論文

2022年1月16日

Central Taurine Attenuates Hyperthermia and Isolation Stress Behaviors Augmented by Corticotropin-Releasing Factor with Modifying Brain Amino Acid Metabolism in Neonatal Chicks

Metabolites
  • Mohamed Z. Elhussiny
  • ,
  • Phuong V. Tran
  • ,
  • Yuriko Tsuru
  • ,
  • Shogo Haraguchi
  • ,
  • Elizabeth R. Gilbert
  • ,
  • Mark A. Cline
  • ,
  • Takashi Bungo
  • ,
  • Mitsuhiro Furuse
  • ,
  • Vishwajit S. Chowdhury

12
1
開始ページ
83
終了ページ
83
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/metabo12010083
出版者・発行元
MDPI AG

The objective of this study was to determine the effects of centrally administered taurine on rectal temperature, behavioral responses and brain amino acid metabolism under isolation stress and the presence of co-injected corticotropin-releasing factor (CRF). Neonatal chicks were centrally injected with saline, 2.1 pmol of CRF, 2.5 μmol of taurine or both taurine and CRF. The results showed that CRF-induced hyperthermia was attenuated by co-injection with taurine. Taurine, alone or with CRF, significantly decreased the number of distress vocalizations and the time spent in active wakefulness, as well as increased the time spent in the sleeping posture, compared with the saline- and CRF-injected chicks. An amino acid chromatographic analysis revealed that diencephalic leucine, isoleucine, tyrosine, glutamate, asparagine, alanine, β-alanine, cystathionine and 3-methylhistidine were decreased in response to taurine alone or in combination with CRF. Central taurine, alone and when co-administered with CRF, decreased isoleucine, phenylalanine, tyrosine and cysteine, but increased glycine concentrations in the brainstem, compared with saline and CRF groups. The results collectively indicate that central taurine attenuated CRF-induced hyperthermia and stress behaviors in neonatal chicks, and the mechanism likely involves the repartitioning of amino acids to different metabolic pathways. In particular, brain leucine, isoleucine, cysteine, glutamate and glycine may be mobilized to cope with acute stressors.

リンク情報
DOI
https://doi.org/10.3390/metabo12010083
URL
https://www.mdpi.com/2218-1989/12/1/83/pdf
ID情報
  • DOI : 10.3390/metabo12010083
  • eISSN : 2218-1989

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