Kohara Michinori - Papers

A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b.

Takashi Imada, Koji Moriya, Masahiko Uchiyama, Naoto Inukai, Mitsuhiro Hitotsuyanagi, Akiko Masuda, Takehiro Suzuki, Shotaro Ayukawa, Yo-Ichi Tagawa, Naoshi Dohmae …

ACS synthetic biology, 7(11) 2537-2546, Nov 16, 2018 Peer-reviewed

MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine.

Okamoto M, Fukushima Y, Kouwaki T, Daito T, Kohara M, Kida H, Oshiumi H

The Journal of biological chemistry, 293(48) 18585-18600, Oct, 2018 Peer-reviewed

Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections.

Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara

Archives of virology, 163(7) 1717-1726, Jul, 2018 Peer-reviewed

Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses.

Hironori Nishitsuji, Keisuke Harada, Saneyuki Ujino, Jing Zhang, Michinori Kohara, Masaya Sugiyama, Masashi Mizokami, Kunitada Shimotohno

Cancer science, 109(1) 241-249, Jan, 2018 Peer-reviewed

Hepatitis C Virus: Viral Quasispecies and Genotypes.

Kyoko Tsukiyama-Kohara, Michinori Kohara

International journal of molecular sciences, 19(1), Dec 22, 2017 Peer-reviewed

Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus

Yusuke Sato, Hideki Matsui, Naoki Yamamoto, Risa Sato, Tsubasa Munakata, Michinori Kohara, Hideyoshi Harashima

JOURNAL OF CONTROLLED RELEASE, 266 216-225, Nov, 2017 Peer-reviewed

Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane

Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo …

SCIENTIFIC REPORTS, 7(1) 15931, Nov, 2017 Peer-reviewed

Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting

Yu Sakurai, Wataru Mizumura, Manami Murata, Tomoya Hada, Shoshiro Yamamoto, Kenichiro Ito, Kazuhiro Iwasaki, Takayuki Katoh, Yuki Goto, Asako Takagi …

MOLECULAR PHARMACEUTICS, 14(10) 3290-3298, Oct, 2017 Peer-reviewed

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/beta-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa …

EBIOMEDICINE, 23 79-87, Sep, 2017 Peer-reviewed

Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys

Tomoko Fujiyuki, Ryo Horie, Misako Yoneda, Takeshi Kuraishi, Fumihiko Yasui, Hyun-jeong Kwon, Keisuke Munekata, Fusako Ikeda, Miho Hoshi, Yuri Kiso …

SCIENTIFIC REPORTS, 7(1) 12017, Sep, 2017 Peer-reviewed

Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri.

Kayesh MEH, Ezzikouri S, Sanada T, Chi H, Hayashi Y, Rebbani K, Kitab B, Matsuu A, Miyoshi N, Hishima T …

Sci Rep., 7(1) 9848-9855, Aug, 2017

Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri

Mohammad Enamul Hoque Kayesh, Sayeh Ezzikouri, Takahiro Sanada, Haiying Chi, Yukiko Hayashi, Khadija Rebbani, Bouchra Kitab, Aya Matsuu, Noriaki Miyoshi, Tsunekazu Hishima …

SCIENTIFIC REPORTS, 7(1) 9848, Aug, 2017 Peer-reviewed

Susceptibility and initial immune response of Tupaia belangeri cells to dengue virus infection

Mohammad Enamul Hoque Kayesh, Bouchra Kitab, Takahiro Sanada, Daisuke Hayasaka, Kouichi Morita, Michinori Kohara, Kyoko Tsukiyama-Kohara

INFECTION GENETICS AND EVOLUTION, 51 203-210, Jul, 2017 Peer-reviewed

Interferon-beta response is impaired by hepatitis B virus infection in Tupaia belangeri

Mohammad Enamul Hoque Kayesh, Sayeh Ezzikouri, Haiying Chi, Takahiro Sanada, Naoki Yamamoto, Bouchra Kitab, Takumi Haraguchi, Rika Matsuyama, Chimene Nze Nkogue, Hitoshi Hatai …

VIRUS RESEARCH, 237 47-57, Jun, 2017 Peer-reviewed

Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles.

Takahiro Sanada, Yuichi Hirata, Yutaka Naito, Naoki Yamamoto, Yoshiaki Kikkawa, Yuji Ishida, Chihiro Yamasaki, Chise Tateno, Takahiro Ochiya, Michinori Kohara

Cellular and molecular gastroenterology and hepatology, 3(2) 272-283, Mar, 2017 Peer-reviewed

Selective inhibitor of Wnt/beta-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model

Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima …

SCIENTIFIC REPORTS, 7(1) 325, Mar, 2017 Peer-reviewed

Immature Core protein of hepatitis C virus induces an unfolded protein response through inhibition of ERAD-L in a yeast model system

Shota Takahashi, Naoko Sato, Junichi Kikuchi, Hideaki Kakinuma, Jun Okawa, Yukiko Masuyama, Singo Iwasa, Hayato Irokawa, Gi-Wook Hwang, Akira Naganuma …

GENES TO CELLS, 22(2) 160-173, Feb, 2017 Peer-reviewed

Corrigendum to 'Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus' [Virology (2014) 157-168].

Yasui F, Kohara M, Kitabatake M, Nishiwaki T, Fujii H, Tateno C, Yoneda M, Morita K, Matsushima K, Koyasu S …

Virology, 499 397-398, Dec, 2016 Peer-reviewed

Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus

Fumihiko Yasui, Yasushi Itoh, Ai Ikejiri, Masahiro Kitabatake, Nobuo Sakaguchi, Keisuke Munekata, Shintaro Shichinohe, Yukiko Hayashi, Hirohito Ishigaki, Misako Nakayama …

SCIENTIFIC REPORTS, 6 37915, Nov, 2016 Peer-reviewed

Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection

Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Takahiro Sanada, Naoki Yamamoto, Edin J. Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto …

FRONTIERS IN IMMUNOLOGY, 7 335, Aug, 2016 Peer-reviewed