Kohara Michinori - My portal

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Degree: Ph.D.

J-GLOBAL ID: 200901002697510088
researchmap Member ID: 0000016762

Research Interests

Research History

Education

Awards

Papers

144

A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b.

Takashi Imada, Koji Moriya, Masahiko Uchiyama, Naoto Inukai, Mitsuhiro Hitotsuyanagi, Akiko Masuda, Takehiro Suzuki, Shotaro Ayukawa, Yo-Ichi Tagawa, Naoshi Dohmae, Michinori Kohara, Masayuki Yamamura, Daisuke Kiga

ACS synthetic biology, 7(11) 2537-2546, Nov 16, 2018 Peer-reviewed
MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine.

Okamoto M, Fukushima Y, Kouwaki T, Daito T, Kohara M, Kida H, Oshiumi H

The Journal of biological chemistry, 293(48) 18585-18600, Oct, 2018 Peer-reviewed
Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections.

Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara

Archives of virology, 163(7) 1717-1726, Jul, 2018 Peer-reviewed
Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses.

Hironori Nishitsuji, Keisuke Harada, Saneyuki Ujino, Jing Zhang, Michinori Kohara, Masaya Sugiyama, Masashi Mizokami, Kunitada Shimotohno

Cancer science, 109(1) 241-249, Jan, 2018 Peer-reviewed
Hepatitis C Virus: Viral Quasispecies and Genotypes.

Kyoko Tsukiyama-Kohara, Michinori Kohara

International journal of molecular sciences, 19(1), Dec 22, 2017 Peer-reviewed
Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

Yusuke Sato, Hideki Matsui, Naoki Yamamoto, Risa Sato, Tsubasa Munakata, Michinori Kohara, Hideyoshi Harashima

JOURNAL OF CONTROLLED RELEASE, 266 216-225, Nov, 2017 Peer-reviewed
Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane

Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara, Hak Hotta

SCIENTIFIC REPORTS, 7(1) 15931, Nov, 2017 Peer-reviewed
Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting

Yu Sakurai, Wataru Mizumura, Manami Murata, Tomoya Hada, Shoshiro Yamamoto, Kenichiro Ito, Kazuhiro Iwasaki, Takayuki Katoh, Yuki Goto, Asako Takagi, Michinori Kohara, Hiroaki Suga, Hideyoshi Harashima

MOLECULAR PHARMACEUTICS, 14(10) 3290-3298, Oct, 2017 Peer-reviewed
Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/beta-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami

EBIOMEDICINE, 23 79-87, Sep, 2017 Peer-reviewed
Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys

Tomoko Fujiyuki, Ryo Horie, Misako Yoneda, Takeshi Kuraishi, Fumihiko Yasui, Hyun-jeong Kwon, Keisuke Munekata, Fusako Ikeda, Miho Hoshi, Yuri Kiso, Mio Omi, Hiroki Sato, Hiroshi Kida, Shosaku Hattori, Michinori Kohara, Chieko Kai

SCIENTIFIC REPORTS, 7(1) 12017, Sep, 2017 Peer-reviewed
Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri.

Kayesh MEH, Ezzikouri S, Sanada T, Chi H, Hayashi Y, Rebbani K, Kitab B, Matsuu A, Miyoshi N, Hishima T, Kohara M, Tsukiyama-Kohara K

Sci Rep., 7(1) 9848-9855, Aug, 2017
Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri

Mohammad Enamul Hoque Kayesh, Sayeh Ezzikouri, Takahiro Sanada, Haiying Chi, Yukiko Hayashi, Khadija Rebbani, Bouchra Kitab, Aya Matsuu, Noriaki Miyoshi, Tsunekazu Hishima, Michinori Kohara, Kyoko Tsukiyama-Kohara

SCIENTIFIC REPORTS, 7(1) 9848, Aug, 2017 Peer-reviewed
Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection

Mohammad Enamul Hoque Kayesh, Bouchra Kitab, Takahiro Sanada, Daisuke Hayasaka, Kouichi Morita, Michinori Kohara, Kyoko Tsukiyama-Kohara

INFECTION GENETICS AND EVOLUTION, 51 203-210, Jul, 2017 Peer-reviewed
Interferon-beta response is impaired by hepatitis B virus infection in Tupaia belangeri

Mohammad Enamul Hoque Kayesh, Sayeh Ezzikouri, Haiying Chi, Takahiro Sanada, Naoki Yamamoto, Bouchra Kitab, Takumi Haraguchi, Rika Matsuyama, Chimene Nze Nkogue, Hitoshi Hatai, Noriaki Miyoshi, Shuko Murakami, Yasuhito Tanaka, Jun-ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Michinori Kohara, Kyoko Tsukiyama-Kohara

VIRUS RESEARCH, 237 47-57, Jun, 2017 Peer-reviewed
Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles.

Takahiro Sanada, Yuichi Hirata, Yutaka Naito, Naoki Yamamoto, Yoshiaki Kikkawa, Yuji Ishida, Chihiro Yamasaki, Chise Tateno, Takahiro Ochiya, Michinori Kohara

Cellular and molecular gastroenterology and hepatology, 3(2) 272-283, Mar, 2017 Peer-reviewed
Selective inhibitor of Wnt/beta-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, Michinori Kohara

SCIENTIFIC REPORTS, 7(1) 325, Mar, 2017 Peer-reviewed
Immature Core protein of hepatitis C virus induces an unfolded protein response through inhibition of ERAD-L in a yeast model system

Shota Takahashi, Naoko Sato, Junichi Kikuchi, Hideaki Kakinuma, Jun Okawa, Yukiko Masuyama, Singo Iwasa, Hayato Irokawa, Gi-Wook Hwang, Akira Naganuma, Michinori Kohara, Shusuke Kuge

GENES TO CELLS, 22(2) 160-173, Feb, 2017 Peer-reviewed
Corrigendum to 'Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus' [Virology (2014) 157-168].

Yasui F, Kohara M, Kitabatake M, Nishiwaki T, Fujii H, Tateno C, Yoneda M, Morita K, Matsushima K, Koyasu S, Kai C

Virology, 499 397-398, Dec, 2016 Peer-reviewed
Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus

Fumihiko Yasui, Yasushi Itoh, Ai Ikejiri, Masahiro Kitabatake, Nobuo Sakaguchi, Keisuke Munekata, Shintaro Shichinohe, Yukiko Hayashi, Hirohito Ishigaki, Misako Nakayama, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara, Michinori Kohara

SCIENTIFIC REPORTS, 6 37915, Nov, 2016 Peer-reviewed
Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection

Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Takahiro Sanada, Naoki Yamamoto, Edin J. Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi

FRONTIERS IN IMMUNOLOGY, 7 335, Aug, 2016 Peer-reviewed
Establishment of an intermittent cold stress model using Tupaia belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor

Chi Hai-Ying, Kiori Nagano, Sayeh Ezzikouri, Chiho Yamaguchi, Mohammad Enamul Hoque Kayesh, Khadija Rebbani, Bouchra Kitab, Hirohumi Nakano, Hiroyuki Kouji, Michinori Kohara, Kyoko Tsukiyama-Kohara

EXPERIMENTAL ANIMALS, 65(3) 285-292, Jul, 2016 Peer-reviewed
Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody

Kenji Sugata, Jun-ichirou Yasunaga, Michi Miura, Hirofumi Akari, Atae Utsunomiya, Kisato Nosaka, Yuko Watanabe, Hitoshi Suzushima, Ki-Ryang Koh, Masanori Nakagawa, Michinori Kohara, Masao Matsuoka

SCIENTIFIC REPORTS, 6 27150, Jun, 2016 Peer-reviewed
Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicits neutralizing antibodies against JEV and hepatitis C virus

Ryohei Saga, Akira Fujimoto, Noriyuki Watanabe, Mami Matsuda, Makoto Hasegawa, Koichi Watashi, Hideki Aizaki, Noriko Nakamura, Shigeru Tajima, Tomohiko Takasaki, Eiji Konishi, Takanobu Kato, Michinori Kohara, Haruko Takeyama, Takaji Wakita, Ryosuke Suzuki

SCIENTIFIC REPORTS, 6 28688, Jun, 2016 Peer-reviewed
Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

Naoki Yamamoto, Yusuke Sato, Tsubasa Munakata, Masakazu Kakuni, Chise Tateno, Takahiro Sanada, Yuichi Hirata, Shuko Murakami, Yasuhito Tanaka, Kazuaki Chayama, Hiroto Hatakeyama, Mamoru Hyodo, Hideyoshi Harashima, Michinori Kohara

JOURNAL OF HEPATOLOGY, 64(3) 547-555, Mar, 2016 Peer-reviewed
M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice

Takahiro Ohtsuki, Kiminori Kimura, Yuko Tokunaga, Kyoko Tsukiyama-Kohara, Chise Tateno, Yukiko Hayashi, Tsunekazu Hishima, Michinori Kohara

JOURNAL OF VIROLOGY, 90(1) 300-307, Jan, 2016 Peer-reviewed
A Multifunctional Envelope-Type Nano Device Containing a pH-Sensitive Cationic Lipid for Efficient Delivery of Short Interfering RNA to Hepatocytes In Vivo.

Sato Y, Harashima H, Kohara M

Methods in molecular biology (Clifton, N.J.), 1364 71-78, 2016 Peer-reviewed
Property of hepatitis B virus replication in Tupaia belangeri hepatocytes

Takahiro Sanada, Kyoko Tsukiyama-Kohara, Naoki Yamamoto, Sayeh Ezzikouri, Soumaya Benjelloun, Shuko Murakami, Yasuhito Tanaka, Chise Tateno, Michinori Kohara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 469(2) 229-235, Jan, 2016 Peer-reviewed
Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication

Naoko Kubota, Masataka Nomoto, Gi Wook Hwang, Toshihiko Watanabe, Michinori Kohara, Takaji Wakita, Akira Naganuma, Shusuke Kuge

World Journal of Hepatology, 8(5) 282-290, 2016 Peer-reviewed
[Persistent infection factor of HBV].

Munakata T, Yamamoto N, Kohara M

Nihon rinsho. Japanese journal of clinical medicine, 73 Suppl 9 357-360, Dec, 2015 Peer-reviewed
Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

Chise Tateno, Yosuke Kawase, Yoshimi Tobita, Satoko Hamamura, Hiroki Ohshita, Hiroshi Yokomichi, Harumi Sanada, Masakazu Kakuni, Akira Shiota, Yuha Kojima, Yuji Ishida, Hiroshi Shitara, Naoko A. Wada, Hiromi Tateishi, Masayuki Sudoh, Shin-ichiro Nagatsuka, Kou-ichi Jishage, Michinori Kohara

PLOS ONE, 10(11) e0142145, Nov, 2015 Peer-reviewed
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/beta-Catenin Reduces Liver Fibrosis in Mice

Yosuke Osawa, Keisuke Oboki, Jun Imamura, Ekumi Kojika, Yukiko Hayashi, Tsunekazu Hishima, Toshiji Saibara, Futoshi Shibasaki, Michinori Kohara, Kiminori Kimura

EBIOMEDICINE, 2(11) 1751-1758, Nov, 2015 Peer-reviewed
Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor

Kenji Sugata, Jun-ichirou Yasunaga, Yuichi Mitobe, Michi Miura, Paola Miyazato, Michinori Kohara, Masao Matsuoka

BLOOD, 126(9) 1095-1105, Aug, 2015 Peer-reviewed
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C

Sayeh Ezzikouri, Kiminori Kimura, Hajime Sunagozaka, Shuichi Kaneko, Kazuaki Inoue, Tomohiro Nishimura, Tsunekazu Hishima, Michinori Kohara, Kyoko Tsukiyama-Kohara

EBIOMEDICINE, 2(6) 604-612, Jun, 2015 Peer-reviewed
Hepatitis C Virus Attenuates Mitochondrial Lipid beta-Oxidation by Downregulating Mitochondrial Trifunctional-Protein Expression

Yutaka Amako, Tsubasa Munakata, Michinori Kohara, Aleem Siddiqui, Chris Peers, Mark Harris

JOURNAL OF VIROLOGY, 89(8) 4092-4101, Apr, 2015 Peer-reviewed
3 beta-Hydroxysterol Delta 24-Reductase on the Surface of Hepatitis C Virus-Related Hepatocellular Carcinoma Cells Can Be a Target for Molecular Targeting Therapy

Makoto Saito, Takashi Takano, Tomohiro Nishimura, Michinori Kohara, Kyoko Tsukiyama-Kohara

PLOS ONE, 10(4) e0124197, Apr, 2015 Peer-reviewed
Inhibitory effects of Pycnogenol (R) on hepatitis C virus replication

Sayeh Ezzikouri, Tomohiro Nishimura, Michinori Kohara, Soumaya Benjelloun, Yoichiro Kino, Kazuaki Inoue, Akira Matsumori, Kyoko Tsukiyama-Kohara

ANTIVIRAL RESEARCH, 113 93-102, Jan, 2015 Peer-reviewed
Animal model for hepatitis C virus infection.

Tsukiyama-Kohara K, Kohara M

Uirusu, 65(2) 255-262, 2015 Peer-reviewed
The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

Seiichi Sato, Kai Li, Takeshi Kameyama, Takaya Hayashi, Yuji Ishida, Shuko Murakami, Tsunamasa Watanabe, Sayuki Iijima, Yu Sakurai, Koichi Watashi, Susumu Tsutsumi, Yusuke Sato, Hidetaka Akita, Takaji Wakita, Charles M. Rice, Hideyoshi Harashima, Michinori Kohara, Yasuhito Tanaka, Akinori Takaoka

IMMUNITY, 42(1) 123-132, Jan, 2015 Peer-reviewed
Tupaia Belangeri as an Experimental Animal Model for Viral Infection

Kyoko Tsukiyama-Kohara, Michinori Kohara

EXPERIMENTAL ANIMALS, 63(4) 367-374, Oct, 2014 Peer-reviewed
Suppression of hepatitis C virus replication by cyclin-dependent kinase inhibitors

Tsubasa Munakata, Makoto Inada, Yuko Tokunaga, Takaji Wakita, Michinori Kohara, Akio Nomoto

ANTIVIRAL RESEARCH, 108 79-87, Aug, 2014 Peer-reviewed
Recent Insights into Hepatitis B Virus-Host Interactions

Sayeh Ezzikouri, Makoto Ozawa, Michinori Kohara, Naima Elmdaghri, Soumaya Benjelloun, Kyoko Tsukiyama-Kohara

JOURNAL OF MEDICAL VIROLOGY, 86(6) 925-932, Jun, 2014 Peer-reviewed
Nonstructural Protein 5A Is Incorporated into Hepatitis C Virus Low-Density Particle through Interaction with Core Protein and Microtubules during Intracellular Transport

Chao-Kuen Lai, Vikas Saxena, Chung-Hsin Tseng, King-Song Jeng, Michinori Kohara, Michael M. C. Lai

PLOS ONE, 9(6) e99022, Jun, 2014 Peer-reviewed
Resistance to cyclosporin A derives from mutations in hepatitis C virus nonstructural proteins

Masaaki Arai, Kyoko Tsukiyama-Kohara, Asako Takagi, Yoshimi Tobita, Kazuaki Inoue, Michinori Kohara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 448(1) 56-62, May, 2014 Peer-reviewed
Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus

Fumihiko Yasui, Michinori Kohara, Masahiro Kitabatake, Tetsu Nishiwaki, Hideki Fujii, Chise Tateno, Misako Yoneda, Kouichi Morita, Kouji Matsushima, Shigeo Koyasu, Chieko Kai

VIROLOGY, 454 157-168, Apr, 2014 Peer-reviewed
In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

Tsunamasa Watanabe, Hiroto Hatakeyama, Chiho Matsuda-Yasui, Yusuke Sato, Masayuki Sudoh, Asako Takagi, Yuichi Hirata, Takahiro Ohtsuki, Masaaki Arai, Kazuaki Inoue, Hideyoshi Harashima, Michinori Kohara

SCIENTIFIC REPORTS, 4 4750, Apr, 2014 Peer-reviewed
B-Cell-Intrinsic Hepatitis C Virus Expression Leads to B-Cell-Lymphomagenesis and Induction of NF-kappa B Signalling

Yuri Kasama, Takuo Mizukami, Hideki Kusunoki, Jan Peveling-Oberhag, Yasumasa Nishito, Makoto Ozawa, Michinori Kohara, Toshiaki Mizuochi, Kyoko Tsukiyama-Kohara

PLOS ONE, 9(3) e91373, Mar, 2014 Peer-reviewed
Histopathological Evaluation of the Diversity of Cells Susceptible to H5N1 Virulent Avian Influenza Virus

Haru Ogiwara, Fumihiko Yasui, Keisuke Munekata, Asako Takagi-Kamiya, Tsubasa Munakata, Namiko Nomura, Futoshi Shibasaki, Kazuhiko Kuwahara, Nobuo Sakaguchi, Yoshihiro Sakoda, Hiroshi Kida, Michinori Kohara

AMERICAN JOURNAL OF PATHOLOGY, 184(1) 171-183, Jan, 2014 Peer-reviewed
DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model

Takeshi Wada, Michinori Kohara, Yasuhiro Yasutomi

VACCINE, 31(50) 5968-5974, Dec, 2013 Peer-reviewed
Isolation and Characterization of Highly Replicable Hepatitis C Virus Genotype 1a Strain HCV-RMT

Masaaki Arai, Yuko Tokunaga, Asako Takagi, Yoshimi Tobita, Yuichi Hirata, Yuji Ishida, Chise Tateno, Michinori Kohara

PLOS ONE, 8(12) e82527, Dec, 2013 Peer-reviewed
Experimental Infection of Macaques with a Wild Water Bird-Derived Highly Pathogenic Avian Influenza Virus (H5N1)

Tomoko Fujiyuki, Misako Yoneda, Fumihiko Yasui, Takeshi Kuraishi, Shosaku Hattori, Hyun-jeong Kwon, Keisuke Munekata, Yuri Kiso, Hiroshi Kida, Michinori Kohara, Chieko Kai

PLOS ONE, 8(12) e83551, Dec, 2013 Peer-reviewed

Misc.

168

Hepatitis C virus replication and pathogenesis

Michinori Kohara

Journal of Dermatological Science, 22(3) 161-168, Apr, 2000
Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation

Masami Hirota, Shinya Satoh, Shin-Ichi Asabe, Michinori Kohara, Kyoko Tsukiyama-Kohara, Nobuyuki Kato, Makoto Hijikata, Kunitada Shimotohno

Virology, 257(1) 130-137, Apr 25, 1999
Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation

Masami Hirota, Shinya Satoh, Shin-Ichi Asabe, Michinori Kohara, Kyoko Tsukiyama-Kohara, Nobuyuki Kato, Makoto Hijikata, Kunitada Shimotohno

Virology, 257(1) 130-137, Apr 25, 1999
Possible association between serum GB virus C RNA level and disease activity in fulminant hepatitis type G

Kazuaki Inoue, Makoto Yoshiba, Kazuhiko Sekiyama, Michinori Kohara

Journal of Hepatology, 30(5) 801-806, 1999
Hepatitis C virus structural proteins induce liver cell injury in transgenic mice

Arata Honda, Yutaka Arai, Norio Hirota, Takako Sato, Junichi Ikegaki, Tamio Koizumi, Masahiko Hatano, Michinori Kohara, Takashi Moriyama, Michio Imawari, Kunitada Shimotohno, Takeshi Tokuhisa

Journal of Medical Virology, 59(3) 281-289, 1999
Possible association between serum GB virus C RNA level and disease activity in fulminant hepatitis type G

Kazuaki Inoue, Makoto Yoshiba, Kazuhiko Sekiyama, Michinori Kohara

Journal of Hepatology, 30(5) 801-806, 1999
Hepatitis C virus structural proteins induce liver cell injury in transgenic mice

Arata Honda, Yutaka Arai, Norio Hirota, Takako Sato, Junichi Ikegaki, Tamio Koizumi, Masahiko Hatano, Michinori Kohara, Takashi Moriyama, Michio Imawari, Kunitada Shimotohno, Takeshi Tokuhisa

Journal of Medical Virology, 59(3) 281-289, 1999
Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates

Abdelmajid Sabile, Gabriel Perlemuter, Fulvia Bono, Kyoko Kohara, France Demaugre, Michinori Kohara, Yoshiharu Matsuura, Tatsuo Miyamura, Christian Bréchot, Giovanna Barba

Hepatology, 30(4) 1064-1076, 1999
Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates

Abdelmajid Sabile, Gabriel Perlemuter, Fulvia Bono, Kyoko Kohara, France Demaugre, Michinori Kohara, Yoshiharu Matsuura, Tatsuo Miyamura, Christian Bréchot, Giovanna Barba

Hepatology, 30(4) 1064-1076, 1999
Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system

Takaji Wakita, Choji Taya, Asao Katsume, Junko Kato, Hiromichi Yonekawa, Yumi Kanegae, Izumu Saito, Yukiko Hayashi, Morio Koike, Michinori Kohara

Journal of Biological Chemistry, 273(15) 9001-9006, Apr 10, 1998
Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system

Takaji Wakita, Choji Taya, Asao Katsume, Junko Kato, Hiromichi Yonekawa, Yumi Kanegae, Izumu Saito, Yukiko Hayashi, Morio Koike, Michinori Kohara

Journal of Biological Chemistry, 273(15) 9001-9006, Apr 10, 1998
Genetic analysis of internal ribosomal entry site on hepatitis C virus RNA: Implication for involvement of the highly ordered structure and cell type-specific transacting factors

Nobuhiko Kamoshita, Kyoko Tsukiyama-Kohara, Michinori Kohara, Akio Nomoto

Virology, 233(1) 9-18, Jun 23, 1997
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

G. Barba, F. Harper, T. Harada, M. Kohara, S. Goulinet, Y. Matsuura, G. Eder, Zs Schaff, M. J. Chapman, T. Miyamura, C. Bréchot

Proceedings of the National Academy of Sciences of the United States of America, 94(4) 1200-1205, Feb 18, 1997
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

G. Barba, F. Harper, T. Harada, M. Kohara, S. Goulinet, Y. Matsuura, G. Eder, Zs Schaff, M. J. Chapman, T. Miyamura, C. Bréchot

Proceedings of the National Academy of Sciences of the United States of America, 94(4) 1200-1205, Feb 18, 1997
Acute hepatitis caused by sexual or household transmission of GBV-C

Takeshi Tanaka, Tomoko Takeuchi, Kazuaki Inoue, Satoshi Tanaka, Michinori Kohara

Journal of Hepatology, 27(6) 1110-1112, 1997
Acute hepatitis caused by sexual or household transmission of GBV-C

Takeshi Tanaka, Tomoko Takeuchi, Kazuaki Inoue, Satoshi Tanaka, Michinori Kohara

Journal of Hepatology, 27(6) 1110-1112, 1997
Detection of hepatitis C virus specific core protein in serum of patients by a sensitive fluorescence enzyme immunoassay (FEIA)

Tomiko Kashiwakuma, Akira Hasegawa, Tadahiro Kajita, Atsumi Takata, Hiroyuki Mori, Yohsuke Ohta, Eiji Tanaka, Kendo Kiyosawa, Takeshi Tanaka, Satoshi Tanaka, Nobu Hattori, Michinori Kohara

Journal of Immunological Methods, 190(1) 79-89, Mar 28, 1996
Detection of hepatitis C virus specific core protein in serum of patients by a sensitive fluorescence enzyme immunoassay (FEIA)

Tomiko Kashiwakuma, Akira Hasegawa, Tadahiro Kajita, Atsumi Takata, Hiroyuki Mori, Yohsuke Ohta, Eiji Tanaka, Kendo Kiyosawa, Takeshi Tanaka, Satoshi Tanaka, Nobu Hattori, Michinori Kohara

Journal of Immunological Methods, 190(1) 79-89, Mar 28, 1996
Hepatitis C virus: Detection of intracellular virus particles by electron microscopy

Yohko K. Shimizu, Stephen M. Feinstone, Michinori Kohara, Robert H. Purcell, Hiroshi Yoshikura

Hepatology, 23(2) 205-209, 1996
Hepatitis C virus: Detection of intracellular virus particles by electron microscopy

Yohko K. Shimizu, Stephen M. Feinstone, Michinori Kohara, Robert H. Purcell, Hiroshi Yoshikura

Hepatology, 23(2) 205-209, 1996
Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase

Akio Kanai, Kyoko Tanabe, Michinori Kohara

FEBS Letters, 376(3) 221-224, Dec 4, 1995
Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase

Akio Kanai, Kyoko Tanabe, Michinori Kohara

FEBS Letters, 376(3) 221-224, Dec 4, 1995
Significance of specific antibody assay for genotyping of hepatitis C virus

Takeshi Tanaka, Kyoko Tsukiyama-Kohara, Kenjiro Yamaguchi, Shintaro Yagi, Satoshi Tanaka, Akira Hasegawa, Yohsuke Ohta, Nobu Hattori, Michinori Kohara

Hepatology, 19(6) 1347-1353, Jun, 1994
Significance of specific antibody assay for genotyping of hepatitis C virus

Takeshi Tanaka, Kyoko Tsukiyama-Kohara, Kenjiro Yamaguchi, Shintaro Yagi, Satoshi Tanaka, Akira Hasegawa, Yohsuke Ohta, Nobu Hattori, Michinori Kohara

Hepatology, 19(6) 1347-1353, Jun, 1994
Hepatitis C virus serotype II responds more favorably to interferon-α therapy

Etsuro Orito, Masashi Mizokami, Naoto Mizoguchi, Ken-Ichi Ohba, Miyako Tohnai, Hiromichi Yamanaka, Takashi Oguri, Noboru Hirashima, Tsuneo Koide, Hideyuki Kano, Kyoko Tsukiyama-Kohara, Michinori Kohara, Johnson Y.N. Lau

Journal of Hepatology, 21(1) 130-132, 1994
Hepatitis C virus serotype II responds more favorably to interferon-α therapy

Etsuro Orito, Masashi Mizokami, Naoto Mizoguchi, Ken-Ichi Ohba, Miyako Tohnai, Hiromichi Yamanaka, Takashi Oguri, Noboru Hirashima, Tsuneo Koide, Hideyuki Kano, Kyoko Tsukiyama-Kohara, Michinori Kohara, Johnson Y.N. Lau

Journal of Hepatology, 21(1) 130-132, 1994
Antigenicities of group I and II hepatitis C virus polypeptides - Molecular basis of diagnosis

Kyoko Tsukiyama-Kohara, Kenjiro Yamaguchi, Noboru Maki, Yoshihiro Ohta, Keizaburo Miki, Masashi Mizokami, Ken-Ichi Ohba, Satoshi Tanaka, Nobu Hattori, Akio Nomoto, Michinori Kohara

Virology, 192(2) 430-437, 1993
Antigenicities of group I and II hepatitis C virus polypeptides - Molecular basis of diagnosis

Kyoko Tsukiyama-Kohara, Kenjiro Yamaguchi, Noboru Maki, Yoshihiro Ohta, Keizaburo Miki, Masashi Mizokami, Ken-Ichi Ohba, Satoshi Tanaka, Nobu Hattori, Akio Nomoto, Michinori Kohara

Virology, 192(2) 430-437, 1993
Purification of enzymatically active poliovirus proteinase 3C produced in Escherichia coli

Takahara Yoshiyuki, Ando Noriko, Kohara Michinori, Hagino-Yamagishi Kimiko, Nomoto Akio, Itoh Heihachi, Numao Naganori, Kondo Kiyosi

Gene, 79(2) 249-258, Jul 15, 1989
Purification of enzymatically active poliovirus proteinase 3C produced in Escherichia coli

Takahara Yoshiyuki, Ando Noriko, Kohara Michinori, Hagino-Yamagishi Kimiko, Nomoto Akio, Itoh Heihachi, Numao Naganori, Kondo Kiyosi

Gene, 79(2) 249-258, Jul 15, 1989
An Infectious cDNA clone of the poliovirus sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine

Michinori Kohara, Shinobu Abe, Shusuke Kuge, Bert L. Semler, Toshihiko Komatsu, Mined Arita, Heihachi Itoh, Akio Nomoto

Virology, 151(1) 21-30, 1986
An Infectious cDNA clone of the poliovirus sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine

Michinori Kohara, Shinobu Abe, Shusuke Kuge, Bert L. Semler, Toshihiko Komatsu, Mined Arita, Heihachi Itoh, Akio Nomoto

Virology, 151(1) 21-30, 1986
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