2021年2月
Improvement of brain function after surgery in infants with posterior quadrant cortical dysplasia
CLINICAL NEUROPHYSIOLOGY
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- 巻
- 132
- 号
- 2
- 開始ページ
- 332
- 終了ページ
- 337
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.clinph.2020.11.020
- 出版者・発行元
- ELSEVIER IRELAND LTD
Objective: To reveal whether neurodevelopmental outcome of infants after epilepsy surgery can be quantitatively assessed by electroencephalography (EEG) functional connectivity analysis. Methods: We enrolled 13 infants with posterior quadrant dysplasia aged <2 years who were treated using posterior quadrantectomy and 21 age-matched infants. EEG was performed both before and one year after surgery. Developmental quotient (DQ) was assessed both before and 3 years after surgery. The phase lag index (PLI) of three different pairs of electrodes in the nonsurgical hemisphere, i.e., the anterior short distance (ASD), posterior short distance (PSD), and long distance (LD) pairs, were calculated as indices of brain connectivity. The relationship between the PLI and DQ was evaluated.Results: Overall, 77% infants experienced seizure freedom after surgery. The betaand gammarange PLI of PSD pairs increased preoperatively. All these pairs normalized postoperatively. Simple linear regression analysis revealed a significant relationship between the postoperative DQ and the postoperative beta-band PLI of ASD pairs.Conclusion: Preoperative abnormal hyper-connectivity was normalized to the control level after surgery. The postoperative hyperconnectivity was associated with long-term neurodevelopmental improvement. Significance: PLI quantifies neurodevelopmental improvements after posterior quadrantectomy.(c) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.clinph.2020.11.020
- ISSN : 1388-2457
- eISSN : 1872-8952
- PubMed ID : 33450555
- Web of Science ID : WOS:000617547100003