論文

査読有り 国際誌
2019年10月

Chronic kidney disease and coronary atherosclerosis: evidences from intravascular imaging.

Expert review of cardiovascular therapy
  • Takamasa Iwai
  • ,
  • Yu Kataoka
  • ,
  • Fumiyuki Otsuka
  • ,
  • Yasuhide Asaumi
  • ,
  • Stephen J Nicholls
  • ,
  • Teruo Noguchi
  • ,
  • Satoshi Yasuda

17
10
開始ページ
707
終了ページ
716
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/14779072.2019.1676150

Introduction: In CKD subjects, atherosclerotic cardiovascular disease (ASCVD) is a major cause of their morbidity and mortality (1-3). Current therapeutic guidelines recommend lowering LDL-C level to prevent ASCVD (4, 5). However, it remains uncertain how this therapeutic approach effectively modifies atherosclerosis of CKD. These findings suggest the need to further understand pathophysiology of atherosclerosis. Given that intravascular imaging modalities have contributed to characterize the natural history of coronary atherosclerosis (13-23), the integration of plaque imaging is expected to help to elucidate targets associated with stabilizing atheroma.Areas covered: This review will outline atherogenic stimuli in patients with CKD. In addition, the characteristics of their coronary atheroma will be presented from finding in clinical studies using a variety of intravascular imaging modalities. The efficacy of current guideline recommended anti-atherosclerotic therapies in CKD patients will be also summarized. All related articles were searched through PubMed.Expert opinion: Integration of intravascular imaging has a great potential to establish effective therapies for slowing progression of atherosclerosis in subjects with CKD. More efforts toward searching therapeutic target associated with atherosclerosis of CKD are required. In particular, identifying drivers associated with plaque calcification will lead to the development of new agents which regress calcium accumulation.

リンク情報
DOI
https://doi.org/10.1080/14779072.2019.1676150
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31592685
ID情報
  • DOI : 10.1080/14779072.2019.1676150
  • ISSN : 1477-9072
  • PubMed ID : 31592685

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