歴

2009年 - 2015年

大阪大学, 微生物病研究所, 准教授
2005年6月 - 2008年12月

大阪大学微生物病研究所, 微生物病研究所, 助手

学歴

- 1984年

大阪大学, 医学部
- 1984年

大阪大学

論文

112

AAV-based gene therapy ameliorated CNS-specific GPI defect in mouse models.

Yoshiko Murakami, Saori Umeshita, Kae Imanishi, Yoshichika Yoshioka, Akinori Ninomiya, Takehiko Sunabori, Shibi Likhite, Masato Koike, Kathrin C Meyer, Taroh Kinoshita

Molecular therapy. Methods & clinical development 32(1) 101176-101176 2024年3月14日
The clinical and genetic spectrum of inherited glycosylphosphatidylinositol deficiency disorders.

Jai Sidpra, Sniya Sudhakar, Asthik Biswas, Flavia Massey, Valentina Turchetti, Tracy Lau, Edward Cook, Javeria Raza Alvi, Hasnaa M Elbendary, Jerry L Jewell …

Brain : a journal of neurology 2024年3月8日
Progressive myoclonic epilepsy as an expanding phenotype of NGLY1-associated congenital deglycosylation disorder: A case report and review of the literature.

Yuri Sonoda, Atsushi Fujita, Michiko Torio, Takahiko Mukaino, Ayumi Sakata, Masaru Matsukura, Kousuke Yonemoto, Ken Hatae, Yuko Ichimiya, Pin Fee Chong …

European journal of medical genetics 67 104895-104895 2024年2月
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.

Alistair T Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M Taylor, Mona Hashim, Eduardo Calpena, Pamela J Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders …

Genome medicine 15(1) 94-94 2023年11月9日
GPIアンカー型タンパク質の新規結合様式の発見

村上良子, 木下タロウ

生化学 2023年5月
Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1.

Yi-Shi Liu, Yicheng Wang, Xiaoman Zhou, Linpei Zhang, Ganglong Yang, Xiao-Dong Gao, Yoshiko Murakami, Morihisa Fujita, Taroh Kinoshita

The Journal of cell biology 222(5) 2023年5月1日査読有り
Case report: Functional analysis of the p.Arg507Trp variant of the PIGT gene supporting the moderate epilepsy phenotype of mutations in the C-terminal region.

Ikhlas Ben Ayed, Olfa Jallouli, Yoshiko Murakami, Amal Souissi, Salma Mallouli, Amal Bouzid, Fatma Kamoun, Ines Elloumi, Fakher Frikha, Abdelaziz Tlili …

Frontiers in neurology 14 1092887-1092887 2023年3月9日査読有り
Excluding Digenic Inheritance of PGAP2 and PGAP3 Variants in Mabry Syndrome (OMIM 239300) Patient: Phenotypic Spectrum Associated with PGAP2 Gene Variants in Hyperphosphatasia with Mental Retardation Syndrome-3 (HPMRS3).

Miles D Thompson, Xueying Li, Michele Spencer-Manzon, Danielle M Andrade, Yoshiko Murakami, Taroh Kinoshita, Thomas O Carpenter

Genes 14(2) 2023年1月30日査読有り
Biallelic variants in PIGN cause Fryns syndrome, multiple congenital anomalies-hypotonia-seizures syndrome, and neurologic phenotypes: A genotype-phenotype correlation study.

Lucy Loong, Agostina Tardivo, Alexej Knaus, Mona Hashim, Alistair T Pagnamenta, Kerstin Alt, Helena Böhrer-Rabel, Alfonso Caro-Llopis, Trevor Cole, Felix Distelmaier …

Genetics in medicine : official journal of the American College of Medical Genetics 25(1) 37-48 2023年1月1日査読有り
Sequential hydrolysis of FAD by ecto-5' nucleotidase CD73 and alkaline phosphatase is required for uptake of vitamin B2 into cells.

Natsuki Shichinohe, Daisuke Kobayashi, Ayaka Izumi, Kazuya Hatanaka, Rio Fujita, Taroh Kinoshita, Norimitsu Inoue, Naoya Hamaue, Keiji Wada, Yoshiko Murakami

The Journal of biological chemistry 298(12) 102640-102640 2022年12月1日査読有り
Case report: Functional characterization of a de novo c.145G>A p.Val49Met pathogenic variant in a case of PIGA-CDG with megacolon.

Roberta Salinas-Marín, Yoshiko Murakami, Carlos Alberto González-Domínguez, Mario Ernesto Cruz-Muñoz, Héctor Manuel Mora-Montes, Eva Morava, Taroh Kinoshita, Susana Monroy-Santoyo, Iván Martínez-Duncker

Frontiers in genetics 13 971473-971473 2022年10月17日査読有り
Ethanolamine-phosphate on the second mannose is a preferential bridge for some GPI-anchored proteins.

Mizuki Ishida, Yuta Maki, Akinori Ninomiya, Yoko Takada, Philippe Campeau, Taroh Kinoshita, Yoshiko Murakami

EMBO reports 23(7) e54352 2022年7月5日査読有り
Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy.

Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-Ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono …

Nature communications 13(1) 3107-3107 2022年6月3日査読有り
Predictive factors for false negatives following sentinel lymph node biopsy in early oral cavity cancer.

Kouki Miura, Daisuke Kawakita, Isao Oze, Motoyuki Suzuki, Masashi Sugasawa, Kazuhira Endo, Tomohiro Sakashita, Shinichi Ohba, Mikio Suzuki, Akihiro Shiotani …

Scientific reports 12(1) 6917-6917 2022年4月28日査読有り
Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis.

Yicheng Wang, Anant K Menon, Yuta Maki, Yi-Shi Liu, Yugo Iwasaki, Morihisa Fujita, Paula A Guerrero, Daniel Varó'n Silva, Peter H Seeberger, Yoshiko Murakami …

Proceedings of the National Academy of Sciences of the United States of America 119(14) e2115083119 2022年4月5日査読有り
Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy.

Ambrin Fatima, Jan Hoeber, Jens Schuster, Eriko Koshimizu, Carolina Maya-Gonzalez, Boris Keren, Cyril Mignot, Talia Akram, Zafar Ali, Satoko Miyatake …

American journal of human genetics 109(3) 542-546 2022年3月3日査読有り
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.

Tetsuya Hirata, Atsushi Kobayashi, Tamio Furuse, Ikuko Yamada, Masaru Tamura, Hiroyuki Tomita, Yuko Tokoro, Akinori Ninomiya, Yoshitaka Fujihara, Masahito Ikawa …

The Journal of biological chemistry 298(3) 101720-101720 2022年3月1日査読有り
C18orf32 loss-of-function is associated with a neurodevelopmental disorder with hypotonia and contractures.

Smrithi Salian, Xin-Yu Guo, Yoshiko Murakami, Taroh Kinoshita, Parneet Kaur, Anju Shukla, Katta M Girisha, Morihisa Fujita, Philippe M Campeau

Human genetics 141(8) 1423-1429 2022年2月2日査読有り
Differential use of p24 family members as cargo receptors for the transport of glycosylphosphatidylinositol-anchored proteins and Wnt1.

Yuko Tashima, Tetsuya Hirata, Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita

Journal of biochemistry 171(1) 75-83 2022年1月7日査読有り
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides.

Paula A Guerrero, Yoshiko Murakami, Ankita Malik, Peter H Seeberger, Taroh Kinoshita, Daniel Varón Silva

ACS chemical biology 16(11) 2297-2306 2021年11月19日査読有り

もっとみる

MISC

GPI Anchor and Its Deficiency

Yoshiko Murakami, Taroh Kinoshita

Trends in Glycoscience and Glycotechnology 36(209) E1-E5 2024年
発作性夜間血色素尿症 : クローン拡大の理解はどこまで進んだか

木下タロウ, 村上良子, 井上徳光

臨床血液 = The Japanese Journal of Clinical Hematology 46(5) 317-323 2005年5月
Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes

Wouter L.W. Hazenbos, Yoshiko Murakami, Jun Ichi Nishimura, Junji Takeda, Taroh Kinoshita

Journal of Immunology 173(6) 3810-3815 2004年9月15日
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor

Yoshiko Murakami, Uamporn Siripanyapinyo, Yeongjin Hong, Ji Young Kang, Sonoko Ishihara, Hideki Nakakuma, Yusuke Maeda, Taroh Kinoshita

Molecular Biology of the Cell 14(10) 4285-4295 2003年10月1日
Inefficient response of T lymphocytes to glycosylphosphatidylinositol anchor-negative cells: implications for paroxysmal nocturnal hemoglobinuria

Y Murakami, H Kosaka, Y Maeda, J Nishimura, N Inoue, K Ohishi, M Okabe, J Takeda, T Kinoshita

BLOOD 100(12) 4116-4122 2002年12月
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2

Reika Watanabe, Yoshiko Murakami, Mina D. Marmor, Norimitsu Inoue, Yusuke Maeda, Jun Hino, Kenji Kangawa, Michael Julius, Taroh Kinoshita

EMBO Journal 19(16) 4402-4411 2000年8月15日
Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by a mouse model of paroxysmal nocturnal hemoglobinuria

Y. Murakami, T. Kinoshita, Y. Maeda, T. Nakano, H. Kosaka, J. Takeda

Blood 94(9) 2963-2970 1999年11月1日
発作性夜間血色素尿症のモデルマウスの解析により明らかになった血球系におけるGPIアンカー型蛋白の役割

Blood 94(9) 2963 1999年
貧血の新しい病態-PNH(発作性夜間ヘモグロビン尿症)(共著)

臨床と研究 74(8) 86-90 1997年
New type of anemia-PNH.

74(8) 86-90 1997年

所属学協会

共同研究・競争的資金等の研究課題

発作性夜間血色素尿症の発症機序に関する研究

その他の研究制度
Study on pathogenesis of paroxysmal nocturnal hemoglobinuria

The Other Research Programs

学術貢献活動

第57回日本補体学会学術集会

企画立案・運営等

日本補体学会 2021年9月