論文

査読有り
2010年9月

Antitumor Agents. 282. 2 '-(R)-O-Acetylglaucarubinone, a Quassinoid from Odyendyea gabonensis As a Potential Anti-Breast and Anti-Ovarian Cancer Agent

JOURNAL OF NATURAL PRODUCTS
  • Yoshihide Usami
  • Kyoko Nakagawa-Goto
  • Jing-Yu Lang
  • Yoon Kim
  • Chin-Yu Lai
  • Masuo Goto
  • Nobuko Sakurai
  • Masahiko Taniguchi
  • Toshiyuki Akiyama
  • Susan L. Morris-Natschke
  • Kenneth F. Bastow
  • Gordon Cragg
  • David J. Newman
  • Mihoyo Fujitake
  • Koichi Takeya
  • Mien-Chie Hung
  • Eva Y. -H. P. Lee
  • Kuo-Hsiung Lee
  • 全て表示

73
9
開始ページ
1553
終了ページ
1558
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/np100406d
出版者・発行元
AMER CHEMICAL SOC

A new quassinoid, designated 2'-(R)-O-acetylglaucarubinone (1), and seven known quassinoids (2-8) were isolated, using bioactivity-guided separation, from the bark of Odyendyea gabonensis (Pierre) Engler [syn. Quassia gabonensis Pierre]. The structure of 1 was determined by spectroscopic analysis and by semisynthesis from glaucarubolone. Complete H-1 and C-13 NMR assignments of compounds 1-8 were also established from detailed analysis of two-dimensional NMR spectra, and the reported configurations in odyendene (7) and odyendane (8) were corrected. Compound 1 showed potent cytotoxicity against multiple cancer cell lines. Further investigation using various types of breast and ovarian cancer cell lines suggested that 1 does not target the estrogen receptor or progesterone receptor. When tested against mammary epithelial proliferation in vivo using a Brcal/p53-deficient mice model, 1 also caused significant reduction in mammary duct branching.

リンク情報
DOI
https://doi.org/10.1021/np100406d
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000282038800016&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-1642-6538
ID情報
  • DOI : 10.1021/np100406d
  • ISSN : 0163-3864
  • ORCIDのPut Code : 45384754
  • Web of Science ID : WOS:000282038800016

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