論文

2012年10月31日

Synthesis of novel tetrazole C5-linked C <inf>0</inf>- and C <inf>2</inf>-ribonucleoside phosphoramidites using MePOM and POM groups for probing RNA catalysis

Tetrahedron Letters
  • Shinya Harusawa
  • ,
  • Hiroki Yoneyama
  • ,
  • Daiki Fujisue
  • ,
  • Masayoshi Nishiura
  • ,
  • Mihoyo Fujitake
  • ,
  • Yoshihide Usami
  • ,
  • Zheng Yun Zhao
  • ,
  • Scott A. Mcphee
  • ,
  • Timothy J. Wilson
  • ,
  • David M.J. Lilley

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44
開始ページ
5891
終了ページ
5894
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.tetlet.2012.08.082

Novel C5-linked C 0- and C 2-tetrazole ribonucleoside phosphoramidites were designed and synthesized via tetrazole C-nucleosides. Pivaloyloxymethyl (POM) and methyl-substituted POM (MePOM) groups were introduced as N-protecting groups in the tetrazole ring that can be readily removed under mild basic conditions. The phosphoramidites were successfully incorporated into the VS ribozyme substrate and hence providing a chemogenetic approach to determine which nucleobases of ribozymes function as the acid or base, in the studies of ribozyme general acid and base catalysis. © 2012 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.tetlet.2012.08.082
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866746906&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84866746906&origin=inward
ID情報
  • DOI : 10.1016/j.tetlet.2012.08.082
  • ISSN : 0040-4039
  • eISSN : 1873-3581
  • SCOPUS ID : 84866746906

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