Kazunori Toma - My portal

Profile Information

Affiliation: 上級研究員, 調査部, （株）旭リサーチセンター
: 非常勤講師, 理工学部, 青山学院大学

Degree: Dr. Sci.

J-GLOBAL ID: 200901086281117700
researchmap Member ID: 1000286574

Research Interests

Research Areas

Research History

2016 - Present

College of Science and Engineering, Aoyama Gakuin University
2013 - Present

主幹研究員, 調査部, （株）旭リサーチセンター
2007 - 2013

旭化成（株）主幹研究員
2007

- Asahi-Kasei Corporation
1999 - 2006

（財）野口研究所主任研究員
1999 - 2006

The Noguchi Institute
1982 - 1998

旭化成(株) 研究員
1982 - 1998

Asahi-Kasei Corporation

Education

1980 - 1982

化学専攻, 理学系研究科, 東京大学大学院
- 1982

Graduate School, Division of Science, The University of Tokyo
- 1980

Faculty of Science, The University of Tokyo
- 1980

Faculty of Science, The University of Tokyo

Awards

2001

化学素材研究開発振興財団記念基金グラント

Papers

Composition-dependent sol-gel transition of amphiphilic blend of PEG with hydrophobic gallamide components

Akihiro Aso, Kazutaka Taki, Tomoki Maeda, Kazunori Toma, Hitoshi Tamiaki, Atsushi Hotta

Journal of Applied Polymer Science, 135(24), Jun 20, 2018 Peer-reviewed
Binding of Sperm to the Zona Pellucida Mediated by Sperm Carbohydrate-Binding Proteins is not Species-Specific in Vitro between Pigs and Cattle.

Kazuya Takahashi, Kazuhiro Kikuchi, Yasuomi Uchida, Saeko Kanai-Kitayama, Reiichiro Suzuki, Reiko Sato, Kazunori Toma, Masaya Geshi, Satoshi Akagi, Minoru Nakano …

Biomolecules, 3(1) 85-107, Jan 25, 2013 Peer-reviewed
Laminin active peptide/agarose matrices as multifunctional biomaterials for tissue engineering

Yuji Yamada, Kentaro Hozumi, Akihiro Aso, Atsushi Hotta, Kazunori Toma, Fumihiko Katagiri, Yamato Kikkawa, Motoyoshi Nomizu

BIOMATERIALS, 33(16) 4118-4125, Jun, 2012 Peer-reviewed
Early entry and deformation of macropinosomes correlates with high efficiency of decaarginine-polyethylene glycol-lipid-mediated gene delivery

Shouhei Kobayashi, Yoshiyuki Hattori, Hiroko Osakada, Kazunori Toma, Yoshie Maitani, Yasushi Hiraoka, Tokuko Haraguchi

JOURNAL OF GENE MEDICINE, 14(4) 262-271, Apr, 2012 Peer-reviewed
Cell line-dependent internalization pathways determine DNA transfection efficiency of decaarginine-PEG-lipid

Tomohiro Izumisawa, Yoshiyuki Hattori, Masataka Date, Kazunori Toma, Yoshie Maitani

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 404(1-2) 264-270, Feb, 2011 Peer-reviewed
Decaarginine-PEG-liposome enhanced transfection efficiency and function of arginine length and PEG

Masahiko Furuhata, Tomohiro Izumisawa, Hiroko Kawakami, Kazunori Toma, Yoshiyuki Hattori, Yoshie Maitani

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 371(1-2) 40-46, Apr, 2009 Peer-reviewed
Isolation and characterization of anti-T-antigen single chain antibodies from a phage library

Ayano Matsumoto-Takasaki, Jinichiro Horie, Keiko Sakai, Yoshihiro Furui, Reiko Sato, Hiroko Kawakami, Kazunori Toma, Atsushi Takayanagi, Nobuyoshi Shimizu, Yoko Fujita-Yamaguchi

BIOSCIENCE TRENDS, 3(3) 87-95, 2009 Peer-reviewed
High gene delivery in tumor by intratumoral injection of tetraarginine-PEG lipid-coated protamine/DNA

Takashi Fujita, Masahiko Furuhata, Yoshiyuki Hattori, Hiroko Kawakami, Kazunori Toma, Yoshie Maitani

JOURNAL OF CONTROLLED RELEASE, 129(2) 124-127, Jul, 2008 Peer-reviewed
In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin

Masato Watanabe, Kumi Kawano, Kazunori Toma, Yoshiyuki Hattori, Yoshie Maitani

JOURNAL OF CONTROLLED RELEASE, 127(3) 231-238, May, 2008 Peer-reviewed
Artificial lipids stabilized camptothecin incorporated in liposomes.

Maitani Y, Katayama S, Kawano K, Hayama A, Toma K

Biol Pharm Bull., 31(5) 990-993, May, 2008 Peer-reviewed
Decaarginine-PEG-artificial lipid/DNA complex for gene delivery: Nanostructure and transfection efficiency

Masahiko Furuhata, Radostin Danev, Kuniaki Nagayama, Yoshifumi Yamada, Hiroko Kawakami, Kazunori Toma, Yoshiyuki Hattori, Yoshie Maitani

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 8(5) 2308-2315, May, 2008 Peer-reviewed
Fullerene Nanowires: Self-Assembled Structures of a Low-Molecular-Weight Organogelator Fabricated by the Langmuir-Blodgett Method

Ryo Tsunashima, Shin-ichiro Noro, Tomoyuki Akutagawa, Takayoshi Nakamura, Hiroko Kawakami, Kazunori Toma

CHEMISTRY-A EUROPEAN JOURNAL, 14(27) 8169-8176, 2008 Peer-reviewed
Identification of the catalytic acid-base residue of Arthrobacter endo-beta-N-acetylglucosaminidase by chemical rescue of an inactive mutant

Kiyotaka Fujita, Reiko Sato, Kazunori Toma, Kanefumi Kitahara, Toshihiko Suganuma, Kenji Yamamoto, Kaoru Takegawa

JOURNAL OF BIOCHEMISTRY, 142(3) 301-306, Sep, 2007 Peer-reviewed
Isolation and characterization of phage-displayed single chain antibodies recognizing nonreducing terminal mannose residues. 1. A new strategy for generation of anti-carbohydrate antibodies

Keiko Sakai, Yoshitaka Shimizu, Tomoki Chiba, Ayano Matsumoto-Takasaki, Yu Kusada, Wei Zhang, Munehiro Nakata, Naoya Kojima, Kazunori Toma, Atsushi Takayanagi …

BIOCHEMISTRY, 46(1) 253-262, Jan, 2007 Peer-reviewed
Oligomethylene spacer length dependent interaction of synthetic galactolipids incorporated in phospholipid layers with ricin

Hitoshi Tamiaki, Yasuo Azefu, Reiko Shibata, Reiko Sato, Kazunori Toma

COLLOIDS AND SURFACES B-BIOINTERFACES, 53(1) 87-93, Nov, 2006 Peer-reviewed
Intracellular delivery of proteins in complexes with oligoarginine-modified liposomes and the effect of oligoarginine length

Masahiko Furuhata, Hiroko Kawakami, Kazunori Toma, Yoshiyuki Hattori, Yoshie Maitani

BIOCONJUGATE CHEMISTRY, 17(4) 935-942, Jul, 2006 Peer-reviewed
Design, synthesis and gene delivery efficiency of novel oligo-arginine-linked PEG-lipids: Effect of oligo-arginine length

M Furuhata, H Kawakami, K Toma, Y Hattori, Y Maitani

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 316(1-2) 109-116, Jun, 2006 Peer-reviewed
Effect of eel calcitonin glycosylation on incorporation and channel formation in planar phospholipid membranes

D Meleleo, S Micelli, K Toma, K Haneda, E Gallucci

PEPTIDES, 27(4) 805-811, Apr, 2006 Peer-reviewed
Novel carbohydrate-binding activity of pancreatic trypsins to N-linked glycans of glycoproteins

H Takekawa, C Ina, R Sato, K Toma, H Ogawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13) 8528-8538, Mar, 2006 Peer-reviewed
Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures

K Haneda, M Takeuchi, M Tagashira, T Inazu, K Toma, Y Isogai, M Hori, K Kobayashi, M Takeuchi, K Takegawa …

CARBOHYDRATE RESEARCH, 341(2) 181-190, Feb, 2006 Peer-reviewed

Misc.

Isolation and characterization of phage-displayed single chain antibodies recognizing nonreducing terminal mannose residues. 1. A new strategy for generation of anti-carbohydrate antibodies

Keiko Sakai, Yoshitaka Shimizu, Tomoki Chiba, Ayano Matsumoto-Takasaki, Yu Kusada, Wei Zhang, Munehiro Nakata, Naoya Kojima, Kazunori Toma, Atsushi Takayanagi …

BIOCHEMISTRY, 46(1) 253-262, Jan, 2007
One-dimensional array of an nanoparticles fixed on nanofibers of organogelators by the Langmuir-Blodgett method

Ryo Tsunashima, Shin-ichiro Noro, Tomoyuki Akutagawa, Takayoshi Nakamura, Tomohiro Karasawa, Hiroko Kawakami, Kazunori Toma

JOURNAL OF PHYSICAL CHEMISTRY C, 111(2) 901-907, Jan, 2007
Oligomethylene spacer length dependent interaction of synthetic galactolipids incorporated in phospholipid layers with ricin

Hitoshi Tamiaki, Yasuo Azefu, Reiko Shibata, Reiko Sato, Kazunori Toma

COLLOIDS AND SURFACES B-BIOINTERFACES, 53(1) 87-93, Nov, 2006
The structure of artificial lipids possessing oligo(ethylene glycol) and their behavior in water

Taichi Yoshitomi, Sawataka Yabuki, Hiroko Kawakami, Reiko Sato, Kazunori Toma, Masahiko Furuhata, Yoshie Maitani

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 284 276-283, Aug, 2006
The structure of artificial lipids possessing oligo(ethylene glycol) and their behavior in water

Taichi Yoshitomi, Sawataka Yabuki, Hiroko Kawakami, Reiko Sato, Kazunori Toma, Masahiko Furuhata, Yoshie Maitani

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 284 276-283, Aug, 2006
Intracellular delivery of proteins in complexes with oligoarginine-modified liposomes and the effect of oligoarginine length

Masahiko Furuhata, Hiroko Kawakami, Kazunori Toma, Yoshiyuki Hattori, Yoshie Maitani

BIOCONJUGATE CHEMISTRY, 17(4) 935-942, Jul, 2006
Design, synthesis and gene delivery efficiency of novel oligo-arginine-linked PEG-lipids: Effect of oligo-arginine length

M Furuhata, H Kawakami, K Toma, Y Hattori, Y Maitani

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 316(1-2) 109-116, Jun, 2006
Novel carbohydrate-binding activity of pancreatic trypsins to N-linked glycans of glycoproteins

H Takekawa, C Ina, R Sato, K Toma, H Ogawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13) 8528-8538, Mar, 2006
Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures

K Haneda, M Takeuchi, M Tagashira, T Inazu, K Toma, Y Isogai, M Hori, K Kobayashi, M Takeuchi, K Takegawa …

CARBOHYDRATE RESEARCH, 341(2) 181-190, Feb, 2006
Eeffect of Eel Calcitonin Glycosylation on Incorporation and Channel Formation in Planar Phospholipid Membranes

Meleleo, D, Micelli, S, Toma, K, Haneda, K, Gallucci, E

Peptides, 27 109-116, 2006
Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform-ion cyclotron resonance mass spectrometry

MB Renfrow, HJ Cooper, M Tomana, R Kulhavy, Y Hiki, K Toma, MR Emmett, J Mestecky, AG Marshall, J Novak

JOURNAL OF BIOLOGICAL CHEMISTRY, 280(19) 19136-19145, May, 2005
Glycolipid-based Bionanomaterials

"Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, Nalwa, H. S. (ed.), American Scientific Publishers, vol. 1, pp. 239-271, 2005
Design, Synthesis and Gene Delivery Efficiencies of Novel Oligo-Arginine Linked PEG-Lipid: Effect of Oligo-Arginine Length

"Peptide Science 2004," Shimohigashi, Y. (ed.), The Japanese Peptide Society, pp241-242, 2005
Effect of Peptide Glycosylation on the Conformation of the Peptide Backbone

Trends Glycosci. Glycotechnol., 17, 145-157, 2005
Glycolipid-based Bionanomaterials

"Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, Nalwa, H. S. (ed.), American Scientific Publishers, vol. 1, pp. 239-271, 2005
Design, Synthesis and Gene Delivery Efficiencies of Novel Oligo-Arginine Linked PEG-Lipid: Effect of Oligo-Arginine Length

"Peptide Science 2004," Shimohigashi, Y. (ed.), The Japanese Peptide Society, pp241-242, 2005
Effect of the PEG-linker Chain Length of Folate-linked Microemulsions Loaded Aclacinomycin A on Targeting Ability and Antitumor Effect in vitro and in vivo

Clinical Cancer Research, 11, 2018-2025, 2005
Effect of Peptide Glycosylation on the Conformation of the Peptide Backbone

Trends Glycosci. Glycotechnol., 17, 145-157, 2005
Effect of heparin addition on expansion of cord blood hematopoietic progenitor cells in three-dimensional coculture with stromal cells in nonwoven fabrics

Toru Okamoto, Mutsumi Takagi, Toshihiro Soma, Hiroyasu Ogawa, Manabu Kawakami, Masaaki Mukubo, Kazusuke Kubo, Reiko Sato, Kazunori Toma, Toshiomi Yoshida

Journal of Artificial Organs, 7(4) 194-202, Dec, 2004
The Carbohydrate Recognition of Mini-lectin in View of the Three-dimensional Structure of Lectin

Peptide Science 2003, Ueki, M. (ed.), The Japanese Peptide Society, pp435-438, 2004

Professional Memberships

Research Projects

中空糸を用いた幹細胞大量培養法の開発

A-STEP, 科学技術推進機構, 2013

戸澗一孔
細胞輸送用ヒドロゲルの開発

A-STEP, 科学技術推進機構, 2010

戸澗一孔
Biomedical Device

The Other Research Programs