2007年
Adrenal participation in thymocyte death by anti-CD3 antibodies in vivo
MICROBIOLOGY AND IMMUNOLOGY
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- 巻
- 51
- 号
- 2
- 開始ページ
- 243
- 終了ページ
- 251
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1348-0421.2007.tb03896.x
- 出版者・発行元
- CENTER ACADEMIC PUBL JAPAN
The deletion of CD4- and CD8-double-positive (DP) cells in the thymus after treatment with anti-CD3 antibodies has long been considered as a useful model for clonal deletion during T cell development, although it was reported that DP cell death was not observed in neonates where self-tolerance should be developing. We dealt with the cellular basis of this enigmatic phenomenon in this report. Due to the similar susceptibility to the antibody-treatment in vitro between neonatal and adult thymocytes, critical factors may be outside rather than within the thymus. Indeed, newborn thymus lobes transplanted into recipients of different ages showed an increased susceptibility to the thymo-toxicity as the age of the recipient increased. The thymo-toxicity seems to be based on the adrenal function of glucocorticoid (GC) synthesis, because administration of an inhibitor of GC synthesis significantly reduced the DP cell death by the antibody-treatment. Finally, adrenalectomy completely prevented DP cell death by anti-CD3 antibodies in adult mice. Therefore, the thymocyte death by anti-CD3 antibodies in vivo may not be due to the T cell-receptor mediated selection in the thymus.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1348-0421.2007.tb03896.x
- ISSN : 0385-5600
- PubMed ID : 17310093
- Web of Science ID : WOS:000244208800011