論文

2010年8月

Bisphenol A 3,4-quinone induces the conversion of xanthine dehydrogenase into oxidase in vitro

FOOD AND CHEMICAL TOXICOLOGY
  • Satoru Sakuma
  • ,
  • Masahiko Nakanishi
  • ,
  • Kazuhiro Morinaga
  • ,
  • Mihoyo Fujitake
  • ,
  • Shun-ichi Wada
  • ,
  • Yohko Fujimoto

48
8-9
開始ページ
2217
終了ページ
2222
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.fct.2010.05.051
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

In the present study, we assessed the influence of bisphenol A (BPA) and bisphenol A 3,4-quinone (BPAQ) on the conversion of xanthine dehydrogenase (XD) into xanthine oxidase (XO) in the rat liver in vitro. BPA up to 100 mu mol/L did not affect the XO and XD activities in the partially purified cytosolic fraction from rat liver, whereas BPAQ (2-10 mu mol/L) dose-dependently enhanced the XO activity concomitant with a decrease in the XD activity, implying that BPAQ but not BPA, can convert XD into the reactive oxygen species (ROS) producing the form XO. Furthermore, it was found that BPAQ could increase the generation of ROS and oxidize the guanine moiety of deoxyguanosine in the DNA of primary rat hepatocyte cultures. These results suggest that BPAQ has the potential to convert XD into XO in the liver, which in turn may lead to ROS generation and oxidative DNA damage in this region. (C) 2010 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.fct.2010.05.051
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20594952
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000280991100032&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955052231&origin=inward
ID情報
  • DOI : 10.1016/j.fct.2010.05.051
  • ISSN : 0278-6915
  • PubMed ID : 20594952
  • SCOPUS ID : 77955052231
  • Web of Science ID : WOS:000280991100032

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