論文

国際誌
2020年

Prediction of improvement after extended thymectomy in non-thymomatous myasthenia gravis patients.

PloS one
  • Mitsuteru Yoshida
  • ,
  • Kazuya Kondo
  • ,
  • Naoko Matsui
  • ,
  • Yuishinn Izumi
  • ,
  • Yoshimi Bando
  • ,
  • Michihiro Yokoishi
  • ,
  • Kouichirou Kajiura
  • ,
  • Akira Tangoku

15
10
開始ページ
e0239756
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0239756

BACKGROUND: It is popularly believed that myasthenia gravis (MG) patients show acetylcholine receptor antibody (AChRAb) production associated with the thymus (germinal centers, approximately 80%). It has been suggested that thymectomy can remove the area of autoantibody production. This study aimed to determine whether the solid volume of the thymus calculated using three-dimensional (3D) imaging could be used to predict the efficacy of thymectomy. Additionally, the study assessed the relationships of the solid volume with germinal centers, change in the serum AChRAb level, postoperative MG improvement, and prednisolone (PSL) dose reduction extent. METHODS: This retrospective study included 12 consecutive non-thymomatous MG patients (9 female and 3 male patients), who underwent extended thymectomy at our institution over the last 10 years. The mean patient age was 43.3 ± 14.2 years (range, 12-59 years). The study assessed the number of germinal centers per unit area, change in the serum AChRAb level, postoperative MG improvement, PSL dose reduction extent, and solid volume of the thymus. RESULTS: The number of germinal centers per unit area was significantly correlated with the solid volume of the thymus. The PSL dose reduction extent tended to be correlated with the solid volume. CONCLUSIONS: Our findings suggest that the solid volume of the thymus can possibly predict steroid dose reduction. Additionally, the solid volume of the thymus in 3D images is the most important indicator for predicting the efficacy of extended thymectomy.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0239756
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33017427
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535042
ID情報
  • DOI : 10.1371/journal.pone.0239756
  • PubMed ID : 33017427
  • PubMed Central 記事ID : PMC7535042

エクスポート
BibTeX RIS