Koutarou NISHIMURA - My portal

Profile Information

Degree: 修士（生物資源科学）(Mar, 2009, 筑波大学)
博士（医学）(Mar, 2013, 東京大学)

J-GLOBAL ID: 202101005913555240
researchmap Member ID: R000020117

研究内容：血球分化におけるクロマチン高次構造変化

Research Interests

Research Areas

Research History

2022 - Present

主任研究員, 血液・腫瘍研究部, 神戸医療産業都市推進機構先端医療研究センター
2021 - 2022

助教, 免疫学教室, 横浜市立大学大学院医学系研究科
2020 - 2021

Research associate, Helin lab, メモリアルスローンケタリングがんセンター
2018 - 2020

Assistant professor, Helin group, コペンハーゲン大学BRIC研究所
2016 - 2018

Guest researcher, Copenhagen University, BRIC
2013 - 2016

博士研究員, 細胞生化学, 名古屋市立大学医学研究科

Education

2009 - 2013

医学系研究科博士課程生殖・発達・加齢医学専攻, 国立東京大学大学院
2007 - 2009

生命環境科学研究科博士前期課程, 国立筑波大学大学院
2003 - 2007

第二学群生物資源学類, 国立筑波大学

Papers

Minor introns impact on hematopoietic malignancies.

Koutarou Nishimura, Wataru Saika, Daichi Inoue

Experimental hematology, 132 104173-104173, Feb 1, 2024
Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies.

Yasutaka Hayashi, Koutarou Nishimura, Atsushi Tanaka, Daichi Inoue

International journal of hematology, Apr 12, 2023
Dysregulated minor intron splicing in cancer.

Koutarou Nishimura, Hiromi Yamazaki, Weijia Zang, Daichi Inoue

Cancer science, 113(9) 2934-2942, Jun 29, 2022
PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination.

Petros Kolovos, Koutarou Nishimura, Aditya Sankar, Simone Sidoli, Paul A Cloos, Kristian Helin, Jesper Christensen

Genome research, 30(8) 1119-1130, Aug, 2020
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.

Karl Agger, Koutarou Nishimura, Satoru Miyagi, Jan-Erik Messling, Kasper Dindler Rasmussen, Kristian Helin

Blood, 134(14) 1154-1158, Oct 3, 2019
TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.

Kasper D Rasmussen, Ivan Berest, Sandra Keβler, Koutarou Nishimura, Lucía Simón-Carrasco, George S Vassiliou, Marianne T Pedersen, Jesper Christensen, Judith B Zaugg, Kristian Helin

Genome research, 29(4) 564-575, Apr, 2019
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.

Koutarou Nishimura, Yoshikazu Johmura, Katashi Deguchi, Zixian Jiang, Kazuhiko S K Uchida, Narumi Suzuki, Midori Shimada, Yoshie Chiba, Toru Hirota, Shige H Yoshimura …

Nature communications, 10(1) 981-981, Feb 28, 2019
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).

Toshio Kitamura, Naoko Watanabe-Okochi, Yutaka Enomoto, Fumio Nakahara, Toshihiko Oki, Yukiko Komeno, Naoko Kato, Noriko Doki, Tomoyuki Uchida, Yuki Kagiyama …

Journal of biochemistry, 159(1) 17-25, Jan, 2016
The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination

D Inoue, K Nishimura, H Kozuka-Hata, M Oyama, T Kitamura

Leukemia, 29(11) 2257-2260, Nov, 2015
A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

Katsuhiro Togami, Jiro Kitaura, Tomoyuki Uchida, Daichi Inoue, Koutarou Nishimura, Kimihito C Kawabata, Reina Nagase, Sayuri Horikawa, Kumi Izawa, Tomofusa Fukuyama …

Experimental hematology, 43(4) 300-8, Apr, 2015
Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis.

Tomoyuki Uchida, Jiro Kitaura, Fumio Nakahara, Katsuhiro Togami, Daichi Inoue, Akie Maehara, Koutarou Nishimura, Kimihito C Kawabata, Noriko Doki, Kazuhiko Kakihana …

Experimental hematology, 42(5) 369-379, May, 2014
A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition.

Toshihiko Oki, Koutarou Nishimura, Jiro Kitaura, Katsuhiro Togami, Akie Maehara, Kumi Izawa, Asako Sakaue-Sawano, Atsushi Niida, Satoru Miyano, Hiroyuki Aburatani …

Scientific reports, 4 4012-4012, Feb 6, 2014
Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations.

Daichi Inoue, Jiro Kitaura, Katsuhiro Togami, Koutarou Nishimura, Yutaka Enomoto, Tomoyuki Uchida, Yuki Kagiyama, Kimihito Cojin Kawabata, Fumio Nakahara, Kumi Izawa …

The Journal of clinical investigation, 123(11) 4627-40, Nov, 2013
APC(CDH1) targets MgcRacGAP for destruction in the late M phase.

Koutarou Nishimura, Toshihiko Oki, Jiro Kitaura, Shinji Kuninaka, Hideyuki Saya, Asako Sakaue-Sawano, Atsushi Miyawaki, Toshio Kitamura

PloS one, 8(5) e63001, 2013
MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia.

Yutaka Enomoto, Jiro Kitaura, Masaya Shimanuki, Naoko Kato, Koutarou Nishimura, Mariko Takahashi, Hideki Nakakuma, Toshio Kitamura, Takashi Sonoki

International journal of hematology, 96(3) 334-41, Sep, 2012
Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis.

Masaki Nakamura, Jiro Kitaura, Yutaka Enomoto, Yang Lu, Koutarou Nishimura, Masamichi Isobe, Katsutoshi Ozaki, Yukiko Komeno, Fumio Nakahara, Toshihiko Oki …

Cancer science, 103(1) 26-33, Jan, 2012

Misc.

C-Terminal-Truncating ASXL1 Mutations Induce MDS Via Inhibition Of PRC2

Daichi Inoue, Jiro Kitaura, Katsuhiro Togami, Koutarou Nishimura, Yutaka Enomoto, Tomoyuki Uchida, Yuki Kagiyama, Kimihito Cojin Kawabata, Fumio Nakahara, Toshihiko Oki …

BLOOD, 122(21), Nov, 2013

Professional Memberships

Dec, 2012 - Present

分子生物学会

Research Projects

単核貪食細胞分化モデルを用いた普遍的細胞分化メカニズムの解読

科学研究費助成事業研究活動スタート支援, 研究活動スタート支援, 日本学術振興会, Aug, 2021 - Mar, 2023

西村耕太郎