小池宏幸 (Hiroyuki Koike) - マイポータル

基本情報

所属: 国立研究開発法人国立精神・神経医療研究センター神経研究所疾病研究第三部リサーチフェロー

学位: 博士（薬学）

研究者番号: 11016049
J-GLOBAL ID: 202501008594621178
researchmap会員ID: R000080381

研究キーワード

研究分野

経歴

2025年1月 - 現在

国立研究開発法人国立精神・神経医療研究センター, 疾病研究第三部, リサーチフェロー
2019年7月 - 2024年12月

大塚製薬株式会社, 中枢神経疾患研究所, 研究員
2009年4月 - 2019年6月

大正製薬株式会社, 薬理第一研究室, 研究員
2014年6月 - 2016年6月

米国マウントサイナイ医科大学, 訪問研究員

論文

Frontal-Sensory Cortical Projections Become Dispensable for Attentional Performance Upon a Reduction of Task Demand in Mice

Kevin J. Norman, Julia Bateh, Priscilla Maccario, Christina Cho, Keaven Caro, Tadaaki Nishioka, Hiroyuki Koike, Hirofumi Morishita

Frontiers in Neuroscience 15 2022年1月11日査読有り
Chemogenetic suppression of anterior cingulate cortical neurons projecting to the visual cortex disrupts attentional behavior in mice

Kevin J. Norman, Hiroyuki Koike, Sarah E. McCraney, Yury Garkun, Julia Bateh, Elisa N. Falk, Susanna Im, Keaven Caro, Michael P. Demars, Hirofumi Morishita

Neuropsychopharmacology Reports 41(2) 207-214 2021年6月査読有り
Post-error recruitment of frontal sensory cortical projections promotes attention in mice

Kevin J. Norman, Justin S. Riceberg, Hiroyuki Koike, Julia Bateh, Sarah E. McCraney, Keaven Caro, Daisuke Kato, Ana Liang, Kazuhiko Yamamuro, Meghan E. Flanigan …

Neuron 109(7) 1202-1213.e5 2021年4月7日査読有り
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation

Elisa N. Falk, Kevin J. Norman, Yury Garkun, Michael P. Demars, Susanna Im, Giulia Taccheri, Jenna Short, Keaven Caro, Sarah E. McCraney, Christina Cho …

Science Advances 7(10) 2021年3月3日査読有り
Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

Lucy K. Bicks, Kazuhiko Yamamuro, Meghan E. Flanigan, Julia Minjung Kim, Daisuke Kato, Elizabeth K. Lucas, Hiroyuki Koike, Michelle S. Peng, Daniel M. Brady, Sandhya Chandrasekaran …

Nature Communications 11(1) 2020年12月1日査読有り
Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

Elisa M. Nabel, Yury Garkun, Hiroyuki Koike, Masato Sadahiro, Ana Liang, Kevin J. Norman, Giulia Taccheri, Michael P. Demars, Susanna Im, Keaven Caro …

Nature Communications 11(1) 2020年12月1日査読有り
Targeting of Metabotropic Glutamate Receptors for the Development of Novel Antidepressants

Shigeyuki Chaki, Hiroyuki Koike, Kenichi Fukumoto

Chronic Stress 3 2019年査読有り招待有り
(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

Jun Ichi Yamaguchi, Hidetoh Toki, Youge Qu, Chun Yang, Hiroyuki Koike, Kenji Hashimoto, Akiko Mizuno-Yasuhira, Shigeyuki Chaki

Neuropsychopharmacology 43(9) 1900-1907 2018年8月1日査読有り
Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

Hiroyuki Koike, Michael P. Demars, Jennifer A. Short, Elisa M. Nabel, Schahram Akbarian, Mark G. Baxter, Hirofumi Morishita

Neuropsychopharmacology 41(4) 1014-1023 2016年3月1日査読有り筆頭著者
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats

Kazuaki Kawaura, Hiroyuki Koike, Kohnosuke Kinoshita, Daiji Kambe, Ayaka Kaku, Jun ichi Karasawa, Shigeyuki Chaki, Hirohiko Hikichi

Behavioural Brain Research 278 186-192 2015年2月1日査読有り
Prefrontal cortex and social cognition in mouse and man

Lucy K. Bicks, Hiroyuki Koike, Schahram Akbarian, Hirofumi Morishita

Frontiers in Psychology 6(NOV) 2015年査読有り
Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

Hiroyuki Koike, Shigeyuki Chaki

Behavioural Brain Research 271 111-115 2014年9月1日査読有り筆頭著者
Effect of an mGlu2/3 receptor antagonist on depressive behavior induced by withdrawal from chronic treatment with methamphetamine

Michihiko Iijima, Hiroyuki Koike, Shigeyuki Chaki

Behavioural Brain Research 246 24-28 2013年6月1日査読有り
Effects of ketamine and LY341495 on the depressive-like behavior of repeated corticosterone-injected rats

Hiroyuki Koike, Michihiko Iijima, Shigeyuki Chaki

Pharmacology Biochemistry and Behavior 107 20-23 2013年6月査読有り筆頭著者
Role of BDNF/TrkB signaling in antidepressant-like effects of a group II metabotropic glutamate receptor antagonist in animal models of depression

Hiroyuki Koike, Kenichi Fukumoto, Michihiko Iijima, Shigeyuki Chaki

Behavioural Brain Research 238(1) 48-52 2013年2月1日査読有り筆頭著者
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

Hiroyuki Koike, Michihiko Iijima, Shigeyuki Chaki

Neuropharmacology 61(8) 1419-1423 2011年12月査読有り筆頭著者
Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

Hiroyuki Koike, Michihiko Iijima, Shigeyuki Chaki

Behavioural Brain Research 224(1) 107-111 2011年10月10日査読有り筆頭著者
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus

Hiroyuki Mizoguchi, Junya Nakade, Masaki Tachibana, Daisuke Ibi, Eiichi Someya, Hiroyuki Koike, Hiroyuki Kamei, Toshitaka Nabeshima, Shigeyoshi Itohara, Kazuhiro Takuma …

Journal of Neuroscience 31(36) 12963-12971 2011年9月7日査読有り
Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: Possible involvement of a brain-specific transcription factor Npas4

Jaesuk Yun, Hiroyuki Koike, Daisuke Ibi, Erika Toth, Hiroyuki Mizoguchi, Atsumi Nitta, Masanori Yoneyama, Kiyokazu Ogita, Yukio Yoneda, Toshitaka Nabeshima …

Journal of Neurochemistry 114(6) 1840-1851 2010年9月査読有り
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood

Daisuke Ibi, Taku Nagai, Hiroyuki Koike, Yuko Kitahara, Hiroyuki Mizoguchi, Minae Niwa, Hanna Jaaro-Peled, Atsumi Nitta, Yukio Yoneda, Toshitaka Nabeshima …

Behavioural Brain Research 206(1) 32-37 2010年1月5日査読有り

もっとみる

MISC

Role of (R)-Ketamine Metabolites in Antidepressant Effects of (R)-Ketamine

Jun-ichi Yamaguchi, Hidetoh Toki, Youge Qu, Chun Yang, Hiroyuki Koike, Kenji Hashimoto, Akiko Mizuno-Yasuhira, Shigeyuki Chaki

NEUROPSYCHOPHARMACOLOGY 43 S556-S557 2017年11月
[Functional analysis of stress-responsible transcription factor Npas4 in stress-induced brain dysfunction].

Taku Nagai, Jaesk Yun, Daisuke Ibi, Hiroyuki Koike, Yoko Hibi, Kiyofumi Yamada

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 139(4) 147-151 2012年4月
Behavioral and glutamatergic abnormalities in a neurodevelopmental mouse model of schizophrenia induced by perinatal viral infection

Yuko Kitahara, Daisuke Bi, Taku Nagai, Hiroyuki Mizoguchi, Hiroyuki Koike, Jinghua Yu, Atsumi Nitta, Yukio Yoneda, Toshitaka Nabeshima, Kiyohumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 110P-110P 2009年
Effect of neonatal polyl: C treatment in transgenic mice with dominant-negative form of DISC1 on emotional and cognitive function in adolescence

Daisuke Ibi, Taku Nagai, Hiroyuki Mizoguchi, Yuko Kitahara, Hiroyuki Koike, Atsumi Nitta, Yukio Yoneda, Akira Sawa, Toshitaka Nabeshima, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 85P-85P 2009年
Effect of methamphetamine on the neuronal PAS domain 4 (NPAS4) expression in the mouse brain

Jaesuk Yun, Taku Nagai, Yoko Hibi, Hiroyuki Koike, Atumi Nitta, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 77P-77P 2009年
Cognitive impairment in a mouse model of viral infection during perinatal stage

Daisuke Ibi, Taku Nagai, Hiroyuki Mizoguchi, Hiroyuki Koike, Kazuhiro Takumo, Kiyofumi Yamada

NEUROSCIENCE RESEARCH 61 S129-S129 2008年
Social isolation rearing reduces neurogenesis in the hippocampal dentate gyrus of juvenile mice and impairs cognitive and behavioral development.

Daisuke Ibi, Kazuhiro Takuma, Hiroyuki Koike, Hiroyuki Mizoguchi, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 58P-58P 2007年
Role of serotonin 5-HT2C receptor in aggressive behavior induced by social isolation in mice

Kazuhiro Takuma, Tomoko Tsuji, Hiroyuki Koike, Taku Nagai, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 101 90-90 2006年

講演・口頭発表等

Psychedelicの機序からの創薬研究

小池宏幸, 堀之北一朗, 安福令子, 鈴木幹生, 舩越竹雄, 二村隆史

第54回日本神経精神薬理学会/第34回日本臨床精神神経薬理学会合同年会 2024年招待有り
Role of 5-HT2AR in the Anti-Anhedonic and Neuroplasticity-Inducing Effects of DOI and TCB-2

Hiroyuki Koike, Ichiro Horinokita, Reiko Yasufuku, Takeo Funakoshi, Mikio Suzuki, Takashi Futamura

ACNP 62nd Annual Meeting 2023年
A Potent 5-HT2A Receptor Agonist TCB-2 Exerts Rapid Antidepressant-Like and Anxiolytic-Like Effects in Mice

Hiroyuki Koike, Ichiro Horinokita, Mikio Suzuki, Takashi Futamura

ACNP 61st Annual Meeting 2022年
Post-Error Adaptation of Attentional, but Not Impulsive, Behavior in Mice

Hiroyuki Koike, Mikio Suzuki, Takashi Futamura

ACNP 60th Annual Meeting 2021年
Prefrontal Top-Down Cortical Projection Controls Attentional Behavior

Hiroyuki Koike, Kevin Norman, Sarah Lopez, Elisa Nabel, Meghan Flanigan, Yury Garkun, Zhe Dong, Michael Demars, Mark Baxter, Scott Russo, Hirofumi Morishita

ACNP 56th Annual Meeting 2017年
Top-Down Control of Attentional Behavior by Long-Range Fronto-Posterior Cortical Circuit

Hiroyuki Koike, Sarah Lopez, Elisa Nabel, Michael Demars, Hirofumi Morishita

ACNP 55th Annual Meeting 2016年
Chemogenetic inactivation of dorsal anterior cingulate cortex neurons disrupts attentional behavior in mouse

Hiroyuki Koike, Michael Demars, Jennifer Shor, Elisa Nabel, Schahram Akbarian, Mark Baxter, Hirofumi Morishita

Neuroscience 2015年

所属学協会

共同研究・競争的資金等の研究課題

確信度判断の的確さの発達とその神経機構の解明

日本学術振興会科学研究費助成事業基盤研究(C) 2026年4月 - 2029年3月

小池宏幸

小池宏幸

基本情報

研究キーワード

研究分野

経歴

論文

MISC

講演・口頭発表等

所属学協会

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧